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AAV-mediated cardiac gene transfer of wild-type desmin in mouse models for recessive desminopathies




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Executable cancer models: successes and challenges




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Telomere-based risk models for the early diagnosis of clinically significant prostate cancer




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Short-term NAD<sup>+</sup> supplementation prevents hearing loss in mouse models of Cockayne syndrome




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Organotypic human skin culture models constructed with senescent fibroblasts show hallmarks of skin aging




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Rodent models of post-traumatic stress disorder: behavioral assessment




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Efficient generation of mouse models with the prime editing system




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A call for a new generation of COVID-19 models

The epidemiological models of COVID-19’s initial outbreak and spread have been useful. The Imperial College model, which predicted a terrifying 2.2 million deaths in the United States, agitated drowsy policymakers into action. The University of Washington’s Institute of Health Metrics and Evaluation (IHME) model has provided a sense of the scale and timeline for peak…

       




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The beginner's guide to new health care payment models

Payment reform in health care is confusing, but the goal is simple: How can health care providers change their economic incentives to encourage value over volume? If you've wondered about how these new payment models work, we’re here to help. And if you want to see Dr. Patrick Conway, the head of the Center for Medicare and Medicaid Innovation, talk about it more in depth at our most recent MEDTalk event about oncology care reform, click here.

Where are we now?

Fee-for-Service. Traditionally, health care providers are paid in a "Fee-for-Service" (FFS) model. This is exactly what it sounds like: every time you have a blood test, a doctor's visit, a CT scan, or any other service, you (and your insurance company) pay separately for what you have received. Over the course of a long treatment or a chronic condition, that can add up to a huge expense.

The Fee-For-Service System

It is well known that FFS is draining the entire health care system. When paying for volume, a sick patient is worth more than a healthy patient , and this status quo results in uncoordinated care, duplication of services, and fragmentation. After all, the more doctors and providers do, the more they get paid.

Reformers hope to replace the traditional FFS model with something better, and they’ve come up with many different models of payment that could allow this to happen. (Note to reader:  these are simplified explanations; policy enthusiasts can learn much more about them through the Engelberg Center’s Merkin Initiative).

Here are four widely proposed and increasingly popular alternative payment models:

Accountable Care Organizations (ACOs) are groups of providers across different settings– primary care, specialty physicians, hospitals, clinics, and others – who chose to come together to jointly share responsibility for overall quality, cost, and care for a large patient population. These providers recognize that poorly coordinated care from these entities can lead to increased costs from things like redundant tests and overlapping care.

Accountable Care Organization Model

Here’s how it works in basic terms: the ACO physicians bill the way they always do, but the total costs get compared to an overall target. Plus, they have to measure some of their patient outcomes, to prove that they hit certain quality benchmarks. If costs are higher than the target, the ACO may get penalized. In the end, if they are under the cost target and satisfy their quality measures, they get a share of the savings.

By bringing all of these providers under the umbrella of an ACO, caregivers can all be on the same page, and the patients ideally receive coordinated care with a focus on prevention – since providers are encouraged to keep their patients healthy and not just earn more by doing more tests and procedures.

Bundles: A health care bundle estimates the total cost of all of the services a patient would receive per episode over a set time period for a certain problem, like a knee replacement or heart surgery. For example, a payer such as Medicare or an insurance company could calculate that a hypothetical 30-day bundle for a knee replacement surgery costs $10,000.

Without Bundled Payment...

The payer reduces the total cost of the episode by 2-3%, and hands the bundle over to the provider – in the knee surgery example, that becomes $10,000 minus 2%, so $9,800. The provider is then responsible for all costs of treatment – whether or not it exceeds the amount of money they were originally given. This encourages the provider (collaborating with the entire care team) to help the patient avoid preventable complications like a hospital readmission by better managing a patient’s care.

With a Bundled Payment...

If the provider keeps costs low, they can keep the margin on the bundle, while the insurance company already saved by reducing the cost of the episode by a small percentage when they created the bundle. So, in our example, if the provider was able to meet quality benchmarks and the total cost of the 30-day episode was $9,000, they get to keep the extra $800.

Patient-Centered Medical Homes set themselves apart by providing set monthly payments on top of existing funding models, in order to fund a highly coordinated team of primary care professionals, which may include, depending on the patient’s needs, physicians, nurse practitioners, medical assistants, nutritionists, psychologists, and possibly even specialists. The team works closely to build a strong relationship with each other,with their patients and their caregivers.

Patient-Centered Medical Home Model...

This extra money can be used to hire nurses or agencies to give special care and attention (by phone or home visits, for example) to high-risk patients, with the goals of reducing emergency room visits and other preventable problems in the long run. Other enhancements might include email communication with patients, more time to call and coordinate care between primary care doctors and specialists, and so on. In the end, the savings from better coordinated care make the extra monthly payments worthwhile.

Pathways, an idea which has gained traction in oncology care, provides a system of choices and decision making tools for providers and patients in order to prescribe the most effective and least costly treatment. For example, let’s say there are two cancer drugs proven to have the same effectiveness, with no differentiation in side effects, but one of them costs less than the other.

Same Effectiveness, Different Cost...

Like the medical home, the pathways model uses a “per-patient” add on fee (often much larger than for medical homes focused on primary care, since cancer patients need intensive treatment) that might encourage the provider to prescribe the less expensive of two equally effective treatments.

How Pathways Creat Savings...

 

 

 

 

 

 

When this is implemented on a broad scale, the savings could add up for payers, and defray the cost of the add-on fees.

Please feel free to use any of these images in your own work, presentations, or educational efforts, and to view and download the interactive versions here.  The images should be attributed to The Merkin Initiative on Clinical Leadership and Payment Reform at Brookings.

Authors

      




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A systematic review of systems dynamics and agent-based obesity models: Evaluating obesity as part of the global syndemic

       




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A systematic review of systems dynamics and agent-based obesity models: Evaluating obesity as part of the global syndemic

       




models

Kaizen Fail: Toyota Recalls 437,000 Hybrids Worldwide, Mostly 2010 Prius Models

Photo: Toyota Ouch We all knew it was coming, but now it's official. Toyota has formally filed a voluntary recall for 437,000 hybrid vehicles worldwide. Most of those are third generation Prius hybrids, but they're also recalling the few Prius PHEV out




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Lighting facts: Did you know that 70% of lightbulbs in the U.S. are still inefficient models?

If every home in the U.S. switched just one inefficient light for an Energy Star one, that would be equivalent to taking 800,000 vehicles off the road in term of greenhouse gas emissions




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Europe is warming faster than climate models projected

More than 90 percent of weather stations studied showed the climate was warming, a percentage too high to purely be from natural climate variability, say researchers




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Computer models show how ancient people responded to climate change

The findings could help us deal with environmental changes happening now and in the future.




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Supercomputer models show severe turbulence will increase with climate change

Aircraft will have to fly new routes to avoid major bumps.




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A Case For Recycled Tire Bags & Chic New Models By Cyclus

If you've been around the green scene for some time, you may feel some ideas get a little tired over time. That could have been the case for bags from recycled tires, but ever since I got one (not from this brand, of course) I've




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Small overlap crash protection, front crash prevention key to 2016 awards; 48 models earn TOP SAFETY PICK+ award, 13 earn TOP SAFETY PICK - 2016 IIHS TOP SAFETY PICKS

2016 IIHS TOP SAFETY PICKS




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Karen Bardsley: 'Panini should do NHS stickers – they're our role models'

The England and Manchester City goalkeeper on career highs and lows, including Covid-19 delaying her comeback from injury

Karen Bardsley has had a lot of time to reflect on her career. The goalkeeper left England’s World Cup quarter-final victory over Norway in 2019 with a hamstring injury, knowing she would not make the semi-final, and has not played since. With cruel irony, her clearance to return to training at Manchester City came as the Lionesses returned from the SheBelieves Cup and went straight into isolation in March.

“I was like: ‘Wow, OK, I just got cleared to train with the whole squad and now I’m gonna have to wait for ever to do it,’ or at least that’s what it felt like,” Bardsley says with a laugh. “I’m just taking this as an opportunity to get as strong and as physically resilient as possible.”

Continue reading...




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India coronavirus: Why celebrating Covid-19 'success models' is dangerous

Experts tell the BBC that euphoria over success models runs the risk of people becoming complacent.




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Photographer makes wedding album with Lego models amid lockdown

All of Chris Wallace's wedding bookings were either cancelled or postponed due to the Coronavirus, but the UK-based wedding photographer didn't let that deter him. Wallace took it upon himself to recreate a wedding ceremony using LEGO figures lying around his house. He named the bride and groom Florence and Fred, and spent many hours preparing for the wedding. He even staged several scenes and big moments seen frequently in Christian weddings and then proceeded to click photos of them. He used his experience capturing weddings to make it seem natural.


The bride getting dolled up for her wedding

The bride walked down the aisle with a Harry Potter figurine, whereas groomsmen Ghostbusters, Chewbacca and a 1980 Lego spaceman stood at the altar to support the groom. "I've found myself with quite a bit of free time on my hands and thought it'll be a fun thing to do," said the photographer to the New York Post. "The ceremony was held outdoors in the most gorgeous of settings, filled with the greenest of plastic leaves and most colourful plastic flowers," he added.

Posing for a family photo. Pics/carpediemphotographycheshire.co.uk/Chris Wallace

Wallace said: "I tried drawing upon the experiences I had with weddings, to capture the big moments while making it seem natural." As the lockdown is anticipated to last till June, he plans to do another shoot soon.

Girl, I want you real clean!

A New Yorker hung fliers to look for a 'germ free' partner during the Coronavirus crisis


Pic/New York Post

A single man from New York, who is looking for love, hung dating fliers across the city, saying that his potential lover must be healthy, fit and clean.

The man, identified only as Brad, also said in the flier that he is "seeking a girlfriend for Coronavirus and beyond." He describes himself as a healthy, attractive, and well-settled man, looking for "germ-free monogamy". "I was single when the lockdown began and was wondering how and when dating would be possible again," Brad told the New York Post.

"This is no time for casual dating or hook-ups, so I am seeking a long-term and exclusive relationship," he added. Brad said that he has already received responses from "high-quality women" and is looking forward to meeting some for six-foot-apart dates.

Papi Gudia 2.0

An area in Mexico City became one of the most searched addresses on Google Maps this week, after photos of a creepy, doll-covered house located there, went viral on social media. The post was first shared by TikTok user Fernando Mata, who was looking for creepy content for his social media. It later turned out that this was the address of a small esoteric shop, and the dolls were merely an advertising strategy to attract prospective customers.

This teen is a gender-bender


Pics/@puutan_318, Instagram

A Japanese 18-year-old boy, has been getting a lot of attention on the Internet for cosplaying as an Asian schoolgirl. Puutan, whose real name is reportedly Tatsuya, has been flaunting selfies in feminine clothes, as well as a long hair wig. He currently has over 27,000 followers on YouTube, and 23,000 followers on Instagram.

Mexicans want beer to survive quarantine

Mexico's decision to halt production of most non-essential products due to the Coronavirus pandemic, has led to a polarising debate in the country on whether beer should be considered an "essential" during lockdown. "Beer supplies should be guaranteed, because beer helps people get through quarantine on better terms," said the National Alliance of Small Business in a press statement.

Village gets ghosts to keep people indoors

Kepuh village in Indonesia has resorted to an unusual way to ensure that the locals stay indoors. Those who step out of their homes at night will have to face pocong—shrouded ghosts believed to represent the souls of dead people. The pocongs are actually volunteer youths trying to help maintain the lockdown.

Crime junkies can get rich in 24 hours flat

A video streaming service is seeking a true crime buff to make $1,000 (R75K) during the Coronavirus lockdown by watching 24 straight hours of documentaries. The chosen candidate will be given a pre-selected list of true crime documentaries to watch.

Bugging you

A swarm of bugs descended over a beach at Cayton Bay, Yorkshire, leaving locals stunned. The bugs, later identified as European Chafer Beetles, are said to have washed up on a few beaches in the area. The cause is still being investigated. "I was stunned to realise they were living creatures. There were just masses and masses of them," said Sue Weatherill, a local resident, to Daily Mail. Pics/@ChrisBull52, Twitter

Catch up on all the latest Crime, National, International and Hatke news here. Also download the new mid-day Android and iOS apps to get latest updates.

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This story has been sourced from a third party syndicated feed, agencies. Mid-day accepts no responsibility or liability for its dependability, trustworthiness, reliability and data of the text. Mid-day management/mid-day.com reserves the sole right to alter, delete or remove (without notice) the content in its absolute discretion for any reason whatsoever




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Adult webcam company ImLive launches 'haircuts with hot models' amid lockdown

Through the new experience, the users looking for haircuts can pair with models who have a soon or barbershop experience.




models

Specialised Anti-Corruption Institutions - Review of Models

This report provides a comparative overview of common standards and key features of specialised anti-corruption institutions and comprehensive descriptions of 19 anti-corruption institutions operating in different parts of the world, presented in a comparable framework.




models

ICTs and the Health Sector: Towards Smarter Health and Wellness Models

The future sustainability of health systems will depend on how well governments are able to anticipate and respond to efficiency and quality of care challenges. Bold action is required, as well as willingness to test innovative care delivery approaches. This book examines the whole new world of possibilities in using mobiles and the Internet to address healthcare challenges.




models

Toward New Models for Innovative Governance of Biomedecine and Health Technologies

This report examines examples of new and emerging governance models to support responsible development of diagnostics and treatments based on the latest advances in biomedicine. It identifies some of the main challenges for policy makers, regulators and other communities involved in the translation of biomedical innovation and health technologies from the lab bench to point of care.




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Business Models of Banks, Leverage and the Distance-to-Default

This study models the distance-to-default (DTD) of a large sample of banks from 2004 to 2011 and examines the results from the perspective of policy approaches that aim to reduce the riskiness of banks.




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Banking in a challenging environment: Business models, ethics and approaches towards risks

This article summarises discussions from a financial roundtable addressing concerns about structural flaws in the way banks operate and are being regulated and supervised in the wake of on-going banking sector problems involving financial fraud and banking scandals.




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Bank Business Models and the Separation Issue

The bank regulator's paradox is that large, complex and interconnected banks need very little capital in the good times, but they can never have enough in an extreme crisis. Separation is required to deal with this problem, which derives mainly from counterparty risk. This paper outlines the OECD’s separation proposal and also compares it to current national approaches to separation.




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Bank Business Models and the Basel System: Complexity and Interconnectedness

The main hallmarks of the global financial crisis were too-big-to-fail institutions taking on too much risk with other people’s money: excess leverage and default pressure resulting from contagion and counterparty risk. This paper looks at whether the Basel III reforms address these issues effectively and proposes improvements to the current reform proposals.




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Short-term indicator models for quarterly GDP growth in the BRIICS: a small-scale bridge model approach

This paper extends the OECD Economics Department’s suite of short-term indicator models for quarterly GDP growth, which currently cover only the G7 countries, to the BRIICS countries.




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Implicit regulatory barriers in the EU Single Market: new empirical evidence from gravity models

Beyond usual determinants of trade such as GDP, distance, contiguity, free trade areas and language, this analysis mainly focuses on the role of product market regulation stringency and heterogeneity, and on the role of employment protection.




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The use of models in producing OECD macroeconomic forecasts

This paper firstly describes the role of models in producing OECD global macroeconomic forecasts; secondly, reviews the OECD's forecasting track record; and finally, considers the relationship between forecast performance and models.




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Changing business models of stock exchanges and stock market fragmentation

This report reviews structural changes in the stock exchange industry and provides data on M&A changes in the aggregate revenue structure of major stock exchanges. It describes the fragmentation of the stock market resulting from an increase in stock exchange-like trading venues, such as alternative trading systems (ATSs) and multilateral trading facilities (MTFs), and a split between dark (non-displayed) and lit (displayed) trading.




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Watches to watch: 10 models from this year’s announcements

Watchmakers press on with new releases, despite the coronavirus




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nextmv picks up $2.7M to optimize and test decision models for the logistics industry

Optimization. Efficiency. Data-driven decisions. If I had a nickel for every time I hear these words from founders I’d be long retired. And yet, the process involved in achieving resource optimization, efficiency and making truly data-driven decisions is laborious to say the least, and usually involves an immense amount of talent and resources. And then […]




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Kylie Jenner models a SKIMS top for sister Kim Kardashian with ring

The siren was seen in several social media posts in a tight black top from SKIMS as well as a pair of leather slacks and a cute purse that looked like a pair of pink lips. The caption read, 'Baby.'




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Kim Kardashian's Skims models resemble a full-on Yeezy fashion show at Nordstrom launch

The star rang up customers buying her shapewear collection on the day of it's Nordstrom launch. Kim held a scanner as she completed the purchase, before handing off the bag.




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Kim Kardashian models her THIRD latex Balmain ensemble of the day during Paris Fashion Week

She's never been one to play it safe with her fashion choices. Yet Kim Kardashian clearly found a look that worked for her on Sunday as she modelled three similar latex Balmain ensembles.




models

Laverne Cox puts on a brave face in NYC as she models bright yellow dress after announcing split

Laverne Cox donned a yellow dress just hours after announcing she and her boyfriend Kyle Draper have ended their relationship. She wore the form fitting dress with tall black heels.




models

Laverne Cox models purple hair that complements her strapless yellow gown at an event in Florida

Laverne Cox made a bold entrance in a bright strapless yellow gown with purple hair at the Rosen Shingle Creek Hotel in Florida on Sunday.




models

Jacqueline Jossa models her new In The Style clothing range

In photos of her new clothing line, the I'm A Celebrity winner, 27, looked sensational as she modelled her collection.




models

Michelle Keegan shows off her incredible figure in a glittering mini as she models clothes

She's proved to a multi-talented threat, excelling in both acting and designing.  And Michelle sent her fans wild as she teased a look at her Christmas range on Sunday.




models

Jenna Dewan shows off her pregnant tummy as she models a funny baby skeleton T-shirt

The star's boyfriend, who celebrated his birthday one day prior, also took to social media to show off his pretty lady and his growing baby.




models

Balenciaga sends models down Paris Fashion Week catwalk with extreme cheekbones and plumped up lips

We're used to Balenciaga breaking the mould when it comes to clothes, but the brand's Paris Fashion Week show creative appears to have used the platform to take aim at modern beauty standards.




models

Blanca Blanco models a nurse costume after slipping into Maleficent's horns

Last week the Mission: Possible actress wore Maleficent's horns in a very impressive outfit after the sequel Mistress Of Evil did well in the international box office - almost $300M worldwide.




models

Nick Jonas models color-block leather jacket and shocking white trousers in NYC

He made his debut as a The Voice judge on Sunday. And Nick Jonas still looked ready for the stage when he was glimpsed enjoying a stroll in New York this Monday during the day.




models

Rise of wrinkly models: Long, lean limbs, razor-sharp cheekbones... and grey hair, laughter lines and a bus pass

Standing at a statuesque 5ft 8in with a slim but curvaceous size ten figure, it's unsurprising that Annabel Davis is a model. But she's also grey haired, with laughter lines.




models

Selena Gomez models a bright look in neon sweatshirt and biker shorts

Her two latest music releases have put her at the top of the Billboard charts, for the first time in her career. And Selena Gomez isn't done making bold statements yet.




models

Bella Hadid models a yellow butterfly shirt in NYC after ex-boyfriend The Weeknd releases Heartless

This sighting comes just hours after ex-boyfriend The Weeknd released his breakup song Heartless which seems to be about the former equestrian.




models

Selena Gomez models one of her own Rare hoodies as she models HUGE hoop earrings

Selena Gomez promoted her new album, Rare, while out in New York City on Wednesday night visiting tattoo artist, Bang Bang.