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Diastereoselective synthesis of functionalized spiroindolines via intramolecular ipso-iodocyclization/nucleophile addition cascade reactions of indole-tethered ynones

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00112E, Paper
Debojyoti Bag, Sanghapal D. Sawant
Herein, we describe a highly diastereoselective approach for synthesizing polyfunctionalized spiroindolines from indolyl-ynones involving an ipso-iodocyclization/nucleophile addition cascade.
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Selective recognition between aromatics and aliphatics by cage-shaped borates supported by a machine learning approach

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00408F, Paper
Open Access
Yuya Tsutsui, Issei Yanaka, Kazuhiro Takeda, Masaru Kondo, Shinobu Takizawa, Ryosuke Kojima, Akihito Konishi, Makoto Yasuda
Exploration of a Lewis acid with high selectivity for hydrocarbon moieties is assisted by a machine learning approach. Molecular polarizability is an essential factor, leading to design guidelines for Lewis acid catalysts with dispersion forces.
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Electrochemical and photochemical reaction of isatins: a decade update

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00202D, Review Article
Nandini M. Gotgi, J. Saurab Jain, Rita Pal, Debashis Ghosh
This review presents all the recent reports on electro- and photochemical reactions of isatins over the last decade.
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Friedel–Crafts reactions for biomolecular chemistry

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00406J, Review Article
Open Access
Jun Ohata
This review demonstrates advances in Friedel–Crafts alkylation and acylation reactions in a variety of biomolecular chemistry fields.
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Electrochemical nickel-catalyzed cross-coupling of glycosyl thiols with preactivated phenols and ketones

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00442F, Communication
Fuxin Li, Hui Liu, Wanyu Xing, Qingju Zhang, Liming Wang
Here we report an efficient electrochemical nickel-catalyzed cross-coupling reaction for the synthesis of S-glycosides from preactivated phenols and ketones.
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Stereoselective Synthesis of gem-Dihalopiperidines via Halo-Aza-Prins Cyclization Reaction: Access to Piperidin-4-ones and Pyridines

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00338A, Paper
Anil Kumar Saikia, Surjya Kumar Bora, Subhamoy Biswas, Bipin Kumar Behera
An efficient methodology for the synthesis of 4,4-dihalopiperidine derivatives has been developed from N-(3-halobut-3-en-1-yl)-4-methylbenzenesulfonamide and aldehyde catalyzed by In(OTf)3 in excellent yields. The reaction involves an initial formation of six...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Vinylogous and stereoselective domino synthesis of pyrano[2,3-c]pyrroles from alkylidene meldrum's acids

Org. Biomol. Chem., 2024, 22,2948-2952
DOI: 10.1039/D4OB00233D, Communication
Mariia Savchuk, Giang Vo-Thanh, Sylvain Oudeyer, Hélène Beucher, Jean-François Brière
An expeditious diatereoselective synthesis of pyrano[2,3-c]pyrroles thanks to a domino Vinylogous aza-Michael-Aldol-Cyclocondensation (aza-VMAC) reaction to alkylidene Meldrum's acid derivatives.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Selective synthesis of an elusive C-functional bis-cyclam and study of its inhibition of the CXCR4 chemokine receptor

Org. Biomol. Chem., 2024, 22,3059-3067
DOI: 10.1039/D3OB02050A, Paper
Marie M. Le Roy, Sandra Claes, Nathalie Saffon-Merceron, Dominique Schols, Thibault Troadec, Raphaël Tripier
A rare example of C,C'-linked bis-cyclam has been synthesized with controlled manner in mild conditions thanks to the “bis-aminal” tool, and its good CXCR4-recognition properties could be demonstated in vitro.
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Palladium-catalyzed (Z)-selective allylation of phosphine oxides with vinylethylene carbonates to construct phosphorus allyl alcohols

Org. Biomol. Chem., 2024, 22,3068-3072
DOI: 10.1039/D4OB00354C, Paper
Hua Huang, Yi-Qi Wu, Lu-Yao Han, Lu Jiang, Zhuo-Zhuo Zhang, Xiang Zhang, Bo Han, Wei Huang, Jun-Long Li
A general and efficient method for the highly stereoselective synthesis of (Z)-phosphorus allylalcohols has been developed using the Pd-catalyzed cross-coupling of phosphine oxides with vinylethylene carbonates.
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Stereoselective synthesis of (R)- and (S)-1,2-diazetidine-3-carboxylic acid derivatives for peptidomimetics

Org. Biomol. Chem., 2024, 22,2974-2977
DOI: 10.1039/D4OB00278D, Communication
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Matthew Nutter, Henry Stone, Michael Shipman, Stefan Roesner
Stereoselective synthesis of both enantiomers of orthogonally protected 1,2-diazetidine-3-carboxylic acid (aAze) from homochiral glycidol and its application in peptidomimetics.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Selective enhancement of (6–4) photoproduct formation in dithymine dinucleotides driven by specific sugar puckering

Org. Biomol. Chem., 2024, 22,3025-3034
DOI: 10.1039/D4OB00279B, Paper
Jouda Jakhlal, Clément Denhez, Stéphanie Coantic-Castex, Agathe Martinez, Dominique Harakat, Thierry Douki, Dominique Guillaume, Pascale Clivio
Evidence is presented that (6–4) photoproduct formation between two thymine residues in dinucleotide analogues is significantly and specifically enhanced when the 5''- and 3''-end sugar puckering are mainly north and south, respectively.
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Iron-catalyzed selective construction of indole derivatives via oxidative C(sp3)–H functionalization of indolin-2-ones

Org. Biomol. Chem., 2024, 22,3073-3079
DOI: 10.1039/D4OB00133H, Paper
Wei Chen, Lang-Qi Wen, Xiao-Bing Lu, Hui Zhou
We have developed a clean and efficient iron-catalyzed C(sp3)–H functionalization of indolin-2-ones for the chemodivergent synthesis of value-added indole derivatives, including isatins, and symmetrical and non-symmetrical isoindigos.
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Photochromism of phenazine-2,3-diol derivatives through excited state intermolecular proton transfer based on keto–enol tautomerization

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00387J, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Kazuki Ohira, Kumpei Kozuka, Naoki Kaneda, Masahiro Yamamoto, Keiichi Imato, Yousuke Ooyama
It was found that phenazine-2,3-diol derivatives exhibit photochromism through excited state intermolecular proton transfer (ESInterPT) processes based on keto–enol tautomerization.
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Nickel-catalysed regio- and stereoselective hydrocyanation of alkynoates and its mechanistic insights proposed by DFT calculations

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00380B, Communication
Shigeru Arai, Koichi Nakazawa, Xiao-Fei Yang, Masaya Nakajima, Shinji Harada, Atsushi Nishida
This work discloses the origin of regio- and stereoselectivity of hydrocyanation of alkynoates.
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Cu(OTf)2/HFIP catalyzed regioselective cycloisomerization of indole-C3-functionalized alkynols to carbazoles

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00421C, Communication
Srinivasarao Yaragorla, Tabassum Khan, Sayonika Chakroborty
We report here a simple and atom economic cycloisomerization reaction of indole-tethered alkynols for constructing diverse carbazoles via 1,2-alkly migration using Cu(OTf)2/HFIP as the excellent promoter system.
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Electro-oxidative three-component cascade coupling of isocyanides with elemental sulfur and amines for the synthesis of 2-aminobenzothiazoles

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00432A, Paper
Peng-Fei Huang, Jia-Le Fu, Ying Peng, Jian-Hong Fan, Long-Jin Zhong, Kewen Tang, Yu Liu
2-Aminobenzothiazoles are commonly encountered in various functional compounds. Herein, we disclose an electro-oxidative three-component reaction for the effective synthesis of 2-aminobenzothiazoles under mild conditions, utilizing non-toxic and abundant elemental sulfur...
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Design, synthesis, biological evaluation and molecular docking studies of quinoline-anthranilic acid hybrids as potent anti-inflammatory drugs

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00040D, Paper
Sidra Siddique, Khalid Hussain, Naureen Shehzadi, Muhammad Arshad, Muhammad Nadeem Arshad, Sadaf Iftikhar, Farhat Saghir, Ayisha Shaukat, Muhammad Sarfraz, Nisar Ahmed
Despite the high global prevalence, rheumatoid arthritis lacks a satisfactory treatment.
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Discovery of selective monosaccharide receptors via dynamic combinatorial chemistry

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00015C, Communication
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Miguel Alena-Rodriguez, Marcos Fernandez-Villamarin, Ignacio Alfonso, Paula M. Mendes
An effective workflow to discover selective saccharide receptors by combining dynamic combinatorial chemistry with isothermal titration calorimetry and NMR.
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Measuring local pH at interfaces from molecular tumbling: A concept for designing EPR-active pH-sensitive labels and probes

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00167B, Paper
Open Access
Maxim A. Voinov, Nicholas Nunn, Roshan Rana, Atli Davidsson, Alex I. Smirnov, Tatyana I. Smirnova
EPR-based local pH measurements based on changes in rotational dynamics of spin-bearing molecules upon protonation.
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A Highly Diastereoselective One-Pot Ugi/Radical Spirocyclization/Aza-Michael Addition Sequence

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00610K, Communication
Chandra Volla, Salman Khan, Abhradeep Chatterjee, Akshay Murali Nair
We hereby report a highly diastereoselective synthesis of chalcogenated azaspirotricycles via a one-pot Ugi/spirocyclization/ aza-Michael addition sequence. The reaction proceeded via a key visible light mediated spirocyclization step under mild,...
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Regioselective synthesis of 4-arylamino-1,2-naphthoquinones in eutectogel as a confined reaction medium using LED light

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00140K, Communication
R. Vara Prasad, Yogendra Kumar, R. Arun Kumar, Tohira Banoo, Subbiah Nagarajan
The use of a simple carbohydrate-derived eutectogel facilitating a LED-light-induced regioselective synthesis of 4-arylamino-1,2-naphthoquinones in good yields is reported.
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Electric aircraft set to transform urban mobility 

Investors are pouring in billions of dollars into eVTOL project (electric vertical take offs and landing aircraft) to ferry passengers




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Perplexity AI CEO says “still haven’t gotten” a green card amid immigration debate ahead of U.S. Presidential Election 2024

Srinivas went on to work with OpenAI for a year before co-founding Perplexity AI in 2022




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Selecting the right candidate

Building a team or an institution requires both courtesy and common sense




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Designing organisations as ‘selfless’ collectives

Reducing complexity and friction between members is important




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Ahead of Telangana election, Turmeric Board constituted

The Board is expected to help develop and grow the spice’s market in India, which controls over 62% share of the turmeric world trade




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Election Commission nod taken before lifting ban on onion exports: Govt sources

The decision assumes importance as it comes before the crucial Lok Sabha polls in key onion belts like Nashik, Ahmednagar and Solapur in Maharashtra




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Nuclear excitation by electron capture seen at long last

Breakthrough could lead to new type of energy source




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Three photons bind together to make a ‘molecule’ of light

Technique could be used to create quantum-information systems




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Becoming a trauma-informed restorative educator [electronic resource] : practical skills to change culture and behavior / Joe Brummer and Margaret Thorsborne ; foreword by Dr. Lori L. Desautels.

London ; Philadelphia : Jessica Kingsley Publishers, 2024.




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Developing inclusive schools [electronic resource] : pathways to success / Mel Ainscow.

Abingdon, Oxon ; New York, NY : Routledge , 2024.




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Educational research and the question(s) of time [electronic resource] / David R. Cole, Mehri Mirzaei Rafe, Gui Ying Annie Yang-Heim, editors.

Singapore : Springer, [2024]




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Embracing relational teaching [electronic resource] : how strong relationships promote student self-regulation and efficacy / Anthony R. Reibel.

Bloomington, IN : Solution Tree Press, [2023]




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Engaging critical pedagogy in education [electronic resource] : global phenomenon, local praxis / edited by Fida Sanjakdar and Michael W. Apple.

Abingdon, Oxon ; New York, NY : Routledge , 2025.




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Equity and inclusion in higher education [electronic resource] : strategies for teaching / edited by Rita Kumar and Brenda Refaei.

Cincinnati : University of Cincinnati Press, 2021.




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Everyday artfulness [electronic resource] : a posthuman perspective on young children's play with materials / Lucy Hill.

Oxford ; New York : Peter Lang, [2024]




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The future of higher education in an age of artificial intelligence [electronic resource] / by Stephen Murgatroyd.

[Cambridge, England] : Ethics International Press Limited, 2024.




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Improving education policy together [electronic resource] : how it's made, implemented, and can be done better / Nansi Ellis and Gareth Conyard.

Abingdon, Oxon ; New York, NY : Routledge , 2024.




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Rethinking writing instruction in the age of AI [electronic resource]: a universal design for learning approach Randy Laist ; with contributions from Nicole Brewer, Cynthia J. Murphy, and Dana Sheehan

Lynnfield, Massachusetts CAST [2024]




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Towards a queer and trans ethic of care in education [electronic resource] : beyond the limitations of white, cisheteropatriarchal, colonial care / Bishop Owis.

New York, NY : Routledge , 2024.




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Embedded formative assessment [electronic resource] / Dylan Wiliam.

Bloomington, Indiana : Solution Tree Press, 2018.




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The Bloomsbury handbook of Hip Hop pedagogy [electronic resource] / edited by Lauren Leigh Kelly and Daren Graves

London : Bloomsbury Academic, [2024]




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Decolonial underground pedagogy [electronic resource] : unschooling and subcultural learning for peace and human rights / Noah Romero.

London : Bloomsbury Academic, 2024.




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How successful schools are more than effective [electronic resource] : principals who build and sustain teacher and student wellbeing and achievement / Christopher Day, David Gurr, editors

Cham : Springer, [2024]




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Neurodevelopment in the post-pandemic world [electronic resource] : the altered trajectory of children's education, mental health, and brain development / Molly Colvin, Jennifer Linton Reesman, Tannahill Glen.

New York, NY : Oxford University Press, [2024]




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Resisting neoliberal schooling [electronic resource] : dismantling the rubricization and corporatization of higher education / edited by Anthony J. Nocella II.

New York : Peter Lang , 2024.




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Smart university [electronic resource] : student surveillance in the digital age / Lindsay Weinberg.

Baltimore : Johns Hopkins University Press, [2024]




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The social studies curriculum [electronic resource] : purposes, problems, and possibilities / edited by E. Wayne Ross

Albany : State University of New York Press, 2024.




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Transformative change through educational leadership [electronic resource] : stories, models, and wonderings / edited by Kenneth H. MacKinnon.

Toronto : Canadian Scholars, 2024.




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Framing futures in postdigital education [electronic resource] : critical concepts for data-driven practices / editors, Anders Buch, Ylva Lindberg and Teresa Cerratto Pargman

Cham, Switzerland : Springer, [2024]