In case you missed the March for Science, last month?  I have the report!  Not that I went, no. Science enthusiasts all, my household was planning on going—  But then my younger teen daughter got felled by "bacteria"—  Possibly brought on by a dubious "pizza day" at her science magnet.

So I spent that Saturday at home, taking care of her— But we streamed the Washington DC and other marches, live on CNN!  So here is my report!

Let's quickly review the main points.  Worldwide, there were 600-plus cities participating, with high levels of enthusiasm.  The March for Science's stated mission was to be a positive, non-partisan march for scientists and scientific principles.  That alone is such a wonderful, counterintuitive idea.  Much humor and wit was seen.

As I did not get to go, and make my own hilarious sign—?  To honor the spirit of the occasion I would like to share two favorite jokes.

First: How do you tell the difference between an introverted and an extroverted mathematician? 
For the whole time the introverted mathematician is talking to you, he looks down at his shoes.  When the extroverted mathematician talks to you, the whole time he looks down at your shoes.  Ba-dum-bum.

I know I used the pronoun "he" in that joke—  As if to imply all left-brained people are male.  But no!  So here's the saying from when I attended Caltech—  Way back in the '80s—  And the male to female ratio was 7 to 1.  "Caltech: where the odds are good, but the good are odd."

Now to some of the funny—and sometimes punny—March for Science signs:

"If you're not the solution, you're the precipitate!"

That was next to: "Protest Cosine, Protest Sine."  Get it?  Protest. . . Sine?  Puns are hard on the radio.  So let's finish with the more "meta": "What do we want?  Evidence based research!  When do we want it?  After peer review!"  

Of course, there were less than non-partisan messages, too.  Just reporting here?  There were signs with the phrases "Black Hole" and "Absolute Zero" ghosted over our president's recognizeable silhouette.  The live feed from San Francisco brought: "Trump believes there's no global warming, as nothing is hotter than Ivanka."

That one made me snort, but I had to quickly tell my daughter, "that is totally inappropriate."
We decided a good sign was: "Mitosis, Not Division."

And a cute one on a dog that everyone can agree on.  "Support Labs."  Labs. 

Next week: Science is Love!

This content is from Southern California Public Radio. View the original story at SCPR.org.

 
So, my 15 year old science magnet daughter and I experienced last month's exciting March for Science—!  From home, as she was temporarily felled by some bacteria.  Consuming an unscientific "cure" of chocolate pudding—?  We watched the march on CNN.

Now, the news changes so quickly you may not remember that just one month ago—?  There were shock waves due to proposed massive federal budget cuts—  Not just to climate change research, but to—surely the more non-controversial —National Institutes of Health.  I mean, health?  Who's anti-health?  Even MacDonald's is serving apple slices now, and kale!

The march was a mix of passion and fun. There were lots of great signs, including one with the classic line: If you're not the solution, you're the precipitate! Marchers came dressed as Einstein, dinosaurs, polar bears.

Then again—  And admittedly, at home, we were wearing bathrobes rather than labcoats—? A couple of humble notes.

 Some of the speakers in DC were less scientists than YouTube science explainers.  And pure research scientists—not to mention philosophers—might question some of the applause lines.  And I quote: "Science is inherently political!"  "Science is objective, but it is not neutral!"  What?  Then some of the marchers chanted back, with a decided New Age lilt: "Science is hope!"  "Science is our planet!"  "Peace, love, science!"  

I heard myself grousing to my daughter: "Sure.  It's like 'Nature.'  To some, 'Nature' is a beautiful flower.  But 'Nature' is also Stage 5 hurricanes and poison frogs who eat their own offspring.  And—and pitcher plants!  Have you seen pitcher plants?" 

The chants continued:  "Health is science!  Safety is science!  Clean water is science!  I yell at the TV: "PS: Nuclear missiles from North Korea?  SCIENCE!"

There were also heartfelt pleas from the stage for more "K-12 hands-on STEM-based learning."  I sympathize. I marched for that when my daughters were in elementary school.  Of course we want our children to be turned on to science—  To the classroom volcanos comically exploding with baking soda. To the wonders of milk carton pea plants, sunny farms of ladybugs.

But eventually, inexorably, comes The Ugly.  The multiplication tables, long division, algebra, trig, then calculus, if a career in science is really being pursued.  I just heard about a senior I know, an exceptional—and well-rounded—student.  He has a 4.5 GPA and almost-perfect SAT's, nosebleed-high!  But he has been shut out by all the UC's he applied to, including his third choice, UC San Diego.  Mwah!  SCIENCE!

Still, quibbles aside, science is the future.  We applaud all, and must forge on. Chocolate pudding recommended.

This content is from Southern California Public Radio. View the original story at SCPR.org.

COVID-19 Research and Development Sean's pick this week is COVID-19 Research and Development by MathWorks. We were recently introduced to this page which highlights uses of... read more >>

A new study has investigated the impacts of human activity on Antarctic Marine and Coastal. Alongside local effects of fishing, pollution and invasive alien species, global climate change is causing sea temperature rises and ocean acidification. Action is therefore needed at all levels to address these impacts.

Full Text:

A new study shows that the West Antarctic Peninsula is experiencing some of the most rapid climate change on Earth, featuring dramatic increases in temperatures, retreats in glaciers and declines in sea ice. The Southern Ocean absorbs nearly half of the carbon dioxide -- the key greenhouse gas linked to climate change -- that is absorbed by all the world's oceans. The study tapped an unprecedented 25 years of oceanographic measurements in the Southern Ocean and highlights the need for more monitoring in the region. The research revealed that carbon dioxide absorption by surface waters off the West Antarctic Peninsula is linked to the stability of the upper ocean, along with the amount and type of algae present. A stable upper ocean provides algae with ideal growing conditions. During photosynthesis, algae remove carbon dioxide from the surface ocean, which in turn draws carbon dioxide out of the atmosphere. From 1993 to 2017, changes in sea ice dynamics off the West Antarctic Peninsula stabilized the upper ocean, resulting in greater algal concentrations and a shift in the mix of algal species. That's led to a nearly five-fold increase in carbon dioxide absorption during the summertime. The research also found a strong north-south difference in the trend of carbon dioxide absorption. The southern portion of the peninsula, which to date has been less impacted by climate change, experienced the most dramatic increase in carbon dioxide absorption, demonstrating the poleward progression of climate change in the region.

Image credit: Drew Spacht/The Ohio State University

NSF documentary about the race against nature to understand and meet the challenges of the rapidly changing Arctic

Source: Streetwise Reports   04/27/2020

Avadel Pharmaceuticals Plc (AVDL:NASDAQ) today announced "positive topline data from its pivotal Phase 3 REST-ON trial assessing the safety and efficacy of FT218, an investigational, once-nightly formulation of sodium oxybate for the treatment of excessive daytime sleepiness and cataplexy in patients with narcolepsy." The firm pointed out that it met all three of the co-primary efficacy endpoints in the study for each of three dosage levels which it claims demonstrates "highly significant, clinically meaningful improvements on the Maintenance of Wakefulness Test, Clinical Global Impression-Improvement and mean weekly cataplexy attacks."

The company's Chief Medical Officer Jordan Dubow, M.D., commented, "We are excited to see these positive topline data from the REST-ON study, where all three dose levels of once-nightly FT218 demonstrated a statistically significant and clinically meaningful improvement on the measures of the two prominent symptoms of narcolepsy, as well as an improvement in overall functioning compared to placebo...Once-nightly FT218 delivered a clinically meaningful response within three weeks of treatment initiation, which was sustained through each treatment period...We think once-nightly FT218, if approved, has the potential to be a meaningful contributor to patient care."

Avadel Pharma's CEO Greg Divis remarked, "The successful outcome of the REST-ON study strengthens our belief that, if approved, once-nightly FT218 has the potential to be a significant advancement for patients in the estimated $1.7 billion twice-nightly sodium oxybate market. Our proprietary market research with physicians and patients informs us that there is a strong interest in a once-nightly sodium oxybate formulation. We look forward to sharing the results from the REST-ON study with the FDA and progressing toward a potential approval that would allow us to bring this important treatment to the patients who need it most. If approved, FT218 would be the first once-nightly therapy to address both excessive daytime sleepiness and cataplexy in patients with narcolepsy."

The REST-ON study is a double-blind, randomized, placebo-controlled Phase 3 trial to assess the efficacy and safety of once-nightly FT218, a formulation of sodium oxybate using Avadel's proprietary Micropump technology for extended-release oral suspension in the treatment of excessive daytime sleepiness and cataplexy in patients suffering from narcolepsy. The company stated that 212 patients were enrolled in the study and result "showed that the 9 g dose of once-nightly FT218 demonstrated a highly significant and clinically meaningful improvement compared to placebo across all three co-primary endpoints."

The company advised that FT218 has been granted Orphan Drug Designation from the U.S. FDA for the treatment of narcolepsy. The firm added that the designation was granted on basis that FT218 may be clinically superior to a formulation of sodium oxybate that is already approved by the FDA for the same indication.

Avadel Pharmaceuticals is biopharmaceutical company headquartered in Dublin, Ireland. The company's primary focus is on the development and potential FDA approval for FT218, which just completed its Phase 3 REST-ON clinical trial for the treatment of narcolepsy patients suffering from excessive daytime sleepiness and cataplexy. The firm also develops and markets sterile injectable drugs for use in hospital settings.

Avadel started off the day with a market capitalization of around $456.2 million with approximately 46.4 million shares outstanding and a short interest of about 14.00%. AVDL shares opened more than 34% higher today at $13.30 (+$3.37, +34.28%) over Friday's $9.83 closing price and reached a new 52-week high price this morning of $13.49. The stock has traded today between $11.90 and $13.49 per share and is currently trading at $12.27 (+$2.44 +24.82%).

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( Companies Mentioned: AVDL:NASDAQ, )

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