We find out how UEFA has helped clubs to learn more about injuries with a groundbreaking study

The Delaware Department of Justice Consumer Protection Unit is alerting residents of a phone scam regarding missed jury duty service. Similar scams have been reported in the past.

The Delaware Department of Justice’s Office of Civil Rights & Public Trust announced Monday that a grand jury has indicted former Wilmington City Council President Theopalis K. Gregory on charges of Profiteering and Official Misconduct. The DOJ alleges that Gregory, 67, used his position on City Council to secure a City grant that would enrich […]

The Delaware Department of Justice’s Office of Civil Rights & Public Trust announced Tuesday that a grand jury has indicted Dewey Beach police officer Gregory Lynch, Jr. in connection to an August 10 incident near Bellevue Road. The DOJ alleges that police and EMTs were dispatched on August 10 to assist a victim who had […]

Wilmington man sentenced for 2017 killing in city A Bridgeville man who turned himself into police three days after fatally shooting another man in 2018 will spend the rest of his life in prison. A Sussex County Superior Court jury convicted Mcarthur Risper, Jr. of Murder First Degree, Conspiracy First Degree, and Possesion of a […]

A Superior Court jury has convicted a Wilmington man for his central role in a June 2016 murder. Witness testimony, cell phone evidence, and collaboration with an FBI task force demonstrated that Brian Wilson, also known as Fudayl Wakim, arranged the murder of Allen Cannon through a $10,000 bounty and a conspiracy with co-defendant Eric […]

The Delaware Department of Justice’s Office of Civil Rights & Public Trust announced Monday that a grand jury has indicted a Pennsylvania man on two counts of the crime of Abusing a Corpse. In two separate incidents, James T. Schaeffer-Patton, 39, of Pennsylvania is accused of having improperly moved decedents’ bodies during his employment as […]

The Virat Kohli-led team had an option of retaining KL Rahul in New Zealand given his rich vein of form in the just-concluded ODI and T20I series, but they opted to reward Prithvi Shaw and Shubhman Gill for their performances in red-ball cricket.

The Redskins quarterback's broken leg led to an insidious infection that could have cost him his life.

The Anatolian geography with its climate, unique location and biodiversity is home to several unique natural beauties. Lakes in the green valleys, mountain plains, unique rock formations, rivers, valleys and beaches… Hürriyet Travel has compiled the must-see natural marvels of Turkey. It is our hope to preserve these landscapes in the future. Click through for our top 10...

Whether it is the gorgeous Bosphorus or the biblical River Euphrates, Turkey provides many options for those who would like to dine at a waterfront venue. Click through for the top 10 waterfront restaurants in Turkey selected by Hürriyet Travel’s jury of experts.

Hamam, or Turkish bath, is one of the defining features of Turkish culture. A culture passed down over history, the baths, besides being a place to get pampered, is a spot for socializing and entertainment. Hürriyet’s jury have chosen the best traditional Roman and Ottoman baths of Turkey. Click through for the full list...

Street food is one of the most delicious ways to get to know a country and its culture. Hürriyet’s Gastronomy Jury has ranked the best street food venues in Turkey. Click through for the best of the best...

Being the capital of three empires, Istanbul hosts 82 different museums. The Hürriyet jury, composed of eminent historians, travelers and journalists, has picked the top 10 museums in Istanbul. Click through for the full list...

Ashvin Kumar recently took a trip down memory lane and reminisced upon Irrfan Khan’s professionalism

Our brains influence all aspects of our lives, including our sexual desires. This means brain injuries can have some surprising effects, says Amee Baird

Title: Amateur Boxers at Risk of Brain Injury
Category: Health News
Created: 5/3/2007 12:00:00 AM
Last Editorial Review: 5/3/2007 12:00:00 AM

Title: Quick Decompression Aids Spinal Injury Recovery
Category: Health News
Created: 4/29/2008 2:00:00 AM
Last Editorial Review: 4/29/2008 12:00:00 AM

Title: Sex Lives Often an Overlooked Casualty of Traumatic Brain Injury
Category: Health News
Created: 4/29/2013 2:35:00 PM
Last Editorial Review: 4/30/2013 12:00:00 AM

Title: Traumatic Brain Injury Common Among Homeless Men
Category: Health News
Created: 4/30/2014 12:35:00 PM
Last Editorial Review: 5/1/2014 12:00:00 AM

Title: Psychiatric Scars of Wartime Brain Injury May Linger for Years
Category: Health News
Created: 5/1/2017 12:00:00 AM
Last Editorial Review: 5/2/2017 12:00:00 AM

Electronic cigarette or vaping product use–associated lung injury (EVALI) is a newly emerging diagnosis in the United States, yet the incidence has surged greatly in the past year. With the trend of using electronic cigarettes (e-cigarettes) and vaping rising at an alarming rate among teenagers, many are resorting to friends, illicit drug dealers, and other informal sources to obtain their e-cigarettes, which is greatly contributing to the national outbreak of EVALI. The incidence of adolescents presenting with the constellation of respiratory, gastrointestinal, and constitutional symptoms characteristic of EVALI has been widely reported within the nation. We present one such case of an adolescent boy with a 2-year history of daily vaping who presented with nausea, vomiting, weight loss, and fever but lacked the respiratory symptoms that have been reported in the majority of EVALI cases reported thus far. Computed tomography scan of the abdomen and pelvis revealed an incidental finding of lung pathology characteristic of EVALI, prompting further workup and diagnosis of EVALI. In this case, it is demonstrated that the presentation of EVALI can be variable and is still poorly defined. The rising morbidity and mortality from EVALI reveal the importance of considering EVALI in all patients with a history of vaping or e-cigarette use, regardless of the presence or absence of respiratory symptoms.

Key Points

Background

After accounting for known risk factors for CKD progression in children, clinical outcomes among children with CKD still vary substantially. Biomarkers of tubular injury (such as KIM-1), repair (such as YKL-40), or inflammation (such as MCP-1, suPAR, TNF receptor-1 [TNFR-1], and TNFR-2) may identify children with CKD at risk for GFR decline.

Background

Kidney injury associated with cold storage is a determinant of delayed graft function and the long-term outcome of transplanted kidneys, but the underlying mechanism remains elusive. We previously reported a role of protein kinase C- (PKC) in renal tubular injury during cisplatin nephrotoxicity and albumin-associated kidney injury, but whether PKC is involved in ischemic or transplantation-associated kidney injury is unknown.

Background

Expression of SerpinB2, a regulator of inflammatory processes, has been described in the context of macrophage activation and cellular senescence. Given that mechanisms for these processes interact and can shape kidney disease, it seems plausible that SerpinB2 might play a role in renal aging, injury, and repair.

“E-cigarettes” are a class of consumer devices designed to deliver drugs, primarily nicotine or marijuana oils, to the lung by vaporization. Regulation of the devices in the United States is relatively minimal, and research on both epidemiology and potential toxicity has focused on nicotine devices. In 2019, an outbreak of an acute respiratory illness in the United States was traced back to the contamination of e-cigarette fluids with vitamin E acetate, which had been used to disguise the dilution of marijuana oils. The outbreak, termed “e-cigarette or vaping associated lung injury” by the U.S. Centers for Disease Control, was characterized by pulmonary infiltrates and hypoxia, which usually required hospitalization and, often, admission to ICUs. The syndrome sickened >2,600 people, mostly young men, and killed >50 people before it began to abate 6 months later. No current regulations exist to prevent a similar event with the same or different chemical contaminants. Absent such regulation, respiratory practitioners should be prepared to evaluate, identify, and treat future cases of acute lung toxicity from e-cigarettes.

Drug-induced liver injury (DILI) is a global medical problem. The risk of DILI is often related to expression and activities of drug-metabolizing enzymes, especially cytochrome P450s (P450s). However, changes on expression and activities of P450s after DILI have not been determined. The aim of this study is to fill this knowledge gap. Acetaminophen (APAP) was used as a model drug to induce DILI in C57BL/6J mice at different ages of days 10 (infant), 22 (child), and 60 (adult). DILI was assessed by levels of alanine aminotransferase and aspartate aminotransferase in plasma with a confirmation by H&E staining on liver tissue sections. The expression of selected P450s at mRNA and protein levels was measured by real-time polymerase chain reaction and liquid chromatography–tandem mass spectrometry, respectively. The activities of these P450s were determined by the formation of metabolites from probe drugs for each P450 using ultraperformance liquid chromatography–quadrupole time of flight mass spectrometry. DILI was induced at mild to severe levels in a dose-dependent manner in 200, 300, and 400 mg/kg APAP-treated groups at child and adult ages, but not at the infant age. Significantly decreased expression at mRNA and protein levels as well as enzymatic activities of CYP2E1, 3A11, 1A2, and 2C29 were found at child and adult ages. Adult male mice were more susceptible to APAP-induced liver injury than female mice with more decreased expression of P450s. These results suggest that altered levels of P450s in livers severely injured by drugs may affect the therapeutic efficacy of drugs, which are metabolized by P450s, more particularly for males.

We investigated dose-fractionated polymyxin B (PB) on acute kidney injury (AKI). PB at 12 mg of drug/kg of body weight per day (once, twice, and thrice daily) was administered in rats over 72 h. The thrice-daily group demonstrated the highest KIM-1 increase (P = 0.018) versus that of the controls (P = 0.99) and histopathological damage (P = 0.013). A three-compartment model best described the data (bias, 0.129 mg/liter; imprecision, 0.729 mg²/liter²; R², 0.652,). Area under the concentration-time curve at 24 h (AUC₂₄) values were similar (P = 0.87). The thrice-daily dosing scheme resulted in the most PB-associated AKI in a rat model.

Fluoroquinolones are reported to possess immunomodulatory activity; hence, a novel benzoquinolizine fluoroquinolone, levonadifloxacin, was evaluated in lipopolysaccharide-stimulated human whole-blood (HWB) and mouse acute lung injury (ALI) models. Levonadifloxacin significantly mitigated the inflammatory responses in an HWB assay through inhibition of proinflammatory cytokines and in the ALI model by lowering lung total white blood cell count, myeloperoxidase, and cytokine levels. The immunomodulatory effect of levonadifloxacin, along with promising antibacterial activity, is expected to provide clinical benefits in the treatment of infections.

BACKGROUND AND PURPOSE:

The use of invasive cerebral angiography with CTA for active treatment of patients with suspected ischemic strokes has been increasing recently. This study aimed to identify the incidence of postcontrast acute kidney injury using baseline renal function when CTA and cerebral angiography were performed sequentially.

BACKGROUND AND PURPOSE:

Anoxic brain injury is a result of prolonged hypoxia. We sought to describe the nonquantitative arterial spin-labeling perfusion imaging patterns of anoxic brain injury, characterize the relationship of arterial spin-labeling and DWI, and evaluate the normalized diffusion-to-perfusion ratio to differentiate patients with anoxic brain injury from healthy controls.

You know who you are. You know what you did. And to the driver who killed Nathan Beaulieu’s dog in a cowardly hit-and-run, the Winnipeg Jets defenceman wants you to ...

Our brains influence all aspects of our lives, including our sexual desires. This means brain injuries can have some surprising effects, says Amee Baird

In a Fox News interview Friday, President Trump was noncommittal on whether FBI Director Christopher Wray would remain in the job following the Justice Department’s decision to drop its case against Michael Flynn.

Chief Justice John Roberts on Friday put a temporary hold on the release of secret materials from former special counsel Robert Mueller's investigation to a Democrat-led House committee.

The order stops the clock on a lower court's ruling requiring the Justice Department to turn over confidential grand jury materials underlying ...

A man has been charged with murder after the death of an 88-year-old widower in a quiet English village.

Actor was struck by vehicle during family walk

Manchester United star Paul Pogba has opened up on his injury frustration, but says his time on the sidelines has reminded him how much he loves football.

Jack Wilshere has admitted his transfer to West Ham "hasn't worked out" as he had hoped amid uncertainty over his future at the club.

Victor Wanyama says he was "p***** off" to be dropped for Tottenham's Champions League Final defeat last season and accused the club of a lack of support following a serious knee injury in 2017.

Christian Pulisic is missing football as much as anyone else, but the lockdown has at least allowed him the time to return to fitness.

Paul Pogba is targeting an immediate comeback from injury for Manchester United when Premier League football returns.

A Sydney jury is unable to reach a unanimous or majority verdict in the case of a Kulwinder Singh, who pleaded not guilty to setting his wife Parwinder Kaur on fire in 2013. She later died in hospital.

South Sydney Rabbitohs forward Sam Burgess has been forced into early retirement from the NRL aged 30 due to a chronic shoulder injury.

A 25-year-old man has been arrested on suspicion of section 18 assault

Investigators will use the money to pinpoint the optimal amount of exercise needed after joint injury to reduce inflammation, speed healing, and minimize osteoarthritis.
Medscape Medical News

Queen guitarist Brian May says he ended up in hospital and was left unable to walk after "ripping his glutes to shreds" while gardening.

"I managed to rip my Gluteus Maximus to shreds," Queen guitarist Brian May shared on Instagram, along with a photo of himself sporting a mask in the hospital.