The usual talking heads in the media are freaking out and making all kinds of wild claims. Those are the rage-y emotional reactions. What's a more sensible take on all of this?

The post Why Did Trump Win And What Happens Now? appeared first on Clash Daily.

Did you know that the Marines just celebrated their 249th birthday? This is one helluva tribute.

The post VETERAN’S DAY: You’re Gonna Love What One Patriotic Coffee Company Did For The Marines! appeared first on Clash Daily.

The race to succeed Bill Beaumont as chairman of World Rugby comes to a conclusion in a vote in Dublin at the governing body's headquarters on Thursday.

Expert

Tricia Rowlison
Dec 1, 2020; 19:2090-2103
Research

Alison M. Kurimchak
Dec 1, 2020; 19:2068-2089
Research

Extracellular vesicles (EVs) secreted by the epididymal epithelium transfer to spermatozoa key proteins that are essential in promoting motility and subsequent fertilization success. Using the domestic cat model, the objectives were to (1) characterize and compare protein content of EVs between segments of the epididymis, and (2) compare EV protein compositions between normo- and teratospermic individuals (producing >60% of abnormal spermatozoa). Epididymal EVs from adult cats were isolated and assessed via liquid chromatography tandem MS. Both male types shared 3008 proteins in total, with 98 and 20 EV proteins unique to normospermic and teratospermic males, respectively. Expression levels of several proteins changed between epididymal segments in both male types. Several proteins in both groups were related to sperm motility (e.g. hexokinase 1, adenylate kinase isoenzyme) and zona pellucida or oolemma binding (e.g. disintegrin and metalloproteinase domain proteins, zona binding proteins 1 and 2). Interestingly, seven cauda-derived EV proteins trended downward in teratospermic compared with normospermic males, which may relate to poor sperm quality. Collective results revealed, for the first time, EV proteins related to sequential sperm maturation with differences observed between normospermic and teratospermic individuals.

Endometrial carcinoma (EC) is the most common gynecologic malignancy in the United States, with limited effective targeted therapies. Endometrial tumors exhibit frequent alterations in protein kinases, yet only a small fraction of the kinome has been therapeutically explored. To identify kinase therapeutic avenues for EC, we profiled the kinome of endometrial tumors and normal endometrial tissues using Multiplexed Inhibitor Beads and Mass Spectrometry (MIB-MS). Our proteomics analysis identified a network of kinases overexpressed in tumors, including Serine/Arginine-Rich Splicing Factor Kinase 1 (SRPK1). Immunohistochemical (IHC) analysis of endometrial tumors confirmed MIB-MS findings and showed SRPK1 protein levels were highly expressed in endometrioid and uterine serous cancer (USC) histological subtypes. Moreover, querying large-scale genomics studies of EC tumors revealed high expression of SRPK1 correlated with poor survival. Loss-of-function studies targeting SRPK1 in an established USC cell line demonstrated SRPK1 was integral for RNA splicing, as well as cell cycle progression and survival under nutrient deficient conditions. Profiling of USC cells identified a compensatory response to SRPK1 inhibition that involved EGFR and the up-regulation of IGF1R and downstream AKT signaling. Co-targeting SRPK1 and EGFR or IGF1R synergistically enhanced growth inhibition in serous and endometrioid cell lines, representing a promising combination therapy for EC.

From Iraq to Ukraine: What did governments learn? 20 March 2023 — 12:00PM TO 1:00PM Anonymous (not verified) 6 March 2023 Chatham House and Online

What were the main lessons for today’s conflicts from the way in which the war in Iraq played out?

This March marks the 20th anniversary of the US and UK-led invasion of Iraq to oust Saddam Hussein. Based primarily on unfounded fears Iraq’s WMD (weapons of mass destruction) capability was buidling up in the absence of UN inspection and constraints on the IAEA (International Atomic Energy Agency) safeguards, the decision to go to war has reverberated throughout the Middle East, the intelligence communities, and Western political decision-making ever since.

In the 2002–03 period when UN inspectors were allowed back into Iraq, Hans Blix, chairman of UNMOVIC (UN Monitoring, Verification and Inspection Commission) and Mohamed ElBaradei, director general of the IAEA, were at the centre of a storm in which they were put under huge pressure to agree with the US/UK narrative on the ‘missing’ WMD.

Their problem was that the evidence they were uncovering did not support the claims, but the war went ahead – and Saddam was overthrown – despite these UN findings.

Much has changed since 2003. As the geopolitical landscape has shifted, so have geopolitics and capabilities. Today’s Russia’s war against Ukraine which includes WMD threats, cyberattacks, and an assertive disinformation campaign has opened up new ways of thinking about communicating information from open source and government intelligence analysis.

This panel explores the experiences of people involved with decision-making at the UN and in the UK in 2003 and how things have changed today.

• What were the lessons from the way in which the war in Iraq played out?
• How has that influenced the way in which NATO has responded to Russia’s wars against Ukraine?
• How should information be communicated within governments and to the public?
• How to deal with disinformation campaigns in the days of open source information and social media?

As with all member events, questions from the audience drive the conversation.

Kevin Costner says he didn't know about his "Yellowstone" character John Dutton's death until after the episode aired on Sunday.

Any discussion in politics of the future of education in Ohio inevitably turns to the Electronic Classroom of Tomorrow.

The Maryland State Department of Education "inappropriately stored" personal information of 1.4 million students and more than 230,000 teachers, leaving them vulnerable to potential bad actors, according to an audit published earlier this month.

Private schools in New York soon will be required to report suspected sexual abuse of students in their schools to law enforcement, bringing the independent schools under the same rules as public schools.

U.S. Secretary of Education Betsy DeVos is not famous for pressuring states into desired outcomes, but did put at least two states' Title I funding on "high-risk" status last year.

"It has become clear over time that [the edTPA] caused unintended barriers and burdens for teachers entering the profession," Georgia's state superintendent said.

Republican gubernatorial nominee Ron DeSantis is renewing a political trend that had fallen dormant: calling for the end of the use of the shared standards.

Where did Georgia land in the latest CFP bracket and rankings? Here’s the College Football Playoff picture for the Bulldogs and path to championship.

In Tuesday night's Republican primary in West Virginia, Robert Karnes, a West Virginia Republican state senator who lashed out at teachers during their nine-day strike, lost to pro-labor candidate Bill Hamilton.

Just announced by the Group of Latin America and the Caribbean Countries (GRULAC)

The Group of Latin American and Caribbean Countries (GRULAC) of FAO in Rome is pleased to endorse the [...]

Rome - José Graziano da Silva, the [...]

Rome, The Africa Regional Group of Ambassadors and Permanent Representatives accredited  to the Rome based UN Agencies have announced the endorsement of the candidature of Dr. José Graziano da Silva [...]

Rome, 02 March 2015 - In a letter addressed to the Director-General, the Chairperson of the Near East Regional Group has announced their endorsement of the candidature [...]

In a letter addressed to the Director-General, the Ambassador of Malaysia to FAO, on behalf of the Chair of the Asia Group, has announced the endorsement of the [...]

FAO member nations to choose head of the UN specialized agency in July during the 43rd session of the FAO Conference

Cocktail historians differ on the birthplace of the word "cocktail," but they cherish America' invention of drinks like the mint julep (Meredith Bragg)

By late September 1918, in a bid to contain the spread of the flu, the U.S. had made the decision to cancel the draft. It was too little, too late—in October alone, over 200,000 Americans were killed by the disease.

On March 10, 1933, a major earthquake caught the Los Angeles area by surprise. The devastation was of sufficient scale to spur scientific interest in earthquakes—and how to predict them.

Man’s best friend is also one of his oldest.

It was no doubt a fantastical death, worthy of a pharaoh

Reclining and dining in the ancient classical world

A ring could explain a mysterious arrangement of impact craters near the equator and might even have caused an ice age, according to a new study

The robbers only made away with two of the screen prints, which they swiped from a gallery in the Netherlands. They abandoned the other artworks on the street

A candidate for the Nova Scotia NDP has apologized and is no longer running for the party in the provincial election after her comments on Israel and the Holocaust drew concern from the Jewish organizations. 

Independent Elizabeth Smith-McCrossin is back on the campaign trail in Cumberland North, but opponents say the riding would be better represented by an MLA from an official party. 

As Nova Scotia politicians make their fall election promises, Julie Leggett is urging them to commit to helping people on income assistance stay cool during heat waves.

Historians say that Sarah Emma Edmonds exaggerated many aspects of her wartime experiences. Still, she bravely served in the Union Army, becoming one of hundreds of women who fought in the conflict in secret

Newspaper editor Horace Greeley unsuccessfully ran against incumbent Ulysses S. Grant in November 1872. Twenty-four days later, he died of unknown causes at a private mental health facility

Figure skating pair Evelyn Walsh and Trennt Michaud didn't qualify for the 2022 Beijing Winter Olympics next month, their coach has all the faith that the pair will come back even stronger. 

High costs could hamper diversification of supply lines in a post-pandemic era.

When God directed Ellianna to Ireland instead of Austria, she discovered a new opportunity to meet refugees.

In the everyday relationships of life, an OM worker finds God working to make His name known.

Almost 30 years after the first charter school legislation passed, guest blogger Sarah Tantillo takes a look at how this movement emerged and spread.

There are five key values to consider when separating campaign rhetoric from how a candidate would actually govern, writes Robert Feirsen.

Are you smarter than a teacher in 1966? Take this real test, taken from the "Equality of Educational Opportunity" report, to find out how you fare.

"It has become clear over time that [the edTPA] caused unintended barriers and burdens for teachers entering the profession," Georgia's state superintendent said.

Vijay wrote in the caption, "I fell and it went crazy"

Avneet Kaur will also be seen in a groundbreaking India-Vietnam collaboration film Love in Vietnam

Vikrant Massey said, "That was the miscommunication, and I should have been a little more careful"

NEW CASTLE (Oct. 10, 2022) – Como parte de su plan estratégico para facilitar el acceso a los servicios para los residentes de Delaware a través del estado, el Departamento de Salud y Servicios Sociales (DHSS) comenzará una fase crítica de participación comunitaria en la que el público puede opinar sobre los tipos de cambios […]