Lisbonne : Impr. de l'Académie royale des sciences, 1881.

Edinburgh : MacLachlan and Stewart, 1870.

[Place of publication not identified] : [publisher not identified], [1897?]

London : printed for Knight and Lacey, 1826.

London : printed for J. Dodsley, 1782.

London : J. & A. Churchill, 1873.

Genova : G. Bonaudo, 1812.

Amstelodami : Typis A. Wolfgang, 1674.

The art within Shing Yin Khor's virtual world represents a sassy response to the game's built-in natural history museum

With many zoos and aquariums closed to the public, keepers let animals roam empty hallways to meet their neighbors

New research reveals the ancient symbiotic relationship behind geosmin, the chemical compound responsible for the scent of fresh rain

Gamers are brushing up on their art history knowledge to spot Redd's counterfeit creations

Coyotes, bears and more are enjoying areas usually reserved for crowds of human visitors

This Sunday, celebrate the moms of the animal kingdom with kittens, polar bear cubs, eaglets and more

Airing on the aquarium's Twitch channel at 4 p.m. EST today, the two-hour session will focus on the video game's diverse insect population

Over many years, the Xenopus laevis embryo has provided a powerful model system to investigate how mechanical forces regulate cellular function. Here, we describe a system to apply reproducible tensile and compressive force to X. laevis animal cap tissue explants and to simultaneously assess cellular behavior using live confocal imaging.

Most of the animals at the B.C. Wildlife Park in Kamloops are unfazed by the absence of paying visitors since it closed in March over COVID-19 concerns. But Blue the turkey appears "bummed," staff say.

Ingrid Newkirk isn’t sure exactly how many times she has been arrested. “Definitely a few dozen,” she’ll say, if you ask. I’ve just done exactly that, so right now the British-born founder of People for the Ethical Treatment of Animals (PETA) is running me through a sort of greatest hits of her law-baiting exploits and the jailtime they have brought her in the name of animal rights.

Practitioners caring for critically ill infants need to acquire competence in insertion of chest tubes for pneumothorax. Ethical and logistic concerns inhibit the use of animals, and there are no realistic simulation models available for neonatal chest tube insertion training.

An inexpensive, nonanimal chest tube insertion model can be easily constructed and used effectively to train interns and residents to improve their knowledge, clinical skills, and comfort levels to perform the chest tube insertion procedure in infants. (Read the full article)

Bacteria of the genus Campylobacter are major foodborne pathogens which have become increasingly resistant to clinically important antimicrobial agents (1)....

KBP-7072 is a semi-synthetic aminomethylcycline with broad-spectrum activity against Gram-positive and Gram-negative pathogens including multidrug resistant bacterial strains. The pharmacokinetics (PK) of KBP-7072 after oral and intravenous (IV) administration of single and multiple doses were investigated in animal models including during fed and fasted states and also evaluated the protein binding and excretion characteristics. In Sprague-Dawley (SD) rats, Beagle dogs, and CD-1 mice, KBP-7072 demonstrated a linear PK profile after administration of single oral and IV and multiple oral doses. Oral bioavailability ranged from 12% to 32%. Mean T_max ranged from 0.5 to 4 hours, and mean half-life ranged from approximately 6 to 11 hours. Administration of oral doses in the fed state resulted in a marked reduction in C_max and AUC compared with dosing in fasted animals. The mean bound fractions of KBP-7072 were 77.5%, 69.8%, 64.5%, 69.3%, and 69.2% in mouse, rat, dog, monkey, and human plasma, respectively. Following a single 22.5 mg/kg oral dose of KBP-7072 in SD rats, cumulative excretion in feces was 64% and in urine was 2.5% of the administered dose. The PK results in animal models are consistent with single and multiple ascending dose studies in healthy volunteers and confirm the suitability of KBP-7072 for once daily oral and IV administration in clinical studies.

The human diseases caused by the fungal pathogens Cryptococcus neoformans and C. gattii are associated with high indices of mortality, and toxic and/or cost-prohibitive therapeutic protocols. The need for affordable antifungals to combat cryptococcal disease is unquestionable. Previous studies suggested benzimidazoles as promising anti-cryptococcal agents combining low cost and high antifungal efficacy, but their therapeutic potential has not been demonstrated so far. In this study, we investigated the antifungal potential of fenbendazole, the most effective anti-cryptococcal benzimidazole. Fenbendazole was inhibitory against 17 different isolates of C. neoformans and C. gattii at a low concentration. The mechanism of anti-cryptococcal activity of fenbendazole involved microtubule disorganization, as previously described for human parasites. In combination with fenbendazole, the concentrations of the standard antifungal amphotericin B required to control cryptococcal growth were lower than those required when this antifungal was used alone. Fenbendazole was not toxic to mammalian cells. During macrophage infection, the anti-cryptococcal effects of fenbendazole included inhibition of intracellular proliferation rates and reduced phagocytic escape through vomocytosis. Fenbendazole deeply affected the cryptococcal capsule. In a mice model of cryptococcosis, the efficacy of fenbendazole to control animal mortality was similar to that observed for amphotericin B. These results indicate that fenbendazole is a promising candidate for the future development of an efficient and affordable therapeutic tool to combat cryptococcosis.

A total of 2,283 Salmonella spp. isolates were recovered from 18,334 samples including patients with diarrhea, food of animal origin and pets across 5 provinces of China. The highest prevalence of Salmonella spp. was detected in chicken meats (39.3%, 486/1,237). Fifteen serogroups and 66 serovars were identified, with Typhimurium and Enteritidis being the most dominant. Most (85.5%, 1,952/2,283) isolates exhibited resistant to ≥ 1 antimicrobial and 56.4% were multi-drug resistant (MDR). A total of 222 isolates harbored extended-spectrum β-lactamases (ESBLs), 200 of which were CTX-M-type that were mostly detected from chicken meat and turtle fecal. Overall, eight bla_CTX-M genes were identified, with bla_CTX-M-65, bla_CTX-M-123, bla_CTX-M-14, bla_CTX-M-79, and bla_CTX-M-130 being the most prevalent. Totally, 166 of the 222 ESBL-producing isolates had amino acid substitutions in GyrA (S83Y, S83F, D87G, D87N, and D87Y) and ParC (and S80I), whilst the PMQR-encoding genes oqxA/B, qepA, and qnrB/S were detected in almost all isolates. Of the fifteen sequence types (STs) identified in the 222 ESBLs, ST17, ST11, ST34, and ST26 ranked among the top 5 in the number of isolates. Our study revealed considerable serovars diversity, high prevalence of co-occurrence of MDR determinants, including CTX-M-type ESBLs, QRDRs mutations and PMQR genes. This is the first report of CTX-M-130 Salmonella spp. from patients with diarrhea and QRDRs mutations from turtle fecal samples. Our study emphasizes the importance of actions, both in the health care settings and in the veterinary medicine sector, to control the dissemination of MDR, especially the CTX-M Salmonella spp. isolates.

With hurricane season about to begin, Delaware agricultural authorities are urging farmers and pet owners to plan ahead and prepare for weather emergencies. Hurricane Preparedness Week runs from May 26 to June 1, with hurricane season beginning June 1. The Department of Agriculture’s Delaware Animal Response Program works with state emergency officials and animal welfare organizations to assist animal owners with preparation, sheltering in place and evacuation. “Preparing and acting early can save animals’ lives,” said Secretary of Agriculture Ed Kee. “The time to take action is now, before storms create disaster conditions.”

Following a starting gate incident related to the fifth race on June 14, 2018, the Delaware Department of Agriculture opened a full animal cruelty investigation into the treatment of the horse, “Accolade.” Based upon a thorough investigation at both the state and track levels, the assistant starter was cleared of any wrong doing.

Agency: HSS Closing Date: 7/16/2020

Officers from the Delaware Division of Public Health (DPH) Office of Animal Welfare (OAW) arrested a Wilmington man following an incident involving the death of a dog left in a hot vehicle.

fficers from the Delaware Division of Public Health (DPH) Office of Animal Welfare (OAW) arrested a Milford woman on Tuesday July 23, 2019, following the death of a dog that was tethered outside of a home during dangerously hot temperatures.

Since rangeomorphs could not move and are preserved where they lived, it is possible to analyse whole populations from the fossil record.

Emission of the green house at the current levels will cause catastrophe in most parts of the world with some ecosystems expected to collapse by 2030.

At our heart, Zoetis is about caring for animals – and some animals need a little more care than others. Adopting an animal from a shelter has many advantages.

Alexandria Ocasio-Cortez just gave her very first commencement address...inside the Nintendo Switch game, Animal Crossing. ......

Google’s 3D animals are the best antidote to lockdown boredom. Here’s how to get them and the comprehensive list of what you can find. ......

The Singapore government is reviewing the sale and slaughter of live animals at wet markets, Dr Amy Khor, Senior Minister of State for the Environment and Water Resources, said on Tuesday. The relevant agencies are doing so while taking into consideration international benchmarking and scientific evidence, she added.Her comments were in response to a parliamentary question from MP for Nee Soon Group Representation Constituency Louis Ng. He asked whether her ministry would consider banning the…

Despite the global outcry against animal sacrifice in Nepal, the tradition persists.

The exhibition Animalesque celebrates what we share with Earth's other species – and offers hope for reforming our relationship with the natural world

We know viruses invaded animals’ genomes in the ancient past, but only now have we actually witnessed it happening and the DNA being passed to offspring

The earliest cave-dwelling animal identified from the dinosaur era is a ghostly white cockroach with tiny eyes and wings that was preserved in amber

All animals rely on oxygen at least at some stage of their life, but a parasite that infects fish seems to have completely lost the ability to use it – where it gets its energy from is still a mystery