Field evidence shows that emplacement of Devonian granites in northern England overlaps in space and time with the end of the supposed Acadian deformation in their country rocks. The age of this Acadian event in England and Wales is in need of review because of revised Rb-Sr and K-Ar decay constants and recently acquired radiometric ages on the granites.

Published K-Ar and Ar-Ar cleavage ages recalculated to the new decay constants range from 404 to 394 Ma (Emsian, Early Devonian). Emplacement of the Skiddaw and Weardale granites at 398.8 ± 0.4 and 399.3 ± 0.7 Ma respectively is indicated by U-Pb zircon ages, and is compatible with the field evidence. However, emplacement of the Shap Granite at a Re-Os molybdenite age of 405.2 ± 1.8 Ma and at the youngest U-Pb zircon age of 403 ± 8 Ma matches the field evidence less well. The apparent paradox in these ages is resolved if the K-Ar ages record only the end of millions of years of cleavage formation. An earlier cluster of K-Ar and Ar-Ar cleavage ages at 426–420 Ma (Ludlow to Přídolí, late Silurian) dates a pre-Acadian resetting event soon after Iapetus closure, an event of uncertain significance.

Ion microprobe U-Pb zircon ages for the Shap Granite have a mean of 415.6 ± 1.4 Ma but a range of 428–403 Ma, compatible with a long magmatic history. Thermal considerations suggest that this history was not at the upper crustal emplacement site but in a mid-crustal mush zone, now preserved at about 10 km depth as a component of the Lake District and North Pennine batholiths.

Oil residues occur as solid bitumen in mineralized zones within the Devonian Weardale Granite of the northern Pennines, northern England. Comparable residues are present in the overlying Mississippian rocks and were probably derived from a Carboniferous source, i.e. during later mineralization of the granite. The bitumen was already solidified during fluorite mineralization, which does not contain oil inclusions. The residues do not show the high thermal maturity of organic matter in the region altered by the earliest Permian Whin Sill. Like the sulphide-fluorite mineralization, oil emplacement post-dated intrusion of the sill. Pyrite associated with the oil residues is enriched in trace elements including lead, silver, gold, selenium and tellurium, which suggests that mineralizing fluids at least shared pathways with migrating hydrocarbons and possibly also suggests undiscovered valuable metal resources.

Jack Nguyen and Meir M. Barak

Cortical bone remodeling is an ongoing process triggered by microdamage, where osteoclasts resorb existing bone and osteoblasts deposit new bone in the form of secondary osteons (Haversian systems). Previous studies revealed regional variance in Haversian systems structure and possibly material, between opposite cortices of the same bone. As bone mechanical properties depend on tissue structure and material, it is predicted that bone mechanical properties will vary in accordance with structural and material regional heterogeneity. To test this hypothesis, we analyzed the structure, mineral content and compressive stiffness of secondary bone from the cranial and caudal cortices of the white-tailed deer proximal humerus. We found significantly larger Haversian systems and canals in the cranial cortex but no significant difference in mineral content between the two cortices. Accordingly, we found no difference in compressive stiffness between the two cortices and thus our working hypothesis was rejected. Seeing that the deer humerus is curved and thus likely subjected to bending during habitual locomotion, we expect that similar to other curved long bones, the cranial cortex of the deer humerus is likely subjected primarily to tensile strains and the caudal cortex is likely subject primarily to compressive strains. Consequently, our results suggest that strain magnitude (larger in compression) and sign (compression vs. tension) affect differently the osteoclasts and osteoblasts in the BMU. Our results further suggest that osteoclasts are inhibited in regions of high compressive strains (creating smaller Haversian systems) while osteoblasts’ osteoid deposition and mineralization is not affected by strain magnitude and sign.

Neuroendocrinelike transdifferentiation of prostate cancer adenocarcinomas correlates with serum levels of chromogranin A (CgA) and drives treatment resistance. The aim of this work was to evaluate whether CgA can serve as a response predictor for ¹⁷⁷Lu-prostate-specific membrane antigen 617 (PSMA) radioligand therapy (RLT) in comparison with the established tumor markers. Methods: One hundred consecutive patients with metastasized castration-resistant prostate cancer scheduled for PSMA RLT were evaluated for prostate-specific antigen (PSA), lactate dehydrogenase (LDH), and CgA at baseline and in follow-up of PSMA RLT. Tumor uptake of PSMA ligand, a known predictive marker for response, was assessed as a control variable. Results: From the 100 evaluated patients, 35 had partial remission, 16 stable disease, 15 mixed response, and 36 progression of disease. Tumor uptake above salivary gland uptake translated into partial remission, with an odds ratio (OR) of 60.265 (95% confidence interval [CI], 5.038–720.922). Elevated LDH implied a reduced chance for partial remission, with an OR of 0.094 (95% CI, 0.017–0.518), but increased the frequency of progressive disease (OR, 2.717; 95% CI, 1.391–5.304). All patients who achieved partial remission had a normal baseline LDH. Factor-2 elevation of CgA increased the risk for progression, with an OR of 3.089 (95% CI, 1.302–7.332). Baseline PSA had no prognostic value for response prediction. Conclusion: In our cohort, baseline PSA had no prognostic value for response prediction. LDH was the marker with the strongest prognostic value, and elevated LDH increased the risk for progression of disease under PSMA RLT. Elevated CgA demonstrated a moderate impact as a negative prognostic marker in general but was explicitly related to the presence of liver metastases. Well in line with the literature, sufficient tumor uptake is a prerequisite to achieve tumor response.

BACKGROUND AND PURPOSE:

Not all tandem occlusions diagnosed on traditional vascular imaging modalities, such as MRA, represent actual complete ICA occlusion. This study aimed to explore the utility of high-resolution vessel wall imaging in identifying true ICA tandem occlusions and screening patients for their suitability for endovascular recanalization.

BACKGROUND AND PURPOSE:

After endovascular coiling of intracranial aneurysms, round dark parenchymal lesions believed to be particulate metal are sometimes encountered in MR imaging studies of the brain. We used SWI to assess the frequency of such occurrences, in addition to exploring likely causes and clinical implications.

Oscar-winning Iranian director Asghar Farhadi said Sunday he will not attend the Academy Awards on Feb. 26, “even if exceptions were to be made for my trip,” as protests over President Donald Trump's immigration ban spread to Hollywood's biggest global stage.

The attempts seem to be experiments that were quickly abandoned, and none of those identified received substantial engagement.

One dog owner has found out the hard way that giving her Pomeranian a haircut at home during the coronavirus lockdown isn't an easy job.

Donald Trump has instructed the US Navy to shoot down and destroy Iranian gunboats "if they harass our ships at sea".

“Ayo, my best friend’s rich check”

Naturally, Kim Kardashian's Bora Bora meltdown makes an appearance...

Granit Xhaka has opened up on the "hatred" he felt towards him following an infamous spat with Arsenal fans earlier this season.

An interview with former Leicester City manager Claudio Ranieri encountered a rather odd technical difficulty on Thursday - with the feed cutting to his unsuspecting wife Rosanna.

Gilead Sciences has captured worldwide attention with its COVID-19 antiviral, remdesivir, cleared late last week by the FDA—not all of it welcome. With bad actors targeting companies at the head of the spear in the pandemic response, Gilead may have found itself in their sights.

An Iranian citizen and his Tehran business have been charged with purchasing helicopter engines and advanced aerial cameras for fighter bombers from U.S. firms and illegally exporting them to Iran using companies in Malaysia, Ireland and the Netherlands. Among the alleged recipients of these U.S. goods was an Iranian military firm that has since been designated by the United States for being owned or controlled by entities involved in Iran’s nuclear and ballistic missile program.

Norfolk Southern Railway Company has agreed to pay a $4 million penalty to resolve alleged violations of the Clean Water Act (CWA) and hazardous materials laws for a 2005 chlorine spill in Graniteville, S.C.

Omid Khalili, an Iranian national, pleaded guilty today in U.S. District Court for the Southern District of Alabama to attempting to illegally export fighter jet or military aircraft parts from the United States to Iran.

Milad Jafari, 36, a citizen and resident of Iran has been indicted for illegally exporting and attempting to export specialized metals from the United States through companies in Turkey to several entities in Iran, including some entities that have been sanctioned for involvement in ballistic missile activities.

A settlement agreement has been reached for the cleanup of the Midnite Mine Superfund Site, located on the Spokane Indian Reservation in Northeastern Washington.

ING Bank N.V., a financial institution headquartered in Amsterdam, has agreed to forfeit $619 million to the Justice Department and the New York County District Attorney’s Office for conspiring to violate the International Emergency Economic Powers Act (IEEPA) and the Trading with the Enemy Act (TWEA) and for violating New York state laws by illegally moving billions of dollars through the U.S. financial system on behalf of sanctioned Cuban and Iranian entities.

A federal grand jury in the District of Columbia has returned a superseding indictment charging Parviz Khaki, a citizen of Iran, and Zongcheng Yi, a resident of China, for their alleged efforts to obtain and illegally export to Iran U.S.-origin materials that can be used to construct, operate and maintain gas centrifuges to enrich uranium, including maraging steel, aluminum alloys, mass spectrometers, vacuum pumps and other items.

Manssor Arbabsiar, aka Mansour Arbabsiar, pleaded guilty today in federal court in the Southern District of New York to participating in a plot to murder the Saudi Arabian Ambassador to the United States while the Ambassador was in the United States.

Amin Ravan, a citizen of Iran, and his Iran-based company, IC Market Iran, have been charged in an indictment unsealed today with conspiracy to defraud the United States, smuggling, and violating the Arms Export Control Act in connection with the unlawful export of 55 military antennas from the United States to Singapore and Hong Kong.

Granite Construction Company, a California-based construction company specializing in roads, tunnels, bridges, airports and other infrastructure-related projects, reached a settlement with the United States following an investigation of alleged false claims in connection with federal construction projects across the country.

Manssor Arbabsiar, aka “Mansour Arbabsiar,” was sentenced today in New York City federal court to 25 years in prison for participating in a plot to murder the Saudi Arabian Ambassador to the U.S. while the Ambassador was in the U.S..

Jan 8, 2020

The smoke is still clearing from the drone strike that killed Quds Force commander Qassem Suleimani, and from the Iranian retaliation against U.S. bases in Iraq, and any conclusions have to be tentative ones. But the history of U.S.-Iran conflict points to a narrow, and possibly dangerous, set of choices ahead.

In a drone strike authorized by President Trump early Friday, Iranian commander Maj. Gen. Qassem Soleimani, who led the Quds Force of the Islamic Revolutionary Guards Corps, was killed at Baghdad International Airport. Below, Brookings experts provide their brief analyses on this watershed moment for the Middle East — including what it means for U.S.-Iran…

Both Saudi Arabia and Iran are conspicuously planning for a post-oil future. The centrality of oil to the legitimacy and autonomy of both regimes means that these plans are little more than publicity stunts. Still, just imagine for a moment what it would mean for Iran, Saudi Arabia, and the Middle East if these grandiose agendas were adopted.

In Saudi Arabia and Iran, emotions are running high, and even an accidental spark could turn the cold war between the two regional powers hot. Their antagonism is a grave threat to the wider region, which isn’t exactly a bastion of stability these days—and it’s contrary to those states' long-term interests.

Both Saudi Arabia and Iran are conspicuously planning for a post-oil future. The centrality of oil to the legitimacy and autonomy of both regimes means that these plans are little more than publicity stunts. Still, just imagine for a moment what it would mean for Iran, Saudi Arabia, and the Middle East if these grandiose agendas were adopted.

In Saudi Arabia and Iran, emotions are running high, and even an accidental spark could turn the cold war between the two regional powers hot. Their antagonism is a grave threat to the wider region, which isn’t exactly a bastion of stability these days—and it’s contrary to those states' long-term interests.

Iran’s January 5, 2020 announcement that it no longer considers itself bound by the restrictions on its nuclear program contained in the Joint Comprehensive Plan of Action (JCPOA, aka the “nuclear deal”) raises the specter of the Islamic Republic racing to put in place the infrastructure needed to produce nuclear weapons quickly and the United…

In a drone strike authorized by President Trump early Friday, Iranian commander Maj. Gen. Qassem Soleimani, who led the Quds Force of the Islamic Revolutionary Guards Corps, was killed at Baghdad International Airport. Below, Brookings experts provide their brief analyses on this watershed moment for the Middle East — including what it means for U.S.-Iran…

Iran’s January 5, 2020 announcement that it no longer considers itself bound by the restrictions on its nuclear program contained in the Joint Comprehensive Plan of Action (JCPOA, aka the “nuclear deal”) raises the specter of the Islamic Republic racing to put in place the infrastructure needed to produce nuclear weapons quickly and the United…

Can a nuclear weary TreeHugger really believe what she's hearing? Could uranium mines be facing shortages? Earlier this

An important, if short, cautionary tale on being dependent on any single foreign source of energy.

Radioactive uranium occurs naturally in soils but farming techniques may be causing it to dissolve into groundwater

Spain extends state of emergency; Danish agency warns of risk of second wave

• Coronavirus – latest updates
• See all our coronavirus coverage

New coronavirus infections in Iran have risen sharply since the country relaxed its restrictions on movement, while France has said it will reimpose strict lockdowns if cases surge when it begins to emerge from confinement next week.

Tehran on Wednesday reported 1,680 new infections, nearly double the figure four days ago and the highest daily figure since 11 April when it allowed a phased return to work amid fears of economic collapse. A ban on travel between cities and business at shopping malls has since also been lifted.

Latvia, Lithuania and Estonia will open their borders to each others’ citizens from 15 May, creating a Baltic “travel bubble” within the EU.

Hundreds of Indian police have tested positive for the coronavirus in recent days, raising alarm among an over-stretched force as it attempts to enforce the world’s largest lockdown.

At least 90,000 healthcare workers worldwide – and possibly twice that – are believed to have been infected with Covid-19, and more than 260 nurses have died, the International Council of Nurses (ICN) said.

Professor Salim Abdool Karim, the South African government’s chief adviser, said the country’s strict lockdown and proactive screening and testing programme had helped limit its death toll to 148.

Interview with Rani Baker, Goon Lurker and Internet Hero.

The last few weeks haven't been easy for Zoa Morani and her family. They all were tested Coronavirus positive and it came as a shock to a lot of people and they were worried about their health. Zoa Morani and Shaza Morani were the first ones to be tested positive and then their father and film producer Karim Morani. Zoa and Shaza recovered a few days back while Karim was still tested positive. But now he too is back and doing well.

First, let's talk about Zoa's recent Instagram post where she shared a family picture and announced happily that they all are Coronavirus negative now. It was indeed a moment of celebration that they all successfully combated the virus. It was a long post straight from the heart.

Read it right here:

 

 

 

View this post on Instagram

#positiverecovery ☀ï¸Â Anddddd my father got home last night , treatment over and now our entire household is Covid-19 negative ! 😁 All of us home now , healthy and in good spirits !!!🌻 Whirlwind of an experience but so happy to be on the other side of it.. Each one of us had a different experience with it in terms of symptoms, so for any advice the best thing is to get in touch with a Doctor or hospital... My Father - no symptoms (9 days in hospital) Sister - head ache and fever (6 days in hospital) Me - fever , fatigue , cough , chest congestion , shortness of breath and head ache ( 7 days in hospital) They were mild , and manageable. To sum it up in short - a flu with a strange over all feeling .. The Doctors and medical staff were fearless , positive and extremely helpful and caring ... @my_bmc @mybmchealthdept were on point with following up with us at every step , from making sure we are getting the right treatment to getting our entire building and road sanitised ! To making sure the other residents in our building are safe ! And yes they are ☀ï¸Â 14 days of self isolation at home along with healthy eating , rest and vitamins has been advised.. So grateful for our Government for dealing with this Pandemic hands on ! Thank you Nanavati Hospital for taking care of my Father and Sister and sending them home fully cured 🌼 Thank you Kokilaben hospital ! Indebted forever ! Thank youuuu everyone from the bottom of my heart for all the concern and warm wishes 🥰 So grateful to be on the positive recovery side of this Pandemic . Sincere and deep prayers for the entire world and their families who got hit with the serious side of the illness ... 🤲🏽 #CovidRecovered #covid #ThankYouGod

A post shared by Zoa💫 (@zoamorani) onApr 17, 2020 at 10:34pm PDT

And now, talking to Mumbai Mirror about the same, Zoa poured her heart out on what the experience taught her and why she's now going to donate her blood. She said, "The most important thing that I have learned is how to be your own best friend. When I was in the hospital, I couldn't tell my parents and my sister I am scared. I had to be strong enough to be able to console myself. I have been very attached and dependent on people in the past, didn't have faith and confidence in myself."

And since the entire family, as stated above, is back home, how are they spending time? Zoa said, "We are all staying in the same house but maintaining distance from each other. We are not having dinner together or doing things together. The isolation period for me and my sister will get over. But it is still time for my father's isolation period to get over." She also revealed that she will be donating her blood this weekend.

"This weekend, we are going to be donating our blood. Apparently, after 14 days once you are tested negative, you can give your blood to other people because you have antibodies in your blood. It might help other people heal and recover." She also spoke about how she and her sister felt after they were tested COVID-19 positive. She stated, "My sister got a terrible headache and fever, I, on the other hand, had developed all these symptoms."

She added, "I was not able to breathe properly and I thought something was stuck in my chest. In the beginning, we all thought it was normal flu, my sister got a fever and the next day I got a fever. On the 8th day, it was pretty bad and we decided to get tested." It's heartening to know that the Morani family has finally recovered and we wish they continue to stay happy, hale, and hearty.

Catch up on all the latest entertainment news and gossip here. Also, download the new mid-day Android and iOS apps.

Mid-Day is now on Telegram. Click here to join our channel (@middayinfomedialtd) and stay updated with the latest news

The Rani Mukerji and Saif Ali Khan starrer Ta Ra Rum Pum stood out as a sports-drama that was set against the backdrop of car racing in the USA with Saif playing a racing prodigy. Directed by Siddharth Anand, the film had a lavish shooting schedule in the United States and Rani has some very fond memories of shooting this project. Today, as the film completes 13 years, the actress speaks about almost everything that you'll love to read!

"Ta Ra Rum Pum was a very, very lovely shooting experience for me because we shot in America, in New York, for nearly 3 months. I was there for 3 months at a stretch and it was lovely living in New York around that time shooting the film. We had two little angels - Ali and Angelina (who played the roles of Priya and Ranveer – Saif and Rani's on-screen kids) and I was single at that point of time but to actually play a mother of these 2 children really got my motherly instincts out," says Rani.

The talented actress adds, "Today when I look back and watch the film when I have Adira with me, it just feels so amazing. When Ta Ra Rum Pum released, I had a lot of children and parents really watching the film with a lot of love. I still get a lot of people telling me that they watched Ta Ra Rum Pum and it's one of their favourite films because it has car racing and it has the story about the children."

Rani feels the film's universal theme of family coming together to overcome all odds is what connected with the audiences. "It's a very nice warm lovely story and I think I connected with the film and the story a lot at that time. It was a very sweet story about this couple who has children and how they fight the odds. I think crisis like these brings families closer and I think that's a very special part of the story," she says.

Rani thoroughly enjoyed the animation in the film which was hailed as a cut above as far Bollywood standard back then was. "Of course, it had the animation song (Ta Ra Rum Pum) with the teddy bears which is one of my favourite songs. I think they had done a lovely job and the animation was one of my first animation songs which I did!" the actress adds.

Rani had a blast acting with Saif, with whom she also delivered the blockbuster Hum Tum, and her co-stars in the film. "Of course, having Saif with me as a co actor was wonderful! Also, Victor Banerjee played my father in the film and it was wonderful having him on set and to be working with him. It was overall a great experience and I remember being really, really happy on the sets of Ta Ra Rum Pum!" she says.

Catch up on all the latest entertainment news and gossip here. Also, download the new mid-day Android and iOS apps.

Mid-Day is now on Telegram. Click here to join our channel (@middayinfomedialtd) and stay updated with the latest news

Every city has spaces that have, over the years, become more than just restaurants. They're like little museums of unwritten history, archiving the city's journey through old chinaware, faded signboards and staff that has probably been around for as long as the establishment. Spaces that leave regulars despondent when they shutter, almost as if they have lost one of their own.

Mumbai has its distinct culinary heritage, represented in part by corner-side cafés run by the Irani Zoroastrians and Muslims who made this city their home in the early 1900s. At this year's The Guide Restaurant Awards 2019 presented by mid-day, we celebrate the culinary contribution of this community by honouring 10 surviving cafés. Unique to Mumbai, these Irani cafés have fought inflation, the fast food invasion and a future generation that would rather pick a professional degree over manning a family establishment at low profits. Back in Iran, the Zoroastrians and Muslims, celebrate the onset of spring with the festival of Navroze (new day) on March 21. In Mumbai, it's a day typified by feasting around family.

Six of the 10 winners of this coveted award, discuss what Navroze means to them and the signature dishes to try at their cafes.

Byculla Restaurant and Bakery

Don't forget to try: Mutton pattice
"Since Navroze is a holiday, we keep the shop closed and enjoy ourselves at home. After offering prayers, we relish a feast of kheema and falooda," says Darius Ferzandi, owner. "At night, we have a glass of beer or a peg of whisky and then, off to sleep," he jokes. The best dish here is the mutton pattice (Rs 18).

At: Alexandra Terrace, Byculla Station, Byculla East.
Time: 8 am to 11 pm
Call: 23727375

Cafe Dela Paix

Gustad Dinshaw

Don't forget to try: Egg akuri
Gustad Dinshaw, owner of the 80-year-old café in Girgaum, tells us, "Navroze is the augment of spring and we worship fire, so it's mostly about getting together and offering prayers. We lay out the sofrah table each year and look forward to the rituals." The top selling dish at this café is the humble egg akuri (Rs 30).

At: 7, Shanker Seth Road, Avantikabai Gokhale Street, Opera House, Girgaum.
Time: 10 am to 10 pm
Call: 23824384

Cafe Colony

Don't forget to try: Mutton biryani
For Mirza Mohammed Nazariyan, owner Aga Nazariyan's son, Navroze is all about celebrating togetherness. "The festival is synonymous with happiness and a time for our family to come together," Mirza tells us, adding that while the mutton biryani (Rs 280) is a crowd pleaser, it's his personal favourite, too.

At: Road 1, Shrikanth Lodge, near Tilak Bridge, Hindu Colony, Dadar East.
Time: 6 am to 10.30 pm
Call: 24142321

Cafe Excelsior

Mutton cutlet gravy

Don't forget to try: Mutton cutlet
"A different animal or bird is associated with every new year. This year, it's white pig," explains Ardeshir Maskoori, owner of one of the most popular Irani cafés in the city, which completed a century last month. "It's very difficult for me to pick one favourite dish, but if I had to, I would suggest the mutton cutlet [Rs 300 dry; Rs 320 with gravy]," he says.

Ardeshir Maskoori

At: 23, AK Nayak Marg, opposite New Excelsior Cinema, Fort.
Time: 8 am to 11 pm
Call: 22074543

Ideal Corner

Don't forget to try: Salli boti
At this Fort eatery, Navroze beckons a special menu featuring all-time favourites like pulao dal, salli boti (Rs 180), and mutton dhansak (Rs 230). When asked what the festival means to the family, partner Parvez Patel says, "To drink and make merry."

At: 12 F/G, Hornby View, Gunbow Street, Fort.
Time: 12 pm to 10 pm
Call: 22621930

Koolar & Co

The sofrah at Irani's home last year

Don't forget to try: Irani delight
At Koolar & Co's owner Amir Koolar Irani's home, sofrah, the laying of the table with a mirror, fruits, nuts, alcohol and other goodies on Navroze, is a big affair. "My favourite festival here is Diwali, but Navroze takes us back to our roots," Irani shares, adding, "You must come and try the Irani delight [Rs 120]. It's a unique dish made with egg and honey."

Amir Koolar Irani

At: 541, Noor Mahal, Dr Babasaheb Ambedkar Road, Adenwada Road, Matunga East.
Time: 7 am to 11 pm
Call: 24125062

Caramel custard

Winning Irani cafes

*Kyani & Co: AT JSS Road, Marine Lines. Call: 61229437
*Cosmopolitan: AT 133, Raja Rammohan Roy Road. Call: 23826737
*Sassanian Boulangerie: AT Dhobi Talao, Marine Lines. Call: 22006198
*Cafe Military: AT Tamarind Lane, Fort. Call: 22654181

Catch up on all the latest Crime, National, International and Hatke news here. Also, download the new mid-day Android and iOS apps to get the latest updates