DAME VERA LYNN played an instrumental role in keeping up wartime morale and is highly respected today - but unearthed accounts reveal why she will still be relevant even in the next millennium.

THE QUEEN's powerful VE Day speech touched the hearts of Britons around the country as she reflected on her personal memories of World War 2 and sent her "warmest good wishes" to everyone celebrating in lockdown.

ALAN TITCHMARSH, celebrated and much loved TV gardener, once revealed a genius gardening hack to ensure one of his favourite flowers will grow even better in your own home.

THE heavy skies matched the sombre mood of the nation. As people across Britain paused yesterday for a minute's silence to honour the healthcare workers who have fallen in the deadly coronavirus pandemic, a heart-rending sense of poignancy was mixed with a profound feeling of gratitude.

THE commemoration was heartfelt, the nostalgia moving, the gratitude profound.

BORIS Johnson praised a 102-year old Second World War veteran as "awesome" yesterday during a VE Day video call.

UP AND down the land yesterday there were appropriately socially distanced events held to pay tribute to the generation of Britons that defeated Nazi Germany.

THE commemoration was heartfelt, the nostalgia moving, the gratitude profound.

French Resistance member Cecile Rol-Tanguy, who risked her life during World War II by working to liberate Paris from Nazi occupation, has died. She was 101.

I love her so much I'd like to send her a bunch of daffs and a hug. I've never met her, but she's 100 percent my Pin-up Pensioner Poster Girl for coronavirus.

REMEMBER the phrase: "He had a good war"? When we heard it at school it seemed an oxymoron. I recall our history teacher, sensing our confusion, elaborating thus: "For some war was deadly. The bereaved and the disabled never recovered. For some it was a hiatus, a long and frightening test of endurance. Yet some excelled.

HE'D BEEN a military hero. Serving with the 1st battalion of the Royal Highland Fusiliers, he'd survived being blown up at least once by the IRA and also served in Iraq.

Indiana Attorney General Curtis Hill's office is appealing the order.

NUVO, others buy tickets for hundreds of Indianapolis youth to see Marvel film with a black superhero

'Tully,' starring Charlize Theron, and Ruth Bader Ginsburg documentary highlight lineup for 15th annual Indy Film Fest

Exercise your super power by voting today.

Gov. Mike Pence's Scott County order allowing a needle-exchange program is a welcome step. But it's just a start.

Even two filmmaking legends can cast the wrong villains amid massive industry change.

Showrunner Damon Lindelof and his writers and producers have finally solved the show's biggest mystery.

The past 10 years have shown superheroes in entertainment aren't going anywhere.

Fanny packs and Kristen Wiig's Cheetah fill the frame in the teaser to the franchise's first sequel.

The black comics audience should be more demanding after seeing what the HBO series accomplished.

Scarlett Johansson gets a "Black Widow" solo movie, and Jared Leto returns in "Morbius."

TidalWave Productions is releasing Buttigieg and Bloomberg comic books to sit alongside its Warren biography.

Mike Luckovich's popular Iwo Jima cartoon is also celebrating those on the front lines of the fight against covid-19.

Those taking on great risk should be appropriately compensated.

TL;DR: Get trained in cybersecurity with The Ultimate 2020 White Hat Hacker Certification Bundle for $39.90, a 97% as of May 9.

When you think of superheroes, you probably picture capes and some sort of otherworldly powers. But in the digital world, superheroes are actually normal people like you and me. They just happen to know a thing or two about stopping cybercriminals in their tracks.

These superheroes are in short supply across the world. In fact, there are over half a million cybersecurity job openings in the U.S. alone. That just means this could be your chance to swoop in, superhero style, and save the day. But first things first, you need to learn the ropes and the Ultimate 2020 White Hat Hacker Certification Bundle is a great place to start. Read more...

Including a shoulder-brush with a livid Steve Waugh, Rob Houwing remembers witnessing SA's heroic finish to an otherwise stormy 2001/02 Australian tour.

Albrecht Gruhler
Mar 1, 2005; 4:310-327
Research

Mohamad Navab
Jun 1, 2004; 45:993-1007
Thematic Reviews

Weerapan Khovidhunkit
Jul 1, 2004; 45:1169-1196
Thematic Reviews

RK Tangirala
Nov 1, 1995; 36:2320-2328
Articles

IJ Goldberg
Apr 1, 1996; 37:693-707
Reviews

The pregnane X receptor (PXR) is a nuclear receptor that can be activated by numerous drugs and xenobiotic chemicals. PXR thereby functions as a xenobiotic sensor to coordinately regulate host responses to xenobiotics by transcriptionally regulating many genes involved in xenobiotic metabolism. We have previously reported that PXR has pro-atherogenic effects in animal models, but how PXR contributes to atherosclerosis development in different tissues or cell types remains elusive. In this study, we generated an LDL receptor-deficient mouse model with myeloid-specific PXR deficiency (PXR^MyeLDLR^–/–) to elucidate the role of macrophage PXR signaling in atherogenesis. The myeloid PXR deficiency did not affect metabolic phenotypes and plasma lipid profiles, but PXR^MyeLDLR^–/– mice had significantly decreased atherosclerosis at both aortic root and brachiocephalic arteries compared with control littermates. Interestingly, the PXR deletion did not affect macrophage adhesion and migration properties, but reduced lipid accumulation and foam cell formation in the macrophages. PXR deficiency also led to decreased expression of the scavenger receptor CD36 and impaired lipid uptake in macrophages of the PXR^MyeLDLR^–/– mice. Further, RNA-Seq analysis indicated that treatment with a prototypical PXR ligand affects the expression of many atherosclerosis-related genes in macrophages in vitro. These findings reveal a pivotal role of myeloid PXR signaling in atherosclerosis development and suggest that PXR may be a potential therapeutic target in atherosclerosis management.

Yipeng Sui
May 1, 2020; 61:696-706
Research Articles

M John Chapman
Apr 15, 2020; 0:jlr.P119000543v1-jlr.P119000543
Patient-Oriented and Epidemiological Research

In this week's inexplicably klaxon-heavy and fish-themed APPLE SPECIAL episode, David Price praises Apple for rescuing us from the tyranny of wired headphones, and reveals a hitherto unsuspected penchant for former Everton strikers. Chris Martin (22:41) dazzles us with his knowledge of the Apple Watch Series Two, and display some unusual headphone usage, and Henry Burell (32:51) reveals that Berlin is big, and sheds some light on the tiny corner of tech that *isn't* Apple flavoured. Join us.  

See acast.com/privacy for privacy and opt-out information.

Atherogenic LDL particles are physicochemically and metabolically heterogeneous. Can bioactive lipid cargo differentiate LDL subclasses, and thus potential atherogenicity?  What is the effect of statin treatment? Obese, hypertriglyceridemic, hypercholesterolemic males (n=12; Lp(a) <10 mg/dL) received pitavastatin calcium (4mg/day) for 180 days in a single-phase, unblinded study. The lipidomic profiles (23 lipid classes) of five LDL subclasses fractionated from baseline and post-statin plasmas were determined by LC-MS. At baseline and on statin treatment, very small dense LDL (LDL5) was preferentially enriched (up to 3-fold) in specific lysophospholipids (lysophosphatidylcholine (LPC); lysophosphatidylinositol (LPI); lyso-platelet activating factor (LPC(O)); 9,0.2 and 0.14 mol/mol apoB respectively; all p<0.001 versus LDL1-4), suggesting  elevated inflammatory potential per particle. In contrast, lysophosphatidylethanolamine was uniformly distributed among LDL subclasses. Statin treatment markedly reduced absolute plasma concentrations of all LDL subclasses (up to 33.5%), including LPC, LPI and LPC(O) contents (up to -52%), consistent with reduction in cardiovascular risk. Despite such reductions, lipotoxic ceramide load per particle in LDL1-5 (1.5 - 3 mol/mol apoB; 3 - 7 mmol/mol phosphatidylcholine) was either conserved or elevated. Bioactive lipids may constitute biomarkers for the cardiometabolic risk associated with specific LDL subclasses in atherogenic dyslipidemia at baseline, and with residual risk on statin therapy.

The pregnane X receptor (PXR) is a nuclear receptor that can be activated by numerous drugs and xenobiotic chemicals. PXR thereby functions as a xenobiotic sensor to coordinately regulate host responses to xenobiotics by transcriptionally regulating many genes involved in xenobiotic metabolism. We have previously reported that PXR has pro-atherogenic effects in animal models, but how PXR contributes to atherosclerosis development in different tissues or cell types remains elusive. In this study, we generated an LDL receptor-deficient mouse model with myeloid-specific PXR deficiency (PXR^MyeLDLR^–/–) to elucidate the role of macrophage PXR signaling in atherogenesis. The myeloid PXR deficiency did not affect metabolic phenotypes and plasma lipid profiles, but PXR^MyeLDLR^–/– mice had significantly decreased atherosclerosis at both aortic root and brachiocephalic arteries compared with control littermates. Interestingly, the PXR deletion did not affect macrophage adhesion and migration properties, but reduced lipid accumulation and foam cell formation in the macrophages. PXR deficiency also led to decreased expression of the scavenger receptor CD36 and impaired lipid uptake in macrophages of the PXR^MyeLDLR^–/– mice. Further, RNA-Seq analysis indicated that treatment with a prototypical PXR ligand affects the expression of many atherosclerosis-related genes in macrophages in vitro. These findings reveal a pivotal role of myeloid PXR signaling in atherosclerosis development and suggest that PXR may be a potential therapeutic target in atherosclerosis management.

Bruce B. Duncan
Jul 1, 2003; 52:1799-1805
Pathophysiology

Andreas Festa
Apr 1, 2002; 51:1131-1137
Complications

Henry N Ginsberg
Sep 1, 1991; 14:839-855
Diet and Diabetes

The ADA announced April 6 the recipients of its third annual 10 Under 10 Awards, which recognizes 10 new dentists who demonstrate excellence early in their careers.

The ADA is thanking Rep. Bill Huizenga, R-Mich., for introducing legislation to assist health care workers serving on the front lines of COVID-19.

OBJECTIVE

We examined detailed renal and cardiovascular (CV) outcomes after gastric bypass (GBP) surgery in people with obesity and type 2 diabetes mellitus (T2DM), across several renal function categories, in a nationwide cohort study.

By Scott T. Allison This blog post is excerpted from: Allison, S. T. (2019). Heroic consciousness. Heroism Science, 4, 1-43.   The philosopher Yuval Noah Harari (2018) recently described consciousness as “the greatest mystery in the universe”. What exactly is heroic consciousness? It is a way of seeing the world, perceiving reality, and making decisions … Continue reading Heroic Consciousness: What it is and How to Acquire it →

Allison, S. T. & Goethals, G. R. (2020). The heroic leadership imperative: How leaders inspire and mobilize change. West Yorkshire: Emerald. Our next book describes a new principle that we call the heroic leadership imperative. We show how leaders who fulfill the imperative will inspire followers and initiate social change.   The imperative consists of … Continue reading The Heroic Leadership Imperative →

By Scott T. Allison William James, who authored the first psychology texbook, was taken and moved by the quiet heroism in everyday working people. He noticed “the great fields of heroism lying round about” him. He was mesmerized by small, seemingly inconsequential everyday acts that, in effect, exemplified unsung heroism in everyone. Before the COVID-19 … Continue reading COVID-19 Pandemic Turns Heroism Upside-Down →