Learn about the risks and benefits of these drugs for symptoms of brain injury.

A commentary, published in the Journal of Neurotrauma, calls for traumatic brain injury to be recognized as a chronic condition as are diabetes, asthma, depression and heart failure. To provide comprehensive care for traumatic brain injury throughout individuals' lifespans, the authors propose that coordinated care models they and others have developed, tested and applied to various populations—including older adults, individuals living with depression and post-intensive care unit survivors—be adapted to improve communication and integration between brain injury specialists—including physical medicine and rehabilitation clinicians—and primary care physicians, fostering better long-term patient care for traumatic brain injury survivors and more support for both patients and their families.

Plasma proteomics of acute tubular injury  Nature.com

Toronto, ON — On Thursday, May 21, the Supreme Court of Canada will render its decision in Kokopenace v. HMTQ. The key issue in the case is the scope of the right to a representative jury under the Canadian Charter of Rights and Freedoms, and whether Ontario’s procedure for creating jury rolls does enough to […]

It has been announced that Strictly Come Dancing Star Amy Dowden will not be returning to this year's series of Strictly.

The Better With Less – Design Challenge had an international jury including packaging design experts from various fields related to packaging, design, brand strategy and innovation. After the judging concluded and the finalists chosen, a roundtable panel discussed what they saw as well as the challenges facing the packaging community.

Room 30, Parliament Buildings

Room 30, Parliament Buildings

The family of an injured teenager filed a lawsuit in federal court claiming she was critically injured while riding on a go-cart attraction on a Norwegian Cruise Line vessel while she and her family were sailing in the western Caribbean.

Fatal shooting of 25-year-old Joshua Mitchell took place outside Café Lungo in November 2023

A new digital tool for roofing contractors allows users to search and download data by year, industry, state, and more.

L.A. County jurors decided largely in favor of a man with silicosis who had to undergo a double lung transplant after years of cutting engineered stone countertops.

Shiffrin made a triumphant comeback to the World Cup Sunday, dominating the season’s penultimate slalom for career win 96 and locking up her record-equaling eighth season title in the discipline.

Shohei Ohtani will play for the Los Angeles Dodgers in Game 3 of the World Series at Yankee Stadium, manager Dave Roberts told ESPN.

When the Nuggets are right, they play a beautiful game. They cut to the hoop, make deft passes, play tenacious defense, and hit the open shot.

Avalanche fans can breathe a sigh of relief about Cale Makar.

The contractor says the company ignored racist behavior.

The ex-captain allegedly targeted Black people for decades.

The tennis icon tore her hamstring at Wimbledon.

Down will be without injured pair Danny Hughes and Dan Gordon for Sunday's National Football League semi-final against Cork.

Tyrone forward Kyle Coney looks certain to be ruled out for the rest of this season after sustaining a groin injury.

The panel of 28 felt it was important to give people choice, but only if they were terminally ill.

A Virginia-based defence contractor is found liable for the abuse of three former prisoners.

Left-wing networks had plenty of bad news for their viewers as former President Donald Trump stormed to victory in the Nov. 5 election. Now, they’re getting plenty of bad news […]

The post Insult to Injury: MSNBC and CNN Suffer Staggering Ratings Plunge Following Trump Victory appeared first on The Western Journal.

Animals can sense the presence of microbes in their tissues and mobilize their own defenses by recognizing and responding to conserved microbial structures (often called microbe-associated molecular patterns (MAMPs)). Successful host defenses may kill the invaders, yet the host animal may fail to restore homeostasis if the stimulatory microbial structures are not silenced. Although mice have many mechanisms for limiting their responses to lipopolysaccharide (LPS), a major Gram-negative bacterial MAMP, a highly conserved host lipase is required to extinguish LPS sensing in tissues and restore homeostasis. We review recent progress in understanding how this enzyme, acyloxyacyl hydrolase (AOAH), transforms LPS from stimulus to inhibitor, reduces tissue injury and death from infection, prevents prolonged post-infection immunosuppression, and keeps stimulatory LPS from entering the bloodstream. We also discuss how AOAH may increase sensitivity to pulmonary allergens. Better appreciation of how host enzymes modify LPS and other MAMPs may help prevent tissue injury and hasten recovery from infection.

Yi-Han Lin
Dec 1, 2020; 19:2030-2046
Research

Ji Eun Kim
Dec 20, 2020; 0:RA120.002159v1-mcp.RA120.002159
Research

Sepsis-induced acute kidney injury (S-AKI) is the most common complication in hospitalized and critically ill patients, highlighted by a rapid decline of kidney function occurring a few hours or days after sepsis onset. Systemic inflammation elicited by microbial infections is believed to lead to kidney damage under immunocompromised conditions. However, although AKI has been recognized as a disease with long-term sequelae, partly because of the associated higher risk of chronic kidney disease (CKD), the understanding of kidney pathophysiology at the molecular level and the global view of dynamic regulations in situ after S-AKI, including the transition to CKD, remains limited. Existing studies of S-AKI mainly focus on deriving sepsis biomarkers from body fluids. In the present study, we constructed a mid-severity septic murine model using cecal ligation and puncture (CLP), and examined the temporal changes to the kidney proteome and phosphoproteome at day 2 and day 7 after CLP surgery, corresponding to S-AKI and the transition to CKD, respectively, by employing an ultrafast and economical filter-based sample processing method combined with the label-free quantitation approach. Collectively, we identified 2,119 proteins and 2950 phosphosites through multi-proteomics analyses. Among them, we identified an array of highly promising candidate marker proteins indicative of disease onset and progression accompanied by immunoblot validations, and further denoted the pathways that are specifically responsive to S-AKI and its transition to CKD, which include regulation of cell metabolism regulation, oxidative stress, and energy consumption in the diseased kidneys. Our data can serve as an enriched resource for the identification of mechanisms and biomarkers for sepsis-induced kidney diseases.

Urinary proteomics studies have primarily focused on identifying markers of chronic kidney disease (CKD) progression. Here, we aimed to determine urinary markers of CKD renal parenchymal injury through proteomics analysis in animal kidney tissues and cells and in the urine of patients with CKD. Label-free quantitative proteomics analysis based on liquid chromatography-tandem mass spectrometry was performed on urine samples obtained from 6 normal controls and 9, 11, and 10 patients with CKD stages 1, 3, and 5, respectively, and on kidney tissue samples from a rat CKD model by 5/6 nephrectomy. Tandem mass tag-based quantitative proteomics analysis was performed for primary cultured glomerular endothelial cells (GECs) and proximal tubular epithelial cells (PTECs) before and after inducing 24-h hypoxia injury. Upon hierarchical clustering, out of 858 differentially expressed proteins (DEPs) in the urine of CKD patients, the levels of 416 decreased and 403 increased sequentially according to the disease stage, respectively. Among 2965 DEPs across 5/6 nephrectomized and sham-operated rat kidney tissues, 86 DEPs showed same expression patterns in the urine and kidney tissue. After cross-validation with two external animal proteome datasets, 38 DEPs were organized; only 10 DEPs, including serotransferrin, gelsolin, poly ADP-ribose polymerase 1, neuroblast differentiation-associated protein AHNAK, microtubule-associated protein 4, galectin-1, protein S, thymosin beta-4, myristoylated alanine-rich C-kinase substrate, and vimentin were finalized by screening human GECs and PTECs data. Among these ten potential candidates for universal CKD marker, validation analyses for protein S and galectin-1 were conducted. Galectin-1 was observed to have a significant inverse correlation with renal function as well as higher expression in glomerulus with chronic injury than protein S. This constitutes the first multi-sample proteomics study for identifying key renal-expressed proteins associated with CKD progression. The discovered proteins represent potential markers of chronic renal cell and tissue damage and candidate contributors to CKD pathophysiology.

Jake Arrieta on Thursday offered an unexpected explanation for his second-half struggles in 2018: he pitched much of last season with an injured left knee.

The Indiana man accused of killing two teenage girls in a wooded area near Delphi was found guilty on Monday and faces a mid-December sentencing date.

The Oilers look to claw themselves up above .500 against the team that started their memorable turnaround last season.

Buffalo’s leading scorer did not return for the third period of the 7-5 loss to Montreal

Tennessee won easily over Mississippi State. Indiana and BYU won nail-biters. So why did they jump over the Vols? We asked the CFP committee chair.

Early in the second half, Ohio State freshman Jaloni Cambridge went down with an apparent lower-back injury.

Sharon G. Kujawa
Nov 11, 2009; 29:14077-14085
BehavioralSystemsCognitive

Injuries to the central nervous system (CNS) can cause severe neurological deficits. Axonal regrowth is a fundamental process for the reconstruction of compensatory neuronal networks after injury; however, it is extremely limited in the adult mammalian CNS. In this study, we conducted a loss-of-function genetic screen in cortical neurons, combined with a Web resource-based phenotypic screen, and identified synaptotagmin 4 (Syt4) as a novel regulator of axon elongation. Silencing Syt4 in primary cultured cortical neurons inhibits neurite elongation, with changes in gene expression involved in signaling pathways related to neuronal development. In a spinal cord injury model, inhibition of Syt4 expression in cortical neurons prevented axonal sprouting of the corticospinal tract, as well as neurological recovery after injury. These results provide a novel therapeutic approach to CNS injury by modulating Syt4 function.

Canadian swingman RJ Barrett was upgraded to day-to-day and engaged in non-contact practise on Monday, two days before Toronto hosts the Cleveland Cavaliers at Scotiabank Arena.

In a survey of educators in an urban Midwest district, 4 in 5 said the witnessed other staff doing things that were morally wrong, while almost half said they themselves had acted in a way that betrayed their values.

Late last month in New Castle County, a Grand Jury indicted multiple residents for insurance fraud. The indictments stem from Department of Insurance Fraud Prevention Bureau investigations, in partnership with the Delaware Department of Justice. They allege that following vehicle accidents, each indicted resident did knowingly present false information to auto insurers or otherwise caused […]

The Delaware Department of Justice’s Fraud & Consumer Protection Division announced Monday that a grand jury has indicted Susan Losey on multiple counts of theft with an aggregate loss of approximately $22,000. In particular, Losey is accused of using her cleaning business, Down & Dirty Cleaning Services, to defraud more than 50 victims, primarily in […]

Attorney General Kathy Jennings and the DOJ’s Division of Civil Rights & Public Trust announced Tuesday that a grand jury has indicted James MacColl, formerly a corporal of the Wilmington Police Department, on two felonies and one misdemeanor. MacColl, 39, is charged with Providing a False Statement to Law Enforcement, Tampering with Physical Evidence, and Official Misconduct for […]

Lengthy DCRPT investigation yields five charges, including felonies Charges include orchestrating State contract with political consultant Indictment alleges McGuiness hired teenage daughter, paid her while enrolled in college   Following an investigation involving dozens of witness interviews, thousands of document reviews, and more than a year of work, Attorney General Kathy Jennings and the DOJ’s […]

Broken bones, head injuries and temporary or permanent disabilities can result from falls. The Delaware Coalition for Injury Prevention’s Falls Prevention Team encourages Delawareans to prevent such mishaps. Governor John Carney and Lieutenant Governor Bethany Hall-Long proclaimed September 18-22, 2023 as Falls Prevention Awareness Week in accordance with the nationally recognized observance. “It’s important that we […]

Title: Swelling After Knee Injury May Hinder Healing
Category: Health News
Created: 8/31/2007 12:00:00 AM
Last Editorial Review: 8/31/2007 12:00:00 AM