Birmingham-based Cure Leukaemia has announced record financial results that will see the charity double the amount of funding for research nurses in the West Midlands.

Fire fighters from Highgate, Kings Norton, Ladywood and Northfield fire stations are taking on a job like no other

Fundraisers share their own poignant memories.

For I know the thoughts that I think toward you, saith the LORD, thoughts of peace, and not of evil, to give you an expected end. Jeremiah 29:11

Austin rapper The Teeta breaks down all the reasons he loves "Bohemian Rhapsody" by Queen and how it influenced the direction he took on "Rain" from his latest record  Teeta World. 

13-Apr-2015 18:52.

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Musician, composer, producer, Jeremiah Cymerman may have created the soundtrack to our current circumstance. Not that his project Systema Munditotius, vol. 1 was conceived and produced after the discovery of the CoronaVirus in 2019, but that it may have prophesied this pandemic... [ read more ]

In the old tin mosque in Broken Hill, Samia made a discovery that disproved what historians had thought for more than 40 years.

Colombian student Angelo Romero, unable to fly home due to coronavirus, is receiving emergency treatment in a Brisbane hospital for a shock leukaemia diagnosis, concerned his private health policy won't cover it.

Wide Bay macadamia grower Kate Rose is crediting 'Korean natural farming', which she says improves the microbiology in the soil using indigenous microorganisms, for a large increase in crop yield.

A woman who says she has only been a fan of the iconic rock band Queen for about a year sets the Guinness World Record for clocking up approximately 240 hours, or 10 consecutive days, watching Bohemian Rhapsody in cinemas.

Legendary Australian boxer Troy Waters, a former junior middleweight world title boxing contender, dies at the age of 53 following a long battle with leukaemia.

Considered the birthplace of human civilisation, Mesopotamia (present-day Iraq, and parts of Kuwait, Turkey and Syria) was situated in the fertile valley between the Tigris and Euphrates rivers. What do we know of this ancient civilisation? What characteristics did Mesopotamia have that made it a civilisation?

Aside from a few wild guesses, Izuku had no idea how this had happened. But here he was, about to bear All Might's child, and all he could think to blame it on was a jar of rice.

Najnowsze wiadomości - TVN24 Little Richard, znany między innymi z przeboju "Tutti Frutti", zmarł w sobotę w wieku 87 lat - poinformował na swojej stronie internetowej magazyn "Rolling Stone". Piosenkarz, pianista i pastor jest uważany za jednego z pionierów rock and rolla. https://ift.tt/37OsBj9

Queen guitarist Brian May is sharing his thoughts on the likelihood of a sequel to the band's 2018 biopic

TMZ reports his bond was set at $1,000.

“We live a very as-normal-as-possible life,” she said.

Your VIP ticket to the season’s biggest event.

The Miami Beach danger zone for mosquitoes carrying Zika virus is expanding. This isn't just about microcephaly in developing fetuses. Since Zika attacks neural progenitor cells it might cause lasting damage in adults too. A case of acute sensory polyneuropathy in an adult caused symptoms that lasted for months. It is suspected that Zika causes inflammation of sensory nerves and possibly an auto-immune response. So Zika is bad. What should we do about it? Wipe out the mosquitoes that carry it. Totally drive them to extinction. These mosquitoes are invasive in the Western Hemisphere. If a mosquito causes major health problems for the human species we should just wipe it out. Wiping out a mosquito species could be done with...

Familial dysautonomia (FD) is the most prevalent form of hereditary sensory and autonomic neuropathy (HSAN). In FD, a germline mutation in the Elp1 gene leads to Elp1 protein decrease that causes sympathetic neuron death and sympathetic nervous system dysfunction (dysautonomia). Elp1 is best known as a scaffolding protein within the nuclear hetero-hexameric transcriptional Elongator protein complex, but how it functions in sympathetic neuron survival is very poorly understood. Here, we identified a cytoplasmic function for Elp1 in sympathetic neurons that was essential for retrograde nerve growth factor (NGF) signaling and neuron target tissue innervation and survival. Elp1 was found to bind to internalized TrkA receptors in an NGF-dependent manner, where it was essential for maintaining TrkA receptor phosphorylation (activation) by regulating PTPN6 (Shp1) phosphatase activity within the signaling complex. In the absence of Elp1, Shp1 was hyperactivated, leading to premature TrkA receptor dephosphorylation, which resulted in retrograde signaling failure and neuron death. Inhibiting Shp1 phosphatase activity in the absence of Elp1 rescued NGF-dependent retrograde signaling, and in an animal model of FD it rescued abnormal sympathetic target tissue innervation. These results suggest that regulation of retrograde NGF signaling in sympathetic neurons by Elp1 may explain sympathetic neuron loss and physiologic dysautonomia in patients with FD.

Tres proyectos que proponen mejorar la interacción y la experiencia de los jóvenes usuarios con servicios bancarios móviles, fueron reconocidos hoy por Banorte, IBM y el Tec de Monterrey como resultado del Reto Banorte en el marco de la Semana i, que la institución educativa llevó a cabo del 21 al 25 de septiembre en todo el país.

Dwayne Wade's home features a chef-caliber kitchen, multiple formal and informal living areas, a master suite, wine room, elevator, professional theater and — of course — a basketball court.

Kawhi Leonard scored 30 points, while reserve Landry Shamet scored 19 in the Clippers' 110-103 loss to the Philadelphia 76ers.

In Miami Beach, retired NBA star Dwyane Wade has trimmed the price of his waterfront mansion with a Heat-themed basketball court to $26.5 million.

BOHEMIAN RHAPSODY 2, a possible Freddie Mercury sequel, has had an update from Brian May.

BOHEMIAN RHAPSODY 2, a possible Freddie Mercury sequel, has had an update from Brian May.

BBC News Brasil apresenta situação do país no cenário internacional a partir de cinco dados: taxa de espalhamento da doença, taxa de morte por 1 milhão de habitantes, taxa de teste por mil habitantes, o número de dias que leva para dobrar o total de casos registrados e a previsão do PIB (soma de todas as riquezas produzidas) em 2020 e 2021.

Para Mirian Goldenberg, que pesquisa envelhecimento há 20 anos, "estamos assistindo horrorizados a discursos sórdidos, recheados de estigmas, preconceitos e violências contra os mais velhos".

Observadores do setor preveem mudanças nos aeroportos e no tráfego de pessoas, além de temer demissões em massa, em meio a uma grande incerteza sobre o futuro próximo.

Enquanto o fundador do Facebook, Mark Zuckerberg, apoia medidas de isolamento, Elon Musk, da Tesla, está cada vez mais cético.

Estudo feito com trabalhadores de quatro Estados brasileiros apontou que 89,7% dos entrevistados tiveram ganhos iguais ou menores em relação ao período antes da pandemia.

Eduardo Massad diz que próxima pandemia depois de coronavírus deve ser avassaladora e defende que o mundo aprenda mais sobre medidas de distanciamento social.

Repórter da BBC volta a entrevistar líder de grupo após vídeo que virou meme.

The Amateur Traveler talks to Kara from Miami about her hometown of Miami. Kara tells us Miami is not as it is pictured in TV shows like Miami Vice and Burn Notice (except perhaps that it is filled with beautiful people). She tells us about some of her favorite hotels and restaurants as well as cafes where you can sit and people watch. Miami is known for its beach life and Kara tells us where the daring can go to bare all or where you can find a quiet spot away from the tourists. Increasingly Miami is known for its fashion district and its food scene. The summers are hot but offer some of the best bargains on restaurants, hotels and spas… if you can deal with the humidity. Miami defines hot in all senses of the word. So whether you want to see snowbirds or eat stone crabs, Miami might be a place you should check out.

News

Muslim hostess and Disney still at odds over headscarf
French Flight Attendant Arrested for Stealing Cash and Jewels From Sleeping Passengers’ Pockets and Carry-Ons

Show Notes

Diamond PR
Miami Vice
Burn Notice
Haulover Beach
South Pointe Park
Top Ten Miami Restaurants
Brickell, Miami
Key Biscayne
Miami Museums
Miami Design District
Van Dyke Cafe
Miami Spice Restaurant Month
Miami Spa Month
Neighborhoods of Miami
Miami Design District
Michael’s Genuine Food and Drink
Calle Ocho Festival
South Beach Food and Wine Festival
Miami Public Transportation
Fontainebleau
Miami Heat
Miami Heat Tickets
Smith and Wollensky
Red, the Steakhouse
Joe’s Stone Crabs
Adrianne Arsht Center
Snowbirds

Community

Scott enjoyed the group interview in Travel to Namibia – Episode 243
Tricia hits the road
Amateur Traveler guest post guidelines
Amateur Traveler site redesign to add countries

Hear about travel to South Florida (Miami, Everglades National Park, and the Florida Keys) as the Amateur Traveler talks to Erik Smith from onmyfeetorinmymind.com about this diverse region.

Previous studies have shown that sphingosine kinase interacting protein (SKIP) inhibits sphingosine kinase (SK) function in fibroblasts. SK phosphorylates sphingosine producing the potent signaling molecule sphingosine-1-phosphate (S1P). SKIP gene (SPHKAP) expression is silenced by hypermethylation of its promoter in acute myeloid leukemia (AML). However, why SKIP activity is silenced in primary AML cells is unclear. Here, we investigated the consequences of SKIP down-regulation in AML primary cells and the effects of SKIP re-expression in leukemic cell lines. Using targeted ultra-HPLC-tandem MS (UPLC-MS/MS), we measured sphingolipids (including S1P and ceramides) in AML and control cells. Primary AML cells had significantly lower SK activity and intracellular S1P concentrations than control cells, and SKIP-transfected leukemia cell lines exhibited increased SK activity. These findings show that SKIP re-expression enhances SK activity in leukemia cells. Furthermore, other bioactive sphingolipids such as ceramide were also down-regulated in primary AML cells. Of note, SKIP re-expression in leukemia cells increased ceramide levels 2-fold, inactivated the key signaling protein extracellular signal-regulated kinase, and increased apoptosis following serum deprivation or chemotherapy. These results indicate that SKIP down-regulation in AML reduces SK activity and ceramide levels, an effect that ultimately inhibits apoptosis in leukemia cells. The findings of our study contrast with previous results indicating that SKIP inhibits SK function in fibroblasts and therefore challenge the notion that SKIP always inhibits SK activity.

Pierre Lairez
J. Amer. Math. Soc. 33 (2019), 487-526.
Abstract, references and article information

Treatment of patients with chronic lymphocytic leukemia (CLL) with inhibitors of Bruton's tyrosine kinase (BTK), such as ibrutinib, is limited by primary or secondary resistance to this drug. Examinations of CLL patients with late relapses while on ibrutinib, which inhibits BTK's catalytic activity, revealed several mutations in BTK, most frequently resulting in the C481S substitution, and disclosed many mutations in PLCG2, encoding phospholipase C-γ2 (PLCγ2). The PLCγ2 variants typically do not exhibit constitutive activity in cell-free systems, leading to the suggestion that in intact cells they are hypersensitive to Rac family small GTPases or to the upstream kinases spleen-associated tyrosine kinase (SYK) and Lck/Yes-related novel tyrosine kinase (LYN). The sensitivity of the PLCγ2 variants to BTK itself has remained unknown. Here, using genetically-modified DT40 B lymphocytes, along with various biochemical assays, including analysis of PLCγ2-mediated inositol phosphate formation, inositol phospholipid assessments, fluorescence recovery after photobleaching (FRAP) static laser microscopy, and determination of intracellular calcium ([Ca2+]i), we show that various CLL-specific PLCγ2 variants such as PLCγ2S707Y are hyper-responsive to activated BTK, even in the absence of BTK's catalytic activity and independently of enhanced PLCγ2 phospholipid substrate supply. At high levels of B-cell receptor (BCR) activation, which may occur in individual CLL patients, catalytically-inactive BTK restored the ability of the BCR to mediate increases in [Ca2+]i. Because catalytically-inactive BTK is insensitive to active-site BTK inhibitors, the mechanism involving the noncatalytic BTK uncovered here may contribute to preexisting reduced sensitivity or even primary resistance of CLL to these drugs.

Margrit Schwarz
Sep 1, 1998; 39:1833-1843
Articles

Tratamento genético foi testado em Layla Richards que estava desenganada pelos médicos. Especialistas ressaltam que os resultados são iniciais e podem não ocorrer em outros pacientes.

The post Terapia inédita reverte leucemia incurável em bebê de 1 ano appeared first on Saúde Próspera.

Dongming Wang, Rina Dong and Chenqi Mou
Math. Comp. 89 (2020), 1993-2015.
Abstract, references and article information

Ekta Singh
Nov 1, 2012; 25:217-221
From Research to Practice

John Zrebiec
Oct 1, 2006; 19:212-215
Clinical Decision Making