Although a robust inflammatory response is needed to combat infection, this response must ultimately be terminated to prevent chronic inflammation. One mechanism that terminates inflammatory signaling is the production of alternative mRNA splice forms in the Toll-like receptor (TLR) signaling pathway. Whereas most genes in the TLR pathway encode positive mediators of inflammatory signaling, several, including that encoding the MyD88 signaling adaptor, also produce alternative spliced mRNA isoforms that encode dominant-negative inhibitors of the response. Production of these negatively acting alternatively spliced isoforms is induced by stimulation with the TLR4 agonist lipopolysaccharide (LPS); thus, this alternative pre-mRNA splicing represents a negative feedback loop that terminates TLR signaling and prevents chronic inflammation. In the current study, we investigated the mechanisms regulating the LPS-induced alternative pre-mRNA splicing of the MyD88 transcript in murine macrophages. We found that 1) the induction of the alternatively spliced MyD88 form is due to alternative pre-mRNA splicing and not caused by another RNA regulatory mechanism, 2) MyD88 splicing is regulated by both the MyD88- and TRIF-dependent arms of the TLR signaling pathway, 3) MyD88 splicing is regulated by the NF-κB transcription factor, and 4) NF-κB likely regulates MyD88 alternative pre-mRNA splicing per se rather than regulating splicing indirectly by altering MyD88 transcription. We conclude that alternative splicing of MyD88 may provide a sensitive mechanism that ensures robust termination of inflammation for tissue repair and restoration of normal tissue homeostasis once an infection is controlled.

(Alfred Wegener Institute, Helmholtz Centre for Polar and Marine Research) Thanks to the support of additional German research vessels, the MOSAiC expedition will continue, despite the coronavirus pandemic. The new team will start in May.

4 March 2020 , Volume 96, Number 2

Invitation Only Research Event

Event participants

Anita Isaacs, Professor of Political Science, Haverford College; Co-Director, Migration Encounters Project
Juan Ricardo Ortega, Principal Advisor for Central America, Inter-American Development Bank
Chair: Amy Pope, Associate Fellow, Chatham House; US Deputy Homeland Security Adviser for the Obama Administration (2015-17)

ROSEAU, Dominica (CMC): A top West Indies Cricket Umpires Association (WICUA) official says regional umpires have also been heavily impacted by the cessation of cricket, stemming from the outbreak of the COVID-19 pandemic. Vivian Johnson, who...

Research Event

Event participants

HE Dr Kayode Fayemi, Minister of Solid Minerals Development, Nigeria
HE Aminu Bello Masari, Governor of Katsina State, Nigeria
Chair: Chi Onwurah MP, Vice Chair, All Party Parliamentary Group on Nigeria

As federal and state governments ramp up efforts to implement the Workforce Innovation and Opportunity Act, these fact sheets compare key characteristics of the foreign born and the U.S. born that are relevant to understanding needs for adult education and workforce training services. The fact sheets cover the United States, the 20 states and 25 counties with the largest immigrant populations, and New York City.

chicken thigh fillets, skinless and cut in to finger length strips 100g melted butter 1 tbsp. native tomato spice mix plum and chilli bottled sauce

North Dakota is the latest state to make a push for integrating Native American or other ethnic studies into school curricula.

Wild plants, Edible.

Rockville, Maryland : The National Institute on Drug Abuse, 1976.

Harjo, a member of the Muskogee Creek Nation, says the appointment "honors the place of Native people in this country, the place of Native people’s poetry"

In 1847, the Choctaw Nation sent $170—more than $5,000 today—to victims of the Irish potato famine

Through their images, these artists combat the stereotypes perpetuated by American history and culture

The first major exhibition of its kind, "Hearts of Our People," boasts 82 pieces from 115 Native women across North America

<span class="topsy_trackback_comment"><span class="topsy_twitter_username"><span class="topsy_trackback_content">Whistleblower-Alternativen, Anonymous-Portrait, Jugendmedienschutz ...: Diese Woche wollen wir pr... http://bit.ly/fed0Um #Whistleblower</span></span>

Penn State is implementing a new opt-in grading system for the spring 2020 semester that will give students flexibility, help preserve GPAs and minimize impacts to students’ transcripts during the academic challenges presented by the novel coronavirus public health crisis.

Investors like something different.

A group of young people were filmed taunting a Native American man and military veteran who was participating in the Indigenous Peoples March.

In the prerotavirus vaccine era, diarrhea-associated hospitalization and outpatient rates among American Indian and Alaska Native children were higher than those among the general US population. Routine rotavirus vaccination has dramatically decreased rotavirus diarrhea burden in the general US population.

Decreases in diarrhea-associated hospitalization and outpatient rates among American Indian and Alaska Native children in postvaccine years were observed in all Indian Health Service regions, with declines greater in each subsequent year after vaccine introduction. (Read the full article)

Complementary and alternative medicine (CAM) use for pediatric asthma is increasing. It is well known that effective asthma management depends on patient adherence to treatment. The authors of previous cross-sectional studies have linked CAM use with decreased adherence to conventional asthma treatment regimens.

This longitudinal data set was unique, allowing us to focus on patients who initiated CAM and to follow subsequent asthma medication adherence. We found that CAM use was not associated with adherence, suggesting that patients may practice CAM alongside conventional therapies. (Read the full article)

Parents are increasingly following alternative immunization schedules. Current studies suggest up to 21% of parents in the United States are intentionally delaying or refusing some or all of the recommended early-childhood vaccines.

This is the first study to use Immunization Information System data to quantify the proportion of children consistently delaying receipt of vaccines. Consistent-limiting children were found to have lower levels of recommended vaccines. (Read the full article)

Disparities in vaccination coverage between American Indian/Alaska Native and white children previously existed between 2001 and 2004 but were not present in 2005.

This study updates a previous study by analyzing data through 2010 and found that these gains have been maintained. (Read the full article)

Complementary and alternative medicine (CAM) use is common among children, especially those with chronic, recurrent, or incurable conditions. Concurrent use of CAM with conventional medications is of concern and needs to be assessed, especially in vulnerable patient populations.

CAM use is high among pediatric cardiology, gastroenterology, neurology, oncology, and respiratory patients, most of whom use CAM concurrently with conventional care. This study provides additional evidence to suggest the use of CAM be included in routine patient history taking. (Read the full article)

Payment arrangements that blend global budgets with pay-for-performance are proliferating. However, little is known about how these contracts affect pediatric health care quality and spending for children with and without special health care needs receiving care from large provider organizations.

A prototypical global budget contract significantly improved preventive care quality measures tied to pay-for-performance, especially for children with special health care needs. It did not alter trends for spending or for quality measures that were not tied to pay-for-performance. (Read the full article)

Hazleton native Megan Bobish has joined the Penn State Hazleton Athletics Department as the newest member of its team.

Instructions for using the new Alternative Grade Calculator and Request Tool in LionPATH are now available for undergraduates and students enrolled in the Graduate School.

Apple started the trend with AirPods, and now completely wire-free earphones are everywhere. But how do they sound? And are they worth the premium? Here's what you need to know, including the best true wireless earbuds we've tested.

You don't need to spend a lot of money for a good pair of true wireless earphones. In fact, you can spend as little as $50.

Teach for America has tapped a longtime teacher and administrator and a member of the new National Advisory Council on Indian Education to lead its fledgling Native Achievement Initiative.

Fin24 took to the streets of Cape Town and Johannesburg asking people to share their views on Finance Minister Pravin Gordhan's Budget Speech.

Programs on Delaware's Lenape and Nanticoke Indian tribes to be featured.

Spotlighting the Lenapé Indian Tribe of Delaware, events will include music, drumming, dancing, crafts and lectures.

With TikTok, Dailyhunt, ShareChat and even OTT players Zee5, Amazon Prime and Hoichoi letting users post, watch and share content in the language of their choice, few are spending considerable time on Facebook.

Delaware’s Native Species Commission will meet at 10 a.m. Wednesday, Feb. 19, in Room 220 at the Kent County Administrative Building, 555 Bay Road, Dover, DE 19901.

The Triber has been projected as a multi utility vehicle that is positioned against 5-seater hatchbacks and is priced lower than them too. In this video, we check out the space, features as well as the engine’s lugging power.

Australian authorities have reported a spike in drug smuggling – but not the kind they usually deal with. Aussies are importing hydroxychloroquine, an anti-malarial medication used as a controversial antidote to Covid-19.
Read Full Article at RT.com

  My name is Antonio De Falco, and I am the creator of the game Planet Conqueror. Having graduated from University as a Game-Designer, I found myself inclined to develop games that are easy to get into...

  Android apps are typically written in Java* because of its elegant object-oriented design and the fact that the Android Software Development Kit (Android SDK) provides cross-platform features in Java....

  Overview With Android x86-based Intel® architecture devices increasing in prominence in the marketplace, the libGDX team set out to ensure developers could seamlessly deploy their games and app...

Kishor said the CM may have brought development in Bihar “in comparison to what Lalu Prasad did” but the development indices remain dismal when compared to other states.

Many workers have moved to their homes, but those who are still in Surat are desperate to move out of Gujarat, as the number of corona positive cases is rapidly surging.

After privacy concerns and a government advisory against popular video conferencing app Zoom, everyone is looking for alternatives.

Is Zoom safe or not? Latest Zoom updates here. Is Zoom safe to download? What are the best Zoom alternatives free? Here’s everything you need to know about Zoom and whether you should continue using Zoom or try a new video conferencing platform instead. We have answered all your queries here and compiled a full […]

The post Zoom Safe? How To Use Safely, Zoom Meetings, Hosting, Top Free Zoom Alternatives first appeared on Trak.in . Trak.in Mobile Apps: Android | iOS.