ces Bearman replaces Magnussen for Haas at Sao Paulo GP By www.bbc.com Published On :: Fri, 01 Nov 2024 21:28:18 GMT Oliver Bearman replaces Kevin Magnussen for the entire Sao Paulo Grand Prix weekend after the Dane had to pull out through illness. Full Article
ces Republicans close in on House. Here are races still to watch By www.bbc.com Published On :: Mon, 11 Nov 2024 11:20:47 GMT Counting is still going on, nearly a week after election day, with Republicans a handful of seats short. Full Article
ces Gold, prices, and jobs: What's at stake in Ghana's elections? By www.bbc.com Published On :: Tue, 12 Nov 2024 00:36:02 GMT In an echo of the US, the current vice-president is up against an ex-president in the 7 December vote. Full Article
ces The London pub where prices jump £2 after 10pm By www.bbc.com Published On :: Tue, 12 Nov 2024 05:35:10 GMT Drinkers at a Soho pub have to pay more for late-night pints as part of a dynamic pricing policy. Full Article
ces Biden Campaign Rejects Trump Campaign Calls For Pre-Debate Inspection For Electronic Earpieces By hispolitica.com Published On :: Tue, 29 Sep 2020 17:58:12 +0000 The Trump campaign wants a third-party inspector to inspect both President Trump and Democratic presidential nominee Joe Biden ears for electronic devices or transmitters prior to Tuesday night’s presidential debate. Trump has consented to the inspection while the Biden campaign has declined. However, according to a source told Floridian Press that the Biden campaign agreed […] The post Biden Campaign Rejects Trump Campaign Calls For Pre-Debate Inspection For Electronic Earpieces appeared first on Hispolitica. Full Article 2020 Election 2020 2020 election 2020 Presidential Race Chris Wallace Cleveland Earpieces fox news Joe Biden Kate Bedingfield president trump Presidential Debate Tim Murtaugh Trump Campaign
ces Princess of Wales to host Christmas carol service again this year By www.bbc.com Published On :: Wed, 13 Nov 2024 06:18:51 GMT The princess has begun to return to some public duties since finishing chemotherapy in September. Full Article
ces Spain braces for torrential rain as new weather system reaches Med coast By www.bbc.com Published On :: Tue, 12 Nov 2024 14:09:57 GMT Two weeks after flash floods devastated eastern Spain, several areas are on alert again. Full Article
ces Coldplay announces fourth show in Ahmedabad on 25 January. Tickets available from… | Today News - Mint By news.google.com Published On :: Wed, 13 Nov 2024 06:38:59 GMT Coldplay announces fourth show in Ahmedabad on 25 January. Tickets available from… | Today News MintColdplay announces new show in Ahmedabad: Check date, how to book tickets and more India TodayColdplay Announces Fourth Concert In India. Check Out Date, Venue And Ticket Prices NDTV MoviesColdplay announces new show in Ahmedabad, check details here CNBCTV18entertainment News Live Today November 13, 2024: Coldplay announced 4th India show in Ahmedabad: Check out ticket sale details Hindustan Times Full Article
ces News24 | ICC chief prosecutor Karim Khan faces sexual misconduct probe By www.news24.com Published On :: Monday Nov 11 2024 20:57:55 The governing body of the International Criminal Court on Monday announced an external investigation into alleged misconduct by chief prosecutor Karim Khan, who has denied the allegations. Full Article
ces News24 | Archbishop of Canterbury Justin Welby announces resignation over abuse scandal By www.news24.com Published On :: Tuesday Nov 12 2024 19:19:02 The leader of the world's Anglican communion, Archbishop of Canterbury Justin Welby, announced Tuesday he was resigning following a damning report that concluded the Church of England covered up a serial abuse case. Full Article
ces velocityconf: Help your dev + ops teams be cross-functional and more successful. http://t.co/1mqGK3zh0U Free webcast 5/22 w/ @lnxchk By twitter.com Published On :: Mon, 20 May 2013 16:58:59 +0000 velocityconf: Help your dev + ops teams be cross-functional and more successful. http://t.co/1mqGK3zh0U Free webcast 5/22 w/ @lnxchk Full Article
ces The Best Places in Brazil for Photography By brendansadventures.com Published On :: Sun, 18 Feb 2024 13:41:25 +0000 I’m not sure why, but Brazil seems to be somewhat overlooked by photographers. It doesn’t quite add up for those who have extensively traveled the country. It’s such a beautiful nation. Hopefully, this guide to the best places in Brazil for photography will encourage a few photographers to give this wonderfully diverse country a chance. In this guide, I’ll delve into some of the top spots to capture stunning photos in Brazil, while also addressing some of the logistical challenges […] The post The Best Places in Brazil for Photography appeared first on Brendan van Son Photography. Full Article Travel Photography Blog Brazil
ces Best early Black Friday MacBook deals: Lowest-ever prices on top models By www.businessinsider.com Published On :: Tue, 12 Nov 2024 18:50:38 +0000 The best early Black Friday MacBook deals include all-time low prices on the latest MacBook Air models. Full Article Deals (Reviews) Reviews Black Friday & Cyber Monday (Reviews) Tech (Reviews) black-friday cyber-monday insider-picks ip-deals deals insider-reviews product-card black-friday-2024
ces 4 Omnichannel Marketing Best Practices for eCommerce By blog.avangate.com Published On :: Wed, 27 Feb 2019 00:00:00 +0000 Nowadays many shoppers don’t even remember how they learned about an eCommerce brand in the first place. If you ask them, the most popular answer is “I found it somewhere on the Internet”. Commercial information is all over the place, so nobody cares about the “channel” they use to find it anymore. Full Article
ces The Efficacy of Digital Media Resources in Improving Children’s Ability to Use Informational Text: An Evaluation of Molly of Denali From PBS KIDS By www.readingrockets.org Published On :: Wed, 31 Aug 2022 14:08:03 EDT Informational text — resources whose purpose is to inform — is essential to daily life and fundamental to literacy. Unfortunately, young children typically have limited exposure to informational text. Two 9-week randomized controlled trials with 263 first-grade children from low-income communities examined whether free educational videos and digital games from the PBS KIDS show “Molly of Denali” supported children’s ability to use informational text to answer real-world questions. Study 1 found significant positive intervention impacts on child outcomes; Study 2 replicated these findings. Full Article
ces Factoring In PayPal Fees When Sending Money Using the Goods and Services Option By www.tipsandtricks-hq.com Published On :: Wed, 12 May 2021 00:48:45 +0000 With more and more online marketplaces popping up, many individuals prefer to pay for items, whether they be new or second hand using the PayPal Goods and Services option. The PayPal ‘Goods and Services’ option gives buyers further peace of mind with the PayPal guarantee. If the seller does not provide what they have described, […] The post Factoring In PayPal Fees When Sending Money Using the Goods and Services Option appeared first on Tips and Tricks HQ. Full Article General Shop Admin Tips Paypal paypal donation PayPal Tutorials Transfer Money
ces Brighter Shores Bank system explained and how to access By readwrite.com Published On :: Tue, 12 Nov 2024 17:21:29 +0000 Since Brighter Shores is a game made by the original co-creator of Runescape, there are many comparisons between the two… Continue reading Brighter Shores Bank system explained and how to access The post Brighter Shores Bank system explained and how to access appeared first on ReadWrite. Full Article Gaming Brighter Shores
ces News24 Business | Facebook, Instagram group bets on normal-looking AR glasses, celeb AI voices By www.news24.com Published On :: Thursday Sep 26 2024 11:49:14 Meta launched AI chatbots voiced by Hollywood celebrities including Judi Dench and John Cena on Wednesday, betting its billions of users are eager to embrace artificial intelligence. Full Article
ces News24 Business | PlayStation 5 Pro goes on sale: But will gamers pay hefty prices? By www.news24.com Published On :: Wednesday Nov 06 2024 14:00:18 The PlayStation 5 Pro hits shops on Thursday with a price tag that has raised eyebrows among gamers, but growing sticker shocks in the tech industry have yet to deter consumers. Full Article
ces News24 | WASTE LAND | Mogale City sewage disaster sees faeces-laden river water testing 100 times above legal limit By www.news24.com Published On :: Tuesday Nov 12 2024 04:45:19 Scientific tests confirm rivers and dams have been poisoned by the raw sewage dumped by the municipality in the Bloubankspruit and Crocodile Rivers, killing aquatic life and destroying businesses and livelihoods. Full Article
ces Travel Trailer Accessories You Absolutely Need (Read This BEFORE Your First Trip) By vagabondish.com Published On :: Fri, 11 Dec 2020 15:57:34 +0000 Iif you're a new owner or just bought your first travel trailer, these are the must-have travel trailer accessories that may not have occurred to you. The post Travel Trailer Accessories You Absolutely Need (Read This BEFORE Your First Trip) appeared first on Vagabondish. Full Article RV Travel travel trailer
ces Trump lies, sows division, and wastes recovery resources as Americans suffer By boingboing.net Published On :: Tue, 01 Oct 2024 15:39:52 +0000 Adjudicated rapist and convicted felon Donald Trump chose to politicize the Federal response to Hurricane Helene, demonstrating little concern about the actual devastation. Responsible leaders who care about the people they govern do not leap into every photo opportunity they can find. — Read the rest The post Trump lies, sows division, and wastes recovery resources as Americans suffer appeared first on Boing Boing. Full Article Post politics
ces Toilet paper buying panic recommences as dockworkers strike By boingboing.net Published On :: Wed, 02 Oct 2024 14:54:07 +0000 We are doing what we do best when something threatens the consumer supply chain: rushing to buy mountains of toilet paper. Experts say the dockworkers' strike won't result in shortages, but the panic-buying might so long as the panic-buying lasts. "They cleaned out the toilet paper at my local Walmart in Virginia. — Read the rest The post Toilet paper buying panic recommences as dockworkers strike appeared first on Boing Boing. Full Article Post consumers mistakes panic strikes toilet paper
ces Online Event Services Industry Continues Evolution By communicationtransformation.blogspot.com Published On :: Fri, 31 Jul 2009 15:40:00 +0000 Steve Vonder Haar recently released an outstanding research report about the online webcasting event services business. He states that consumers of webcasting services have been motivated by two priorities: 1) the desire to keep costs low; and 2) the desire to keep involvement of their own IT departments to a minimum. For this reason, major webcasting event service providers, like ON24, have enjoyed their greatest success at the ends of the market spectrum: low cost self-provisioning services and high touch premium webcasting services.The premium end of the market has been bolstered by the complexity of the client's needs, which has kept fees high and competition at bay. The low end of the market had become increasingly commoditized.He concludes that service providers are going to have to push more to the middle of that spectrum and identify more companies that require well-produced webcasts for the market to continue growing.He also mentions that the complexity of webcast events that has traditionally protected the major service providers is no longer a significant barrier to entry. Sophisticated webcasting software offered on a Software as a Service (SaaS) basis allows any number of production companies, agencies, and event companies to compete on an equal footing with the ON24s and the OnStreams.According to Hoovers, the US marketing and services industry includes about 35,000 companies with combined annual revenue of about $80 billion. The industry is fragmented because the top 50 companies generate less than 40 percent of that revenue. In other words, there are a large number of potential buyers of enterprise webcasting software that want to compete for online event services business at a time when traditional advertising revenues are falling and internet advertising revenues are growing. Internet communications are definitely going to become a greater point of emphasis for these companies.I am unable to attached the report, but you can request a copy at the Interactive Media Strategies website. Full Article
ces Fresh Faces, New Perspectives: Diversity Among New REALTORS® in 2024 By www.nar.realtor Published On :: Wed, 14 Aug 2024 17:57:57 +0000 Diversity Among New REALTORS® in 2024 A notable highlight of the findings in the 2024 NAR Member Profile is that new NAR members are more diverse than their experienced counterparts. By: Amethyst Marroquin Full Article
ces GOP Rep. Luna Says ‘Criminal Prosecutions Necessary’ For Anti-Trump Lawfare Schemers In Government (Video) By conservativefiringline.com Published On :: Sun, 10 Nov 2024 20:15:48 +0000 The following article, GOP Rep. Luna Says ‘Criminal Prosecutions Necessary’ For Anti-Trump Lawfare Schemers In Government (Video), was first published on Conservative Firing Line. As President Donald Trump prepares to re-enter the White House after his landslide victory in Tuesday’s election, a U.S. congresswoman says “criminal prosecutions” are “necessary” for the government officials who have been promoting the massive lawfare campaign against the president-elect. On “Sunday Morning Futures” on the Fox News Channel, host Maria Bartiromo asked U.S. Rep. … Continue reading GOP Rep. Luna Says ‘Criminal Prosecutions Necessary’ For Anti-Trump Lawfare Schemers In Government (Video) ... Full Article Politics criminal Justice lawfare Luna prosecutions schemers Trump
ces Left Already Losing It As Trump Announces Starting Lineup (Video) By conservativefiringline.com Published On :: Tue, 12 Nov 2024 22:15:17 +0000 The following article, Left Already Losing It As Trump Announces Starting Lineup (Video), was first published on Conservative Firing Line. Trump learned some hard lessons from his first kick at the can. This time, he’s not making the same mistakes. Personnel IS policy. Last time around DJT was hamstrung right out of the gate when the Alabama Senator he tapped to be his AG was stuck in purgatory under bogus Russia allegations. The Deep State … Continue reading Left Already Losing It As Trump Announces Starting Lineup (Video) ... Full Article Opinion Politics administration appointments Biden Harris Homan Miller Senate Trump
ces FEMA FAIL: The Claim, The Lie, & The Consequences By clashdaily.com Published On :: Mon, 11 Nov 2024 10:01:00 +0000 Claims that FEMA specifically skipped homes with Trump signs were blown off as 'hoaxes'... until they were proven true. Now the fallout of that story is spreading FAR beyond the official responsible. The post FEMA FAIL: The Claim, The Lie, & The Consequences appeared first on Clash Daily. Full Article News Clash
ces Left Already Losing It As Trump Announces His Starting Lineup (VIDEO) By clashdaily.com Published On :: Tue, 12 Nov 2024 10:20:30 +0000 He learned some hard lessons from his first kick at the can. This time, he's not making the same mistakes. Personnel IS policy. The post Left Already Losing It As Trump Announces His Starting Lineup (VIDEO) appeared first on Clash Daily. Full Article News Clash
ces Flashback: Video of Tom Homan Taking Down AOC Resurfaces, Showing Why Trump Picked Him By www.westernjournal.com Published On :: Tue, 12 Nov 2024 15:27:01 +0000 Shortly after President-elect Donald Trump appointed Tom Homan as “border czar,” the immigration hardliner’s hilarious 2019 smackdown of Democratic Rep. Alexandria Ocasio-Cortez of New York went viral on social media. […] The post Flashback: Video of Tom Homan Taking Down AOC Resurfaces, Showing Why Trump Picked Him appeared first on The Western Journal. Full Article Commentary Alexandria Ocasio-Cortez Border crisis Border security Donald Trump Illegal immigration Trump administration
ces Commentary: Second Assassination Attempt Forces New Reckoning for Trump, Secret Service By deneenborelli.com Published On :: Tue, 17 Sep 2024 14:23:52 +0000 Commentary by Susan Crabtree and Philip Wegmann originally published by The second assassination attempt against former President Donald Trump while he was golfing at one of his Florida courses on Sunday is forcing the United States Secret Service to further tighten security around the Republican presidential nominee and to reevaluate just how much Trump should … Full Article Commentaries News
ces The existence of Zariski dense orbits for endomorphisms of projective surfaces By www.ams.org Published On :: Wed, 16 Oct 2024 14:24 EDT Junyi Xie J. Amer. Math. Soc. 38 (), 1-62. Abstract, references and article information Full Article
ces A novel method produces native light-harvesting complex II aggregates from the photosynthetic membrane revealing their role in nonphotochemical quenching [Bioenergetics] By www.jbc.org Published On :: 2020-12-18T00:06:18-08:00 Nonphotochemical quenching (NPQ) is a mechanism of regulating light harvesting that protects the photosynthetic apparatus from photodamage by dissipating excess absorbed excitation energy as heat. In higher plants, the major light-harvesting antenna complex (LHCII) of photosystem (PS) II is directly involved in NPQ. The aggregation of LHCII is proposed to be involved in quenching. However, the lack of success in isolating native LHCII aggregates has limited the direct interrogation of this process. The isolation of LHCII in its native state from thylakoid membranes has been problematic because of the use of detergent, which tends to dissociate loosely bound proteins, and the abundance of pigment–protein complexes (e.g. PSI and PSII) embedded in the photosynthetic membrane, which hinders the preparation of aggregated LHCII. Here, we used a novel purification method employing detergent and amphipols to entrap LHCII in its natural states. To enrich the photosynthetic membrane with the major LHCII, we used Arabidopsis thaliana plants lacking the PSII minor antenna complexes (NoM), treated with lincomycin to inhibit the synthesis of PSI and PSII core proteins. Using sucrose density gradients, we succeeded in isolating the trimeric and aggregated forms of LHCII antenna. Violaxanthin- and zeaxanthin-enriched complexes were investigated in dark-adapted, NPQ, and dark recovery states. Zeaxanthin-enriched antenna complexes showed the greatest amount of aggregated LHCII. Notably, the amount of aggregated LHCII decreased upon relaxation of NPQ. Employing this novel preparative method, we obtained a direct evidence for the role of in vivo LHCII aggregation in NPQ. Full Article
ces The 2024 US Election: Global Consequences By www.chathamhouse.org Published On :: Tue, 17 Sep 2024 14:32:14 +0000 The 2024 US Election: Global Consequences 26 September 2024 — 5:30PM TO 6:45PM Anonymous (not verified) 17 September 2024 Online This webinar explores what is at stake for US policy in key regions around the globe. In the lead up to the 2024 US presidential election, Chatham House experts discuss:What is at stake for US policy towards China, Europe, and Latin America and what challenges will confront the next US president?Can the US lead when its partners and allies are continually dissatisfied by the new turn in its trade and economic policy?What are the core humanitarian challenges and how can they be addressed? Full Article
ces Fluorescence assay for simultaneous quantification of CFTR ion-channel function and plasma membrane proximity [Methods and Resources] By www.jbc.org Published On :: 2020-12-04T00:06:05-08:00 The cystic fibrosis transmembrane conductance regulator (CFTR) is a plasma membrane anion channel that plays a key role in controlling transepithelial fluid movement. Excessive activation results in intestinal fluid loss during secretory diarrheas, whereas CFTR mutations underlie cystic fibrosis (CF). Anion permeability depends both on how well CFTR channels work (permeation/gating) and on how many are present at the membrane. Recently, treatments with two drug classes targeting CFTR—one boosting ion-channel function (potentiators) and the other increasing plasma membrane density (correctors)—have provided significant health benefits to CF patients. Here, we present an image-based fluorescence assay that can rapidly and simultaneously estimate both CFTR ion-channel function and the protein's proximity to the membrane. We monitor F508del-CFTR, the most common CF-causing variant, and confirm rescue by low temperature, CFTR-targeting drugs and second-site revertant mutation R1070W. In addition, we characterize a panel of 62 CF-causing mutations. Our measurements correlate well with published data (electrophysiology and biochemistry), further confirming validity of the assay. Finally, we profile effects of acute treatment with approved potentiator drug VX-770 on the rare-mutation panel. Mapping the potentiation profile on CFTR structures raises mechanistic hypotheses on drug action, suggesting that VX-770 might allow an open-channel conformation with an alternative arrangement of domain interfaces. The assay is a valuable tool for investigation of CFTR molecular mechanisms, allowing accurate inferences on gating/permeation. In addition, by providing a two-dimensional characterization of the CFTR protein, it could better inform development of single-drug and precision therapies addressing the root cause of CF disease. Full Article
ces High affinity binding of SARS-CoV-2 spike protein enhances ACE2 carboxypeptidase activity [Molecular Bases of Disease] By www.jbc.org Published On :: 2020-12-25T00:06:31-08:00 The novel severe acute respiratory syndrome coronavirus (SARS-CoV-2) has emerged to a pandemic and caused global public health crisis. Human angiotensin-converting enzyme 2(ACE2) was identified as the entry receptor for SARS-CoV-2. As a carboxypeptidase, ACE2 cleaves many biological substrates besides angiotensin II to control vasodilatation and vascular permeability. Given the nanomolar high affinity between ACE2 and SARS-CoV-2 spike protein, we investigated how this interaction would affect the enzymatic activity of ACE2. Surprisingly, SARS-CoV-2 trimeric spike protein increased ACE2 proteolytic activity ∼3-10 fold against model peptide substrates, such as caspase-1 substrate and Bradykinin-analog. The enhancement in ACE2 enzymatic function was mediated by the binding of SARS-CoV-2 spike RBD domain. These results highlighted the potential for SARS-CoV-2 infection to enhance ACE2 activity, which may be relevant to the cardiovascular symptoms associated with COVID-19. Full Article
ces Policy for Recovery in Africa: Rethinking Energy Solutions for Universal Electricity Access By www.chathamhouse.org Published On :: Fri, 20 Nov 2020 15:24:46 +0000 Policy for Recovery in Africa: Rethinking Energy Solutions for Universal Electricity Access 10 December 2020 — 5:00PM TO 6:00PM Anonymous (not verified) 20 November 2020 Online Approximately three quarters of Africa’s population do not have access to clean cooking fuel and face costs to their health. Speakers explore policy opportunities to bridge this gap, the key barriers that remain and the transformative potential of energy transition in delivering sustainable access for all. Speakers explore policy opportunities to bridge the energy access gap, the key barriers that remain and the transformative potential of energy transition in delivering sustainable access for all. African countries face an uphill battle as they confront the shocks of the coronavirus pandemic, seeking recovery in the context of global socio-economic difficulty and fragmented geopolitics. With deficits in terms of governance, public health systems, social protection, and basic service delivery presenting challenges even before the outbreak, careful analysis and creative evidence-based policy solutions, as well as emphasis on implementation, will be crucial if Africa is to progress towards the SDGs and Agenda 2063. The Policy for Recovery in Africa series brings together expert speakers and decision makers to examine and exchange on key challenges, potential solutions, and approaches for implementation. The energy access gap in Africa presents one of the most serious obstacles to the long-term pandemic recovery effort, with almost half of the continent’s population estimated to still lack access to electricity, creating a negative annual GDP impact estimated to be over 25 billion USD. Full Article
ces Targeted Peptide Measurements in Biology and Medicine: Best Practices for Mass Spectrometry-based Assay Development Using a Fit-for-Purpose Approach By www.mcponline.org Published On :: 2014-03-01 Steven A. CarrMar 1, 2014; 13:907-917Technological Innovation and Resources Full Article
ces Complementary Profiling of Gene Expression at the Transcriptome and Proteome Levels in Saccharomyces cerevisiae By www.mcponline.org Published On :: 2002-04-01 Timothy J. GriffinApr 1, 2002; 1:323-333Research Full Article
ces Toward a Comprehensive Atlas of the Physical Interactome of Saccharomyces cerevisiae By www.mcponline.org Published On :: 2007-03-01 Sean R. CollinsMar 1, 2007; 6:439-450Research Full Article
ces Multiplexed Protein Quantitation in Saccharomyces cerevisiae Using Amine-reactive Isobaric Tagging Reagents By www.mcponline.org Published On :: 2004-12-01 Philip L. RossDec 1, 2004; 3:1154-1169Research Full Article
ces Saturday Club introduces young people to international affairs By www.chathamhouse.org Published On :: Thu, 24 Feb 2022 17:15:53 +0000 Saturday Club introduces young people to international affairs News release jon.wallace 24 February 2022 Clubs will help 13-16 year-olds learn more about the forces that are shaping the world and discover how young people can influence the future. National Saturday Club and Chatham House are delighted to announce the launch of the Society&Change Saturday Club. This new programme creates opportunities for UK 13–16-year-olds to develop a global mindset and build awareness of trends that will shape the world in the coming decades. Three pilot Society&Change Clubs will be hosted by the University of Sussex, Manchester Metropolitan University, and the University of Huddersfield. Chatham House will provide speakers and generate ideas for the clubs. National Saturday Club gives 13–16-year-olds across the country the opportunity to study subjects they love at their local university, college or cultural institution, for free. Society&Change Club members will be introduced to a wide range of careers including policy making and diplomacy, advocacy, media and journalism, international trade and business, and the international development and humanitarian sector. Weekly classes will be led by led by professional tutors from the host institutions. Club members will also take part in masterclasses with industry professionals, as well as an end of year summer show and graduation ceremonies. Lucy Kennedy, Chief Executive of the Saturday Club Trust said: ‘We are delighted to be partnering with Chatham House to launch the Society&Change Saturday Club, the sixth subject within the National Saturday Club programme. Over the past 12 years, working nationally with 13–16-year-olds, we have seen that young people are eager to share their hopes and ideas for the future and address the issues the world faces. ‘We hope this new Saturday Club will empower them to shape their own futures and will bring the urgent voice of young people to international debate.’ Rose Abdollahzadeh, Managing Director for Research Partnerships at Chatham House said: ‘We are really excited about the potential for this partnership to encourage young people across the UK to explore their role in the world. The National Saturday Club network will also give Chatham House opportunities to harness the energy, ideas and passion of young people towards positive change. ‘By introducing Club members to contemporary debates on global issues and a range of professions in foreign policy and international relations, our hope is that some Club members will choose to follow a career path into this sector.’ Learn more about the Society&Change Saturday Club. Full Article
ces Health not independence is focus for Sturgeon successor By www.chathamhouse.org Published On :: Wed, 15 Feb 2023 16:36:01 +0000 Health not independence is focus for Sturgeon successor Expert comment NCapeling 15 February 2023 Nicola Sturgeon’s star may have been fading, but Rishi Sunak and Keir Starmer will be relieved at the exit of one of the UK’s most influential politicians. Nicola Sturgeon has left at the right time, maybe even a bit late. Although one of the most influential politicians the UK has seen in recent times, she was also one of the most divisive. Her ability to fan Scotland’s sense of difference from England brought new hope to the independence movement, but this cause – by which she measured herself above all others – has been losing ground and for now, looks to be in abeyance. Neat and disciplined, Sturgeon could not have presented a greater contrast to Boris Johnson in the first months of the pandemic. That was one of her finest moments. She used the powers of the devolved government to make different lockdown decisions for Scotland – never all that different from those in England but often announced just a few hours earlier. Although analysts surmise that these made little difference to the death rate – although poverty and other health support factors make comparisons hard – she used the platform, with the cameras on her, to ram home the point that Scotland could set its own rules. Rallying young voters to independence Her second greatest moment was in the aftermath of Brexit. Scots voted overwhelmingly to stay in the European Union (EU) and so, she argued, they should have the right to leave the UK to join that other union. Younger voters in particular responded, rallying to the independence cause. Neat and disciplined, Sturgeon could not have presented a greater contrast to Boris Johnson in the first months of the pandemic. That was one of her finest moments. But two recent setbacks showed her star was fading. She lost the Supreme Court battle to hold a second independence referendum in November, when she was told Scotland simply did not have the powers to hold one on its own if Westminster said no – and the UK government did just that. It was hard to see how her campaign for independence could move forwards. And her planned reforms to the gender recognition process in Scotland have been blocked by the UK government – but unease about her reforms within Scotland meant this rebuff did not win her the support at home she hoped for. She was also accused of playing politics by pressing ahead with unpopular reforms simply because of their potential to discomfit the UK government. Health, education, and public services need attention Other challenges were also building up and, even if less eye-catching, her successor is likely to focus on health and education above the birth of a new nation. Sturgeon’s critics have long argued that under Scottish National Party rule, health, education, and other public services have declined. In elections, these factors can be eclipsed by passions about independence but it is rare in political life for a leader to be insulated from public anger on this front. This is almost certainly where her successor will want to focus first. Full Article
ces Independent Thinking: Consequences of the Iraq war By www.chathamhouse.org Published On :: Thu, 23 Mar 2023 23:02:24 +0000 Independent Thinking: Consequences of the Iraq war Audio NCapeling 23 March 2023 Episode 20 of our weekly podcast marks 20 years since the invasion of Iraq, with special guest Clare Short who resigned from the UK government over the issue. Launched amid fears that Saddam Hussein was acquiring weapons of mass destruction, the Iraq war changed the Middle East and inflicted huge damage with effects that persist today. This week’s panel examines the war from the perspective of those in power in London when the decision was made to commit UK forces to the invasion, and with those in Iraq who lived with the consequences. Joining Bronwen Maddox is special guest Clare Short, former Secretary of State for International Development, who served in the UK cabinet and resigned after the invasion began, becoming one of the best-known critics of prime minister Tony Blair’s approach to the war. On the panel from Chatham House is Dr Patricia Lewis, director of the International Security programme, and three members of the Middle East and North Africa programme; the director Dr Lina Khatib, senior research fellow Dr Renad Mansour who is also project director of the Iraq Initiative, and research associate Hayder Al-Shakeri. About Independent Thinking A weekly podcast hosted by Chatham House director Bronwen Maddox, in conversation with leading policymakers, journalists, and Chatham House experts providing insight on the latest international issues. Full Article
ces Differential compartmental processing and phosphorylation of pathogenic human tau and native mouse tau in the line 66 model of frontotemporal dementia [Molecular Bases of Disease] By www.jbc.org Published On :: 2020-12-25T00:06:31-08:00 Synapse loss is associated with motor and cognitive decline in multiple neurodegenerative disorders, and the cellular redistribution of tau is related to synaptic impairment in tauopathies, such as Alzheimer's disease and frontotemporal dementia. Here, we examined the cellular distribution of tau protein species in human tau overexpressing line 66 mice, a transgenic mouse model akin to genetic variants of frontotemporal dementia. Line 66 mice express intracellular tau aggregates in multiple brain regions and exhibit sensorimotor and motor learning deficiencies. Using a series of anti-tau antibodies, we observed, histologically, that nonphosphorylated transgenic human tau is enriched in synapses, whereas phosphorylated tau accumulates predominantly in cell bodies and axons. Subcellular fractionation confirmed that human tau is highly enriched in insoluble cytosolic and synaptosomal fractions, whereas endogenous mouse tau is virtually absent from synapses. Cytosolic tau was resistant to solubilization with urea and Triton X-100, indicating the formation of larger tau aggregates. By contrast, synaptic tau was partially soluble after Triton X-100 treatment and most likely represents aggregates of smaller size. MS corroborated that synaptosomal tau is nonphosphorylated. Tau enriched in the synapse of line 66 mice, therefore, appears to be in an oligomeric and nonphosphorylated state, and one that could have a direct impact on cognitive function. Full Article
ces Sinwar’s death does not make Hamas–Fatah reconciliation more likely, whoever his successor may be By www.chathamhouse.org Published On :: Tue, 22 Oct 2024 12:46:19 +0000 Sinwar’s death does not make Hamas–Fatah reconciliation more likely, whoever his successor may be Expert comment jon.wallace 22 October 2024 The killing may aid Hamas recruitment – but it will not make agreement with Fatah any easier to achieve. Western political leaders were quick to argue that Israel’s killing of Hamas leader Yahya Sinwar on 17 October presented an opportunity for a ceasefire in Gaza and the return of Israeli hostages.US President Joe Biden immediately called on Israeli prime minister Benjamin Netanyahu to seize the moment to negotiate, now that Israel has achieved one of its war aims.However, that ‘moment’ has already passed. Israel’s military assault on Gaza has intensified since Sinwar was killed, leading UN Peace Process Co-ordinator Tor Wennesland to say that ‘nowhere is safe in Gaza’. It is abundantly clear Netanyahu is intent on further degrading Hamas, resetting a new ‘power balance’ and carving out a buffer zone, no matter the cost in Palestinian lives or Israeli hostages. But there are other implications of Sinwar’s assassination beyond the zero-sum analysis of will there or won’t there be a ceasefire.Hamas’s ability to fightAt present, everyone has an opinion on how Sinwar’s killing will affect Hamas and its ability to resist and respond to Israel’s military. His death will have been a major blow – symbolically, operationally, and psychologically. Hamas has been downgraded and its capacity to respond compromised.But it will recover, regenerate and retaliate in time – and Sinwar’s death will have been no surprise to Palestinians in Gaza or elsewhere. Hamas is accustomed to seeing its leaders assassinated. Since its formation in 1987, it has been ‘decapitated’ many times, only to continue with its mission to ‘liberate Palestine’. Related content The killing of Yahya Sinwar won’t change the course of the Gaza war Hamas’s portrayal of Sinwar dying in his fatigues, head wrapped in a keffiyeh and resisting until the end will persuade many young Palestinians that he died as a martyr serving the Palestinian cause. Many will be inspired to join and fortify the ranks of Hamas as a result.The IDF’s release of drone footage showing Sinwar’s last moments will have done nothing to undermine his credibility. On the contrary, it will serve as a rallying call to disaffected and disenfranchised young Palestinians horrified by Israel’s bombing of civilian targets in Gaza and disaffected with Fatah’s inability to prevent Israeli settler expansion and violence in the West Bank.ReconciliationSome hope that if Sinwar is replaced by a more ‘moderate’ leader, his killing may smooth the path to Hamas–Fatah reconciliation – and that this could provide a foundation for a patchwork political solution when Israel and Gaza arrive at the ‘day after.’ Prospective new Hamas leaders such as Khaled al Meshaal and Khalil al-Hayya are based in Qatar (and) their ability to influence events on the ground in Gaza will be limited. But the idea that a downgraded and ‘leaderless’ Hamas will be susceptible to international pressure to reconcile with Fatah is divorced from reality. Prospective new Hamas leaders such as Khaled al Meshaal and Khalil al-Hayya are based in Qatar. They may be more pliable to external pressure to reconcile with Fatah in search of a political outcome, but their ability to influence events on the ground in Gaza will be limited. That was demonstrated by the Sinwar-orchestrated attacks on 7 October 2023, which took place without the blessing of the exiled leadership in Doha.Hamas has long gone to ground in Gaza and become far more decentralized than it was before 7 October. It is now more typical of an insurgency, where Hamas cadres exercise a great degree of operational autonomy.In other words, the disconnect between Hamas in Gaza and its political leadership in Qatar has only grown wider since this round of conflict started.International effortsThat will undermine international efforts made by Qatar, Egypt, Saudi Arabia, China, Russia and others to bring about a reconciliation. Moscow and Beijing already hosted reconciliation talks in February and April early this year but made no progress in closing the chasm between the two parties. Saudi Arabia has also hosted talks.The three Arab states, none of which have so far commented publicly on Sinwar’s killing, will likely view his death as an opportunity to bolster the political wing of Hamas – backing it with pledges of political, diplomatic and financial support. Hamas’s military wing is not about to concede ground and reconcile with Fatah. Saudi Arabia and Egypt will have next to no influence over the succession process, but Qatar’s long-established relationship with the political wing of Hamas affords it leverage over the organization, albeit limited. They may be able to strengthen the hand of those based in Doha by promising to work harder at securing a ceasefire, guaranteeing the provision of humanitarian relief, and working towards a political solution. Full Article
ces The UK needs to address growth and debt problems if it is to match resources to ambitions on international priorities By www.chathamhouse.org Published On :: Tue, 05 Nov 2024 09:34:10 +0000 The UK needs to address growth and debt problems if it is to match resources to ambitions on international priorities Expert comment LJefferson 5 November 2024 The budget marks the lowest amount in decades the country has spent on development, and it is struggling to fund other international priorities too. The UK’s Chancellor Rachel Reeves unveiled her much-anticipated budget last week, the first of the new Labour government. Labour is in a difficult place. There are numerous calls on the public purse and public services are not performing well. Meanwhile, public debt remains close to 100 per cent of GDP, and there has been a long run of sluggish growth. Reeves argues with some justification that the previous government left her a challenging inheritance – gaps in this year’s spending plans, and persistent debt questions left unresolved. More importantly, there are longer-term concerns about the sustainability of UK public spending – the country’s Office for Budget Responsibility has warned public debt could triple by the 2070s due to an ageing population, the climate crisis, and security risks. The focus has understandably been on kitchen table questions about tax rises and funding public services. But this picture also has longstanding implications for international policy – on whether the UK can afford to invest in its foreign policy. The Chancellor did announce an increase of £2.9bn for defence. But the question of whether the UK can get on a sustainable path to spending 2.5 per cent of GDP on defence is still being worked through in the ongoing Strategic Review, and remains challenging despite increasingly urgent warnings from parliamentary committees about the UK’s defence readiness. Related content Independent Thinking: Will debt constrain Western foreign policy? The budget also marks one of the lowest amounts in recent years the UK will spend on development overseas, despite setting an ambition to reset relations with the Global South and recover the UK’s role as a leader in international development. The UK needs to either match resources to ambition, spend much more efficiently, or, in the case of the aid budget, it could seek to focus on priorities that are less dependent on spending. But even this will still require consistent resources, alongside significant diplomatic attention, intellectual leadership, and focus.Longer-term, the UK may need to consider larger questions: addressing broader problems with its lack of growth and productivity will be critical to fund an expansive international role.With this budget, UK aid spent overseas is at a historic lowIn 2020 the UK government cut its goal for spending on international development to 0.5 per cent of Gross National Income (GNI), ending a longstanding policy of spending 0.7 per cent. Labour have echoed this, promising to only return to previous levels when fiscal circumstances allow. But this masks a bigger issue. Since 2022, significant amounts of the UK’s aid budget have been spent on accommodation for asylum seekers in the UK. This is within the rules governing aid, but reduces the amount spent on reducing poverty overseas. In 2023 this spending was 28 per cent of the £15.4bn aid budget. In 2016, it was 3.2 per cent. Previous Chancellor Jeremy Hunt quietly allowed a top-up of aid spending over the last two fiscal years to offset how much is being spent at home on asylum seeker accommodation. That provided an additional £2.5 billion for 2022–23 and 2023–24. Related content In conversation with the Rt Hon Anneliese Dodds But Rachel Reeves declined to provide extra funding this time, meaning the amount being spent overseas is likely the lowest its been since 2007 – an effective cut – under a Labour government.The Minister for Development, Anneliese Dodds, speaking at Chatham House last month, said the government is working on clearing the backlog of asylum claims, which should free up more to spend overseas.But beyond this there has been little clarity on plans to address the issue. And costs for asylum seeker accommodation have increased significantly – the UK appears to spend much more than comparator countries per head, according to the Center for Global Development, raising questions about how this spending is managed.Development is not just about money – but money is importantThe UK debate about development has often focused on the 0.7 per cent figure, which can distract from larger questions about what development policy is intended to achieve. As many experts have argued, development aid is about more than spending, and the wider, complex process by which the UK contributes to broad-based growth and stability for poorer countries is not about hitting a specific number. There are things the UK can do that aren’t about spending more directly. This might include focusing on priorities like reforming multilateral development banks so they provide more low-cost public finance, and more flexible and agile loans to poorer countries – a priority echoed by Dodds. It might also incorporate focusing more broadly on helping developing countries attract more investment to bolster growth. The UK debate about development has often focused on the 0.7 per cent figure, which can distract from larger questions about what development policy is intended to achieve. There is also the issue of developing country debt, much of which is held by the private sector. Dodds previously said, when she was shadow chancellor, she might consider changing the law to address this issue. However, she declined to recommit to this when questioned at Chatham House. None of this can be done unilaterally – on debt, for example, the UK has spearheaded some creative policies. Its UK Export Finance body developed climate-resilient debt clauses – agreements that countries can pause debt repayments in the event of a climate shock – but the UK holds limited amounts of developing country debt. Impact will only come by galvanizing and coordinating others to adopt similar approaches. 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