David Maycock and LeVinc Samuels made a great start to the 2024 PANAM Bowling Champion of Champions, which is being contested at the VIDENA Bowling Center of La Villa Deportiva Nacional [VIDENA] in Lima, Peru. On day one in the doubles, Maycock and Samuels finished 5th after 8 games with a total of 3,081 pins, […]

Second spring senior bowling league action at the Warwick Lanes saw the Pinsplitters fall 4 – 0 to the Blue Angels, the Star Lites defeat the Islanders 3 – 1, and the New Comers defeat the Drifters 3 – 1. Men Handicap Game: Teddy Swainson 250 Michael Vassell 242 Nathan Stevens 235 Handicap Series: Willoughby […]

Second spring senior bowling league action at the Warwick Lanes saw seventh place Star Lites fall 3 – 1 to the league leaders Drifters, third placed New Comers defeat the sixth placed team Islanders 3 – 1, while second placed Blue Angels defeated the fifth placed Last Pin 3 – 1. Men Handicap Game: Michael […]

Second spring senior bowling league action at the Warwick Lanes saw the Blue Angels defeat the Star Lites 3 – 1, the Last Pin and New Comers draw 2 – 2, while the Islanders defeated the Pinsplitters 3 – 1. Men Handicap Game: McNeil Simmons 233 Willoughby Tucker 231 Teddy Swainson 229 Handicap Series: Teddy […]

1. Exclusive: McLennan urges RA to put Super team in Sydney's west with 'NRL's worst nightmare' Suaalii as marquee  The Roar
2. Ten touches and eight magic moments in Suaalii’s stunning debut  Sydney Morning Herald
3. Proof NRL will survive without Suaalii; why Rugby should be thanking league bosses: Crawls  Fox Sports
4. EXCLUSIVE: How new Wallabies 'freak' plans to get even better in encore against Wales  Nine
5. No regrets for Nawaqanitawase after Suaalii’s Wallabies debut  Daily Telegraph

1. Albanese flies to South America on trade rescue mission after Trump victory  Sydney Morning Herald
2. Albanese channels Turnbull in Trump tariff fight  The Australian Financial Review
3. Live: Albanese lands in Peru ahead of APEC forum  ABC News
4. Australia news LIVE: Trade tussle awaits PM at APEC meeting in Peru; Trump’s appointment spree continues  The Age

The city has repeatedly pressed for a special regulation from the national government

Filed under: North America, United States

Continue reading MapQuest Unveils 10 Top Destinations of 2013

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Most fans still have a difficult time picturing Jose Bautista wearing anything besides a Blue Jays uniform. In the future, few will be able to name the three organizations Bautista played for in 2018. Some athletes will always be remembered for wearing one uniform in one city, and Bautista is one of those.

The countdown to pitchers and catchers reporting is down to single digits for all 30 MLB clubs, but as exciting as it is to see the return of Major League stars, it's also a time to dream about the next wave of baseball talent.

The Blue Jays are less than one week away from the start of Spring Training. Here's a brief rundown of everything fans need to know before the Grapefruit League season officially begins.

What unheralded prospect could break out in 2019? Beat reporter Gregor Chisholm answers that and more in this edition of the Inbox.

The Blue Jays spent the past two years clinging to the past. Now, they're embracing the future.

The start of Spring Training is almost here and it's time for the annual tradition of predicting the Blue Jays' 25-man roster. MLB.com will revisit these projections midway through camp, and then again at the end of Spring Training to see how close we came.

Charlie Montoyo is about to embark on the first spring of his managerial career, and based on the number of decisions he has to make, it's going to be a challenging six weeks.

The Blue Jays have followed the lead of several other teams around Major League Baseball by using a Rapsodo machine to analyze spin-rate data. A Rapsodo camer is used to understand how much movement, velocity and spin pitchers are getting on every toss.

The Blue Jays officially added another veteran to their bullpen Saturday morning by signing right-hander John Axford to a Minor League deal with an invitation to Spring Training. Axford hasn't received any guarantees with the short-term contract, but he is a strong candidate to make Toronto's 25-man roster and head north at the end of camp.

Who do the Blue Jays have in the pipeline? Get scouting reports, video, stats, projected ETAs and more for Toronto's Top 30 Prospects on MLB Pipeline's Prospect Watch.

The next five weeks will see lots of shuffling on Major League rosters. Here are the most intriguing positional battles on each of the 30 MLB clubs.

Freddy Galvis conceded things might eventually change, but the veteran infielder is under the impression that he will be the Blue Jays' everyday shortstop at the start of the season.

It's not rare to see former Major League sons in Major League uniforms, but is it unusual to find four in one clubhouse?

The activation of autonomic and hypothalamo-pituitary-adrenal (HPA) systems occurs interdependently with behavioral adjustments under varying environmental demands. Nevertheless, laboratory rodent studies examining the neural bases of stress responses have generally attributed increments in these systems to be monolithic, regardless of whether an active or passive coping strategy is employed. Using the shock probe defensive burying test (SPDB) to measure stress-coping features naturalistically in male and female rats, we identify a neural pathway whereby activity changes may promote distinctive response patterns of hemodynamic and HPA indices typifying active and passive coping phenotypes. Optogenetic excitation of the rostral medial prefrontal cortex (mPFC) input to the ventrolateral periaqueductal gray (vlPAG) decreased passive behavior (immobility), attenuated the glucocorticoid hormone response, but did not prevent arterial pressure and heart rate increases associated with rats’ active behavioral (defensive burying) engagement during the SPDB. In contrast, inhibition of the same pathway increased behavioral immobility and attenuated hemodynamic output but did not affect glucocorticoid increases. Further analyses confirmed that hemodynamic increments occurred preferentially during active behaviors and decrements during immobility epochs, whereas pathway manipulations, regardless of the directionality of effect, weakened these correlational relationships. Finally, neuroanatomical evidence indicated that the influence of the rostral mPFC->vlPAG pathway on coping response patterns is mediated predominantly through GABAergic neurons within vlPAG. These data highlight the importance of this prefrontal->midbrain connection in organizing stress-coping responses and in coordinating bodily systems with behavioral output for adaptation to aversive experiences.

Basolateral amygdala (BLA) neurons are engaged by emotionally salient stimuli. An area of increasing interest is how BLA dynamics relate to evolving reward-seeking behavior, especially under situations of uncertainty or ambiguity. Here, we recorded the activity of individual BLA neurons in male rats across the acquisition and extinction of conditioned reward seeking. We assessed ongoing neural dynamics in a task where long reward cue presentations preceded an unpredictable, variably time reward delivery. We found that, with training, BLA neurons discriminated the CS+ and CS– cues with sustained cue-evoked activity that correlated with behavior and terminated only after reward receipt. BLA neurons were bidirectionally modulated, with a majority showing prolonged inhibition during cued reward seeking. Strikingly, population-level analyses revealed that neurons showing cue-evoked inhibitions and those showing excitations similarly represented the CS+ and behavioral state. This sustained population code rapidly extinguished in parallel with conditioned behavior. We next assessed the contribution of the orbitofrontal cortex (OFC), a major reciprocal partner to the BLA. Inactivation of the OFC while simultaneously recording in the BLA revealed a blunting of sustained cue-evoked activity in the BLA that accompanied reduced reward seeking. Optogenetic disruption of BLA activity and OFC terminals in the BLA also reduced reward seeking. Our data indicate that the BLA represents reward-seeking states via sustained, bidirectional cue-driven neural encoding. This code is regulated by cortical input and is important for the maintenance of vigilant reward-seeking behavior.

God is working to transform lives in Mozambique through the efforts of the local OM team.

Limardes Domingo, an OM worker in Mecula, Mozambique, has seen church growth over two years through God's faithful answers to prayer.

More than 15 years after catching the vision to bring teenagers to TeenStreet Europe, OM worker Markus, serving in Turkey, sees God answer his prayer.

In the midst of the refugee crisis in Greece, OM country leader says OM acts as ‘the glue,’ doing behind-the-scenes work to bond churches and other Christian organisations.

Local man suddenly decides to become a believer, long after workers had given up on his spiritual interest.

A group from the Sharing Lives Course visits a mosque in Lausanne, Switzerland, and learns that greater awareness can lead to greater sensitivity.

Footage released by the Phoenix Police Department shows officers rescuing a man from a car submerged in a swimming pool. The man told authorities that he accidentally stepped on the gas pedal too hard

Podcasts are looking like an increasingly viable channel to engage with customers

Marketers have a lot on their plate these days. Omnichannel shouldn't be an issue anymore

Vitals inquiry expert Miroslava Milenović faces heated scrutiny over qualifications and methods for her role in uncovering complex financial links

Eliminated Ateneo refused to easily let University of the East move on to Final Four of the UAAP Season 87 men’s basketball tournament. The Blue Eagles added to the woes of the Red Warriors with a 71-67 victory on Wednesday at the UST Quadricentennial Pavilion. “I was just very happy with the team today because they played with so much effort and resolve,” coach Tab Baldwin said. SCHEDULE: UAAP Season 87 basketball “When you haven’t been able to gel as well as we would like to as a team throughout the year, it really comes down to effort, and I […]...

Keep on reading: UAAP: Also-ran Ateneo thwarts Final Four hopeful UE

MANILA, Philippines — Parañaque City police arrested three foreign nationals for shooting a Chinese man and for possessing drugs worth P1.2 million during their arrest on Wednesday, Nov. 13. The victim was identified as “Li”, a 35-year-old Chinese national who works as a money changer employee in Parañaque City. He was shot at a residential complex in Barangay Don Galo on Wednesday morning and was taken to Juan De Dios Hospital in Pasay City for treatment. According to the Southern Police District’s (SPD) report, alias “Syncell”, a 32-year-old Filipino online agent who also lives in the complex, witnessed the incident. […]...

Keep on reading: Chinese man shot in Parañaque; suspects with P1.2-M in drugs nabbed

"I’m more concerned about France’s attack on the pitch than anything that might happen off it" Ben Shimon said, regarding possible threats to the upcoming game.

The request requires the approval of ICC judges, but their decision has been delayed, partly because of several rounds of legal filings by Israel that have challenged the court's jurisdiction.

KARACHI: At a time when cities across Punjab are facing the worst air pollution in their history, two members of the ruling coalition on Tuesday made “insensitive” jibes over the issue in their posts on social media.

In his post on X, PPP Chairman Bilawal Bhutto-Zardari shared a chart of the air quality index readings of Pakistan’s major cities on November 10 at 9pm.

The chart showed Peshawar as the most polluted city with an AQI of 591, followed by Multan 573 and Lahore 479. Karachi was 7th with AQI of 78.

“Dear Pakistan, move to Karachi,” wrote Mr Bhutto-Zardari in his post.

Late at night, Defence Minister Khawaja Muhammad Asif said crop burning was unreasonably blamed for the smog when vehicles were the biggest polluters.

He shared a chart showing that total emissions from transport were 127 gigagrams, while that from stubble burning was 5.97gg.

The minister’s post did not mention the chart’s source or when the readings were taken.

He said the chart shows the “real culprits” contributing to the smog, but the people are being misled into believing that stubble burning, which has been going on “since the time of Mohenjo Daro”, was causing the pollution.

In another post, he referred to an order by Lahore High Court Justice Shahid Karim to close markets at 8pm, which was “yet to be implemented”.

According to the minister, the markets in Lahore remained open from 2pm to 2am and blamed the traders for being “intransigent” on this issue.

He also called out political leaders who are not ready to address this issue due to “political expediency”.

Published in Dawn, November 13th, 2024

Security forces killed four terrorists, including a “high-value target”, during an exchange of fire in Balochistan’s Kech district, the military’s media wing said on Wednesday.

According to a statement by Inter-Services Public Relations (ISPR), security forces conducted an intelligence-based operation in the general Balgatar area of Kech District on the “reported presence of terrorists”.

“During [the] conduct of the operation, after an intense fire exchange between own troops and the terrorists, four terrorists including a high-value target, terrorist ring leader Sana [alias] Baru were killed,” the statement said.

It added that the killed terrorist was a focal recruitment agent, “especially suicide bombers, for the so-called Majeed Brigade in District Kech and was highly wanted by the law enforcement agencies.”

A sanitisation operation is being conducted to eliminate any other terrorists found in the area.

Pakistan’s security forces “remain determined to thwart attempts of sabotaging peace, stability and progress of Balochistan,” the statement said.

The country has lately witnessed a sharp uptick in the number of attacks targeting security forces, other law enforcement agencies, and security checkpoints, particularly in Balochistan and KP.

Attacks escalated after the TTP broke a fragile ceasefire agreement with the government in 2022 and vowed to target security forces.

Last Sunday, security forces killed 10 terrorists and injured eight others during three different engagements in North Waziristan.

On Nov 7, security forces killed five terrorists during an exchange of fire in South Waziristan, while four soldiers were martyred in the operation.

In another incident on Nov 4, security forces killed seven terrorists in separate operations, with one terrorist killed in Balochistan and the other six killed during two operations in KP.

Likewise, on November 2, four terrorists were killed during an intelligence-based operation in KP’s South Waziristan region.

SUCCESS Corporation announced the twin-stick roguelite shooter, HEAVEN SEEKER: The Savior of This Cruel World, will launch for the PlayStation 5, PlayStation 4, and Nintendo Switch on December 5.

Read details on the game below:

HEAVEN SEEKER: The Savior of This Cruel World is a twin-stick roguelite shooter where you take your own shot at the castle in the sky! A dungeon with a different structure each time you enter, a variety of magic bullets—and a formidable barrage of bullets—await you.

Story

In this world, Pentagaia, there were five countries that had been transferred from five different worlds.

Magi Province, the land of wizards, where magical technology flourished. A land of priestesses and samurai, a land of warriors and the four seasons. A land of elves, with the blessings of the World Tree. A land of mechanical ingenuity, where super-science rules the world. A land of wilderness and dust, ruled by demons.

The rulers of each nation sent explorers to the Castle of Heaven, where the secrets of Pentagaia were said to lie. They did so with the longing to return to the original world. These explorers were called Heaven Seekers.

Explore a Dungeon That Changes Each Time You Enter

In this title, you move with the left stick and aim with the right stick. This is a bullet hell shooting game where you freely control your character and explore random dungeons. When your HP reaches 0, you will lose all the items you have gained during this exploration. The player gains experience by exploring many times and learning the patterns of the rooms and the nature of the enemies.

Create Your Own Magic Shot!

The shot fired by the player character can be modified by freely combining over 20 customizable items to change its properties. Since items are randomly acquired during each quest, players will fight with a different personalized shot each time they dive into a dungeon.

Dot Art Style Game Visuals

All in-game elements in this title, including player characters, enemies, and dungeons, are rendered in high-quality dot art.

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463057/heaven-seeker-the-savior-of-this-cruel-world-releases-december-5-for-ps5-ps4-and-switch/

Following its Cannes-winning run, French director Jacques Audiard talks about how ‘Emilia Pérez’ reshapes the musical genre, with its lead star’s dazzling spectacle of contradiction and rebirth

‘Aitraaz’ starred Akshay Kumar, Priyanka Chopra Jonas and Kareena Kapoor Khan

<p>On 25 September&nbsp;2024, the Brazilian Society of Rheumatology (SBR,&nbsp;<i>Sociedade Brasileira de Reumatologia</i>) shared its position&nbsp;and consensus&nbsp;on the interchangeability between reference products and biosimilars, a topic of great importance for clinical practice, especially in light of recent regulatory developments by&nbsp;Brazilian Health Regulatory Agency, ANVISA (<i>Agência Nacional de Vigilância Sanitária</i>)&nbsp;and other international authorities.&nbsp;</p>