Domino's plans to start delivering pizzas using an autonomous, unmanned vehicle. The announcement is the latest example of technology companies using robots to deliver food.

In Ann Arbor, Mich., the creators of a new autonomous vehicle have designed their robot to operate on local streets — but more so like a bicycle than a car.

After nearly eight months of knowledge-gathering street tests and thousands of successful deliveries, Amazon has announced that its delivery robots have begun delivering packages to customers in Irvine, Calif.

For months now, Nuro’s robotically piloted vehicles have been quietly delivering groceries to restaurants and homes around Houston, the vehicles’ sensors mapping the city as they go.

Boston Dynamics began began leasing their robotic dogs to the public this year. One of their first customers: The Massachusetts State Police.

Walmart, the nation's largest employer, announced a partnership with Nuro, a Silicon Valley startup called this week. The two companies will begin delivering groceries to customers in Houston this year using autonomous vehicles.

Cousins's next opponent, the Seattle Seahawks, has been kind to fantasy quarterbacks of late, surrendering at least 21 fantasy points in each of the last four contests.

Welcome to Wall Street Insider, where we take you behind the scenes of the finance team's biggest scoops and deep dives from the past week. 

If you aren't yet a subscriber to Wall Street Insider, you can sign up here.

For certain corners of Wall Street, dealmaking is happening faster than ever. While M&A activity has plunged, bankers primed to help companies navigate the financial fallout, especially restructuring and debt-raising specialists, have been crushed with demand.

Alex Morrell took a look at how top bankers — known for putting in long hours curating a white-glove experience for clients — are finding they can still provide service from afar. It turns out, when you take away the time spent at airports and restaurants, and when Zoom calls can be arranged in minutes, things can move at lightning speed. 

Read the full story here: 

'Stunning efficiency': How remote dealmaking could mean a permanent lifestyle change for some bankers

Meanwhile, it's been a tale of two approaches to job cuts in recent days. On Tuesday, Airbnb CEO and cofounder Brian Chesky emailed staff about sweeping layoffs that were impacting 1,900 people, highlighting where the company will focus in the future and what exit packages employees should expect. You can read the full email here. 

Over at WeWork, things have been rolling out gradually. Meghan Morris and Dakin Campbell wrote about a leaked WeWork document that revealed a huge reorg under way for people who manage its buildings. Here's how the new structure works — and the complex process for staff to save their jobs. Alex Nicoll and Meghan also reported that Flatiron School has slashed at least 100 jobs, building on their scoop last week that WeWork started making cuts in several key departments, with IT alone losing some 200 jobs. 

Keep reading for a preview of changes in store for Bloomberg terminals, a rundown of Blackstone's giant commercial real estate business, and a look at how PIMCO stocked up with $5.5 billion for private-credit strategies since the beginning of the year.

Have a safe and healthy weekend, 

Meredith 

Inside Blackstone's massive CRE business

Blackstone is the largest commercial real-estate investor in the world, with $160 billion in investor capital. Alex Nicoll chatted with Blackstone real estate's three heads of acquisition, and its head of debt origination, to learn more about their business. 

They spoke about some of their most interesting deals, and why Blackstone's global scale and thematic investing style is a huge advantage. 

Read the full story here: 

Meet the 4 dealmakers driving Blackstone's $325 billion commercial real estate portfolio. They walked us through how they're thinking about opportunities in the downturn.

A Facebook office deal is a key test 

The coronavirus crisis has thrown into question whether tenants will ever occupy office space the same way again as companies and workforces around the world grow accustomed to remote work.

Facebook has been in negotiations for months to lease over 700,000 square feet at the Farley Building on Manhattan's West Side. The rapid expansion of tech in recent years has propelled the city's office market, and Dan Geiger spoke with real-estate execs who laid out why Facebook's deal is a key barometer. 

Read the full story here:

A blockbuster Facebook office deal is a make-or-break moment for the future of commercial real estate. 3 leasing experts lay out the stakes.

Coming soon to a terminal near you

As remote work becomes a long-term reality, a technology staple of Wall Street is in store for a makeover. Mark Flatman, global head of core terminal at Bloomberg, told Dan DeFrancesco that the financial technology giant is considering ways to revamp its ubiquitous terminal.

One particular area of focus for Flatman and his team has been screen space, as many customers aren't working with the typical four-screen display. Another area that has gotten increased attention is mobile, where usage has jumped. 

Read the full story here: 

Bloomberg is eyeing big changes to its iconic terminals to make work-from-home easier. The exec leading its strategy laid out how he's rethinking screen space and mobile features.

A new pile of cash for private credit

Industry observers expect a surge in interest in specialized credit shops that have proven to be winners in distressed situations. And Bradley Saacks revealed how PIMCO has tapped into that demand, with sources saying that the fixed-income giant has raised $5.5 billion in private-credit strategies since the beginning of the year.

PIMCO's nearly $4 billion Tactical Opportunities fund lost roughly 15% in March, but was able to avoid forced selling, sources tell Business Insider, and even added to positions in the month. That fund alone has raised $250 million — and is just one of several private-credit funds that PIMCO has raised money for.

Read the full story here: 

PIMCO has raised $5.5 billion for private-credit funds despite a hellacious March — and is telling investors it's the best opportunity in a decade

A tax break for big companies with heavy debt

But some tax experts are concerned that the tax break is too indiscriminate: In addition to helping troubled companies, they say, boosting tax deductions on interest payments is going to give a lift to companies that aren't being hurt by the pandemic, or whose problems have nothing to do with the coronavirus. 

Read the full story here:

A $13 billion tax break tucked into the coronavirus stimulus plan will save some big companies tens of millions — even if they aren't ailing. Here's how it works and who could benefit.

On the move

Dakin Campbell reported that Goldman Sachs has hired the distressed-situations and bankruptcy expert Kurt Hoffman as a managing director in a business that handles one-off loans for clients. The move comes just as industries battered by the economic shutdown are in need of emergency financing. 

Investing and hedge funds

• SoftBank's brutal treatment of WeWork founder Adam Neumann shows that it has given up any hope for Silicon Valley and it's leaving a scorched landscape in its wake
• April hedge fund performance numbers are in — here's how big names like Third Point and Renaissance turned things around after a rough March
• WeWork pain is still hitting mom and pops' mutual funds as managers like Fidelity slash valuations further
• 'Quantamental' investing is suddenly a buzzword in the hedge fund world, and we talked to the CEO of a fintech that just nabbed $8 million to help power the approach
• Steve Cohen's former right-hand man is launching his own fund. Here's everything we know about Tom Conheeney's EmeraldRidge Advisors.
• A data 'super contango' makes oil the new data, not the other way around. Here's why.

Careers

• Deloitte is delaying many of its full-time hires and switched summer internships to a 2-week online intro course. Here's everything we know.
• Jobs for thousands of young consultants are being upended. From delaying start dates to cutting internships, here's what 8 top firms are doing.
• Investment manager TIAA is offering 75% of its US employees buyouts and some could get their full salaries for nearly 2 years

Real estate 

• The CEO of real estate heavy-hitter Eastdil explains the types of deals that are must-do right now — and warns that a 'de-retailing' trend is set to accelerate
• Inside the drama over control of the iconic Chrysler Building: A real-estate tycoon and a prestigious college are renegotiating a critical $150 million deal

Fintech and e-commerce

Join the conversation about this story »

NOW WATCH: How waste is dealt with on the world's largest cruise ship

The small town mayor is raking in some cash from A-list donors.

The former first daughter and her spouse welcomed a son on Monday.

If you run a WordPress website where you intend on adding eCommerce functionality at one stage or another, you cannot go past the free Stripe Payment Plugin. This plugin is designed to allow admin to sell either digital or tangible goods from their website through simple Stripe ‘Buy Now’ buttons. Just like PayPal, Stripe is […]

The post How to Make a Stripe Text Link Payment Button appeared first on Tips and Tricks HQ.

Messages between a GOP strategist and a Census Bureau official make clear the politics and bias behind the proposed citizenship census question.

She has apparently tricked the president into thinking she supports his fiscal ideas. Her actual ideas are worse.

Every single one of them is supposed to be exercising oversight of the executive branch.

America only benefits from U.S.-trained scientists.

strataconf: RT @bostontweetup: WEDS 6PM #BostonHealth7 hosted by @bostonpainpoint @mrkrieger @health_box @strataconf http://t.co/U6tj1uLR2Q @kalyankalwa

NAR commends Senators Cotton, Duckworth for Work on...

Swimming with Whales off Tonga

Washington D.C.

Seattle, Washington

Edmonton and Jasper, Alberta Canada

Kingston, Ontario

Boston, Massachusetts

The Amateur Traveler talks to Erik Smith (who was a guest on Travel to America’s National Parks - Amateur Traveler Episode 121) about Yellowstone and Grand Teton National Parks. We talk about all the different geothermal highlights of the park including Old Faithful, other geysers, thermal pools, etc. We also talk about wildlife, hiking, camping, floating down the Snake river, the grand canyon of the yellowstone, the grandeur of the Tetons (and the strange original of the name Teton).

The Amateur Traveler talks to travel writer Jeanine Barone about Estonia. Estonia is a small forested country with picturesque islands, medieval fortifications, a thriving design community, a great restaurant scene and a young and vibrant culture. Estonia only recently regained its independence from the U.S.S.R. (1991) but is thriving and filled with innovation. This interview, like all the Amateur Traveler interviews, was recorded with Skype… which is headquartered in Estonia. We talked about hotels, restaurants, guide books, wine bars and chocolate.

The Amateur Traveler talks to Carlos Gutierrez about his home town of San Antonio, Texas. Carlos gives us a guide to some of the obvious spots like the Alamo but also shares some of his favorite hole in the wall restaurants, a tip about the best time to come to San Antonio, and a great drive in the Texas countryside.

Hear about travel to Baton Rouge as the Amateur Traveler talks to Lindsay Thomas from TheTraveluster.com about her hometown. Baton Rouge is the capital of Louisiana. It can be a great gateway to Cajun food and culture.

Hear about travel to Charleston, South Carolina as the Amateur Traveler talks to Jen Leo from This Week in Travel and her husband John Caldwell about their many trips to one of their favorite U.S. cities.

Hear about travel to Namibia's Skeleton Coast as the Amateur Traveler talks again to Susan Portnoy of theinsatiabletraveler.com about her trip to this memorable reagion of Africa. Namibia is the size of France and Great Britain combined but with only 2 million people.

Hear about travel to Seattle, Washington as the Amateur Traveler talks to Mary Jo Manzanares from travelingwithmj.com about her hometown.

Hear about travel to the state of Washington as the Amateur Traveler talks to Anne and Mike Howard from HoneyTrek.com about their recent road trip from the ocean to the mountains to the wine region.

Hear about travel to Boston, Massachusetts as the Amateur Traveler talks to Lillie Marshall from AroundTheWorldL.com about her hometown.

Hear about National Parks in Washington D.C. and the vicinity as the Amateur Traveler talks to Erik Smith about monuments, memorials, mansions, battlefields, gardens and more.

In a startling turn for a robot that has long haunted your dreams, Boston Dynamics' Spot has been tasked to encourage healthy behavior. 

According to the Straits Times, the robot "dog" has been assigned to patrol the Bishan-Ang Mo Kio park in Singapore with the express purpose of encouraging social distancing. 

"Let's keep Singapore healthy," sounds a recording from the robot as it trots by two terrified people relaxing on a park bench in the above video. "For your own safety, and those around you, please stand at least one meter apart. Thank you."

Notably, Spot's jaunt is part of a two-week trial that began Friday. The robot will supposedly not collect any personal information on the people it admonishes.  Read more...

Jennifer Usellis-Mackay, aka the Klingon Pop Warrior, sings "Somewhere Over the Rainbow" in her native tongue. The performance took place in 2015 at Chicago's iO Theater. From the video description:

Opening for Improvised Star Trek, I sang a new (old) song. Got some newly translated words the day of the performance... enjoy this little slice of nerdiness... or don't.

Vocals - The Klingon Pop Warrior (Jennifer Usellis-Mackay) Guitar - The Red Shirt (Joe Mizzi) Translation - Admiral qurgh (Christopher Lipscombe) Video - Eric Scull

(via r/ObscureMedia) Read the rest

A transit centre in north Edmonton was evacuated for about two hours Saturday morning due to a suspicious package.

Six-time world champion Lewis Hamilton has said he feels "fresher than ever" following an unexpected break from Formula One.

After seven weeks, Honda Canada in Alliston will gradually begin operations next week.

The plasmas of diabetic or uremic patients and of those receiving peritoneal dialysis treatment have increased levels of the glucose-derived dicarbonyl metabolites like methylglyoxal (MGO), glyoxal (GO), and 3-deoxyglucosone (3-DG). The elevated dicarbonyl levels can contribute to the development of painful neuropathies. Here, we used stimulated immunoreactive Calcitonin Gene–Related Peptide (iCGRP) release as a measure of nociceptor activation, and we found that each dicarbonyl metabolite induces a concentration-, TRPA1-, and Ca2+-dependent iCGRP release. MGO, GO, and 3-DG were about equally potent in the millimolar range. We hypothesized that another dicarbonyl, 3,4-dideoxyglucosone-3-ene (3,4-DGE), which is present in peritoneal dialysis (PD) solutions after heat sterilization, activates nociceptors. We also showed that at body temperatures 3,4-DGE is formed from 3-DG and that concentrations of 3,4-DGE in the micromolar range effectively induced iCGRP release from isolated murine skin. In a novel preparation of the isolated parietal peritoneum PD fluid or 3,4-DGE alone, at concentrations found in PD solutions, stimulated iCGRP release. We also tested whether inflammatory tissue conditions synergize with dicarbonyls to induce iCGRP release from isolated skin. Application of MGO together with bradykinin or prostaglandin E2 resulted in an overadditive effect on iCGRP release, whereas MGO applied at a pH of 5.2 resulted in reduced release, probably due to an MGO-mediated inhibition of transient receptor potential (TRP) V1 receptors. These results indicate that several reactive dicarbonyls activate nociceptors and potentiate inflammatory mediators. Our findings underline the roles of dicarbonyls and TRPA1 receptors in causing pain during diabetes or renal disease.

Chatham House is pleased to announce that Tim Benton has joined the institute as a Distinguished Visiting Fellow in the Energy, Environment and Resources Department.

Chatham House is pleased to announce that Professor Tim Benton has been appointed as research director of the Energy, Environment and Resources Department.

Histone H2B monoubiquitylation (H2Bub1) has central functions in multiple DNA-templated processes, including gene transcription, DNA repair, and replication. H2Bub1 also is required for the trans-histone regulation of H3K4 and H3K79 methylation. Although previous studies have elucidated the basic mechanisms that establish and remove H2Bub1, we have only an incomplete understanding of how H2Bub1 is regulated. We report here that the histone H4 basic patch regulates H2Bub1. Yeast cells with arginine-to-alanine mutations in the H4 basic patch (H42RA) exhibited a significant loss of global H2Bub1. H42RA mutant yeast strains also displayed chemotoxin sensitivities similar to, but less severe than, strains containing a complete loss of H2Bub1. We found that the H4 basic patch regulates H2Bub1 levels independently of interactions with chromatin remodelers and separately from its regulation of H3K79 methylation. To measure H2B ubiquitylation and deubiquitination kinetics in vivo, we used a rapid and reversible optogenetic tool, the light-inducible nuclear exporter, to control the subcellular location of the H2Bub1 E3 ligase, Bre1. The ability of Bre1 to ubiquitylate H2B was unaffected in the H42RA mutant. In contrast, H2Bub1 deubiquitination by SAGA-associated Ubp8, but not by Ubp10, increased in the H42RA mutant. Consistent with a function for the H4 basic patch in regulating SAGA deubiquitinase activity, we also detected increased SAGA-mediated histone acetylation in H4 basic patch mutants. Our findings uncover that the H4 basic patch has a regulatory function in SAGA-mediated histone modifications.

Yue Chen
May 1, 2007; 6:812-819
Research

Treatment of patients with chronic lymphocytic leukemia (CLL) with inhibitors of Bruton's tyrosine kinase (BTK), such as ibrutinib, is limited by primary or secondary resistance to this drug. Examinations of CLL patients with late relapses while on ibrutinib, which inhibits BTK's catalytic activity, revealed several mutations in BTK, most frequently resulting in the C481S substitution, and disclosed many mutations in PLCG2, encoding phospholipase C-γ2 (PLCγ2). The PLCγ2 variants typically do not exhibit constitutive activity in cell-free systems, leading to the suggestion that in intact cells they are hypersensitive to Rac family small GTPases or to the upstream kinases spleen-associated tyrosine kinase (SYK) and Lck/Yes-related novel tyrosine kinase (LYN). The sensitivity of the PLCγ2 variants to BTK itself has remained unknown. Here, using genetically-modified DT40 B lymphocytes, along with various biochemical assays, including analysis of PLCγ2-mediated inositol phosphate formation, inositol phospholipid assessments, fluorescence recovery after photobleaching (FRAP) static laser microscopy, and determination of intracellular calcium ([Ca2+]i), we show that various CLL-specific PLCγ2 variants such as PLCγ2S707Y are hyper-responsive to activated BTK, even in the absence of BTK's catalytic activity and independently of enhanced PLCγ2 phospholipid substrate supply. At high levels of B-cell receptor (BCR) activation, which may occur in individual CLL patients, catalytically-inactive BTK restored the ability of the BCR to mediate increases in [Ca2+]i. Because catalytically-inactive BTK is insensitive to active-site BTK inhibitors, the mechanism involving the noncatalytic BTK uncovered here may contribute to preexisting reduced sensitivity or even primary resistance of CLL to these drugs.

Kindlins are focal adhesion proteins that regulate integrin activation and outside-in signaling. The kindlin family consists of three members, kindlin-1, -2, and -3. Kindlin-2 is widely expressed in multiple cell types, except those from the hematopoietic lineage. A previous study has reported that the Drosophila Fit1 protein (an ortholog of kindlin-2) prevents abnormal spindle assembly; however, the mechanism remains unknown. Here, we show that kindlin-2 maintains spindle integrity in mitotic human cells. The human neuroblastoma SH-SY5Y cell line expresses only kindlin-2, and we found that when SH-SY5Y cells are depleted of kindlin-2, they exhibit pronounced spindle abnormalities and delayed mitosis. Of note, acetylation of α-tubulin, which maintains microtubule flexibility and stability, was diminished in the kindlin-2–depleted cells. Mechanistically, we found that kindlin-2 maintains α-tubulin acetylation by inhibiting the microtubule-associated deacetylase histone deacetylase 6 (HDAC6) via a signaling pathway involving AKT Ser/Thr kinase (AKT)/glycogen synthase kinase 3β (GSK3β) or paxillin. We also provide evidence that prolonged hypoxia down-regulates kindlin-2 expression, leading to spindle abnormalities not only in the SH-SY5Y cell line, but also cell lines derived from colon and breast tissues. The findings of our study highlight that kindlin-2 regulates mitotic spindle assembly and that this process is perturbed in cancer cells in a hypoxic environment.

6 February 2014 , Volume 70, Number 1

The author of books on love, religion and Proust, explains why the news agenda should be more positive

Linda J. Pike
Jul 1, 2006; 47:1597-1598
Report

Invitation Only Research Event

Event participants

John Zogby, Founder and Senior Partner, John Zogby Strategies
Chair: Dr Lindsay Newman, Senior Research Fellow, US and Americas Programme, Chatham House

The plasmas of diabetic or uremic patients and of those receiving peritoneal dialysis treatment have increased levels of the glucose-derived dicarbonyl metabolites like methylglyoxal (MGO), glyoxal (GO), and 3-deoxyglucosone (3-DG). The elevated dicarbonyl levels can contribute to the development of painful neuropathies. Here, we used stimulated immunoreactive Calcitonin Gene–Related Peptide (iCGRP) release as a measure of nociceptor activation, and we found that each dicarbonyl metabolite induces a concentration-, TRPA1-, and Ca2+-dependent iCGRP release. MGO, GO, and 3-DG were about equally potent in the millimolar range. We hypothesized that another dicarbonyl, 3,4-dideoxyglucosone-3-ene (3,4-DGE), which is present in peritoneal dialysis (PD) solutions after heat sterilization, activates nociceptors. We also showed that at body temperatures 3,4-DGE is formed from 3-DG and that concentrations of 3,4-DGE in the micromolar range effectively induced iCGRP release from isolated murine skin. In a novel preparation of the isolated parietal peritoneum PD fluid or 3,4-DGE alone, at concentrations found in PD solutions, stimulated iCGRP release. We also tested whether inflammatory tissue conditions synergize with dicarbonyls to induce iCGRP release from isolated skin. Application of MGO together with bradykinin or prostaglandin E2 resulted in an overadditive effect on iCGRP release, whereas MGO applied at a pH of 5.2 resulted in reduced release, probably due to an MGO-mediated inhibition of transient receptor potential (TRP) V1 receptors. These results indicate that several reactive dicarbonyls activate nociceptors and potentiate inflammatory mediators. Our findings underline the roles of dicarbonyls and TRPA1 receptors in causing pain during diabetes or renal disease.