See nature in close-up in these stunning photographs
Shortlisted for the Close-up Photographer of the Year contest, these images zoom in on animals in all their glory
Shortlisted for the Close-up Photographer of the Year contest, these images zoom in on animals in all their glory
Simple words like "force" and "particle" can mislead us as to what reality is actually like. Physicist Matt Strassler unpacks how to see things more clearly
Claudia de Rham has spent much of her life dedicated to unravelling the true nature of gravity, thinking deeply about gravitons, the hypothetical carrier of this enigmatic force
Simple words like "force" and "particle" can mislead us as to what reality is actually like. Physicist Matt Strassler unpacks how to see things more clearly
A well in Nebraska is the first in the world to have been drilled in search of naturally occurring geologic hydrogen, but tests to determine how much of the gas it might supply are on hold because of a broken pump
Companies are searching all over the world for deposits of geologic hydrogen that could be used as clean fuel, and a mine in Albania could give them clues about where to look
Although the COP16 summit in Colombia ended with some important agreements, countries still aren’t moving fast enough to stem biodiversity loss
Fibres in wet wipes and clothes often make their way into soil - and natural versions could be more damaging than synthetic ones
Shortlisted for the Close-up Photographer of the Year contest, these images zoom in on animals in all their glory
Title: Getting Kids Out in Nature Boosts Lung Health, Study Finds
Category: Health News
Created: 7/27/2022 12:00:00 AM
Last Editorial Review: 7/27/2022 12:00:00 AM
Title: Scientists Unravel Secrets of People Who Naturally Suppress HIV
Category: Health News
Created: 8/26/2020 12:00:00 AM
Last Editorial Review: 8/27/2020 12:00:00 AM
Title: 26 Natural Ways to Lower Your Cholesterol Levels
Category: Health and Living
Created: 7/6/2022 12:00:00 AM
Last Editorial Review: 7/6/2022 12:00:00 AM
Neuronal ceroid lipofuscinoses are a group of neurodegenerative disorders. Recently, enzyme replacement therapy (ERT) was approved for neuronal ceroid lipofuscinosis type 2 (CLN2), a subtype of neuronal ceroid lipofuscinoses. The aim of this study was to quantify brain volume loss in CLN2 disease in patients on ERT in comparison with a natural history cohort using MRI.
Nineteen (14 female, 5 male) patients with CLN2 disease at 1 UK center were studied using serial 3D T1-weighted MRI (follow-up time, 1–9 years). Brain segmentation was performed using FreeSurfer. Volume measurements for supratentorial gray and white matter, deep gray matter (basal ganglia/thalami), the lateral ventricles, and cerebellar gray and white matter were recorded. The volume change with time was analyzed using a linear mixed-effects model excluding scans before treatment onset. Comparison was made with a published natural history cohort of 12 patients (8 female, 4 male), which was re-analyzed using the same method.
Brain volume loss of all segmented brain regions was much slower in treated patients compared with the natural history cohort. For example, supratentorial gray matter volume in treated patients decreased by a mean of 3% (SD, 0.74%) (P < .001) annually compared with an annual volume loss of a mean of 16.8% (SD, 1.5%) (P < .001) in the natural history cohort.
Our treatment cohort showed a significantly slower rate of brain parenchymal volume loss compared with a natural history cohort in several anatomic regions. Our results complement prior clinical data that found a positive response to ERT. We demonstrate that automated MRI volumetry is a sensitive tool to monitor treatment response in children with CLN2 disease.
Veterans are at an increased risk for prostate cancer, a disease with extraordinary clinical and molecular heterogeneity, compared with the general population. However, little is known about the underlying molecular heterogeneity within the veteran population and its impact on patient management and treatment. Using clinical and targeted tumor sequencing data from the National Veterans Affairs health system, we conducted a retrospective cohort study on 45 patients with advanced prostate cancer in the Veterans Precision Oncology Data Commons (VPODC), most of whom were metastatic castration-resistant. We characterized the mutational burden in this cohort and conducted unsupervised clustering analysis to stratify patients by molecular alterations. Veterans with prostate cancer exhibited a mutational landscape broadly similar to prior studies, including KMT2A and NOTCH1 mutations associated with neuroendocrine prostate cancer phenotype, previously reported to be enriched in veterans. We also identified several potential novel mutations in PTEN, MSH6, VHL, SMO, and ABL1. Hierarchical clustering analysis revealed two subgroups containing therapeutically targetable molecular features with novel mutational signatures distinct from those reported in the Catalogue of Somatic Mutations in Cancer database. The clustering approach presented in this study can potentially be used to clinically stratify patients based on their distinct mutational profiles and identify actionable somatic mutations for precision oncology.
The experts behind Beyoncé, Kerry Washington and Serena Williams' tresses reveal their all-time favorite products for natural hair.
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As a Predoctoral Research Fellow at the Belfer Center’s Environment and Natural Resources Program and Science, Technology, and Public Policy Program, Lydia Zemke has spent the last two years studying climate finance in developing countries. As she rounds out her time at the Belfer Center, Zemke she reflects on her research interests, her experience conducting fieldwork in Kenya and Costa Rica, and her advice for other early-career researchers.
hello products are a solution to the struggle at the sink. This advertisement shows the frustrations moms and dads can face when it�s brush time and they need to negotiate with their kids to brush.
Natural Light lamps, handheld solar lamps, are now bringing light and a better life to people in Zambia. The lamps are particularly crucial in Zambia as only 20 per cent of the population have access to electricity. When darkness falls, the remainder live without electric power, with their only light source being paraffin lamps, candles or bonfires. Even childbirth at night must often take place by the light of a mobile phone alone.
While trying to generate XML in java utility in ITR 3, I am getting an error of "Please specify the nature". Please help in solving it. While clicking on error it redirect to schedule BP. I have already selected code under the nature of business. Pls Help
Once again, we take a look at the traditional "if (boolean) return true; else return false;" pattern. But today's, from RJ, offers us a bonus twist.
public override bool IsValid
{
get
{
if (!base.IsValid)
return false;
return true;
}
}
As promised, this is a useless conditional. return base.IsValid
would do the job just as well. Except, that's the twist, isn't it. base
is our superclass. We're overriding a method on our superclass to… just do what the base method does.
This entire function could just be deleted. No one would notice. And yet, it hasn't been. Everyone agrees that it should be, yet it hasn't been. No one's doing it. It just sits there, like a pimple, begging to be popped.
Although the COP16 summit in Colombia ended with some important agreements, countries still aren’t moving fast enough to stem biodiversity loss
Fibres in wet wipes and clothes often make their way into soil - and natural versions could be more damaging than synthetic ones
Thanks to Sivakumar ji for the ID
Hycleus zigzagus Gear: Sony A7 III Blister beetles are beetles of the family Meloidae, so called for their defensive secretion of a blistering agent, cantharidin. About 7,500 species are known worldwide. Many are conspicuous and some are aposematically colored, announcing their toxicity to would-be predators.The flowers of the snakeweed plant are popular with many butterflies, including the
South Asian crimson rose, Malabar banded swallowtail, grass yellow, and hummingbirds. Smaller species of butterflies, like the Common Palmfly and the Bush Browns, are often seen feeding on the flowers. Larger butterflies, like the Polyura and Lexias, have not been seen feeding on the plant.Rusty marsh dart (Ceriagrion olivaceum) (Female here) is a species of damselfly found in south and southeast Asia. Two subspecies are mentioned. Ceriagrion olivaceum olivaceum and Ceriagrion olivaceum aurantiacum.C. o. olivaceum is widespread in India and Southeast Asia and probably the one here C. o. aurantiacum is only known from southwest India. It is a medium-sized damselfly with olivaceous brown capped greenish eyes. Its thorax is olive green, paler on the sides. Female is similar to the male. Male @ http://www.indianaturewatch.net/displayimage.php?id=663008
Rusty marsh dart (Ceriagrion olivaceum) (Male here) is a species of damselfly found in south and southeast Asia. Two subspecies are mentioned. Ceriagrion olivaceum olivaceum and Ceriagrion olivaceum aurantiacum.C. o. olivaceum is widespread in India and Southeast Asia and probably the one here C. o. aurantiacum is only known from southwest India. It is a medium-sized damselfly with olivaceous brown capped greenish eyes. Its thorax is olive green, paler on the sides. Female is similar to the male. Female @ http://www.indianaturewatch.net/displayimage.php?id=662987