The present invention provides variable mass labeling reagents, a set of the variable mass labeling reagents, and a multiplexed set of variable mass labeling reagents.

The present invention provides processes for the manufacturing of polypeptide conjugates. In particular, the invention provides methods for the purification of polypeptide conjugates, which include at least one polymeric modifying groups, such as a poly(alkylene oxide) moiety. Exemplary poly(alkylene oxide) moieties include poly(ethylene glycol) (PEG) and poly(propylene glycol). In an exemplary process, hydrophobic interaction chromatography (HIC) is used to resolve different glycoforms of glycoPEGylated polypeptides.

The present invention relates to treating a tissue in a mammal from the effects of reperfusion using flagellin.

A machine which provides for both leaf stripping and grading can be used to process plants, such as burley tobacco plants, by continuously moving the plants in a first direction while simultaneously varying the position of the plants in a second direction relative to a defoliating apparatus. The plants may be moved horizontally through a machine by a transporter engaging the plant stalks while the vertical distance between the transporter (and thus the plants) is varied relative to the defoliating apparatus. The transporter and defoliating apparatus may be positioned at an angle to one another. Due to the changing amount of vertical distance, leaves from different sections of the plants, such as leaves at different stalk heights, can be contacted and removed at different corresponding horizontal locations in the machine. Accordingly, leaves can be graded based on the location(s) from which they are retrieved after removal.

Methods and systems for extending or stretching muscles on an animal carcass by separating a hip joint of the carcass. Hip joint separation may be carried out while the carcass is suspended from a conveyor system as part of a commercial meat processing operation.

A knife having a hook incorporated into the blade for skinning, wherein the hook is a belly hook that is positioned on the belly side or under side of the knife opposite a finger guard area. Methods of the using the knife include steps for using the cutting edge to cut and using the hook to cut by pressure applied away from the user's body.

Collectable fingerprinted items, and methods of making such fingerprinted items, including original and simulated fingerprints for application to an item to create a collectable item. The processes may be used to create a variety of collectable items, such as instrument picks, pendants, key fobs, charms, and other collectables. The process includes taking an original fingerprint impression, using the original impression to create a simulated fingerprint impression. The methods optionally include altering at least one identifying characteristic in a manner that prevents identity theft of other misuse of the fingerprint impression. The process optionally includes applying the simulated fingerprint impression to an item, such as by making a mold incorporating the simulated fingerprint, such as by using CAD/CAM technology and molding an item using the created mold.

A server for facilitating real-time betting, wherein the server communicates with clients via a distributed computing network. The server includes a memory storing an operating system, an instruction set, event data related to a sporting event, gambler data related to gamblers participating in a competition based upon the sporting event and site data related to electronic pages associated with the real-time para-mutuel betting. A processor runs the instruction set and communicates with the memory and the distributed computing network. The processor is operative to enroll the gamblers by presenting betting rules associated with the sporting event, collect wagering from the gamblers, accept predictions for discrete events within the sporting event from each gambler and determine a first winner of the competition based upon the predictions. Applications include lotteries with entries received from mobile devices.

Apparatus and method for secure transactions between gaming machines and portable devices are described. The secure transactions may include a transfer of an amount of an indicia of credit with a cash value from the portable device to the gaming machine or a transfer of an amount of an indicia of credit with a cash value from the gaming machine to the portable device. A logic device, separate from a master gaming controller on the gaming machine and placed in the gaming machine, may be operable to authenticate a portable device, such as a smart card, and authorize transactions involving transfers of indicia of credit between the portable device and the gaming machine. The logic device may be operable to send authentication information relating to the portable device to a remote host where a value amount of transactions involving the portable device authorized by the logic device may be higher when the logic device and the remote host authenticate the portable device as opposed to when the portable is only authenticated by the logic device.

A system and method may provide sets or packets of playing cards for forming part or all of a hand of playing cards. Each set or packet may be formed before starting to form another set or packet. Sets or packets may be formed in respective playing card receiving compartments. The playing cards may be withdrawn from a plurality of playing card receiving compartments of an intermediary playing card receiver in random or pseudo-random fashion, which may, or may not, be based at least in part on the selected payout or house odds and/or house advantage.

Mechanisms and methods for clamping force generation are described. In one embodiment, a clamping force generator system includes a permanent magnet bearing coupled to a traction ring and to a torque coupling. The traction ring can be provided with an electromagnetic bearing rotor and the torque coupling can be provided with an electromagnetic bearing stator. In some embodiments, a mechanical load cam, a permanent magnet bearing, and an electromagnetic bearing cooperate to generate a clamping force between the traction rings, the power rollers, and the idler. In other embodiments, a series of permanent magnet bearings and a mechanical bearing are configured to produce a clamping force. In one embodiment an electromagnetic bearing is coupled to a control system and produces an optimal clamping force that is associated with a torque transmitted in the transmission during operation. In some embodiments, a mechanical load cam produces a clamping force proportional to torque, while a permanent magnet bearing provides a minimum clamping force.

Inventive embodiments are directed to components, subassemblies, systems, and/or methods for infinitely variable transmissions (IVT). In one embodiment, a control system is adapted to facilitate a change in the ratio of an IVT. In another embodiment, a control system includes a carrier member configured to have a number of radially offset slots. Various inventive carrier members and carrier drivers can be used to facilitate shifting the ratio of an IVT. In some embodiments, the traction planet assemblies include planet axles configured to cooperate with the carrier members. In one embodiment, the carrier member is configured to rotate and apply a skew condition to each of the planet axles. In some embodiments, a carrier member is operably coupled to a carrier driver. In some embodiments, the carrier member is configured to couple to a source of rotational power. Among other things, shift control interfaces for an IVT are disclosed.

Disclosed here are inventive systems and methods for a powertrain of an electric vehicle (EV). In some embodiments, said powertrain includes a continuously variable transmission (CVT) coupled to an electric drive motor, wherein a control system is configured to control the CVT and/or the drive motor to optimize various efficiencies associated with the EV and/or its subsystems. In one specific embodiment, the control system is configured to operate the EV in an economy mode. Operating in said mode, the control system simultaneously manages the CVT and the drive motor to optimize the range of the EV. The control system can be configured to manage the current provided to the drive motor, as well as adjust a transmission speed ratio of the CVT. Other modes of operation are also disclosed. The control system can be configured to manage the power to the drive motor and adjust the transmission speed ratio of the CVT taking into account battery voltage, throttle position, and transmission speed ratio, for example.

Inventive embodiments are directed to components, subassemblies, systems, and/or methods for continuously and infinitely variable transmissions (IVT). In one embodiment, a variator is adapted to receive a control system that cooperates with a shift nut to actuate a ratio change in an IVT. In another embodiment, a neutral lock-out mechanism is adapted to cooperate with the variator to, among other things, disengage an output shaft from a variator. Various inventive mechanical couplings, such as an output engagement mechanism, are provided to facilitate a change in the ratio of an IVT for maintaining a powered zero operating condition. In one embodiment, the output engagement mechanism selectively couples an output member of the variator to a ratio adjuster of the variator. Embodiments of a ratio adjuster cooperate with other components of the IVT to support operation and/or functionality of the IVT. Among other things, user control interfaces for an IVT are disclosed.

A method of controlling a prime mover and a continuously variable transmission (CVT) is described. The CVT has a group of spherical power adjusters. Each power adjuster has a tiltable axis of rotation. A method of optimizing a vehicle having a drive motor and a continuously variable transmission is also described. The CVT has a plurality of spherical power adjusters, each power adjuster having a tiltable axis of rotation. A drive system having a prime mover and a continuously variable transmission can be optimized in another method.

Systems and methods are provided that may be implemented to provide a mechanical indicator to correlate magnetic disk drive IOP performance with features of mechanical and/or acoustic vibrational frequencies that are generated and captured or sensed outside of the disk drive itself. In one example, disk drive PES data may be collected concurrently with the capture of mechanical and/or acoustic vibrational data at different and progressive locations of vibration source, vibration path and vibration receiver in a disk drive operating environment, e.g., such as for disk drives installed within a server and/or storage chassis enclosure. In such case, PES threshold may be utilized to correlate performance of Drive IOP or drive servo-mechanical performance as a function of measured characteristics of vibration source/s that impart vibration to a disk drive.

Recording heads for data storage systems are provided. Recording heads illustratively include a write pole, a bumper, a dielectric layer, and a surface. In some embodiments, a portion of the surface includes portions of the write pole, bumper, and dielectric layer. The write pole, bumper, and dielectric layer are illustratively made from materials that have polishing rates. In some embodiments, the polishing rate for the write pole material is more similar to the polishing rate for the bumper material than it is to the polishing rate for the dielectric layer material.

A dual-stack read sensor is utilized in a storage device having an actuator arm that positions the read sensor over a rotating storage medium. The dual-stacked read sensor includes a primary read sensor having a first set of read sensor characteristics and a secondary read sensor having a second set of read sensor characteristics that differ from the first set of read sensor characteristics, wherein the secondary read sensor is positioned relative to the primary read sensor to be radially offset from the primary read sensor relative to a data track being read.

Methods for providing magnetic storage elements with high magneto-resistance using Heusler alloys are provided. One such method includes depositing a substrate including NiFe, depositing a seed layer on the substrate, depositing a buffer layer on the seed layer, and growing, epitaxially, an upper layer on the buffer layer, the upper layer including a Heusler alloy.

Embodiments of the invention are directed to bearing assemblies configured to effectively provide heat distribution from and/or heat dissipation for bearing element, bearing apparatuses including such bearing assemblies, and methods of operating such bearing assemblies and apparatuses. In an embodiment, a bearing assembly includes a plurality of superhard bearing elements distributed about an axis. Each superhard bearing element of the plurality of superhard bearing elements has a superhard material including a superhard surface. Additionally, a support ring structure that includes a support ring that supports the plurality of superhard bearing elements and a thermally-conductive structure in thermal communication with the superhard table of each of the plurality of superhard bearing elements. The thermally-conductive structure has a higher thermal conductivity than the support ring of the support ring structure.

A hub bearing assembly includes a hub made of lightweight metallic material and forming a cylindrical portion, on which a tubular inner ring providing a raceway is mounted; a second inner ring is fixed on the first tubular inner ring and provides a second raceway; a cylindrical interstice is formed between the cylindrical portion of the hub and the tubular inner ring and contains a bonding brazing material which integrally joins the hub to the first tubular inner ring.

The present disclosure provides methods and apparatus for constructing a secure and flexible operating system. The presently disclosed system executes different user applications in different operating systems on different virtual machines. Each user application communicates with other processes via the hypertext transfer protocol (HTTP). In particular, each user application's user interface is implemented in a web browser that is running in its own operating system on its own virtual machine, and each user application interacts with the user interface by exchanging HTTP messages between the virtual machines.

The invention includes an API gateway server that monitors and controls the distribution of API elements from API sources to application developers based on a distribution rule set.

System and methods are provided. In one embodiment, a system includes a master data archiver configured to store a data related to a turbomachine system and a first data collector service system configured to collect the data from the master data archiver. The system also includes a second data collector service system communicatively coupled to the first data collector system and configured to pull or to push the data from the first data collector system and a first data archiver configured to receive at least some of the data from the second data collector system. The system further includes an asset model database storing a plurality of turbomachine tags, wherein the turbomachine tags are configured to categorize the data and a data access system (DAS) configured to provide data access to the first data archiver, the asset model database, or a combination thereof.

An exemplary method includes a broker-based messaging system detecting a request provided by a software application for the software application to connect to any one of a plurality of brokers included in a cluster of brokers, dynamically identifying, in response to the request and in accordance with a connection distribution heuristic, a broker included in the cluster of brokers and that is available for connection to the software application, and attempting to establish a connection between the software application and the broker. Corresponding methods and systems are also disclosed.

A polymer reactor-blend comprising at least a first component having a polydispersity index of greater than about 20 and is present in an amount of from about 1 wt. % to about 99 wt. % based on the total weight of the polymer and a second component having a polydispersity index of less than about 20 and is present in an amount of from about 1 wt. % to about 99 wt. % based on the total weight of the polymer wherein a molecular weight distribution of the second component lies within a molecular weight distribution of the first component.

A true tetrafluoroethylene (TFE) copolymer of the fine powder type is provided, wherein the copolymer contains polymerized comonomer units of at least one comonomer other than TFE in concentrations of at least or exceeding 1.0 weight percent, and which can exceed 5.0 weight percent, wherein the copolymer is expandable, that is, the copolymer may be expanded to produce strong, useful, expanded TFE copolymeric articles having a microstructure of nodes interconnected by fibrils. Articles made from the expandable copolymer may include tapes, membranes, films, fibers, and are suitable in a variety of end applications, including medical devices.

A method of constructing a pump island protector to alleviate continuous maintenance required for a deteriorating existing steel pump island base, and a pump island protector constructed by the method. Using an adjustable form system and the combination of stainless steel members and new concrete, the existing pump island is re-wrapped with the stainless steel member and the new concrete.

A method of constructing a pump island protector to alleviate continuous maintenance required for a deteriorating existing steel pump island base, and a pump island protector constructed by the method. Using an adjustable form system and the combination of stainless steel members and new concrete, the existing pump island is re-wrapped with the stainless steel member and the new concrete.

A system for converting an existing traffic intersection into an intersection having a roundabout traffic control feature includes a center island framework, one or more splitter island frameworks, and one or more diverter frameworks. The frameworks are secured to the road surface, and fill material is added to free spaces defined in the frameworks to thereby form a center island, one or more splitter islands, and one or more diverters. The system allows a roundabout to be implemented into an existing intersection on a temporary or semi-permanent basis, in a minimal amount of time and without requiring significant construction at the site of the intersection.

A system for measuring the height of paving material distributed by an auger of a paving machine in front of a grading implement, such as a screed, is disclosed. The system includes a sonic sensor and a laser pointer. The sonic sensor generates a sonic signal which is directed at the paving material distributed by the auger. The laser pointer generates a laser beam which is similarly directed at the paving material that has been distributed by the auger. The laser beam and the sonic signal meet at a common position on the paving material.

A method for installing a paver system includes positioning a first grid substrate adjacent to a second grid substrate, the first and second grid substrates form a paver support surface. At least the first grid substrate includes an integrated boundary ridge extending along the first paver support surface. The first grid substrate is interlocked with the second grid substrate with a first paver piece bridging the first and second grid substrates to form a paver linkage. Movement of at least the first paver piece is arrested beyond the integrated boundary ridge by directly or indirectly engaging at least the first paver piece against the integrated boundary ridge. In another example, movement of the first paver piece is arrested by anchoring at least the first paver piece on the first and second paver support surfaces through distribution of forces incident on at least the first paver piece through the paver linkage.

A mobile wireless communications device may include a portable housing, a circuit board carried by the portable housing, a wireless communications circuit carried by the circuit board, and an audio circuit carried by the circuit board. The mobile wireless communications device may further include an antenna assembly including an antenna carrier frame coupled to the circuit board and defining a cavity therein, and an antenna element carried on the antenna carrier frame and having a plurality of spaced apart signal feed points coupled to the wireless communications circuit. In addition, an audio transducer may be carried within the cavity of the antenna carrier frame and coupled to the audio circuit.

Various embodiments provide for systems and methods for signal conversion of one modulated signal to another modulated signal using demodulation and then re-modulation. According to some embodiments, a signal receiving system may comprise an I/Q demodulator that demodulates a first modulated signal to an in-phase (“I”) signal and a quadrature (“Q”) signal, an I/Q signal adjustor that adaptively adjusts the Q signal to increase the signal-to-noise ratio (SNR) of a transitory signal that is based on a second modulated signal, and an I/Q modulator that modulates the I signal and the adjusted Q signal to the second modulated signal. To increase the SNR, the Q signal may be adjusted based on a calculated error determined for the transitory signal during demodulation by a demodulator downstream from the I/Q modulator.

The present invention is directed to apparatus and methods for cooling computer servers and/or electrical equipment in a rack device for data centers or telecommunication centers.

In various embodiments, an illumination apparatus includes an air gap between a sub-assembly and a waveguide attached thereto at a plurality of discrete attachment points, as well as a bare-die light-emitting diode encapsulated by the waveguide.

An instrument for delivering a suture transfascially may include a handle, a shaft extending from the handle, and at least one needle that is moveable to an extended position beyond the end of the shaft. A suture may be delivered transfascially with the instrument. The instrument may include a suture catch associated with each needle for retaining and releasing a suture segment. A shield may be provided to shield the sharp end of each needle when it is moved to the extended position. A method of delivering a transfascial suture may include inserting an instrument into an abdominal cavity and deploying, from within the abdominal cavity, each needle through a soft tissue repair patch and then through at least part of the abdominal wall. A suture or suture segment may be advanced across the fascia with the at least one needle.

A system for treating heart disease, such as pulmonary hypertension or right heart failure, including an implantable component and external components for monitoring the implantable component is provided. The implantable component may include a compliant member, e.g., balloon, coupled to a reservoir via a conduit. Preferably, the compliant member is adapted to be implanted in a pulmonary artery and the reservoir is adapted to be implanted subcutaneously. The external components may include a clinical controller component, monitoring software configured to run a clinician's computer, a patient monitoring device, and a mobile application configured to run on a patient's mobile device.

Apparatus for sealing a puncture communicating with a blood vessel includes a porous carrier formed from lyophilized hydrogel or other material. The plug may include at least first and second hydrogel precursors and a pH adjusting agent carried by the porous carrier in an unreactive state prior to exposure to an aqueous physiological environment. Once exposed to bodily fluids, the carrier expands as the lyophilized material hydrates to enhance and facilitate rapid hemostasis of the puncture. When the plug is placed into the puncture, the natural wetting of the plug by bodily fluids (e.g., blood) causes the first and second precursors to react and cross-link into an adhesive or “sticky” hydrogel that aids in retaining the plug in place within the puncture.

Methods and devices for ophthalmic tissue closure and fixation of ophthalmic prostheses are provided. In accordance with some embodiments, devices for both grasping and clipping a plurality of ocular tissue and ocular prostheses are provided. Various device embodiments are provided for both malleable clips and delivery of normally closed clips (i.e. shape memory). The device may accommodate a plurality of clips which include, but are not limited to: malleable metals, absorbable, shape memory, drug-eluting, and adhesive dispensing. The clips may be pigmented to match the colors of associated tissue (cornea, iris, conjunctiva, sclera, retina) to serve to camouflage fixation clips for healing duration or permanently. According to one aspect, shallow angle access to anatomy may be provided by specialized angulation of device shaft and closure jaws that are intended to access the eye through a small self-healing cornea incision and/or any ocular tissue.

Devices, systems and methods for dynamically stabilizing the spine are provided. The devices include an expandable spacer having an undeployed configuration and a deployed configuration, wherein the spacer has axial and radial dimensions for positioning between the spinous processes of adjacent vertebrae. The systems include one or more spacers and a mechanical actuation means for delivering and deploying the spacer. The methods involve the implantation of one or more spacers within the interspinous space.

The sacral-iliac joint between an iliac and a sacrum is fused either by the creation of a lateral insertion path laterally through the ilium, through the sacral-iliac joint, and into the sacrum, or by the creation of a postero-lateral insertion path entering from a posterior iliac spine of an ilium, angling through the sacral-iliac joint, and terminating in the sacral alae. A bone fixation implant is inserted through the insertion path and anchored in the interior region of the sacrum or sacral alea to fixate the sacral-iliac joint.

A medical device for blood flow restoration and/or for use as an implantable member in a human vessel includes a self-expanding member, a guidewire, and a connection mechanism. The self-expanding member includes a plurality of cells and filaments having specific ranges of thicknesses, widths, and heights. The self-expanding member can take on a volume-reduced coiled form with overlapped edges, and can generate optimal radial forces against a vessel wall and/or thrombus when deployed and expanded.

Disclosed herein are a private key generation apparatus and method, and storage media storing programs for executing the methods on a computer. The private key generation apparatus includes a root private key generation unit and a sub-private key generation unit. The root private key generation unit sets a root master key and predetermined parameters capable of generating private keys, and generates a first sub-master key set capable of generating a number of private keys equal to or smaller than a preset limited number. The sub-private key generation unit generates private keys with the root private key generation unit by receiving the first sub-master key set from the root private key generation unit, to generate a private key corresponding to a user ID using the first sub-master key set, and issues the private key to a user.

A system that incorporates the subject disclosure may include, for example, instructions which when executed cause a device processor to perform operations comprising sending a service request to a remote management server; receiving from the management server an authentication management function and an encryption key generator for execution by a secure element and an encryption engine for execution by a secure device processor, sending a request to establish a communication session with a remote device; and communicating with the remote device via a channel established using an application server. The secure element and the secure device processor authenticate each other using a mutual authentication keyset. The secure element, the secure device processor and the device processor each have a security level associated therewith; the security level associated with the secure device processor is intermediate between that of the secure element and that of the device processor. Other embodiments are disclosed.

A method, non-transitory computer readable medium and application manager computing device comprises obtaining at least one cryptographic key from a request by a client computing device for a user session. User information corresponding to a user is encrypted or decrypted using the cryptographic key. The request is authenticated based on encryption or decryption of the user information. The cryptographic key is deleted after the completion or termination of the user session.

Disclosed are methods and apparatus for managing services within a computer network. In one embodiment, a message interchange network for exchanging application-level messages between services, which are located outside the message interchange network, is provided. At the message interchange network, a plurality of application-level messages, which each specify which one or more receiving services are to receive the each application-level message, are received. Each received application-level message is forward towards the one or more receiving services. Correlation information regarding each application-level message that is received into message interchange network is retained. The application-level messages are sent between pairs of the services, and the retained correlation information for each application-level message pertains to each application-level message and any other application-level messages related to the each application-level message. A query can then be received, at the message interchange network from a first service, to search the retained correlation information for specific one or more portions of the retained correlation information. A response to the query, which includes the specific one or more portions of the retained correlation information, is sent to the first service.

A method, an apparatus, and a computer program product for wireless communication are provided in which a UE is equipped to generate an expression associated with a wireless device for use in a peer discovery signal, generate an expression set from the expression, a first temporal frequency, and a first time duration, and transmit the generated expression set to a base station to allow the base station to broadcast each of the expressions included in the expression set at the first temporal frequency over the first time duration. Another method, apparatus, and computer program product for wireless communication are provided in which a base station is equipped to receive an expression set from a wireless device, process the received expression set to determine each of one or more instances of an expression, and transmit each of the one or more instances of the expression.

Methods, apparatus, and articles of manufacture to encode auxiliary data into text data and methods, apparatus, and articles of manufacture to obtain encoded data from text data are disclosed. An example method to embed auxiliary data into text data includes assigning source data to one of a plurality of groups, the source data comprising text data, identifying a symbol to be added to the source data based on an assigned group of the source data, and generating encoded data by including in the source data a text character representative of the symbol.

There is provided solid imaging methods and apparatus for making three-dimensional objects from solid imaging material. A tray with a film bottom is provided to hold solid imaging material that is selectively cured into cross-sections of the three-dimensional object being built. A coater bar is moved back and forth over the film to remove any uncured solid imaging material from a previous layer and to apply a new layer of solid imaging material. A sensor is provided to measure the amount of resin in the tray to determine the appropriate amount of solid imaging material to be added, from a cartridge, for the next layer. A shuttle, which covers the tray when the exterior door to the solid imaging apparatus is opened for setting up a build or removing a three-dimensional object, can also be used to move the coater bar and to selectively open one or more valves on the cartridge to dispense the desired amount of solid imaging material.