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Primary Care Providers in California and Florida Report Low Confidence in Providing Type 1 Diabetes Care

People with type 1 diabetes may receive a significant portion of their care from primary care providers (PCPs). To understand the involvement of PCPs in delivering type 1 diabetes care, we performed surveys in California and Florida, two of the most populous and diverse states in the United States. PCPs fill insulin prescriptions but report low confidence in providing type 1 diabetes care and difficulty accessing specialty referrals to endocrinologists.




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Total Antioxidant Capacity and Pancreatic Cancer Incidence and Mortality in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial

Background:

Total antioxidant capacity (TAC) reflects an individual's overall antioxidant intake. We sought to clarify whether higher TAC is associated with lower risks of pancreatic cancer incidence and mortality in the U.S. general population.

Methods:

A total of 96,018 American adults were identified from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. A ferric-reducing ability of plasma score was used to reflect an individual's TAC intake from diet and/or supplements. Cox regression was used to calculate hazard ratios (HR) for pancreatic cancer incidence, and competing risk regression was used to calculate subdistribution HRs for pancreatic cancer mortality. Restricted cubic spline regression was used to test nonlinearity.

Results:

A total of 393 pancreatic cancer cases and 353 pancreatic cancer–related deaths were documented. Total (diet + supplements) TAC was found to be inversely associated with pancreatic cancer incidence (HR quartile 4 vs. quartile 1 = 0.53; 95% confidence interval, 0.39–0.72; Ptrend = 0.0002) and mortality (subdistribution HR quartile 4 vs. quartile 1 = 0.52; 95% confidence interval 0.38–0.72; Ptrend = 0.0003) in a nonlinear dose–response manner (all Pnonlinearity < 0.01). Similar results were observed for dietary TAC. No association of supplemental TAC with pancreatic cancer incidence and mortality was found.

Conclusions:

In the U.S. general population, dietary but not supplemental TAC level is inversely associated with risks of pancreatic cancer incidence and mortality in a nonlinear dose–response pattern.

Impact:

This is the first prospective study indicating that a diet rich in antioxidants may be beneficial in decreasing pancreatic cancer incidence and mortality.




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Further Guidance in Implementing the Standardized 2018 World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) Score

The 2018 World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) Score was developed to establish a simple, standardized scoring system for researchers to quantify adherence to the 2018 WCRF/AICR Cancer Prevention Recommendations and assess its impact on cancer risk and other health-related outcomes. The aim of this commentary is to clarify potential points of ambiguity in its application, focusing on aspects related to specific subscore components (physical activity, fast foods, alcohol, and sugar-sweetened drinks), how to address different data needs due to varied data collection instruments, and future exploratory score approaches. Overall, we encourage researchers to utilize the standardized score to enhance comparability across populations and countries. Researchers who may adapt or augment the 2018 WCRF/AICR Score are strongly encouraged to provide detailed descriptions of their methods to promote transparency and reproducibility.




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Detecting {beta}-Galactosidase-Labeled Cells

β-Galactosidase has been used extensively both as a label in enzyme immunoassays and for immunocytochemistry. One good substrate is 5-bromo-4-chloro-3-indolyl-β-d-galactopyranoside (X-gal), which gives an intense blue product. The product is stable and insoluble in alcohol as well as H2O.




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Risks from tax avoidance in real estate transaction

As home sellers commonly propose to state a lower price in the sale contract than the actual transaction value, home buyers have to bear additional risks from such real estate transactions.




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Unemployment fears mount in UK holiday hotspots with mass job cuts predicted



BRITAIN'S summer holiday destinations will face some of the biggest economic hits of the coronavirus pandemic with fears of massive job losses in coastal communities, a study has claimed.




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Video Friday: This Wearable Robotic Tail Will Improve Your Balance

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Video Friday: Watch Robots Make a Crepe and Twist the Perfect Pretzel

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Video Friday: AlienGo Quadruped Robot Can Now Do Backflips

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Video Friday: This Robotic Thread Could One Day Travel Inside Your Brain

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Video Friday: Misty Robotics Begins Shipping Its Programmable Personal Robot

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Video Friday: Watch This Robot Dog Explore an Underground Tunnel Autonomously

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Video Friday: Roller-Skating Quadruped Has Best of Both Worlds Mobility

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Video Friday: Boston Dynamics' Atlas Robot Shows Off New Gymnastics Skills

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Video Friday: Caltech's Drone With Legs Takes First Steps

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Video Friday: This Humanoid Robot Will Serve You Ice Cream

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Video Friday: Transferring Human Motion to a Mobile Robot Manipulator

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Video Friday: Kuka's Robutt Is a Robot Designed to Assess New Car Seats

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Video Friday: DJI's Mavic Mini Is a $400 Palm-Sized Foldable Drone

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Video Friday: Invasion of the Mini Cheetah Robots

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Video Friday: Robotic Endoscope Travels Through the Colon

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Video Friday: This Robot Refuses to Fall Down Even if You Hit, Shove It

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Air India Crew Involved in Repatriation Flights Should Stay Back in Delhi, Says Noida Police Commissioner

Noida Police Commissioner has written to national carrier Air India, requesting the airline to ensure that pilots and crew involved in repatriation flights should stay back in Delhi.






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Justin Amash on third-party presidential campaign: 'I think it hurts both candidates'

Rep. Justin Amash believes his White House bid is bad for both President Trump and his Democratic challenger, the Michigan Libertarian indicated in a recent interview.

Mr. Amash, a former Republican who left the GOP last year, told Time that he expects his presence in the presidential race will not ...




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The Push for Tidal Power Faces Its Biggest Challenge Yet

The renewable energy source has never quite lived up to its potential, but a new experiment in Nova Scotia could flip the script




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Google announces company holiday on May 22 to stem virus burnout

Alphabet Inc's Google said on Friday it has asked employees to take a day off on May 22, to address work-from-home-related burnout during the coronavirus pandemic.




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UK weather forecast: Britain to see mix of sunshine and April showers over Easter Bank Holiday weekend

Temperatures in parts of Britain are likely to soar to 24C over the Easter Bank Holiday weekend, but the sunshine could be interrupted by some April showers.




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UK &apos;must not ruin&apos; coronavirus lockdown progress over Bank Holiday weekend as Boris Johnson &apos;rests up&apos; after leaving intensive care

Follow our live Covid-19 updates HERE Coronavirus: The symptoms




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Donald Trump accuses World Health Organisation of &apos;horrible, tragic mistake&apos; over early coronavirus guidance

Follow our live coronavirus updates here




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Your morning briefing: What you should know for Friday, April 17




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Britons should not book summer holidays amid &apos;no certainty&apos; on when lockdown will lift, Downing Street suggests

Brits should not book summer holidays because there is no end in sight to the lockdown, the Government has suggested.




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Crowds fill Florida beaches after Donald Trump calls for US states to be &apos;liberated&apos; amid lockdowns

People flocked to beaches in Florida after the state lifted some of its coronavirus lockdown restrictions.




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Missouri sues China over handling of coronavirus outbreak as Beijing calls for solidarity rather than &apos;finger pointing&apos;

The US state of Missouri is suing the Chinese government over its handling of the coronavirus as Beijing calls for solidarity and less "finger pointing" during the pandemic.




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Your morning briefing: What you should know for Friday, April 24




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Six-year-old with Spina Bifida raises £200k for NHS by walking 10 metres every day

A six-year-old boy with Spina Bifida has raised more than £200,000 for NHS charities by walking 10 metres every day in his walking frame.




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Poundland boss hands &apos;hero&apos; workers extra week of holiday as reward for efforts during Covid-19 crisis

Retailer also doubles staff discounts and commits to guaranteeing time off for employees over Christmas period




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Holiday in Greece, it&apos;s safer than Britain, says tourist chief

Greece's tourism minister today told Britons he wants them to holiday in his country this summer as he declared they could be safer there than here.




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British schools will not open during summer holidays and return in phases, Gavin Williamson says

English schools will reopen after coronavirus lockdown in a "phased manner", the Education Secretary confirmed.




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Donald Trump says US will not renew social distancing guidance after it expires today

Donald Trump has announced that the federal government will not be extending its coronavirus social distancing guidelines after they expire on Thursday.




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Your morning briefing: What you should know for Friday, May 1

The top stories you're waking up to Listen to your Morning Bulletin on Google Assistant and Amazon Alexa smart speakers from 7am every weekday




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UK weather forecast: Britain braced for wet weekend before temperatures soar for May Bank Holiday

The UK is braced for a wet weekend with sunny spells as temperatures drop ahead of the May Bank Holiday.




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UK weather forecast: Sizzling 25C heat to arrive just in time for Bank Holiday weekend

Britons will enjoy another mini heatwave as temperatures soar to an unseasonably high 25C just in time for the Bank Holiday weekend.




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Police warn Bank Holiday drivers after 142 per cent surge in &apos;extreme&apos; speeding during lockdown




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UK weather forecast: Brits set for 26C heat over Bank Holiday weekend

Brits are set to bask in two days of glorious sunshine over the May Bank Holiday weekend, with temperatures creeping up to 26C.




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Hundreds evacuated as wildfires rage in Florida Panhandle

Around 500 people have been forced to flee their homes due to raging wildfires in the Florida Panhandle, authorities have confirmed.




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Sadiq Khan urges Londoners not to relax &apos;monumental effort&apos; to beat coronavirus over Bank Holiday weekend

Mayor Sadiq Khan today made an urgent appeal to Londoners not to relax their "monumental effort" to beat coronavirus as the death toll in the capital's hospitals rose to 5,414.




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Brits urged not to flout coronavirus lockdown over Bank Holiday weekend as temperatures set to soar

Brits have been urged to stick to the coronavirus lockdown rules over the Bank Holiday weekend as temperatures are set to soar.




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Police complain they are &apos;villains of pandemic&apos; as they prepare for Bank Holiday weekend crackdown

Cabinet Secretary Oliver Dowden admitted on Friday morning that the lockdown is facing a major test from the sunny weekend ahead.