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Pragmatic vs Explanatory Trials

To the Editor We read with interest the study by Sepehrvand et al, which described secular trends in the conduct of pragmatic or explanatory cardiovascular randomized clinical trials over 2 decades. We believe extension of this thoughtful analysis can provide additional insights into pragmatic vs explanatory trials.




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Pragmatic vs Explanatory Trials—Reply

In Reply We thank Fernandes et al for their interest in our study and agree that this field requires further exploration. Explanatory trials are primed to maximize the likelihood of finding efficacy of an intervention by testing it in an ideal setting, whereas pragmatic trials aim to test effectiveness of an intervention in a more generalizable setting. Hence, they are expected to generate more generalizable results, with the risk understood that there may be more variation in less tightly controlled environments, which may result in differing results.




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Jellyfish : a natural history / Lisa-Ann Gershwin

Gershwin, Lisa-Ann, author




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Perspectives on oceans past : a handbook of marine environmental history / Kathleen Schwerdtner Máñez, Bo Poulsen, editors




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The marine world : a natural history of ocean life / Frances Dipper ; illustrated by Marc Dando

Dipper, Frances, 1951- author




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Aquatic pollution : an introductory text / Edward A. Laws, Los Angeles, US

Laws, Edward A., 1945- author




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History of water. Series III




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The nature state : rethinking the history of conservation / edited by Wilko Graf von Hardenberg, Matthew Kelly, Claudia Leal and Emily Wakild




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Estuarine and coastal hydrography and sediment transport / edited by R.J. Uncles (Plymouth Marine Laboratory), S.B. Mitchell (University of Portsmouth)




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The oceans : a deep history / Eelco J. Rohling

Rohling, Eelco J., author




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Wild sea : a history of the Southern Ocean / Joy McCann

McCann, Joy, 1954- author




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Aquatic ecosystems in a changing climate / editors, H.C. Donat-P. Häder (Department of Biology, Friedrich-Alexander University, Erlangen-Nuremberg, Germany), Kunshan Gao (State Key Laboratory of Marine Environmental Science, Xiamen University, Fujian




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Tricarabrols A–C, three anti-inflammatory sesquiterpene lactone trimers featuring a methylene-tethered linkage from Carpesium faberi

Org. Chem. Front., 2020, Advance Article
DOI: 10.1039/D0QO00093K, Research Article
Jie Yuan, Xuelan Wen, Chang-Qiang Ke, Tian Zhang, Ligen Lin, Sheng Yao, Jason D. Goodpaster, Chunping Tang, Yang Ye
Three anti-inflammatory trimeric compounds constructed from carabrol-type sesquiterpenoids through a methylene-tethered linkage were characterized from Carpesium faberi.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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A laboratory course in nanoscience and nanotechnology / Gérrard Eddy Jai Poinern

Poinern, Gérrard Eddy Jai




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Hunter wine - a history / Julie McIntyre ; John Germov

Hayden Library - TP559.A8 M35 2018




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Chemical projects scale up: how to go from laboratory to commercial / Joe M. Bonem

Online Resource




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Aerosol Science and Technology: History and Reviews / edited by David S. Ensor

Online Resource




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NATURAL HISTORY OF BEER.

Hayden Library - TP577.D48 2019




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The chemical history of lithography / Uzodinma Okoroanyanwu

Online Resource




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Ethnic fermented foods and beverages of India: science history and culture / Jyoti Prakash Tamang, editor

Online Resource




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Back to beer...and hockey: the story of Eric Molson / Helen Antoniou

Hayden Library - TP573.5.M657 A58 2018




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The secret history of RDX: the super-explosive that helped win World War II / Colin F. Baxter

Hayden Library - TP290.R39 B39 2018




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The ministry of Paul the Apostle : history and redaction / G. Roger Greene

Greene, G. Roger, 1944- author




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How the Gospels became history : Jesus and Mediterranean myths / M. David Litwa

Litwa, M. David, author




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A history of the Bible : the book and its faiths / John Barton

Barton, John, 1948- author




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Christobiography : memory, history, and the reliability of the Gospels / Craig S. Keener

Keener, Craig S., 1960- author




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John the Baptist in history and theology / Joel Marcus

Marcus, Joel, 1951- author




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Kyrios Christos : a history of the belief in Christ from the beginnings of Christianity to Irenaeus / Wilhelm Bousset ; with a new introduction by Larry W. Hurtado ; translated by John E. Steely

Bousset, Wilhelm, 1865-1920




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Jesus, skepticism & the problem of history : criteria & context in the study of Christian origins / Darrell L. Bock and J. Ed Komoszewski, editors ; foreword by N.T. Wright




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Story as history--history as story : the gospel tradition in the context of ancient oral history / by Samuel Byrskog

Byrskog, Samuel




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Reception History and Biblical Studies : theory and practice / edited by Emma England and William John Lyons




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Mosaic of joy : a continuing history of multicultural ministry commission / Kay Keng Khoo

Khoo, Kay Keng, author




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History and eschatology : Jesus and the promise of natural theology / N.T. Wright

Wright, N. T. (Nicholas Thomas), author




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The New Testament in its world : an introduction to the history, literature, and theology of the first Christians / N.T. Wright, Michael F. Bird

Wright, N. T. (Nicholas Thomas), author




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Marked for life : a prison chaplain's story / Nancy Hastings Sehested

Sehested, Nancy Hastings, author




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We are Market Basket [electronic resource] : the story of the unlikely grassroots movement that saved a beloved business / Daniel Korschun & Grant Welker

Korschun, Daniel




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What great salespeople do [electronic resource] : the science of selling through emotional connection and the power of story / Michael Bosworth, Ben Zoldan

Bosworth, Michael T





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Product :: Animated Storytelling, 2nd Edition




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Product :: Animated Storytelling, 2nd Edition




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Big History Ebooks Now Available For WH & BHP Classes

Cynthia Stokes Brown wrote BIG HISTORY, SMALL WORLD to help Big History Project students and their teachers, many of whom she knew and befriended in the earliest days of big history education. David Christian's THIS FLEETING WORLD is widely used in AP World History as well as big history courses. BIG HISTORY: A BERKSHIRE ESSENTIAL is a collection of essays by

The post Big History Ebooks Now Available For WH & BHP Classes appeared first on Berkshire Publishing.




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Separate: the story of Plessy v. Ferguson, and America's journey from slavery to segregation / Steve Luxenberg

Hayden Library - KF223.P56 L88 2019




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Regulatory counter-terrorism: a critical appraisal of proactive global governance / Nathanael Tilahun Ali

Dewey Library - KZ7220.A9565 2018




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Good kids, bad city: a story of race and wrongful conviction in America / Kyle Swenson

Dewey Library - KF224.A38 S94 2019




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History and Power in the Study of Law: New Directions in Legal Anthropology.

Online Resource




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Contributory fault and investor misconduct in investment arbitration / Martin Jarrett, University of Mannheim

Dewey Library - K3830.J368 2019




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Blockchain and cryptocurrency: legal and regulatory challenges / Dean Armstrong QC, Dan Hyde, Sam Thomas

Dewey Library - K564.C6 A76 2019




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The governance of credit rating agencies: regulatory regimes and liability issues / Andrea Miglionico, School of Law, University of Reading, UK

Dewey Library - K1096.M54 2019




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High crimes and misdemeanors: a history of impeachment for the age of Trump / Frank O. Bowman III

Dewey Library - KF5075.B69 2019




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Cryptoassets: legal, regulatory, and monetary perspectives / edited by Chris Brummer

Dewey Library - K4431.C786 2019