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Australian research identifies cause of mRNA vaccine side effects




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Lithuania's Social Democratic Party signs coalition agreement




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Alix Didier Fils-Aime swears in as new Haiti PM




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Pezzella to miss Argentina's World Cup qualifiers due to injury




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Most Italians deem adaptation to climate change priority: Survey




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Mauritius's opposition coalition wins legislative election




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Gujarat govt announces Rs 1419 crore relief package for farmers ahead of Diwali




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Reliance Jio slashes price of JioBharat 4G phone by ₹300 for Diwali

BL Mumbai Bureau Users of JioBharat 4G phones can make unlimited voice calls, get access to over 455 television channels, and 14 GB data at ₹123 per month




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Xiaomi India President Muralikrishnan B steps down

He will continue to support Xiaomi India as an independent strategic advisor




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Freshworks asks 660 employees to leave as part of ‘global realignment’

The move is expected to result in $11 million to $13 million in charges in the fourth quarter of 2024, consisting primarily of cash expenditure for separation-related payments, employee benefits and related costs




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Dream realised

One man decided to do something different. He travelled, studied the needs of people and finally set down roots to create a self-sufficient village and create abundance.




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BODIPY(aryl)iodonium salts in the efficient synthesis of diversely functionalized BODIPYs and selective detection of serum albumin

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00336E, Paper
Open Access
Bintu Kumar, Anindita Bhatta, Prakriti Saraf, Taur Prakash Pandurang, Krishnan Rangan, Madhushree Sarkar, Sivaprasad Mitra, Dalip Kumar
Using readily available BODIPY and iodoarenes various BODIPY(aryl)iodonium salts were prepared and successfully utilized for the direct syntheses of functionalized BODIPYs, bis-BODIPYs and for the selective detection of serum protein.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Diastereoselective synthesis of functionalized spiroindolines via intramolecular ipso-iodocyclization/nucleophile addition cascade reactions of indole-tethered ynones

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00112E, Paper
Debojyoti Bag, Sanghapal D. Sawant
Herein, we describe a highly diastereoselective approach for synthesizing polyfunctionalized spiroindolines from indolyl-ynones involving an ipso-iodocyclization/nucleophile addition cascade.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Selective recognition between aromatics and aliphatics by cage-shaped borates supported by a machine learning approach

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00408F, Paper
Open Access
Yuya Tsutsui, Issei Yanaka, Kazuhiro Takeda, Masaru Kondo, Shinobu Takizawa, Ryosuke Kojima, Akihito Konishi, Makoto Yasuda
Exploration of a Lewis acid with high selectivity for hydrocarbon moieties is assisted by a machine learning approach. Molecular polarizability is an essential factor, leading to design guidelines for Lewis acid catalysts with dispersion forces.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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An efficient synthesis of mono-, di-, and tri-substituted 1,3-thiazoles employing functionalized thioamides as thiocarbonyl precursors

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00229F, Paper
Kalleshappa Sheela, Chikkappaiahnayaka Santhosh, Krishna Ravi Singh, Kalleshappa Sharath, Maralinganadoddi P. Sadashiva
Herein, we report an efficient strategy to synthesize functionalized 1,3-thiazoles using alkyl 2-amino-2-thioxoacetates.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Asymmetric synthesis of the fully functionalized six-membered A-ring of siphonol A

Org. Biomol. Chem., 2024, 22,2958-2962
DOI: 10.1039/D4OB00104D, Communication
Ying Sun, Shaomin Fu, Bo Liu
The asymmetric synthesis of the fully functionalized six-membered A-ring of siphonol A is presented.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Iron-catalyzed selective construction of indole derivatives via oxidative C(sp3)–H functionalization of indolin-2-ones

Org. Biomol. Chem., 2024, 22,3073-3079
DOI: 10.1039/D4OB00133H, Paper
Wei Chen, Lang-Qi Wen, Xiao-Bing Lu, Hui Zhou
We have developed a clean and efficient iron-catalyzed C(sp3)–H functionalization of indolin-2-ones for the chemodivergent synthesis of value-added indole derivatives, including isatins, and symmetrical and non-symmetrical isoindigos.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Cu(OTf)2/HFIP catalyzed regioselective cycloisomerization of indole-C3-functionalized alkynols to carbazoles

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00421C, Communication
Srinivasarao Yaragorla, Tabassum Khan, Sayonika Chakroborty
We report here a simple and atom economic cycloisomerization reaction of indole-tethered alkynols for constructing diverse carbazoles via 1,2-alkly migration using Cu(OTf)2/HFIP as the excellent promoter system.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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N-Functionalization of beta-aminophosphonates; Cytotoxic effect of the new derivatives

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00243A, Paper
György Keglevich, Petra Regina Varga, Emőke Dinnyési, Zsuzsanna Szalai, Szilvia Bősze, Rita Oláhné Szabó, Laszlo Drahos, Konstantin Karaghiosoff
Beta-Aminophosponates obtained by the Michael addition of primary amines to the double bond of diethyl vinylphosphonate proved to be suitable starting materials (amine components) in the Kabachnik–Fields reaction with formaldehyde...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Efficient synthesis of SCF3-containing 3-alkenylquinoxalinones via three-component radical cascade reaction

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00363B, Paper
Si-Yu Wang, Chu Liu, Wei Yang, Zhong-Ying Tian, Lin Yuan, Long-Yong Xie
A three-component cascade reaction of quinoxalinones, alkynes and AgSCF3 toward complete E-selective SCF3-containing 3-alkenylquinoxalinones was developed.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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 Instagram downgrades quality of less popular videos

Last year, Meta had admitted in a blog to having separate encoding configurations for different videos based on how popular they were




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Jio’s Diwali Dhamaka plan offers year-long prepaid plan for ₹3,599

Jio is offering a prepaid plan of 2.5 GB of data per day for an entire year, priced at₹3,599, as part of a Diwali offer




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I Didn’t Realize How Much I Rely on GitHub Codespaces Until This week

How much do I rely on GitHub Codespaces for open source development? Super double-plus much. I can illustrate exactly how much with one short anecdote. Gulp 5 was recently released and I created several PRs across repos in the H5BP organization to update Gulp across the board. I missed one issue with the encoding of […]




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Air pollution: Centre warns of the rising ill-effects of deteriorating air quality

In a letter to States and UTs, the Director General of Health Services Atul Goel has said to discourage stubble and waste burning, and spread awareness among people about reducing firecrackers during festivities




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Drugs regulator finds 49 samples not of standard quality, manufacturers asked to withdraw their products

Four spurious drugs were also found and action has been initiated against the makers, the DCGI said




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Doctors urge National Medical Commission to simplify centralised registration process

The register is a centralised repository that contains the name, address, and qualifications of licensed medical practitioners; however the registration process is complex and cumbersome, say doctors




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'Bhansali teaches you without a danda'

'When you walk on to a Sanjay Leela Bhansali set, it is complete surrender. You have to become a sponge.'




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'Bombay Has An Intoxicating Personality'

'It's such a mishmash of wonderful things, so many different cultures, subsections of society and weird histories.'




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'Shivani Is Thali Ka Baigan'

'I always wanted to be a part of a platform like this which enables you to show your true personality to the world. But after entering the show, I realised this show is more suitable for people like Armaan Malik, who backbite and indulge in unnecessary arguments. I am not cut out for such things.'




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'It's Not Sexualised Nudity'

'I made it very clear even at the casting process that there was going to be a lot of nudity.''And I wanted to be sure that it would be done with ease.'




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Flipkart Big Diwali Sale 2024: Best deals on iPhone 16 Pro Max, others; buy Apple iPad 9th Gen for just Rs...

The iPhone 16 series made its debut in India in September, with the flagship iPhone 16 Pro Max starting at Rs. 1,44,900 for the 256GB variant.




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Bringing alive the essence

Amrita Lahiri showcased her versatility in her performance in New Delhi.




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Behind the colours of Kathakali

Writer-photographer K.K. Gopalakrishnan describes vividly every aspect of the art form in his book. Lalithaa Krishnan has the details.




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Sandhya Raju: The National Awards for ‘Natyam’ are a validation of our efforts

Sandhya Raju, who won the national award for best choreography for ‘Natyam’, discusses how she wanted to make the dance compositions appeal to moviegoers 




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Co-driving is the reality, and AutoPilot- the desired state




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Realigning HR in the post-Covid era

Handling the organisation’s ‘resources’ in a ‘humane’ manner is the way forward for HR




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Should Minimum Support Price be legalised?




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World music: New Internationalist picks the best album releases of the month

Rûwâhîne by Ifriqiyya Electrique; The Underside of Power by Algiers: our music reviews of the month.




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This capitalism theme park will make you shudder

KidZania is an unashamed shrine to the sterile, dystopian human-made landscapes, comedian Steve Parry writes.




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Scaling Platforms Through Use Cases

New technology companies often have grand ambitions. And for good reasons - ambitious plans help recruit talent, raise capital, and set the bar high. But progress toward these high-level goals relies on identifying and excelling at much lower-level use cases.

It's very common for new technology companies to aspire being "the platform for... the Internet of things, AI analytics, mobile testing, etc." Being a platform means you capture a lot of uses cases or to put it more simply... people use your service for a lot of different things. And more use equals more value.

But vision is not the same as strategy. Vision is about the end goal. It paints a picture of the future state you're aiming for. It’s what you want to achieve. Strategy, on the other hand, is how you get there.

When you use a broad vision as a strategy, you end up having a hard time making decisions and rationalizing a never-ending set of opinions. With a strategy like “we’ll be the platform for the Internet of things”, everyone has an opinion on how things on the Internet should work -which one do we listen to?

Consider instead a specific market for the Internet of things, like home automation, and an even more specific use case for home automation like "controlling the temperature in your house". It's much easier to evaluate decisions about what a good experience for controlling the temperature in your house is than for "we’ll be the platform for the Internet of things”.

But if you focus on such a narrow use case, how will you ever build a big business? I'm not suggesting abandoning the big vision instead I'm advocating for having a strategy based on solving concrete uses cases to get there. Let's look at another example: Yelp.

Today, Yelp is used for recommendations for all kinds of services: skydiving training, auto body shops, tea parlors, and more. But it didn't start that way. Yes, Yelp likely started with the ambitious vision of being a platform for all service recommendations. But it first launched in San Francisco with restaurant reviews. A very specific market and very specific use case.

Why start with restaurants? A good starting use case is the one with the most acute pain. In the context of services, people need to eat three times a day. They get their hair cut once a month and maybe need a plumber once a year. So where should Yelp start? Probably restaurants.

When solving for a specific use case, it's important to build with the bigger vision in mind and not paint yourself into a corner of only being useful for one thing. But you definitely have to be great at solving each use case your platform supports. How else will you convince people to adopt your solution? Once you can demonstrate clear value for a specific use case, you can tackle more (likely adjacent ones).

This way of scaling ensures your solution is actually good at addressing a concrete problem people have not just an abstract vision. When you hear "What's your platform for? Well... you can use it for pretty much anything." in a sales pitch, that's a warning sign.

When you instead address specific use cases well, you learn what parts of your platform matter the most by identifying patterns and doubling down on them. It's only from solving highly specific use cases that you actually get to a platform that can be broadly used for many different things. And why Amazon started by only selling books on the Web.




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Whither Italian humour?

Diplomacy is like a woman. You never know what diplomats think or feel. The recent Ford controversy also makes us wonder whether Italy gave up its humour for tough diplomacy



  • M R Subramani

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LGBTQ+ educators in Catholic schools: embracing synodality, inclusion, and justice / Ish Ruiz.

Lanham, MD : Rowman and Littlefield, 2024.




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Alice Birch’s adaptation of David Cronenberg’s ‘Dead Ringers’ converts the anarchic physicality of childbirth into something laboratory-like

The Mantle twins want to “change the way women give birth” — the body horror subgenre has always been nimble and alert to the red-button political issues of the day




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Trial against actor Saif Ali Khan to begin after 11 years in assault case

The trial against actor Saif Ali Khan is likely to begin from June 15 as the court issued summons to witnesses in the case




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Watch | Directors’ Take | Venkatesh Maha: I began seeing the real world from the age of 16; it shaped my personality 

Venkatesh Maha, director of ‘Care of Kancharapalem’ and ‘Uma Maheswara Ugra Roopasya’, recalls his formative years and why he stands firm to make the films he believes in




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Dell Technologies, Alienware launch Alienware X15 R2 and X17 R2

The Alienware X15 R2 price starts at ₹2.49 lakh while the Alienware X17 R2 starts at ₹2.99 lakh



  • Computers & Laptops

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Penshurst and beyond / Alison Findlay, guest editor.

San Marcos, Texas : Texas State University, [2023]




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Un barrage contre le Pacifique / Marguerite Duras ; dossier et notes réalisés par Jean-Luc Vincent ; lecture d'image par Isabelle Varloteaux.

[Paris] : Éditions Gallimard, 2005.




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Iphigenia; Phaedra; Athaliah / translated and introduced by John Cairncross.

Harmondsworth : Penguin, 2004.




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L'après-coup : temporalité de l'événement et approches critiques du trauma / Alice Laumier.

Paris : Presses Sorbonne nouvelle, 2024.