pep

Gas-phase Förster resonance energy transfer in mass-selected ions with methylene or peptide linkers between two dyes: a concerted dance of charges

Phys. Chem. Chem. Phys., 2020, Advance Article
DOI: 10.1039/D0CP01287D, Paper
Christina Kjær, Ying Zhao, Mark H. Stockett, Li Chen, Klavs Hansen, Steen Brøndsted Nielsen
Emission from gaseous rhodamine 640 is redshifted when the dye is tethered to rhodamine 575 due to internal Coulomb interaction.
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The content of this RSS Feed (c) The Royal Society of Chemistry




pep

[ASAP] Synthesis of Tri(4-formylphenyl) Phosphonate Derivatives as Recyclable Triple-Equivalent Supports of Peptide Synthesis

The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.9b03023




pep

Enzyme-activated anchoring of peptide probes onto plasma membranes for selectively lighting up target cells

Analyst, 2020, Advance Article
DOI: 10.1039/D0AN00487A, Paper
Julan Xia, Sujuan Sun, Xianhua Wu, Yan Huang, Chunyang Lei, Zhou Nie
Enzyme-activated membrane insertion peptide probes were developed for selectively lighting up target cells.
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The content of this RSS Feed (c) The Royal Society of Chemistry




pep

Label-free analytical performances of a peptide-based QCM biosensor for trypsin

Analyst, 2020, 145,3329-3338
DOI: 10.1039/D0AN00308E, Paper
Zong-Mu Dong, Lu Cheng, Ping Zhang, Guang-Chao Zhao
Peptide chains that can be specifically hydrolyzed by trypsin were synthesized and fabricated with Au NPs-MCA on a QCM electrode for the sensitive quantification of trypsin in a complex matrix.
The content of this RSS Feed (c) The Royal Society of Chemistry




pep

Development of a chromophore-solid phase peptide reaction assay (C-SPRA) for assessing skin sensitization in vitro

Analyst, 2020, 145,3211-3216
DOI: 10.1039/C9AN02514F, Communication
Hiroshi Miyazaki, Yoshio Hamada, Hikaru Takaishi, Yuuki Minamino, Hidefumi Ikeda, Hideaki Mekata, Masayuki Takaishi, Kunihiko Yamashita, Kenji Usui
We developed an in vitro chromophore-solid phase peptide reaction assay (C-SPRA) using chromophores and immobilized peptides on microbeads. C-SPRA would enable accurate and high-throughput assessments of various chemicals.
The content of this RSS Feed (c) The Royal Society of Chemistry




pep

Selective ratiometric red-emission detection of In3+ in aqueous solutions and in live cells using a fluorescent peptidyl probe and metal chelating agent

Analyst, 2020, Advance Article
DOI: 10.1039/D0AN00288G, Paper
Joohee Park, Hyeongseok Yu, See-Hyoung Park, Keun-Hyeung Lee
A ratiometric fluorescent detection method for In3+ in aqueous buffered solution, ground water, and live cells was developed.
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The content of this RSS Feed (c) The Royal Society of Chemistry




pep

Core–shell magnetic microporous covalent organic framework with functionalized Ti(IV) for selective enrichment of phosphopeptides

Analyst, 2020, Advance Article
DOI: 10.1039/D0AN00038H, Paper
Fengjuan Ding, Yameng Zhao, Haiyan Liu, Weibing Zhang
We fabricated a core-shell magnetic Ti4+-functionalized covalent organic framework composite to selectively capture phosphopeptides in biosamples. This method is applicable to achieve rapid, selective and efficient phosphopeptide analysis.
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The content of this RSS Feed (c) The Royal Society of Chemistry




pep

[ASAP] Discovery of Peptide Boronate Derivatives as Histone Deacetylase and Proteasome Dual Inhibitors for Overcoming Bortezomib Resistance of Multiple Myeloma

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b02161




pep

[ASAP] Correction to Toggling Preassembly with Single-Site Mutation Switches the Cytotoxic Mechanism of Cationic Amphipathic Peptides

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00608




pep

[ASAP] Triazolo-Peptidomimetics: Novel Radiolabeled Minigastrin Analogs for Improved Tumor Targeting

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b01936




pep

[ASAP] Chimeric Peptidomimetics of SOCS 3 Able to Interact with JAK2 as Anti-inflammatory Compounds

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.9b00664




pep

[ASAP] Peptoid NPhe<sup>4</sup> in AGRP-Based c[Pro<sup>1</sup>-Arg<sup>2</sup>-Phe<sup>3</sup>-Phe<sup>4</sup>-Xxx<sup>5</sup>-Ala<sup>6</sup>-Phe<sup>7</sup>

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.9b00641




pep

[ASAP] Combined Peptide and Small-Molecule Approach toward Nonacidic THIQ Inhibitors of the KEAP1/NRF2 Interaction

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.9b00594




pep

[ASAP] De-risking Drug Discovery of Intracellular Targeting Peptides: Screening Strategies to Eliminate False-Positive Hits

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00022




pep

Simultaneous co-assembly of fenofibrate and ketoprofen peptide for the dual-targeted treatment of nonalcoholic fatty liver disease (NAFLD)

Chem. Commun., 2020, 56,4922-4925
DOI: 10.1039/D0CC00513D, Communication
Zhongyan Wang, Chuanrui Ma, Yuna Shang, Lijun Yang, Jing Zhang, Cuihong Yang, Chunhua Ren, Jinjian Liu, Guanwei Fan, Jianfeng Liu
An ingenious co-assembled nanosystem based on fenofibrate and ketoprofen peptide for the dual-targeted treatment of NAFLD by reducing hepatic lipid accumulation and inflammatory responses.
The content of this RSS Feed (c) The Royal Society of Chemistry




pep

Intra-mitochondrial self-assembly to overcome the intracellular enzymatic degradation of L-peptides

Chem. Commun., 2020, Advance Article
DOI: 10.1039/D0CC02029J, Communication
M. T. Jeena, Seokyoung Lee, Ayan Kumar Barui, Seongeon Jin, Yuri Cho, Suk-Won Hwang, Sehoon Kim, Ja-Hyoung Ryu
The design of peptide-based therapeutics is generally based on the replacement of L-amino acids with D-isomers to obtain improved therapeutic efficiency.
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pep

Transition Metal Ions Induced Secondary Structural Transformation in Hydrophobized Short Peptide Amphiphile

New J. Chem., 2020, Accepted Manuscript
DOI: 10.1039/D0NJ01501F, Paper
Khashti B Joshi, RAMESH SINGH, Narendra K Mishra, Narendra Singh, Puneet Gupta, Parveen Rawal
A precise control over self-assembling structures of rationally designed hydrophobized short peptide amphiphile (sPA) was studied. Bioactive transition metal ions were used to transform the supramolecular structures of this sPA....
The content of this RSS Feed (c) The Royal Society of Chemistry




pep

Whole Genome Sequence Analysis and Homology Modelling of Main Protease and Non-Structural Protein 3 of the SARS-CoV-2 reveals an Aza-Peptide and a Lead Inhibitor with Possible Antiviral Properties

New J. Chem., 2020, Accepted Manuscript
DOI: 10.1039/D0NJ00974A, Paper
Arun K Shankar, Divya Bhanu, Anjani Alluri, Samriddhi Gupta
The family of viruses belonging to Coronaviridae consist of virulent pathogens that have a zoonotic property, Severe Acute Respiratory Syndrome (SARS-CoV) and Middle East Respiratory Syndrome (MERS-CoV) of this family...
The content of this RSS Feed (c) The Royal Society of Chemistry




pep

[ASAP] Design, Synthesis, and Bioactivity of Cyclic Lipopeptide Antibiotics with Varied Polarity, Hydrophobicity, and Positive Charge Distribution

ACS Infectious Diseases
DOI: 10.1021/acsinfecdis.0c00056




pep

[ASAP] Dilipid Ultrashort Tetrabasic Peptidomimetics Potentiate Novobiocin and Rifampicin Against Multidrug-Resistant Gram-Negative Bacteria

ACS Infectious Diseases
DOI: 10.1021/acsinfecdis.0c00017




pep

Salt peppers TMC-Oppn verbal duel

Mullick blames Cong, CPM, BJP for spreading rumours to fuel crisis, gets called mad in return.




pep

Salt peppers TMC-Oppn verbal duel

Mullick blames Cong, CPM, BJP for spreading rumours to fuel crisis, gets called mad in return.




pep

Salt peppers TMC-Oppn verbal duel

Mullick blames Cong, CPM, BJP for spreading rumours to fuel crisis, gets called mad in return.




pep

A pepper boat sinks

The pungent aroma of pepper no longer floats in Wayanad''s Pulpally village once the largest producer of the famous...




pep

N-Hydroxy peptides: solid-phase synthesis and β-sheet propensity

Org. Biomol. Chem., 2020, Advance Article
DOI: 10.1039/D0OB00664E, Paper
Matthew P. Sarnowski, Juan R. Del Valle
Backbone amide hydroxylation of peptide strands enhances β-hairpin folding.
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The content of this RSS Feed (c) The Royal Society of Chemistry




pep

Insights into the secondary structures of lactam N-substituted stapled peptides

Org. Biomol. Chem., 2020, Accepted Manuscript
DOI: 10.1039/D0OB00767F, Communication
Aldrin Vasco Vidal, Celia Gonzalez, Stefan Gröger, W Brandt, Jochen Balbach, Carlos Perez, Ludger A. Wessjohann, Daniel G. Rivera
Stapled peptides derived from the Ugi macrocyclization comprise a special class of cyclopeptides with an N-substituted lactam bridge cross-linking two amino acid side chains. Herein we report a comprehensive analysis...
The content of this RSS Feed (c) The Royal Society of Chemistry




pep

[ASAP] Quadruply Stranded Metallo-Supramolecular Helicate [Pd<sub>2</sub>(hextrz)<sub>4</sub>]<sup>4+</sup> Acts as a Molecular Mimic of Cytolytic Peptides

Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.0c00061




pep

Let’s Catch Up With Pepper, the Dancing, Surprisingly Helpful Humanoid

Pepper is part of the first wave of intelligent machines that promise to not only make our lives easier, but to bring a strange new form of interaction into being.




pep

Obsessed - How This Guy Made the World's Hottest Peppers

PuckerButt Pepper Company founder Ed Currie is on a mission to create the world's hottest peppers. Ed is the evil genius who brought the world the Carolina Reaper, one of the hottest hot peppers in existence; but he's not stopping there.




pep

Fast chemical force microscopy demonstrates that glycopeptidolipids define nanodomains of varying hydrophobicity on mycobacteria

Nanoscale Horiz., 2020, Advance Article
DOI: 10.1039/C9NH00736A, Communication
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Albertus Viljoen, Felipe Viela, Laurent Kremer, Yves F. Dufrêne
We use chemical force microscopy with high spatiotemporal resolution to study the nanoscale distribution of hydrophobicity on living mycobacterial cells.
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The content of this RSS Feed (c) The Royal Society of Chemistry




pep

[ASAP] Dissecting the Dynamics during Enzyme Catalysis: A Case Study of Pin1 Peptidyl-Prolyl Isomerase

Journal of Chemical Theory and Computation
DOI: 10.1021/acs.jctc.9b01279




pep

[ASAP] Binding Dynamics of siRNA with Selected Lipopeptides: A Computer-Aided Study of the Effect of Lipopeptides’ Functional Groups and Stereoisomerism

Journal of Chemical Theory and Computation
DOI: 10.1021/acs.jctc.9b01261




pep

[ASAP] Comprehensive Evaluation of Fourteen Docking Programs on Protein–Peptide Complexes

Journal of Chemical Theory and Computation
DOI: 10.1021/acs.jctc.9b01208




pep

The devil's dinner: a gastronomic and cultural history of chili peppers / Stuart Walton

Browsery SB307.P4 W35 2018




pep

Diketopyrrolopyrrole-based multifunctional ratiometric fluorescent probe and γ-glutamyltranspeptidase-triggered activatable photosensitizer for tumor therapy

J. Mater. Chem. C, 2020, Accepted Manuscript
DOI: 10.1039/D0TC01836H, Paper
Jianli Hua, Zhicheng Yang, Weibo Xu, Jian Wang, Lingyan Liu, Yanmeng Chu, Yu Wang, Yue Hu, Tao Yi
Photosensitizers can generate highly reactive oxygen (ROS) by light exciting, causing cell damage and apoptosis. However, conventional photosensitizers cannot kill cancer cells selectively. In this work, we report a series...
The content of this RSS Feed (c) The Royal Society of Chemistry




pep

Lost in La Mancha de Keith Fulton, Louis Pepe (Bande annonce)

L'Homme qui tua Don Quichotte, dernier projet en date de Terry Gilliam, réunissant des stars telles que Johnny Depp, Jean Rochefort et Vanessa Paradis, contenait tous les ingrédients pour devenir un grand film. Il s'agissait en tout cas d'un des plus gros budgets européens de l'histoire du cinéma. Début septembre 2000, deux semaines après le début du tournage, tout s'arrête. Comment en est-on arrivé là ?




pep

Sgt. Pepper's Lonely Hearts Club Band / the Beatles

Browsery DVD P B38 sgt




pep

Peptide-based drug discovery: challenges and new therapeutics / ediror: Ved Srivastava

Online Resource




pep

Mid-size Drugs Based on Peptides and Peptidomimetics: A New Drug Category / by Hirokazu Tamamura, Takuya Kobayakawa, Nami Ohashi

Online Resource




pep

Antimicrobial peptides: basics for clinical application / Katsumi Matsuzaki, editor

Online Resource




pep

Peptide therapeutics: strategy and tactics for chemistry, manufacturing, and controls / editor: Ved Srivastava

Online Resource




pep

[ASAP] In Situ Phase Transition of Elastin-Like Polypeptide Chains Regulates Thermoresponsive Properties of Elastomeric Protein-Based Hydrogels

Biomacromolecules
DOI: 10.1021/acs.biomac.0c00206




pep

[ASAP] Structures and Antifouling Properties of Self-Assembled Zwitterionic Peptide Monolayers: Effects of Peptide Charge Distributions and Divalent Cations

Biomacromolecules
DOI: 10.1021/acs.biomac.0c00062




pep

[ASAP] Role of Sheet-Edge Interactions in ß-sheet Self-Assembling Peptide Hydrogels

Biomacromolecules
DOI: 10.1021/acs.biomac.0c00229




pep

[ASAP] A6 Peptide-Tagged Core-Disulfide-Cross-Linked Micelles for Targeted Delivery of Proteasome Inhibitor Carfilzomib to Multiple Myeloma In Vivo

Biomacromolecules
DOI: 10.1021/acs.biomac.9b01790




pep

[ASAP] Amphiphilic Star Polypept(o)ides as Nanomeric Vectors in Mucosal Drug Delivery

Biomacromolecules
DOI: 10.1021/acs.biomac.0c00381




pep

[ASAP] Synthesis and Characterization of a Leucine-Based Block Co-Polypeptide: The Effect of the Leucine Zipper on Self-Assembly

Biomacromolecules
DOI: 10.1021/acs.biomac.0c00420




pep

[ASAP] Genome Mining and Heterologous Expression Reveal Two Distinct Families of Lasso Peptides Highly Conserved in Endofungal Bacteria

ACS Chemical Biology
DOI: 10.1021/acschembio.9b00805




pep

[ASAP] Remodeling of Cross-bridges Controls Peptidoglycan Cross-linking Levels in Bacterial Cell Walls

ACS Chemical Biology
DOI: 10.1021/acschembio.0c00002




pep

[ASAP] Substrate Recognition by the Class II Lanthipeptide Synthetase HalM2

ACS Chemical Biology
DOI: 10.1021/acschembio.0c00127