Saif Khalil, founder and CEO of Aevumed, won first place at the REV-UP Center for Entrepreneurship's Lion Cage pitch competition. Aevumed develops medical devices designed to help reduce rotator cuff re-tear rates.

The Financial Sector Conduct Authority warns the public not to conduct financial services business with Masibekele Funeral Parlour and MISI Burial Society.

Boston Public Schools is turning innovative ideas into action through a new professional development network.

The planning team of the district's Innovation Incubator applied the same hacking mindset taught in the professional-development program to improve the program itself.

16 May 2013The Regulatory Reform (Scotland) Bill was introduced in the Scottish Parliament on 27 March 2013. This briefing provides background information on existing regulatory regimes, and the introduction of the Bill.

13 January 2013This briefing provides a summary of the parliamentary scrutiny of the Regulatory Reform (Scotland) Bill prior to Stage 3 proceedings which are scheduled to take place on 16 January 2014.

Female teachers, principals, and superintendents in Pennsylvania earn significantly less money than their male counterparts, a new study shows.

The National Sustainable Structures Center of Pennsylvania College of Technology, the mid-Atlantic administrator of the Building Operator Certification, will offer two BOC Level I courses at a 75% discount made possible by a grant from the Pennsylvania Department of Environmental Protection.

The requests put the nation's special education administrators in conflict with disability rights advocates who fear waivers will place millions of special education students at risk.

Le 1er juin dernier à Mugamba (province de Bururi), Pierre Nkurunziza a lancé un ultimatum. « Du haut d’une camionnette, micro à la main, sous très haute protection de l’armée et de la police », rapporte l’AFP, le président burundais a ordonné aux insurgés de cette commune du Sud du pays de déposer les armes dans les quinze jours : « Téléphonez à vos frères qui ont pris les armes, dites-leur que nous leur donnons quinze jours pour qu’ils y renoncent […] Quinze jours, pas plus. Dites-leur cela ». Hasard ou préméditation, la fin de cet ultimatum devrait coïncider avec la reprise prévue des discussions à Arusha, en Tanzanie, entre le gouvernement et l’opposition.

Background: This study summarizes drug resistance analyses in 4 recent phase 2b trials of the respiratory syncytial virus (RSV) fusion inhibitor presatovir in naturally infected adults.

Methods: Adult hematopoietic cell transplant (HCT) recipients, lung transplant recipients, or hospitalized patients with naturally acquired, laboratory-confirmed RSV infection were enrolled in 4 randomized, double-blind, placebo-controlled studies with study-specific presatovir dosing. Full-length RSV F sequences amplified from nasal swabs obtained at baseline and postbaseline were analyzed by population sequencing. Substitutions at RSV fusion inhibitor resistance-associated positions are reported.

Results: Genotypic analyses were performed on 233 presatovir-treated and 149 placebo-treated subjects. RSV F variant V127A was present in 8 subjects at baseline. Population sequencing detected treatment-emergent substitutions in 10/89 (11.2%) HCT recipients with upper and 6/29 (20.7%) with lower respiratory tract infection, 1/35 (2.9%) lung transplant recipients, and 1/80 (1.3%) hospitalized patients treated with presatovir; placebo-treated subjects had no emergent resistance-associated substitutions. Subjects with substitutions at resistance-associated positions had smaller decreases in viral load during treatment relative to those without, but similar clinical outcomes.

Conclusions: Subject population type and dosing regimen may have influenced RSV resistance development during presatovir treatment. Subjects with vs without genotypic resistance development had decreased virologic responses but comparable clinical outcomes.

Objectives: Carbapenemase-producing Enterobacterales and specifically KPC-producing Klebsiella pneumoniae (KPC-Kp) are rapidly spreading worldwide. The prognosis of ventilator-associated pneumonia (VAP) caused by KPC-producing Klebsiella pneumoniae (KPC-Kp) is not well known. Our study tries to assess whether ventilator-associated pneumonia caused by a KPC-Kp strain is associated with higher all-cause mortality than if caused by carbapenem-susceptible isolates.

Study design and methods: This is a retrospective cohort study of patients with VAP due to K. pneumoniae from a 35-bed polyvalent Intensive Care Unit in a university hospital (> 40,000 annual admissions) between January 2012 and December 2016. Adjusted multivariate analysis was used to study the association of KPC-Kp with 30-day all-cause mortality (Cox regression).

Results. We analyze 69 cases of K. pneumoniae VAP of which 39 were produced by a KPC-Kp strain with high-level resistance to meropenem (MIC > 16 mg/mL). All-cause mortality at 30 days was 41% in the KPC-Kp group (16/39) and 33.3% in the carbapenem-susceptible cases (10/30). KPC-Kp etiology was not associated with higher mortality when controlled for confounders (adjusted hazard ratio [lsqb]HR[rsqb] 1.25; 95% CI: 0.46–3.41). Adequate targeted therapy (HR 0.03; 95% CI: <0.01–0.23) was associated with all-cause mortality.

Conclussion. Assuming the limitations due to the available sample size, the prognosis of VAP caused by KPC-Kp is similar to VAPs caused by carbapenem-susceptible K. pneumoniae when appropriate treatment is used.

Gepotidacin, a triazaacenaphthylene bacterial type II topoisomerase inhibitor, is in development for treatment of uncomplicated urinary tract infection (uUTI). This Phase 2a study in female participants with uUTI evaluated the pharmacokinetics (primary objective), safety, and exploratory efficacy of gepotidacin. Eligible participants (N = 22) were confined to the clinic at baseline, received oral gepotidacin 1,500 mg twice daily for 5 days (on-therapy; Days 1 to 5), and returned to the clinic for test-of-cure (Days 10 to 13) and follow-up (Day 28±3). Pharmacokinetic, safety, clinical, and microbiological assessments were performed. Maximum plasma concentrations were observed approximately 1.5 to 2 hours postdose. Steady state was attained by Day 3. Urinary exposure over the dosing interval increased from 3,742 μg.h/ml (Day 1) to 5,973 μg.h/ml (Day 4), with trough concentrations of 322 to 352 μg/ml from Day 3 onward. Gepotidacin had an acceptable safety-risk profile with no treatment-limiting adverse events and no clinically relevant safety trends. Clinical success was achieved in 19 (86%) and 18 (82%) of 22 participants at test-of-cure and follow-up, respectively. Eight participants had a qualifying baseline uropathogen (growth; ≥10⁵ CFU/ml). A therapeutic (combined clinical and microbiological [no growth; <10³ CFU/ml]) successful response was achieved in 6 (75%) and 5 (63%) of 8 participants at test-of-cure and follow-up, respectively. Plasma area under the free-drug concentration-time curve over 24 hours at steady state divided by the MIC (fAUC_0-24/MIC) and urine AUC_0-24/MIC ranged from 6.99 to 90.5 and 1,292 to 121,698, respectively. Further evaluation of gepotidacin in uUTI is warranted. (NCT03568942)

BACKGROUND:

Approximately 25% of children with concussion have persistent postconcussive symptoms (PPCS) with resultant significant impacts on quality of life. Melatonin has significant neuroprotective properties, and promising preclinical data suggest its potential to improve outcomes after traumatic brain injury. We hypothesized that treatment with melatonin would result in a greater decrease in PPCS symptoms when compared with a placebo.

HostGator is an excellent web hosting service that's simple to use and offers an array of useful plans for consumers and small businesses. It's our top pick for shared web hosting and for novice webmasters in general.

A new protocol using aerosolized hydrogen peroxide to decontaminate N95 respirators could allow them to be safely reused in hospital settings. The protocol, optimized by a team of Penn State researchers, inactivates viruses without deforming or damaging the respirator and could help hospitals overcome the current respirator shortage due to the COVID-19 pandemic.

Olivia M. Vaz
Feb 1, 2020; 145:e20190620-e20190620
ARTICLES

The requests put the nation's special education administrators in conflict with disability rights advocates who fear waivers will place millions of special education students at risk.

T. Michael O'Shea
Jul 1, 1999; 104:15-21
ARTICLES

G. C. Liggins
Oct 1, 1972; 50:515-525
ARTICLES

The IMpact-RSV Study Group
Sep 1, 1998; 102:531-537
ARTICLES

Instructions for using the new Alternative Grade Calculator and Request Tool in LionPATH are now available for undergraduates and students enrolled in the Graduate School.

The tiny, rugged Atom smartphone is being followed up with the Atom XL, which increases the display size to 4-inches and adds a 48MP camera.

New European champion Renato Sanches has been chosen above Kingsley Coman and Portugal team-mate Raphael Guerreiro for the SOCAR Young Player of the Tournament award.

The 'accelerator suppression function' is a new safety feature which ignores accelerator pedal input if the car thinks the driver pressed it by mistake.

While Acer's Predator CG437K aims for the stars with its impressive feature set, this gaming monitor's achievements aren't as lofty as its goals. Some gamers may be willing to sacrifice picture quality for its size, but others should save their money and look at alternatives.

An initiative to improve the use of apps and mobile technology in the instruction of special education students finds that teachers aren't receiving the professional development they want.

The cell phone can be a powerful distraction or an educational tool. You have to decide which it will be in your classroom.

One of the giants of the literacy world is grappling with the recent push for the "science of reading"—and responding to critics who say her early reading program doesn't align to evidence-based practice.

029 - Six clubs fulfil conditions set out by CFCB

The pandemic has disrupted internships and student teaching in Pennsylvania’s teacher education programs. Teacher educators in K-4 Professional Development School partnership between Penn State and the State College Area School District have taken an inquiry stance to empower interns to navigate learning to teach during these times.

Governor Markell will attend the ribbon cutting ceremony at Heron Run Apartments in Smyrna.

DSHA has partnered with the Department of Education (DOE) to offer reduced interest rates on mortgages for teachers in the Delaware Talent Cooperative, a group of high performing educators who have committed to work in schools with a significant proportion of disadvantaged students

Delaware Governor Jack Markell, Senator Chris Coons and Newark Mayor Polly Sierer were among the officials who joined representatives from Ingerman today to break ground on Alder Creek, Delaware’s newest affordable housing community. Other attendees included State Representative Paul Baumbach, DSHA Director Anas Ben Addi, HUD Regional Administrator Jane Vincent, Newark Housing Authority Executive Director Marene Jordan, Ingerman Development Principal David Holden and Capital One Vice President Thomas Houlihan.

Sydney Chaffee, the 2017 National Teacher of the Year, went to the capital of Ethiopia for a week to deliver workshops to teachers and students. She ended up learning important lessons, too.

In this episode of the Getting Smart Podcast, Tom sits down with Daniel to learn more about his life as an international educator, the American School of Paris, Daniel's goals and challenges in international education, and what he thinks all American educators should know about international educat

Google Assistant Scheduled Actions lets you schedule actions in advance—so you can tell your coffee maker to start at 6 a.m. or your air conditioner to stop at 10 p.m.

Accreditation is the highest recognition afforded to museums in the United States.

Accreditation is the highest recognition afforded to museums in the United States.

Policymakers, Public Join Together for Women’s History Month Celebration and Lecture DOVER, Del. – Governor John Carney, Delaware’s Office for Women’s Advocacy and Advancement, the Delaware Department of Human Resources, the Delaware Commission for Women, and Delaware Women’s Workforce Council, today hosted the first lecture of its kind titled “Redefining Women in the Workplace” in honor […]

Post the NTO implementation, the dynamics have tilted in favour of the broadcasters.