North lashed out at neighbour for holding military exercises, as Kim Jong Un sent message of praise to Xi Jinping.

An arson case is being investigated after a tavern was torched in Hambanathi, Tongaat, outside Durban, following the discovery of human remains in the nearby Wewe River, KwaZulu-Natal police say.

Hear about travel to Extremadura in Spain as the Amateur Traveler talks to Sam from indefiniteadventure.com about living and working there. Extremadura is a lesser known region in southwest Spain on the border with Portugal and adjacent to Andalusia, Madrid and Castilla. Sam lived in the city of Medira for 3 months teaching English.

Hear about travel to remote parts of Alaska as the Amateur Traveler talks again to Sherry Ott from ottsworld.com about travel to Wrangell-St. Elias National Park in the east, above the Arctic Circle to Coldfoot Camp and far to the west to Nome Alaska.

Freeman Dyson died last week at the age of 96 after injuring himself in a fall in the cafeteria at the Institute of Advanced Studies in Princeton, where he had continued to work right up to the end. I can’t resist adding to the outpouring of appreciation and love that has ensued. He has an […]

Ironic toxic masculinity is in fashion! The Duke Cannon Naval Supremacy Big Brick of Bar Soap for Men [Amazon] promises that those thusly-soaped will smell of "naval supremacy", "productivity" or other humorously-abstract scents. (More traditionally "manly" odors such as tobacco, leather, burned vegetation, etc. are also available).

The veil of humor is threadbare -- "get clean and smell good without using feminine shower gels and accessories" -- but I'll admit that I do bathe in warm turpentine and it really helps.

Are you ready for images of the best “soap but for MEN” product you’ve ever seen? pic.twitter.com/kVAWb57UlF

— Shayna Moon, Unity Lich (@qorquiq) May 8, 2020

UPDATE: Here's a balding treatment called "Lethal Uprising", spotted by Greg Sideyr.

I'll see your Naval Supremacy, and raise you pic.twitter.com/UJE9wxeRvp

— ????Greg | Applied Eschatology ???? (@Greg_Sideyr) May 8, 2020

Looking forward to Internecine Violence Toothpaste, Shambolic Venezeulan Coup Ice Cream, and Silently Endure Prison Abuse Hemmorhoid Cream with Aloe Vera. Read the rest

Dan Greenberg, co-founder and CEO of native advertising solutions provider Sharethrough, discusses how buyers’ increased desire for contextual targeting and native advertising will benefit premium publishers in 2018.

People are always curious about work-from-home (WFH), remote working setups. So, I posted a Basecamp message asking our employees to share a photo of their home office, desk, table, whatever. Here’s what came in. First, the ask: And the answers, in the order they came in: Andy Didorosi, Marketing Justin White, Programmer Jonas Downey, Designer… keep reading

In this livesteam, David and I answer audience questions about how to work remotely. At Basecamp we’ve been working remotely for nearly 20 years, so we have a lot of experience to share. This nearly 2-hour video goes into great detail on a wide variety of topics. Highly recommended if you’re trying to figure out… keep reading

For many, moving from everyone’s-working-from-the-office to everyone’s-working-at-home isn’t so much a transition as it is a scramble. A very how the fuck? moment. That’s natural. And people need time to figure it out. So if you’re in a leadership position, bake in time. You can’t expect people to hit the ground running when everything’s different.… keep reading

The Shelburne Retirement Residence has been devastated by an outbreak of COVID-19, with 90 per cent of its residents becoming infected.

Human remains located in Mulmur Township in March have been confirmed to be those of an 88-year-old Caledon man who was reported missing seven months ago.

Grey Bruce provincial police say the OPP canine unit found human remains in Meaford, and one person is under arrest.

The following article, NY Shame: Workers Who Tested Positive For COVID-19 Were Allowed To Remain On The Job At Nursing Homes, As Death Toll For Nursing Home Patients Exceeds 3,000, was first published on 100PercentFedUp.com.

The coronavirus crisis at New York’s nursing homes is even worse than previously thought. Monday night, the state Department of Health issued new data, adding more than 1,600 people who were presumed to have died of the virus in nursing homes, but did not have a confirmed diagnosis, to the official toll. As of May […]

Continue reading: NY Shame: Workers Who Tested Positive For COVID-19 Were Allowed To Remain On The Job At Nursing Homes, As Death Toll For Nursing Home Patients Exceeds 3,000 ...

Dame Margaret Anstee, the first female UN under-secretary general, who died last year after a long and distinguished career as a diplomat, was remembered this week at Chatham House.

Protease-activated receptor 2 (PAR-2) is activated by secreted proteases from immune cells or fungi. PAR-2 is normally expressed basolaterally in differentiated nasal ciliated cells. We hypothesized that epithelial remodeling during diseases characterized by cilial loss and squamous metaplasia may alter PAR-2 polarization. Here, using a fluorescent arrestin assay, we confirmed that the common fungal airway pathogen Aspergillus fumigatus activates heterologously-expressed PAR-2. Endogenous PAR-2 activation in submerged airway RPMI 2650 or NCI–H520 squamous cells increased intracellular calcium levels and granulocyte macrophage–colony-stimulating factor, tumor necrosis factor α, and interleukin (IL)-6 secretion. RPMI 2650 cells cultured at an air–liquid interface (ALI) responded to apically or basolaterally applied PAR-2 agonists. However, well-differentiated primary nasal epithelial ALIs responded only to basolateral PAR-2 stimulation, indicated by calcium elevation, increased cilia beat frequency, and increased fluid and cytokine secretion. We exposed primary cells to disease-related modifiers that alter epithelial morphology, including IL-13, cigarette smoke condensate, and retinoic acid deficiency, at concentrations and times that altered epithelial morphology without causing breakdown of the epithelial barrier to model early disease states. These altered primary cultures responded to both apical and basolateral PAR-2 stimulation. Imaging nasal polyps and control middle turbinate explants, we found that nasal polyps, but not turbinates, exhibit apical calcium responses to PAR-2 stimulation. However, isolated ciliated cells from both polyps and turbinates maintained basolateral PAR-2 polarization, suggesting that the calcium responses originated from nonciliated cells. Altered PAR-2 polarization in disease-remodeled epithelia may enhance apical responses and increase sensitivity to inhaled proteases.

6 February 2014 , Volume 70, Number 1

Ghana’s leading undercover reporter uses disguises to expose trafficking rings and government corruption. His work has led to convictions and the recovery of millions of dollars in state funds. He talks to Libby Powell

7 October 2016

Oswald Quehenberger
Nov 1, 2010; 51:3299-3305
Research Articles

JF Oram
Dec 1, 1996; 37:2473-2491
Reviews

Robert W. Mahley
Jan 1, 1999; 40:1-16
Reviews

Invitation Only Research Event

Event participants

Invitation Only Research Event

Research Event

I. A. Sheipak and T. A. Garmanova
Trans. Moscow Math. Soc. 80 (2020), 189-210.
Abstract, references and article information

Publication Date: May 4 2020 On May 1, 2020, Nasdaq adopted Rule 5636T, operative through, and including, June 30, 2020, to provide listed companies with a temporary exception from certain shareholder approval requirements. A Company must submit an application to Nasdaq’s Listing Qualifications Department demonstrating that the transaction satisfies the requirements in Rule 5636T and must provide the Notification Form: Listing of Additional Shares (“LAS Form”) required by...

Researcher: Christopher Butson, Scientific Computing and Imaging Institute, University of Utah. Christopher Butson talks about work he's done to help treat Parkinson's disease.

Tropical rainforests are the world's richest land habitats for biodiversity, harbouring stunning numbers of plant and animal species. The Amazon and the Congo basins, together with Asian rainforests, represent only 6 per cent of earth's land surface, and yet more than 50 per cent of global biodiversity can be found under their shade.

Research from Chazen Senior Scholar Christian Moser suggests that who gets hired and how much they get paid could make the difference between a startup’s success and its failure.