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New Brunswick and the liberation of The Netherlands: 75 years later

Canadians helped liberate the Netherlands 75 years ago this week.



  • News/Canada/New Brunswick

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The Stuck-Insider Guide: To finding your inner Wicker Man

IT'S the day after May Day and perhaps you’re feeling you’ve missed out on a good, sweaty Scottish pagan spring ritual of the type done particularly well at Beltane on Edinburgh’s Calton Hill, though not in a year of quarantine. Never fear. There are still ways of channelling the fertility rites of spring, the chief one being, of course, the folk horror classic The Wicker Man. Put on a goat mask, get in touch with your inner Wicker – or even Wicca – and revel in a bit of self-isolation




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Hot List 2020: Anna Acquroff, Francine Toon, SHHE and Helen Sedgwick

ANNA ACQUROFF, MODEL/MUSICIAN




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David Torrance: 'The SNP don’t really want to make nice with wicked Tories in London'

Shortly before the second general election of 1974, the late John P Mackintosh attempted to explain the rise of the Scottish National Party to a predominantly left-wing (and English) audience in an essay for the New Statesman.




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Coronavirus: PPE shipment from China remains at Prestwick Airport due to 'labelling issue'

MILLIONS of face masks to protect Scottish health and care workers against coronavirus could be stuck in limbo at Prestwick airport for a week, it has emerged.




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Telephone Peer Counseling of Breastfeeding Among WIC Participants: A Randomized Controlled Trial

In-person peer counseling to pregnant and new mothers has been shown to improve breastfeeding modestly in three US RCTs. But this level of support for WIC is unlikely to be scaled up nationally in the current fiscal environment.

We randomly assigned WIC clients to a telephone peer counseling program relative to standard WIC support for breastfeeding. Nonexclusive breastfeeding among Spanish-speakers increased at 1, 3, and 6 months, but the program had much less of an effect on English-speaking clients. (Read the full article)




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Wicked Lasers LaserCube

The Wicked Lasers LaserCube is a portable, battery-powered laser projector that can deliver light shows, play games, and even etch wood.




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Wearables Will Be Twice as Popular in 2021

Amid rumors of Apple's upcoming AR glasses, head-mounted displays are looking to be the highest-growth category.






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Move Over Regular Sandwich, Try This Crispy Bombay Toasty For Breakfast Instead

The Bombay toasty is a special sandwich sold on the streets of Bombay which is made with lots of fresh vegetables, mint chutney and butter.



  • Food & Drinks

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WIC participants can now use WIC Farmers’ Market coupons at select Delaware farmers’ markets

Participants in Delaware's Women, Infants and Children (WIC) program can now use special coupons to purchase fresh fruits and vegetables at 11 Delaware farmers' markets under a pilot program beginning this week.



  • Delaware Health and Social Services
  • Department of Agriculture
  • Division of Public Health

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WIC-EBT (eWIC) Processing Services

Agency: HSS Closing Date: 6/2/2020




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'I'm not immune to this': Footballer who TWICE flouted lockdown for orgy & home-cooked meals blames media for HARASSMENT

Manchester City’s Kyle Walker has asked the media to end their “harassment” of him and his family for the sake of his mental health after AGAIN being caught flouting UK lockdown rules to collect home-cooked meals.
Read Full Article at RT.com




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India vs New Zealand, 1st Test: Ruthless Kiwis thrash Virat Kohli’s men by 10 wickets at Basin Reserve

India were all out for 191 in 81 overs in their second innings. New Zealand then scored the 9 runs to win in the second over, wrapping up the opening Test in just over three days.




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IPL matches postponed, broadcaster, franchises on a sticky wicket

IPL’s official broadcaster Star India is staring at big losses after the BCCI on Friday suspended the start of the tournament’s 13th edition this year from March 29 to April 15 in the wake of the COVID-19 pandemic.




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~$CPIL$372150$title$textbox$Wicklow Site Acquisition Part of Wider Irish Expansion Plan - Zoetis$/CPIL$~





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Can Italy strike twice?

Italy’s National Energy Strategy aims to increase wind and solar power’s share of gross final energy consumption by 2030. The country boasts a track record of meeting past renewables targets, but can it be successful once more? Stefania Belisario, associate director, Infrastructure, S&P Global Ratings, assesses the factors either driving or impeding progress.




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New Cable Technology Can Carry Twice as Much Power from Offshore Wind Farms

ABB Ltd. said a power-cable technology that allows offshore wind farms to transmit more than twice the energy of current set-ups will boost orders at the company’s power systems division in coming years.




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Can Italy strike twice?

Italy’s National Energy Strategy aims to increase wind and solar power’s share of gross final energy consumption by 2030. The country boasts a track record of meeting past renewables targets, but can it be successful once more? Stefania Belisario, associate director, Infrastructure, S&P Global Ratings, assesses the factors either driving or impeding progress.




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27. Februar 2020 - IPC veröffentlicht PCB Branchen-Entwicklung für Januar 2020




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26. Februar 2020 - IPC veröffentlicht PCB Branchen-Entwicklung für Februar 2020




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30. April 2020 - IPC veröffentlicht PCB Branchen-Entwicklung für März 2020




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The Wickedness of Gospel Distorters (Galatians 5:7–12)

Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.




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The Best Friend of the Wicked (Matthew 27)

Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.




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Lemon Sandwich Cookies

From Gourmet magazine. -- posted by Vicki Kaye




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Zesty Chicken Barbecue Sandwiches

Source: Gooseberry Patch, adapted -- posted by Sassy J




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Serafin v Malkiewicz – Guidance on responsible journalism

Abstract: This articles reviews the Court of Appeal decision in Serafin v Malkiewicz reversing the dismissal at first instance of a libel claim relating to an article which made serious allegations about the claimant.  The ruling makes clear th...




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Coronavirus: Hong Kong researchers find three-drug combination suppresses virus nearly twice as fast as drug held up as major hope against pandemic

A combination of three drugs suppressed the coronavirus within seven days when used on patients in Hong Kong, nearly twice as fast as a single medicine did, in a result seen as a leading hope in the fight against the pandemic, a study has found.The findings of the research, led by University of Hong Kong academics and published in The Lancet on Saturday, could signal progress in the search for a standard form of therapy for Sars-CoV-2, the virus that causes the Covid-19 disease.It discovered…




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New Brunswick reports no new cases of COVID-19 on Saturday

On Friday the province conducted 397 COVID-19 tests. Since the outbreak began New Brunswick has conducted a total of 17,426 tests.




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Monkeys made their way from Africa to South America at least twice

Two lineages of ancient monkey migrated from Africa to South America more than 30 million years ago. But we’re not sure which ones got there first




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Black people in England and Wales twice as likely to die with covid-19

The latest coronavirus news updated every day including coronavirus cases, the latest news, features and interviews from New Scientist and essential information about the covid-19 pandemic




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Arteries Age Twice as Fast in Smokers

Title: Arteries Age Twice as Fast in Smokers
Category: Health News
Created: 4/26/2010 6:10:00 PM
Last Editorial Review: 4/27/2010 12:00:00 AM




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Exercise Twice a Day Vital for Your Dog's Health, Expert Says

Title: Exercise Twice a Day Vital for Your Dog's Health, Expert Says
Category: Health News
Created: 4/30/2012 6:06:00 PM
Last Editorial Review: 5/1/2012 12:00:00 AM




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Workers With Cluster Headaches Take Twice as Many Sick Days

Title: Workers With Cluster Headaches Take Twice as Many Sick Days
Category: Health News
Created: 2/6/2020 12:00:00 AM
Last Editorial Review: 2/6/2020 12:00:00 AM




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Hepatic Transporter Alterations by Nuclear Receptor Agonist T0901317 in Sandwich-Cultured Human Hepatocytes: Proteomic Analysis and PBPK Modeling to Evaluate Drug-Drug Interaction Risk [Metabolism, Transport, and Pharmacogenomics]

In vitro approaches for predicting drug-drug interactions (DDIs) caused by alterations in transporter protein regulation are not well established. However, reports of transporter regulation via nuclear receptor (NR) modulation by drugs are increasing. This study examined alterations in transporter protein levels in sandwich-cultured human hepatocytes (SCHH; n = 3 donors) measured by liquid chromatography–tandem mass spectrometry–based proteomic analysis after treatment with N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamide (T0901317), the first described synthetic liver X receptor agonist. T0901317 treatment (10 μM, 48 hours) decreased the levels of organic cation transporter (OCT) 1 (0.22-, 0.43-, and 0.71-fold of control) and organic anion transporter (OAT) 2 (0.38-, 0.38-, and 0.53-fold of control) and increased multidrug resistance protein (MDR) 1 (1.37-, 1.48-, and 1.59-fold of control). The induction of NR downstream gene expression supports the hypothesis that T0901317 off-target effects on farnesoid X receptor and pregnane X receptor activation are responsible for the unexpected changes in OCT1, OAT2, and MDR1. Uptake of the OCT1 substrate metformin in SCHH was decreased by T0901317 treatment. Effects of decreased OCT1 levels on metformin were simulated using a physiologically-based pharmacokinetic (PBPK) model. Simulations showed a clear decrease in metformin hepatic exposure resulting in a decreased pharmacodynamic effect. This DDI would not be predicted by the modest changes in simulated metformin plasma concentrations. Altogether, the current study demonstrated that an approach combining SCHH, proteomic analysis, and PBPK modeling is useful for revealing tissue concentration–based DDIs caused by unexpected regulation of hepatic transporters by NR modulators.

SIGNIFICANCE STATEMENT

This study utilized an approach combining sandwich-cultured human hepatocytes, proteomic analysis, and physiologically based pharmacokinetic modeling to evaluate alterations in pharmacokinetics (PK) and pharmacodynamics (PD) caused by transporter regulation by nuclear receptor modulators. The importance of this approach from a mechanistic and clinically relevant perspective is that it can reveal drug-drug interactions (DDIs) caused by unexpected regulation of hepatic transporters and enable prediction of altered PK and PD changes, especially for tissue concentration–based DDIs.




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The view from 95 [STICKY WICKET]

Mole




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SpaceX has plans to fly space tourists twice as high as the ISS

SpaceX and the space tourism firm Space Adventures have announced a plan to fly paying customers into Earth orbit, higher than the International Space Station




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Don't Forget, Michael Flynn Pleaded Guilty. Twice.




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Can you catch the coronavirus twice? We don’t know yet

We don’t have enough evidence yet to know if recovering from covid-19 induces immunity, or whether any immunity would give long-lasting protection against the coronavirus




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Black people in England and Wales twice as likely to die with covid-19

The latest coronavirus news updated every day including coronavirus cases, the latest news, features and interviews from New Scientist and essential information about the covid-19 pandemic




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‘Hamilton’ Meets ‘Wicked’: BroadwayCon Fans Bring the Cosplay

At BroadwayCon, the phrase “I’ve never seen ‘Cats’” draws gasps and painted green witches are as common as colonial gear and trios of Schuyler sisters from the hit musical “Hamilton.” BroadwayCon took over part of the Javits Center in New York this past weekend with fans belting word-perfect renditions of show tunes amid a rotating […]




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Norwich City 0-0 Chelsea: Blues stars rated and slated

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Scientists discover supernova 'twice as bright and energetic' than any ever recorded before

An international team of scientists said two massive stars could have merged before exploding to create the "the most light we have ever seen emitted by a supernova".




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Moment Woolwich Ferry twirls in middle of River Thames in thank you to NHS staff

Follow our live coronavirus updates HERE Coronavirus: The symptoms




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Joe Wicks says he'll be back for PE class on Monday after hand surgery

Joe Wicks says he will be back for his PE class on Monday after undergoing hand surgery.




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Testing positive twice for Covid-19 does not mean people have been reinfected, World Health Organisation says

If someone tests positive for coronavirus more than once, it does not necessarily mean they have been reinfected, according to the World Health Organisation (WHO).




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Danny Pearce death: Man charged with murder after fatal stabbing of young father in Greenwich in 2017




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Astronomers discover supernova 'twice as bright or energetic' as any ever recorded

Death of massive star 4.6 billion light years away could aid search for universe's oldest stars