Panelistas analizaron las pistas que ha dado el nuevo gobierno en materia del modelo económico y en seguridad que busca impulsar.

Desde el cierre del Congreso de Andesco en Cartagena, cuatro expertos analizaron el panorama del sector y los desafíos de cara a una reforma a la ley de servicios públicos.

Panelistas analizaron las implicaciones fiscales y de seguridad en la descentralización. Creen que no se debería emular modelos de otros países.

Panelistas analizaron las implicaciones fiscales y de seguridad en la descentralización. Creen que no se debería emular modelos de otros países.

Daniel García, director del IDRD estuvo en 6AM de Caracol Radio explicando cómo van las adecuaciones para ser la sede del próximo mundial femenino sub-20

Nestor Rosanía estuvo en los micrófonos de Caracol Radio explicando las dinámicas del Tren de Aragua

En Caracol Radio estuvo Santiago Chamorro, presidente y director de General Motors Sudamérica, dando detalles sobre el futuro de la compañía

Augusto Rodríguez, director de la Unidad Nacional de Protección, entregó detalles en 6AM de la manera en la que se otorgan medidas de protección a los funcionarios del INPEC

En el programa 6AM de Caracol Radio, habló Jennifer Pedraza, representante a la Cámara, y afirmó que la implementación del nuevo modelo de salud de los maestros ha sido incumplida por el gobierno. 

OpenCoder is an open and reproducible code LLM family which matches the performance of Top-Tier Code LLM. We provide not just the final models, but also the reproducible training data, the complete data processing pipeline, rigorous experimental ablation results, and detailed training protocols for open scientific research.

Business Design. Een up-and-coming discipline. En dat is niet vreemd. De opkomst van Business Design kun je niet los zien van het huidige business klimaat. Technologische en sociale ontwikkelingen volgen elkaar in hoog tempo op. Er is simpelweg geen tijd meer om eindeloos te sleutelen aan producten en diensten voordat ze naar de markt gaan. […]

Shaun Ross discusses his #InMySkinIWin movement.

The growing Hispanic populations in Colorado and the U.S. and their increasing buying power are the focus of Ahorra Mucho.

[Written by Stephen Wright] Aspiring model Nalia Mitchell had the experience of a lifetime strutting down the catwalk at the recent New York Fashion Week Festival. Mitchell was among a handful of Bermudians who successfully applied for the Model Experience, which allowed participants to walk the runway, connect with brands and designers, share the stage […]

Bermudian Aliana King has been featured by British beauty brand Charlotte Tillbury as a model for the company’s skin care products. Ms. King has also appeared in a number of other campaigns for well-known brands, including David Yurman, SKKN, FREDDY WR.UP, Nordstrom x Nike [NxN], Skims, Redken, L’Oréal, Aveda, Garnier, Maybelline, and Allure, as well as style magazines including Elle Australia, Vogue Mexico, Vogue Arabia, and Elle Mexico. […]

[Written by Stephen Wright] Asia Smith has described her experience on the runway at the recent New York Fashion Week Festival as a “breathtaking” experience. Ms Smith was among several Bermudians who successfully applied for the Model Experience, allowing participants to walk the runway, share the stage with A-List talent, connect with brands and designers, […]

Bermudian model Aliana King made an appearance in the Winter 2023 edition of C Magazine as a face of Chanel’s cruise collection of clothing. The roller skating-themed campaign, dubbed “Skate It Till You Make It,” sees Ms. King “taking the L.A.-inspired Chanel cruise collection for a spin.”  Ms. King has also appeared in a […]

[Written by Stephen Wright] Sancho Jackson has reflected on his “inspiring experience” strutting down the catwalk at the recent New York Fashion Week Festival. The 22-year-old was selected to participate in The Model Experience, a coveted programme that offers aspiring models the chance to walk the runway, collaborate with brands and designers, share the stage […]

Sancho Jackson has completed his second modelling assignment after walking the runway at the Fig Buffalo Cut and Sewn show at Seneca One Tower in Buffalo, New York, last weekend. Mr Jackson, who lives in Birmingham, England, was invited to model at the event by Austin Guyett, the designer behind By A Guy, whom the […]

Osud České pirátské strany, která v několika volbách za sebou dostala výprask, je příkladem selhání progresivistického politického modelu. Když pak nedávno premiér Petr Fiala vyhodil z vlády Ivana Bartoše za nezvládnutou digitalizaci stavebního řízení, prezentovali se Piráti sérií emotivních a dětinských prohlášení. Uraženě opustili koaliční kabinet a naivně si myslí, že je to zachrání před dalším propadem. Za předsedu si teď zvolili Zdeňka Hřiba, kterého Pražané v pozici náměstka a předtím primátora hlavního města skutečně nemusí.

1. New Model Predicts Intelligent Life Odds in Universe  Mirage News
2. Formula for alien life: Drake Equation gets a dark energy update  Cosmos

It shouldn’t be a big story that a desktop computer has upgradeable internal storage, but with Apple’s cute new 2024 Mac mini, that’s exactly where we are. It’s possible to pop the SSD out after removing a screw, and then switch in a bigger one. We didn’t run into the software blocks we saw in the…

Join our daily and weekly newsletters for the latest updates and exclusive content on industry-leading AI coverage. Learn More Google DeepMind has unexpectedly released the source code and model weights of AlphaFold 3 for academic use, marking a significant advance that could accelerate scientific…

We've bought our first home, and we are so excited to remodel the kitchen! We're keeping our updates simple and on a budget, but the imact will be HUGE!

The post Mini Kitchen Remodel – The “Before” – Virginia Beach, VA appeared first on Joyful Abode.

This post may contain affiliate links. If you make a purchase through an affiliate link, the site author may receive a small commission. The mini kitchen remodel reveal Have you been on the edge of your seat, wondering how my DIY mini kitchen remodel turned out? Well, here we go! We didn’t do a full […]

The post Mini Kitchen Remodel – Bright & Airy AFTER (You’ll love it!) appeared first on Joyful Abode.

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Cybersecurity researchers have disclosed six security flaws in the Ollama artificial intelligence (AI) framework that could be exploited by a malicious actor to perform various actions, including denial-of-service, model poisoning, and model theft. "Collectively, the vulnerabilities could allow an attacker to carry out a wide-range of malicious actions with a single HTTP request, including

A Princeton-led team of astrophysicists has measured a surprising value for the “clumpiness” of the universe’s dark matter.

In this talk, Graham Neubig will discuss a new frontier in AI models, vision-language models that understand the world's cultures. The talk will be in two parts. First, Neubig will discuss training of multilingual multimodal multicultural models that understand images and text, and have increased ability to answer culture-specific questions about multimodal data. Second, he will discuss work on "image transcreation", where models have been developed that can transform images to make them more relevant to a particular culture. This work has applications in a number of areas, such as cultural localization of educational materials (to accompany translated text). While these methods cover many languages, African and not, the talk will focus on examples specifically from the African context, and challenges we currently face therein.

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Hdac3 is a lysine deacetylase that removes acetyl groups from histones and additional proteins. Although Hdac3 functions within mesenchymal lineage skeletal cells are defined, little is known about Hdac3 activities in bone-resorbing osteoclasts. In this study we conditionally deleted Hdac3 within Ctsk-expressing cells and examined the effects on bone modeling and osteoclast differentiation in mice. Hdac3 deficiency reduced femur and tibia periosteal circumference and increased cortical periosteal osteoclast number. Trabecular bone was likewise reduced and was accompanied by increased osteoclast number per trabecular bone surface. We previously showed that Hdac3 deacetylates the p65 subunit of the NF-κB transcriptional complex to decrease DNA-binding and transcriptional activity. Hdac3-deficient osteoclasts demonstrate increased K310 NF-κB acetylation and NF-κB transcriptional activity. Hdac3-deficient osteoclast lineage cells were hyper-responsive to RANKL and showed elevated ex vivo osteoclast number and size and enhanced bone resorption in pit formation assays. Osteoclast-directed Hdac3 deficiency decreased cortical and trabecular bone mass parameters, suggesting that Hdac3 regulates coupling of bone resorption and bone formation. We surveyed a panel of osteoclast-derived coupling factors and found that Hdac3 suppression diminished sphingosine-1-phosphate production. Osteoclast-derived sphingosine-1-phosphate acts in paracrine to promote bone mineralization. Mineralization of WT bone marrow stromal cells cultured with conditioned medium from Hdac3-deficient osteoclasts was markedly reduced. Expression of alkaline phosphatase, type 1a1 collagen, and osteocalcin was also suppressed, but no change in Runx2 expression was observed. Our results demonstrate that Hdac3 controls bone modeling by suppressing osteoclast lineage cell responsiveness to RANKL and coupling to bone formation.

Synapse loss is associated with motor and cognitive decline in multiple neurodegenerative disorders, and the cellular redistribution of tau is related to synaptic impairment in tauopathies, such as Alzheimer's disease and frontotemporal dementia. Here, we examined the cellular distribution of tau protein species in human tau overexpressing line 66 mice, a transgenic mouse model akin to genetic variants of frontotemporal dementia. Line 66 mice express intracellular tau aggregates in multiple brain regions and exhibit sensorimotor and motor learning deficiencies. Using a series of anti-tau antibodies, we observed, histologically, that nonphosphorylated transgenic human tau is enriched in synapses, whereas phosphorylated tau accumulates predominantly in cell bodies and axons. Subcellular fractionation confirmed that human tau is highly enriched in insoluble cytosolic and synaptosomal fractions, whereas endogenous mouse tau is virtually absent from synapses. Cytosolic tau was resistant to solubilization with urea and Triton X-100, indicating the formation of larger tau aggregates. By contrast, synaptic tau was partially soluble after Triton X-100 treatment and most likely represents aggregates of smaller size. MS corroborated that synaptosomal tau is nonphosphorylated. Tau enriched in the synapse of line 66 mice, therefore, appears to be in an oligomeric and nonphosphorylated state, and one that could have a direct impact on cognitive function.

The break-up of Scholz’s coalition government signals the end of Germany’s old economic model Expert comment jon.wallace 12 November 2024

The coalition could not agree how to fund new support for Ukraine and failed to fully implement the ‘Zeitenwende’. A new government must push through reform.

As Europeans were still processing Donald Trump’s victory in the 2024 US presidential election, an acrimonious break up occurred 4000 miles east of Washington DC.

Reports had been circulating for weeks about the fragile state of Germany’s ‘traffic light’ coalition government led by German Chancellor Olaf Scholz, consisting of the centre-left Social Democratic Party (SPD), the Green Party, and liberal Free Democratic Party (FDP).

The expectation had been that the coalition would hold on for a few more weeks and might even be given a new lease of life by Trump’s re-election. Instead, it collapsed on the day Trump’s win was confirmed. An unusually angry Scholtz announced in a live address that he had fired FDP Finance Minister Christian Lindner, effectively breaking up the coalition.

At the heart of the dispute was the so-called ‘debt brake’ – a constitutional mechanism which restricts Germany’s annual public deficit to 0.35 per cent of GDP. Lindner proposed a set of reforms which were unpalatable to the SPD and the Greens. 

In response, Scholz suggested declaring an emergency, which would have suspended the debt brake. That in turn was unacceptable to Lindner, leading to his sacking by the Chancellor.

Practically, this means the SPD and the Greens are now in a minority coalition, without agreement on the 2025 budget or the votes in parliament to pass it. They also still face the challenge of the debt brake.

A vote of confidence will take place in December, with elections to be held before the end of February 2025 latest.

The end of Germany’s economic model

At the root of Germany’s political crisis is the country’s economic model. For decades, Germany relied on a system that depended on cheap Russian gas, cheap imports of consumer goods from China, high-value exports – particularly in the automotive sector – and the US security umbrella.

With Russian energy no longer viable, the global economic landscape shifting, and Donald Trump on his way back to the White House, that model is no longer workable. And Germany’s economy is expected to contract by 0.2 per cent in 2024 – a contraction for the second year running.

The ‘Zeitenwende’, announced by Scholz in the wake of Russia’s full-scale invasion of Ukraine, should have signalled a turnaround of both foreign and economic policy, given how much the two are interconnected. Yet on both fronts, too little changed.

Germany’s reliance on Russian gas did come to an abrupt end in 2022. And Germany is Ukraine’s second largest military aid donor after the US, while accepting the most Ukrainian refugees.

But the ‘Zeitenwende’ turnaround ended there. Scholz’s coalition government failed to prepare for long-term investment in defence at the levels required by creating an off-budget defence spending fund which would have run out in 2027. The draft budget for 2025 showed defence spending would have been cut, as would support for Ukraine.

Germany has also struggled to turn around its economic woes, with the car industry particularly affected. Cheap Chinese EVs and new energy technologies are competing with Germany’s most powerful companies. Volkswagen, the country’s largest car manufacturer, has announced plant closures and layoffs due to shrinking profit margins.  

To the west, Trump’s threat to impose 10 to 20 per cent tariffs on all EU imports meant share prices of Volkswagen, BMW, Mercedez-Benz and Porsche all dropped between 4 to 7 per cent following news of his re-election.

To the east, trade tensions between the EU and China are intensifying. Yet rather than choosing to diversify, German companies have doubled down on their bets in China, with German investment in the country rising from €6.5bn for the whole of 2023 to €7.3bn in the first half of 2024 alone – only exposing carmakers further.

Germany’s support for Ukraine

Like French President Emmanuel Macron, Scholz had already been weakened by the results of the European Parliamentary elections in June. With the collapse of his traffic light coalition, the EU’s Franco-German ‘engine’ is now well and truly stalled – until new leadership can be found. This weakness comes at a perilous moment when clear, united European leadership, and much increased funding, is needed to shore up support for Ukraine.

RK Tangirala
Nov 1, 1995; 36:2320-2328
Articles

Evolving evidence suggests that nicotine may contribute to impaired asthma control by stimulating expression of nerve growth factor (NGF), a neurotrophin associated with airway remodeling and airway hyperresponsiveness. We explored the hypothesis that nicotine increases NGF by reducing lung fibroblast (LF) microRNA-98 (miR-98) and PPARγ levels, thus promoting airway remodeling. Levels of NGF, miR-98, PPARγ, fibronectin 1 (FN1), endothelin-1 (EDN1, herein referred to as ET-1), and collagen (COL1A1 and COL3A1) were measured in human LFs isolated from smoking donors, in mouse primary LFs exposed to nicotine (50 μg/ml), and in whole lung homogenates from mice chronically exposed to nicotine (100 μg/ml) in the drinking water. In selected studies, these pathways were manipulated in LFs with miR-98 inhibitor (anti-miR-98), miR-98 overexpression (miR-98 mimic), or the PPARγ agonist rosiglitazone. Compared with unexposed controls, nicotine increased NGF, FN1, ET-1, COL1A1, and COL3A1 expression in human and mouse LFs and mouse lung homogenates. In contrast, nicotine reduced miR-98 levels in LFs in vitro and in lung homogenates in vivo. Treatment with anti-miR-98 alone was sufficient to recapitulate increases in NGF, FN1, and ET-1, whereas treatment with a miR-98 mimic significantly suppressed luciferase expression in cells transfected with a luciferase reporter linked to the putative seed sequence in the NGF 3'UTR and also abrogated nicotine-induced increases in NGF, FN1, and ET-1 in LFs. Similarly, rosiglitazone increased miR-98 and reversed nicotine-induced increases in NGF, FN1, and ET-1. Taken together, these findings demonstrate that nicotine-induced increases in NGF and other markers of airway remodeling are negatively regulated by miR-98.

A. V. Domrina
Trans. Moscow Math. Soc. 83 (), 201-215.
Abstract, references and article information

A. Kh. Khachatryan, Kh. A. Khachatryan and A. Zh. Narimanyan
Trans. Moscow Math. Soc. 83 (), 183-200.
Abstract, references and article information

A. G. Sergeev, A. Kh. Khachatryan and Kh. A. Khachatryan
Trans. Moscow Math. Soc. 83 (), 55-65.
Abstract, references and article information

Decarbonizing Heat: A New Frontier for Technologies and Business Models 27 February 2019 — 8:15AM TO 9:45AM Anonymous (not verified) 3 December 2018 Chatham House | 10 St James's Square | London | SW1Y 4LE

Building space and water heating accounts for over 35 percent of global energy consumption - nearly double that of transport. However, there has been limited progress in decarbonizing the sector to date. International cooperation is required to ensure harmonized policies drag low carbon heating technologies down the cost curve to the extent that low carbon heating is cost competitive and affordable. The initial presentations and discussion focus on:

• Demand reduction technologies and policies that speed up transformation of the sector.
• The different challenges for energy efficiency of retrofitting as opposed to new build.
• The impact of electrification on GHG emissions and the power sector.
• The comparative role of national and city level initiatives.

The meeting concludes by looking at the challenges and risks in accelerating the transformation of heating and the lessons that can be learned from other sectors.

Otto Overkamp
Trans. Amer. Math. Soc. 377 (), 5863-5903.
Abstract, references and article information

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