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Microphysiological pancreas-on-chip platform with integrated sensors to model endocrine function and metabolism

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Published On ::

Lab Chip, 2024, 24,2080-2093
DOI: 10.1039/D3LC00838J, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Katharina Schlünder, Madalena Cipriano, Aline Zbinden, Stefanie Fuchs, Torsten Mayr, Katja Schenke-Layland, Peter Loskill
Pancreatic in vitro models are crucial for research on diseases such as diabetes mellitus. A novel thermoplastic organ-on-chip with integrated real-time read-outs models the complex microphysiological structure and function of the endocrine pancreas.
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Spatially controlled diffusion range of tumor-associated angiogenic factors to develop a tumor model using a microfluidic resistive circuit

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Lab Chip, 2024, Advance Article
DOI: 10.1039/D3LC00891F, Paper
Yu-Hsiang Hsu, Wen-Chih Yang, Yi-Ting Chen, Che-Yu Lin, Chiou-Fong Yang, Wei-Wen Liu, Subhashree Shivani, Pai-Chi Li
The DC-MPS device uses a velocity V-clamp to create a partition with a steep concentration gradient for simultaneously developing vasculogenic vessels and a tumor. It enables vessel–tumor interaction to develop a tumor model with angiogenic vessels.
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Evaluating thrombosis risk and patient-specific treatment strategy using an atherothrombosis-on-chip model

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Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00131A, Paper
Fahima Akther, Hedieh Fallahi, Jun Zhang, Nam-Trung Nguyen, Hang Thu Ta
An atherothrombosis-on-chip model to evaluate thrombosis risk and patient-specific treatment strategy.
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A microfluidic model to study the effects of arrhythmic flows on endothelial cells

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Lab Chip, 2024, 24,2347-2357
DOI: 10.1039/D3LC00834G, Paper
Austin Lai, Adam Hawke, Mokhaled Mohammed, Peter Thurgood, Gianmarco Concilia, Karlheinz Peter, Khashayar Khoshmanesh, Sara Baratchi
We created a versatile microfluidic system for studying the effect of arrhythmic flow patterns on endothelial cells in vitro. This system provides unique opportunities to identify the molecular machineries that control endothelial biology in response to arrhythmia.
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A microfluidic-based gut-on-a-chip model containing the gut microbiota of patients with depression reveals physiological characteristics similar to depression

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Lab Chip, 2024, Advance Article
DOI: 10.1039/D3LC01052J, Paper
Wenxin Wang, Yiyuan Liu, Zhikai Yao, Dengbo Chen, Yue Tang, Jingwei Cui, Jiangjiang Zhang, Hong Liu, Zikai Hao
A depression-on-gut-chip (DoGC) is prepared and enables extended co-culture of aerobic human intestinal epithelial cells and anaerobic gut microbiota, and allows direct study of interactions between human gut microbiota and depression.
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Closed-loop identification of enzyme kinetics applying model-based design of experiments

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React. Chem. Eng., 2024, 9,2984-2993
DOI: 10.1039/D4RE00127C, Paper
Leon Hennecke, Lucas Schaare, Mirko Skiborowski, Andreas Liese
This study presents an automated reactor platform for the identification of enzyme kinetic models using model-based design of experiments on the example of the reduction of NAD+ by formate dehydrogenase from Candida boidinii.
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Complete kinetic model and process reengineering of glyoxal oxidation by nitric acid in a capillary microreactor

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React. Chem. Eng., 2024, 9,3016-3028
DOI: 10.1039/D4RE00313F, Paper
Junnan Wang, Wei Zhan, Yating Li, Ting Wang, Chengxiang He, Chunying Zhu, Youguang Ma, Taotao Fu
The oxidation of glyoxal by nitric acid to glyoxylic acid is a complex process with parallel and consecutive side reactions.
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Kinetic analysis of kraft lignin conversion via the Fenton process: process optimization and stochastic modelling

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React. Chem. Eng., 2024, Advance Article
DOI: 10.1039/D4RE00401A, Paper
Lucas Ramos, Giovani Maltempi-Mendes, Adriano Francisco Siqueira, Diovana Aparecida dos Santos Napoleão, Anuj Kumar Chandel
Lignin conversion through an advanced oxidative process.
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Two-temperature model of the non-thermal chemical dissociation of CO2

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React. Chem. Eng., 2024, Advance Article
DOI: 10.1039/D4RE00300D, Paper
Q. Shen, A. Pikalev, F. J. J. Peeters, J. Gans, M. C. M. van de Sanden
A two-temperature model with a vibrational temperature different from the gas temperature is presented for the decomposition of CO2.
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Selective Separation of Li, Ni, Co and Mn from Model Spent Li Ion Battery Cathode by Dry Processing using Combination of Chlorination and Oxidation

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Published On ::

React. Chem. Eng., 2024, Accepted Manuscript
DOI: 10.1039/D4RE00328D, Paper
Naoto Tsubouchi, Yuuki Mochizuki
The volatilization of Li, Ni, Co, and Mn during chlorination treatment of LNO, LCO, and LMO (model materials for used LIB cathode material) was investigated with the aim of developing...
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Agent-based modeling of stress anisotropy driven nematic ordering in growing biofilms

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Soft Matter, 2024, Advance Article
DOI: 10.1039/D3SM01535A, Paper
Open Access
Changhao Li, Japinder Nijjer, Luyi Feng, Qiuting Zhang, Jing Yan, Sulin Zhang
Our agent-based model reveals complex spatiotemperal evolution of the morphology and internal cell ordering of Vibrio cholerae biofilms.
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A computational study of cell membrane damage and intracellular delivery in a cross-slot microchannel

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Soft Matter, 2024, Advance Article
DOI: 10.1039/D4SM00047A, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Ruixin Lu, Peng Yu, Yi Sui
The inertial effect increases the cell deformation and membrane damage in the channel cross-slot; however, the enhancement can be reversed by the cell membrane viscosity.
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Measuring mechanical cues for modeling the stromal matrix in 3D cell cultures

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Soft Matter, 2024, Advance Article
DOI: 10.1039/D3SM01425H, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Linda Srbova, Ossi Arasalo, Arttu J. Lehtonen, Juho Pokki
An approach to quantify microscale viscoelasticity in breast-cancer-associated stromal tissues was developed for cell-scale analyses of physiologically stiff 3D cell cultures.
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Hydrogen bonding enhanced drug–polymer interaction for efficient drug loading and delivery

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Soft Matter, 2024, Advance Article
DOI: 10.1039/D4SM00003J, Communication
Xiaotian Qu, Junran Li, Yishu Yu, Jie Yang
A carrier design strategy of hydrogen bonding enhanced drug–carrier interaction is developed to prepare a polymeric nanomedicine with high drug loading content and superb loading efficiency as well as tunable nanostructures.
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Particle-based and continuum models for confined nematics in two dimensions

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Soft Matter, 2024, Advance Article
DOI: 10.1039/D3SM01684F, Paper
Humberto Híjar, Apala Majumdar
Particle-based mesoscopic simulations conduct 2D nematics confined in polygons through consistent defect annihilation dynamics and produce unstable structures that transform into equilibrium textures predicted by the Landau-de Gennes theory.
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A prediction model for CO2/CO adsorption performance on binary alloys based on machine learning

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RSC Adv., 2024, 14,12235-12246
DOI: 10.1039/D4RA00710G, Paper
Open Access
Xiaofeng Cao, Wenjia Luo, Huimin Liu
Machine-learning models were constructed to accurately predict CO2 and CO adsorption affinity on a wide range of binary alloying.
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Construction of glutathione-responsive paclitaxel prodrug nanoparticles for image-guided targeted delivery and breast cancer therapy

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RSC Adv., 2024, 14,12796-12806
DOI: 10.1039/D4RA00610K, Paper
Open Access
Weiwei Ma, Qiufeng Zhao, Shilong Zhu, Xinyue Wang, Chuangchuang Zhang, Daming Ma, Na Li, Yanyan Yin
HA-coated redox sensitive visualized nano-prodrug HA/TPE-CS-SS-PTX were exploited in order to highly efficient treatment of cancer and real-time monitoring of drug localization.
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On the use of modelling antagonistic enzymes to aid in temporal programming of pH and PVA–borate gelation

By pubs.rsc.org
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Mol. Syst. Des. Eng., 2024, 9,372-381
DOI: 10.1039/D3ME00138E, Paper
Open Access
Nadeem Bashir, Anna S. Leathard, Madeline McHugh, Imogen Hoffman, Fahima Shaon, Jorge A. Belgodere, Annette F. Taylor, John A. Pojman
A model was developed to help predict how enzymes can be used to temporally control the gelation of polyvinyl alcohol (PVA) with borate.
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Tight-binding model describes frontier orbitals of non-fullerene acceptors

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Mol. Syst. Des. Eng., 2024, 9,382-398
DOI: 10.1039/D3ME00195D, Paper
Vishal Jindal, Michael J. Janik, Scott T. Milner
HOMO and LUMO of conjugated molecules as superposition of HOMO and LUMO of individual moieties.
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Crystal structure of poly(trimethylene 2,5-furandicarboxylate) redux – a new model supported by computational spectroscopy

By pubs.rsc.org
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Polym. Chem., 2024, 15,4349-4363
DOI: 10.1039/D4PY00779D, Paper
Catarina F. Araújo, Simão V. Pandeirada, Inês M. Oliveira, Guilherme B. Rosa, Beatriz Agostinho, Armando J. D. Silvestre, Andreia F. Sousa, Svemir Rudić, Pedro D. Vaz, Mariela M. Nolasco, Paulo Ribeiro-Claro
The crystal structure of biobased poly(trimethylene 2,5-furandicarboxylate) is revisited following new evidence from vibrational spectroscopy and computational chemistry tools.
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Acid-labile and non-degradable cross-linked star polymer model networks by aqueous polymerization for in situ encapsulation and release

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Polym. Chem., 2024, 15,4454-4464
DOI: 10.1039/D3PY00677H, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Gavin Irvine, Stuart Herron, Daniel W. Lester, Efrosyni Themistou
Aqueous RAFT polymerization for the preparation of degradable and non-degradable cross-linked star polymer model networks, in situ dye encapsulation and release.
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Polymer chemistry informed neural networks (PCINNs) for data-driven modelling of polymerization processes

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Polym. Chem., 2024, 15,4580-4590
DOI: 10.1039/D4PY00995A, Paper
Nicholas Ballard, Jon Larrañaga, Kiarash Farajzadehahary, José M. Asua
A method for training neural networks to predict the outcome of polymerization processes is described that incorporates fundamental chemical knowledge. This permits generation of data-driven predictive models with limited datasets.
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Long-term leaching kinetics and solution chemistry of aqueous BaTiO3 powder suspensions: a numerical model supported experiment

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Published On ::

J. Mater. Chem. B, 2024, Advance Article
DOI: 10.1039/D4TB01708K, Paper
Marcus Bentzen, Vojtěch Lindauer, Pavel Mokrý, Ragnhild Elizabeth Aune, Julia Glaum
The advent of lead-free perovskite materials with favorable toxicity profiles has made them candidates for in vivo and environmental applications.
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Intercellular lipid-cored, hectorite nanoplatelet-armored pickering emulsions with enhanced transdermal delivery and epidermal hydration

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J. Mater. Chem. B, 2024, Advance Article
DOI: 10.1039/D4TB01610F, Paper
Boryeong Lee, Lakshmishri Prabakaran, Minkyoung Jang, Song Hua Xuan, Kyounghee Shin, Sung Ho Lee, Jin Woong Kim
An intercellular lipid-cored, hectorite nanoplatelet-armored Pickering emulsion system is proposed to enhance dermal penetration and moisture retention.
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Nanocrystalline alloy-mediated delivery of mosaic epitope peptides for universal influenza vaccine

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J. Mater. Chem. B, 2024, Advance Article
DOI: 10.1039/D4TB00742E, Paper
Hongyu Wang, Han Fu, Liyan Zhai, Jiaqing Le, Bohan Guo, Yuyang Zhou, Chenlin Ji, Dapeng Li, Yue Zhang
Mosaic influenza antimicrobial peptide-like epitopes (Ampitopes) co-crystalize with poly(I:C), a TLR3 agonist, into nanocrystalline vaccine, which boosts immunogenicity via multivalent toll like receptor 3 (TLR3) binding and immune activation.
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Multimodal layer-by-layer nanoparticles: a breakthrough in gene and drug delivery for osteosarcoma

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Published On ::

J. Mater. Chem. B, 2024, Advance Article
DOI: 10.1039/D4TB01541J, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Eugenia Crisafulli, Annachiara Scalzone, Chiara Tonda-Turo, Joel Girón-Hernández, Piergiorgio Gentile
This study explored biodegradable nanoparticles for treating osteosarcoma. Co-delivery of miRNA-34a, doxorubicin, and resveratrol by LbL nanocoating enhanced apoptosis and cell disruption with promise to improve efficacy and reduce drug resistance.
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Acellular dermal matrix hydrogels promote healing of radiation-induced skin injury in a rat model

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J. Mater. Chem. B, 2024, 12,11218-11229
DOI: 10.1039/D4TB00941J, Paper
Xin Liu, Tian Guo, Zhifeng Huang, Sen Chen, Li Chen, Chenyang Li, Tian Tian, Yerong Qian, Lifei Yang, Junxi Xiang, Qiufang Liu, Peng Liu
Using a novel rat model of RISI, the research demonstrates that ADM hydrogel effectively reduces wound area and severity, increases epithelial thickness, and accelerates healing compared to controls.
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Drug-delivery and biological activity in colorectal cancer of a supramolecular porous material assembled from heptameric chromium-copper-adenine entities

By pubs.rsc.org
Published On ::

J. Mater. Chem. B, 2024, 12,11156-11164
DOI: 10.1039/D4TB01521E, Paper
Sandra Mena-Gutiérrez, Ekain Maiza-Razkin, Jon Pascual-Colino, Marcos J. Araúzo-Bravo, Garikoitz Beobide, Oscar Castillo, Ainara Castellanos-Rubio, Daniela Gerovska, Antonio Luque, Sonia Pérez-Yáñez
Supramolecular metal-organic porous materials as drug delivery systems, modulation of the release kinetics using cholesterol as pore blocking agent and its impact on colorectal cancer cell cultures: cytotoxicity and RNA-seq transcriptomics studies.
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Nanobiopolymers in cancer therapeutics: advancing targeted drug delivery through sustainable and controlled release mechanisms

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J. Mater. Chem. B, 2024, Advance Article
DOI: 10.1039/D4TB00599F, Review Article
Shikha Gulati, Nabeela Ansari, Yamini Moriya, Kumud Joshi, Disha Prasad, Gargi Sajwan, Shefali Shukla, Sanjay Kumar, Rajender S. Varma
Nanobiopolymers in cancer therapeutics offer sustainable and targeted drug delivery with controlled release, enhancing treatment efficacy while ensuring sustainability and biodegradability for improved patient care.
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Correction: Blood-clotting model and simulation analysis of polyvinyl alcohol–chitosan composite hemostatic materials

By pubs.rsc.org
Published On ::

J. Mater. Chem. B, 2024, 12,11265-11266
DOI: 10.1039/D4TB90174F, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Yifan Zhao, Junhong Hao, Zexin Chen, Mengmeng Li, Jianxun Ren, Xiaobing Fu
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Controlled therapeutic cholesterol delivery to cells for the proliferation and differentiation of keratinocytes

By pubs.rsc.org
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J. Mater. Chem. B, 2024, 12,11110-11122
DOI: 10.1039/D4TB01015A, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Krzysztof Berniak, Ahmadreza Moradi, Agata Lichawska-Cieslar, Weronika Szukala, Jolanta Jura, Urszula Stachewicz
The research concept involves investigating how cholesterol endocytosis impacts cells using electrospun fibers as a carrier. We studied keratinocyte proliferation and evaluated gene expression levels for markers of early and late differentiation.
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Development of enzymatically crosslinked natural deep eutectogels: versatile gels for enhanced drug delivery

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J. Mater. Chem. B, 2024, Advance Article
DOI: 10.1039/D4TB01672F, Paper
Liane Meneses, Dimitra Antonia Bagaki, Ana Roda, Alexandre Paiva, Ana Rita C. Duarte
We propose a new injectable eutectogel prepared by enzymatic crosslinking, using NADES, betaine : glycerol (2 : 1), as solvent. The potential of using this material with improved rheological properties as drug delivery system, has also been evaluated.
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Navigating predictions at nanoscale: a comprehensive study of regression models in magnetic nanoparticle synthesis

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J. Mater. Chem. B, 2024, Advance Article
DOI: 10.1039/D4TB02052A, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Lukas Glänzer, Lennart Göpfert, Thomas Schmitz-Rode, Ioana Slabu
The transformative power of support vector regression in optimizing magnetic nanoparticle synthesis intricate relationships between process parameters and particle size, enabling the production of particles with tailored properties.
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Raising a hospital: The Akole model

By www.thehindubusinessline.com
Published On :: Thu, 15 Jul 2021 11:30:55 +0530

When finding a hospital bed proved daunting during the devastating second wave of Covid-19, the villagers of the Maharashtra taluk got together to set up makeshift healthcare centres


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PIX: Beyonce, Adele, Lady Gaga at the Grammys

By www.rediff.com
Published On :: Mon, 13 Feb 2017 13:17:53 +0530

The 59th Grammy Awards was held in Los Angeles, California.


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A simple spectrogram model for high-accuracy spectral calibration of VIPA spectrometers

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Published On ::

Analyst, 2024, 149,5455-5462
DOI: 10.1039/D4AN00965G, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Hao Zhou, Weixiong Zhao, Weihua Cui, Bingxuan Lv, Bo Fang, Nana Yang, Guangfeng Xiang, Weijun Zhang, Lunhua Deng, Weidong Chen
A simple five-parameters spectrogram model for the VIPA spectrometer frequency calibration is developed, which has the advantages of high accuracy, simple setup and easy-to-solve.
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Modeling interfacial electric fields and the ethanol oxidation reaction at electrode surfaces

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Phys. Chem. Chem. Phys., 2024, 26,27544-27560
DOI: 10.1039/D4CP02765E, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Yuhan Mei, Fanglin Che, N. Aaron Deskins
The electrochemical environment present at surfaces can have a large effect on surface reactivity.
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Crystallographic models of ribbons and ribbon-based J-aggregate nanotubes from the geometry of tube ends

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Phys. Chem. Chem. Phys., 2024, Advance Article
DOI: 10.1039/D4CP03559C, Paper
Valery V. Prokhorov, Kirill A. Prusakov, Sergey I. Pozin, Olga M. Perelygina, Eugene I. Mal’tsev, Alexander A. Nekrasov
We propose the procedure of establishing the crystal structure of ribbons and ribbon-based tubes on the basis of crystallographic analysis of the tube-end geometry.
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Intermolecular Hydrogen Bonding Delineates Stability of Non-canonical Adenine Base Pairs: A First-Principles Study

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Published On ::

Phys. Chem. Chem. Phys., 2024, Accepted Manuscript
DOI: 10.1039/D4CP02875A, Paper
Nicholas Adu-Effah, Nabanita Saikia
Non-canonical nucleobase pairs differ from canonical Watson-Crick (WC) pairs in their hydrogen bonding patterns. This study uses density functional theory with empirical dispersion correction to examine the stability and electronic...
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Breaking the Brownian Barrier: Models and Manifestations of Molecular Diffusion in Complex Fluids

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Phys. Chem. Chem. Phys., 2024, Accepted Manuscript
DOI: 10.1039/D4CP01813C, Perspective
H. Srinivasan, Veerendra Kumar Sharma, Subhankur Mitra
Over a century ago, Einstein formulated a precise mathematical model for describing Brownian motion. While this model adequately explains the diffusion of micron-sized particles in fluids, its limitations become apparent...
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Delhi’s Broadway 2.0 – The return of an icon

By www.thehindu.com
Published On :: Wed, 30 Oct 2024 13:27:31 +0530

Established in 1956, Hotel Broadway hosted diplomats, politicians, artists, and writers till it closed in 2020. It is now gearing up for another innings, starting with the reopening of Chor Bizarre featuring a longer menu, but the same music playlist


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SERS in 3D cell models: a powerful tool in cancer research

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Published On ::

Chem. Soc. Rev., 2024, Advance Article
DOI: 10.1039/D3CS01049J, Review Article
Open Access
Lara Troncoso-Afonso, Gail A. Vinnacombe-Willson, Clara García-Astrain, Luis M. Liz-Márzan
3D cancer models recapitulate the tumor microenvironment and serve as a platform to study cancer cell behavior, drug discovery and early diagnosis, which can be monitored chemically with subcellular resolution in real time, via SERS.
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Motorsport FMSCI | Triple delight for Jaden and Abhay

By www.thehindu.com
Published On :: Sun, 25 Feb 2024 18:28:59 +0530


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Delhi to host India-Germany hockey series in October

By www.thehindu.com
Published On :: Tue, 24 Sep 2024 16:42:36 +0530

The last time India faced Germany was in the semifinal of the Paris Olympics, where the European giants emerged victorious


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India eyes Paris revenge against Germany in Test series as international hockey returns to Delhi

By www.thehindu.com
Published On :: Tue, 22 Oct 2024 15:10:22 +0530

For the last 10 years, the capital's Major Dhyan Chand National Stadium, once considered the spiritual home of the game, has not hosted any international match.


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Delhi govt plans to cut school syllabus

By www.thehindu.com
Published On :: Sun, 06 Sep 2015 00:00:00 +0530


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Delhi University drops controversial book

By www.thehindu.com
Published On :: Sat, 30 Apr 2016 00:00:00 +0530


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Eklavya Model Residential Schools face teacher shortage

By www.thehindu.com
Published On :: Fri, 16 Sep 2022 23:34:51 +0530

The Tribal Affairs Ministry works towards centralising administration and doing away with state-level societies  


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Not declaring deletions on Mahatma Gandhi, RSS in textbooks an ‘oversight’, says NCERT head

By www.thehindu.com
Published On :: Wed, 05 Apr 2023 14:55:00 +0530

The issue is being blown out of proportion, says D.P. Saklani, reacting to the controversy over the removal of sentences on Gandhiji and the RSS; Congress president Kharge says the BJP cannot erase history, no matter how hard it tries


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