The biologic Griffithsin (GRFT) has recently emerged as a candidate to safely prevent sexually transmitted infections (STIs) including human immunodeficiency virus (HIV-1) and herpes simplex virus 2 (HSV-2). However, to date, there are few delivery platforms that are available to effectively deliver biologics to the female reproductive tract (FRT). The goal of this work was to evaluate rapid-release polyethylene oxide (PEO), polyvinyl alcohol (PVA) and polyvinylpyrrolidone (PVP) fibers, that incorporate GRFT, in in vitro (HIV-1 and HSV-2) and in vivo (HSV-2) infection models. GRFT loading was determined via ELISA, and the bioactivity of GRFT fibers was assessed using in vitro HIV-1 pseudovirus and HSV-2 plaque assays. Afterwards, the efficacy of GRFT fibers was assessed in a murine model of lethal HSV-2 infection. Finally, murine reproductive tracts and vaginal lavages were evaluated for histology and cytokine expression, 24 and 72 hr after fiber administration, to determine safety. All rapid-release formulations achieved high levels of GRFT incorporation and were completely efficacious against in vitro HIV-1 and HSV-2 infections. Importantly, all rapid-release GRFT fibers provided potent protection in a murine model of HSV-2 infection. Moreover, histology and cytokine levels, evaluated from collected murine reproductive tissues and vaginal lavages treated with blank fibers, showed no increased cytokine production or histological aberrations, demonstrating the preliminary safety of rapid-release GRFT fibers in vaginal tissue.

BACKGROUND AND OBJECTIVES:

Rates of sexually transmitted infections (STIs) have increased over the decade. Guidelines recommend HIV testing with incident STIs. Prevalence and factors associated with HIV testing in acute STIs are unknown in adolescents. Our objective was to determine the prevalence of completed HIV testing among adolescents with incident STIs and identify patient and health care factors associated with HIV testing.

BACKGROUND:

In the United States, transgender youth are at especially high risk for HIV infection. Literature regarding HIV prevention strategies for this vulnerable, often-hidden population is scant. Before effective, population-based HIV prevention strategies may be adequately developed, it is necessary to first enhance the contextual understanding of transgender youth HIV risk and experiences with HIV preventive services.

Millicent Collins
Aug 1, 2017; 140:e20160719-e20160719
CASE REPORTS

One Uzbek woman gains new hope after receiving the help she needs after finding out she is HIV positive.

SYNOPSIS INTRODUCTION: To mark the 44th anniversary of the landmark judgement of ADM Jabalpur, this article revisits the case. The article also talks about Justice H.R. Khanna, who has ben regarded as the brave, unsung hero of the India Justice sy

State officials hope a new addition at the Blackbird Forest Education Center in Townsend will become a "hive of activity" as its occupants get "busy as bees" teaching visitors about the natural environment, the valuable role bees play in crop pollination and honey production, and how forests and flowering tree species can contribute to bee health and well-being. “Trees for Bees” is the theme of the 10th “National Pollinator Week” (June 20-26, 2016). The 2016 theme highlights the many natural benefits that flowering native tree species such as tulip tree (Liriodendron tulipifera), black willow (Salix nigra), northern catalpa (Catalpa speciosa), flowering dogwood (Cornus florida), and maples (Acer spp.) can offer to foraging bees.

Healthy Bees are essential to Delaware’s vegetable production and agricultural economy. Delaware's beekeeping laws aim to reduce the impact of stressors through specific requirements of all beekeepers in the state, such as hive registration, colony and equipment inspection for sale, trade or gifting of bees.

Agency: HSS Closing Date: 7/9/2020

Free HIV testing will be offered through the Division of Public Health (DPH) at two Delaware state service centers on Wednesday, June 27, 2018, in observance of National HIV Testing Day. The Centers for Disease Control and Prevention (CDC) recommends that everyone between the ages of 13 and 64 get tested for HIV at least once as part of routine health care.

Dr Gallo and Dr Chumakov briefly talk about research showing non-specific protection from vaccines such as BCG, measles and other live attenuated (weakened) vaccines.

Researchers who wish to perform research on site may make an appointment by calling (302) 744-5000 or e-mailing archives@delaware.gov

The post Attention: Researchers who wish to perform research on-site may make an appointment by calling (302) 744-5000 or e-mailing archives@delaware.gov appeared first on Delaware Public Archives - State of Delaware.

Shiv Sena MP Sanjay Raut says Maharashtra govt’s work will be based on issues, not Hindutva.

The above mentioned Trust is the authorised body to manage and supervise the day-to-day activities and facilities of the samadhi temple.

5 May 1986: Moscow has seen many Russians arriving by train from Kiev in the disaster area

Moscow
The first real signs of alarm among the Soviet public began to emerge over the weekend as Russians arriving by train from Kiev in the Chernobyl disaster area, began saying frankly that they were worried by radiation.

In the last two days large numbers of unescorted children have been arriving here from the city by train, to be met by relatives and grandparents.

Related: From the archive, 30 April 1986: Russia admits blast as death fears rise

Related: Revisiting Chernobyl: 'It is a huge cemetery of dreams'

શુભ મૂર્હૂતમાં તમે ઓમ નમ: શિવાયનો જાપ કરી કરો શિવજીને પ્રસન્ન

visit News18 Urdu for latest news, breaking news, news headlines and updates from Shivpuri on politics, sports, entertainment, cricket, crime and more.

Slackware Security Advisory - New libarchive packages are available for Slackware 14.1, 14.2, and -current to fix security issues.

Various Kaspersky products suffer from a malformed archive bypass vulnerability. The parsing engine supports the ZIP archive format. The parsing engine can be bypassed by specifically manipulating an ZIP Archive so that it can be accessed by an end-user but not the Anti-Virus software. The AV engine is unable to scan the container and gives the file a "clean" rating.

Various ESET products suffer from a malformed archive bypass vulnerability. The parsing engine supports the ZIP archive format. The parsing engine can be bypassed by specifically manipulating an ZIP Archive Compression Information Field so that it can be accessed by an end-user but not the Anti-Virus software. The AV engine is unable to scan the container and gives the file a "clean" rating.

The parsing engine in various Kaspersky products supports the ZIP archive format. The parsing engine can be bypassed by specifically manipulating an ZIP Archive (Compression Size Flag) so that it can be accessed by an end-user but not the Anti-Virus software. The AV engine is unable to scan the container and gives the file a "clean" rating.

The parsing engine for various Bitdefender products supports the RAR archive format. The parsing engine can be bypassed by specifically manipulating an RAR Archive (HOST_OS) so that it can be accessed by an end-user but not the anti-virus software. The AV engine is unable to scan the archive and issues the file a "clean" rating.

The Kaspersky parsing engine supports the ZIP archive format. The parsing engine can be bypassed by specifically manipulating an ZIP Archive (File Name Length Field) so that it can be accessed by an end-user but not the Anti-Virus software. The AV engine is unable to scan the container and gives the file a "clean" rating. A vast array of Kaspersky products are affected.

The Bitdefender parsing engine supports the RAR archive format. The parsing engine can be bypassed by specifically manipulating an RAR Archive (Compressed Size) so that it can be accessed by an end-user but not the Anti-Virus software. The AV engine is unable to scan the archive and issues the file a "clean" rating. All Bitdefender Products and Vendors that have licensed the Engine before Dec 12, 2019 are affected.

The Bitdefender parsing engine supports the RAR archive format. The parsing engine can be bypassed by specifically manipulating an RAR Archive (RAR Compression Information) so that it can be accessed by an end-user but not the Anti-Virus software. The AV engine is unable to scan the archive and issues the file a "clean" rating. All Bitdefender Products and Vendors that have licensed the Engine before Dec 12, 2019 are affected.

The ESET parsing engine can be bypassed by specifically manipulating a ZIP Archive Compression Information Field so that it can be accessed by an end-user but not the Anti-Virus software. The AV engine is unable to scan the container and gives the file a "clean" rating.

The Kaspersky parsing engine supports the ZIP archive format. The parsing engine can be bypassed by specifically manipulating an ZIP Archive (File Name length Field) so that it can be accessed by an end-user but not the Anti-Virus software. The AV engine is unable to scan the container and gives the file a "clean" rating.

The Bitdefender parsing engine supports the GZIP archive format. The parsing engine can be bypassed by specifically manipulating a GZIP Archive (Compression Method) so that it can be accessed by an end-user but not the Anti-Virus software. The AV engine is unable to scan the archive and issues the file a "clean" rating.

The AVAST parsing engine supports the ZIP archive format. The parsing engine can be bypassed by specifically manipulating a ZIP archive so that it can be accessed by an end-user but not the anti-virus software. The AV engine is unable to scan the container and gives the file a "clean" rating.

The QuickHeal parsing engine supports the ZIP archive format. The parsing engine can be bypassed by specifically manipulating an ZIP Archive (GPFLAG) so that it can be accessed by an end-user but not the Anti-Virus software. The AV engine is unable to scan the archive and issues the file a "clean" rating.

Extreme Networks Aerohive HiveOS versions 11.x and below remote denial of service exploit. An unauthenticated malicious user can trigger a denial of service (DoS) attack when sending specific application layer packets towards the Aerohive NetConfig UI. This proof of concept exploit renders the application unusable for 305 seconds or 5 minutes with a single HTTP request using the action.php5 script calling the CliWindow function thru the _page parameter, denying access to the web server hive user interface.

By Tim Brown and Wiwat Peerapatanapokin HONOLULU (September 17, 2019)—In 2018, roughly 6 million people were living with HIV in Asia and the Pacific, and 310,000 were newly infected, according to UNAIDS estimates. Despite these troubling numbers, financial support for the fight against AIDS is stagnant, and international resources for HIV programs in the region are declining. Given the continued HIV infection levels and limited funds for halting the epidemic, it is more important than ever for prevention efforts to achieve maximum impact with the resources available. This means that programs need to target the key populations most at risk of contracting HIV. In Asia, these key populations are female sex workers and their clients, people who inject drugs, and men who have sex with men....

This is a summary only. Click the title for the full article, or visit www.EastWestCenter.org/Research-Wire for more.

ADB's $5 million HIV/AIDS prevention project for the Greater Mekong Subregion helped the Lao PDR and Viet Nam reach high risk and vulnerable people in border region economic corridors.

The ancient practice of water divining is still used across the world to locate water sources. Forty years ago, we wondered whether it might actually work

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