1. Man die slapende dakloze in Rotterdam ernstig verwondde met steen mogelijk aangehouden in Franse stad Toulon  VRT.be
2. Man die zware tegel op hoofd van slapende dakloze gooide mogelijk gearresteerd in Frankrijk  Het Laatste Nieuws
3. Verdachte (32) van aanval met betonblok op slapende dakloze in Rotterdam opgepakt in Franse stad Toulon  Het Nieuwsblad
4. Poging moord op slapende, dakloze man  Opsporing Verzocht
5. Arrestatie in Frankrijk na dood dakloze, link met Rotterdamse zaak onderzocht  NOS

At least 10 Ukrainian soldiers died in the Donetsk region after the Kurakhovo Reservoir dam was blown up, TASS reported, citing Russian security forces. The blast flooded nearby areas, trapping soldi...

By Matt Solomon Published: November 11th, 2024

New Disney+ Star Wars TV series The Mandalorian premiered on Tuesday and people haven't been able to stop tweeting about "Baby Yoda." Can you blame them? He's just so goddamn cute. The catch here is that Baby Yoda isn't actually Yoda at all, but rather of the same species. Either way, people are positively freaking over him, and we don't blame them.

You probably spend more time at work than you spend at home. When you consider the amount of time you spend just sleeping when you're at home, you really do spend more quality time in the workplace on a lot of days. So shouldn't you be working in a healthy, beautiful and inspiring workspace?[...]

An ongoing phishing campaign is employing copyright infringement-related themes to trick victims into downloading a newer version of the Rhadamanthys information stealer since July 2024. Cybersecurity firm Check Point is tracking the large-scale campaign under the name CopyRh(ight)adamantys. Targeted regions include the United States, Europe, East Asia, and South America. "The campaign

Amsterdam is a city of contrasts, where historic charm meets vibrant modernity. A city break in Amsterdam offers a chance to explore picturesque canals, world-renowned museums, and eclectic neighbourhoods, all within a compact and walkable setting. In this guide, I’ll take you through an unforgettable three-day itinerary designed to capture the essence of Amsterdam. From strolling along cobblestone streets to indulging in Dutch delicacies, here’s how to make the most of your Amsterdam city break. Considering taking a cruise to Amsterdam? Arriving by sea is not only a unique way to start your adventure but also offers breathtaking views of the city from the water. Cruises often include extras like guided tours or exclusive shore excursions, making it a convenient option for those looking to experience Amsterdam’s maritime charm from the moment they arrive. Day 1: Uncovering Amsterdam’s Historic Canals and Culinary Scene Morning: Arrive and Settle In If you’re arriving by cruise, you’ll dock at the Port of Amsterdam, just a stone’s throw away from the city centre. Once you’ve disembarked and checked into your accommodation, it’s time to start exploring. Begin your visit with a leisurely walk through Amsterdam’s Canal Belt, a UNESCO World Heritage site that embodies the city’s rich history and iconic architecture. As you wander, you’ll find charming bridges, historic houseboats, and narrow townhouses adorned with ornate gables. Each canal has its own character, but Prinsengracht, Herengracht, and Keizersgracht are among the most famous. You’ll quickly see why these canals are one of Amsterdam’s most photographed attractions. Afternoon: Dive into Amsterdam’s Maritime History with a Canal Cruise One of the best ways to immerse yourself in the city’s history is to take a canal cruise. Various operators offer guided tours, ranging from hour-long excursions to multi-course dinner cruises. As you glide along the water, you’ll get a sense of how Amsterdam’s intricate canal system helped shape its trade and commerce over the centuries. Plus, you’ll enjoy views of iconic landmarks like the Anne Frank House, the Rijksmuseum, and Westerkerk from a unique vantage point. Evening: Sample Amsterdam’s Diverse Culinary Offerings Amsterdam’s food scene is as diverse as its population. For your first evening, treat yourself to a traditional Dutch dinner. Try local dishes like stamppot, a hearty blend of potatoes, vegetables, and sausage, or erwtensoep, a thick pea soup perfect for chilly evenings. If you’re in the mood for something sweet, don’t miss poffertjes—tiny pancakes dusted with powdered sugar. For a more eclectic dining experience, Amsterdam is home to countless international restaurants, reflecting its role as a global melting pot. You’ll find everything from Indonesian rijsttafel (a feast of small dishes) to Middle Eastern mezze. Many restaurants are located along the canals, offering atmospheric outdoor seating and views of the water. Day 2: Art, Parks, and Local Markets Morning: Explore the Treasures of the Rijksmuseum Amsterdam is a haven for art lovers, and the Rijksmuseum is a must-visit. Housing masterpieces from the Dutch Golden Age, including Rembrandt’s The Night Watch and Vermeer’s The Milkmaid, the museum offers a comprehensive journey through Dutch art and history. Set aside at least a couple of hours to explore the galleries, as the collection is extensive. For an insider’s tip, arrive early to avoid crowds, especially if you want to get a close-up view of Rembrandt’s renowned pieces. If you’re visiting during spring or summer, don’t miss the museum’s garden, which features beautiful sculptures and tranquil spots for a mid-morning break. Afternoon: Discover Van Gogh’s Vibrant World and Stroll Through Vondelpark Just a short walk from the Rijksmuseum is the Van Gogh Museum, dedicated to the life and work of one of the most iconic artists in history. With over 200 paintings, including famous works like Sunflowers and The Bedroom, this museum provides an intimate look at Van Gogh’s creative genius and turbulent life. After you’ve soaked in Van Gogh’s vivid colours and swirling brushstrokes, take a break in nearby Vondelpark. This sprawling green space is a favourite among locals and visitors alike, offering a peaceful escape from the city’s hustle and bustle. Pack a picnic or grab a coffee from one of the park’s cafés, and spend some time people-watching, cycling, or simply soaking up the scenery. Evening: Dinner in De Pijp and a Stroll Through the Albert Cuyp Market For dinner, head to De Pijp, a lively neighbourhood known for its multicultural vibe and delicious food scene. Here, you’ll find everything from trendy eateries to traditional eetcafés, where you can enjoy hearty Dutch fare in a casual setting. While you’re in De Pijp, be sure to explore the Albert Cuyp Market, the largest outdoor market in Europe. With over 250 stalls selling everything from fresh produce and cheese to clothing and souvenirs, it’s a fantastic place to soak up the local atmosphere. Grab a snack like a freshly made stroopwafel, or pick up some Dutch cheese to take home as a tasty souvenir. Day 3: History and Shopping in Amsterdam’s Iconic Neighbourhoods Morning: Reflect on History at the Anne Frank House Begin your day with a visit to the Anne Frank House, where the young diarist and her family hid during World War II. The museum offers a poignant glimpse into the hardships faced by Anne and her family, as well as the resilience of those who lived through the era. Due to its popularity, it’s best to book tickets in advance to avoid long wait times. If you’re interested in exploring more of Amsterdam’s wartime history, consider adding a visit to the Resistance Museum, which offers further insights into the city’s experiences during the German occupation. Afternoon: Shop and Dine in the Negen Straatjes (Nine Streets) Next, head to the Negen Straatjes, or Nine Streets, a charming area within the Canal Belt known for its quirky boutiques, vintage shops, and cosy cafés. This is the perfect place to indulge in some retail therapy, with stores selling everything from high-end fashion and handmade jewellery to unique home decor and antique books. Take your time browsing the shops, and be sure to stop for lunch at one of the many cafés lining the streets. The area is famous for its atmospheric coffee shops and bakeries, offering everything from freshly baked pastries to artisanal sandwiches. For a sweet treat, try a slice of Dutch apple pie, which pairs perfectly with a strong espresso. Evening: Wrap Up Your Trip at a Cosy Brown Café As your city break in Amsterdam comes to a close, spend your last evening unwinding at a traditional Dutch brown café. These cosy pubs are named for their dark wood interiors and smoky atmospheres, and they’re a staple of local culture. Café Hoppe and Café De Dokter are both great choices, offering a warm ambiance and a selection of Dutch beers to sample. Whether you’re sharing a drink with friends or simply savouring a quiet moment, the relaxed atmosphere of a brown café is the perfect way to end your Amsterdam adventure. Tips for an Unforgettable Amsterdam City Break When to Visit: Spring and autumn are the best times to visit Amsterdam, as the weather is mild, and there are fewer tourists. Spring is particularly beautiful due to the blooming tulips, while autumn offers colourful foliage along the canals. Getting Around: Amsterdam’s public transport system includes trams, buses, and ferries, making it easy to navigate the city. However, the city centre is highly walkable, and cycling is a popular way to get around. Many hotels offer bike rentals, or you can rent one from a local shop. Accommodations: Amsterdam offers a wide range of accommodation options, from boutique hotels and cosy bed-and-breakfasts to trendy hostels and luxurious canal-side apartments. Consider staying in a central area like the Jordaan or De Pijp for easy access to the city’s top attractions. Must-Try Foods: Beyond traditional Dutch dishes like stamppot and haring (raw herring), Amsterdam is known for its cheese, with varieties like gouda and edam readily available. Street foods like patat (thick-cut fries) served with mayo and bitterballen (fried meatballs) are also popular, especially at local markets and pubs. Cultural Etiquette: While Amsterdam is known for its liberal attitudes, it’s essential to respect local customs. Keep in mind that cycling is a primary mode of transportation, so be cautious when crossing bike lanes, and always look both ways.

The post Amsterdam City Break: Discovering the Heart of the Netherlands in Three Magical Days appeared first on Geeky Traveller.

"No início da minha carreira, coisas como boas maneiras importavam e havia um nível esperado de decoro", disse Susan ao site Politico, descrevendo o partido Republicano como significativamente diferente do de várias décadas atrás.

By Mariane Angela Democratic New York City Mayor Eric Adams’ office announced Thursday that New York City will stop providing food vouchers to migrants, CBS News New York reported. NYC will phase out out a program that gave prepaid debit cards to migrant families in city-funded hotels to purchase their own meals and essentials, according to […]

The post NYC Mayor Eric Adams Announces End To NYC Food Vouchers For Illegal Immigrants appeared first on Liberty Unyielding.

A mother-of-three shared her story with Dame Deborah's mother Heather on BBC Breakfast.

I haven’t written for Powdered Wig since October 2020. This once profitable site has now been destroyed by Big Tech, especially Fascistbook, Twitter, and Google. So, at 66 years old, I find myself making a living in the construction field […]

The post Is populism dead? Are We the People now forever under the thumb of unbridled global tyranny? Madame Defarge chimes in appeared first on Powdered Wig Society.

Pro-Palestinian demonstrators gathered following violence against Israeli football fans earlier in the week.

A tram is vandalised in new rioting in Amsterdam, days after the attacks on Israeli football fans.

Scotland call up Stuart Armstrong for the games against Croatia and Poland as Che Adams and Lewis Morgan withdraw from the squad.

Teacher question: I understand your claims that teaching students with grade-level texts instead of instructional level texts increases children’s opportunities to learn. However, what about children’s emotional needs, self-esteem, motivation, and self-starting skills when text is challenging. Children who struggle with sight words or sounding out words who are given a hard piece of text will shut down and refuse to try or will act out in the classroom.

We all know that *one* guy who acts like he's doing the world a favor just by showing up.

The post Demonic & Damned to Ridiculously Redeemed! (Eph.2:1-10) appeared first on Clash Daily.

Harris and Trump's shared goal masks a fundamental AI policy divide Expert comment rgold.drupal 3 November 2024

Both presidential candidates will pursue US tech dominance but differ on the means to achieve it.

There remain some differences between the US presidential candidates’ positions on the governance of artificial intelligence and other emerging technology, notably around competition. 

But under either future administration, US decision-making looks set to be heavily influenced by growing securitization, the aims of the US technology industry and broader competition with China. 

‘Safe’ AI development 

Vice President Kamala Harris attended the inaugural Global AI Safety summit in the UK in 2023, where she announced President Joe Biden’s Executive Order on AI. This significant move by the federal government sought to define national and cyber security guidelines for AI developers and outline privacy and transparency guarantees. It also committed the federal government to a review of the National Security implications of this emerging technology, which was published last week.

In her remarks at the summit, Harris was clear that her definitions of safety extended beyond catastrophic risk mitigation to societal and personal harm. She noted the corrosive effects of some algorithmic decision-making and disinformation on democracy, appealing for AI that is developed ‘in the service of the public interest’.

A number of initiatives developed during the Biden administration have attempted to steer emerging technology as it takes root in society. This includes the establishment of the US AI Safety Institute, various schemes on global AI governance and investment in Public AI projects like the National AI Research Resource (NAIRR).

The US public is largely supportive: polling by the AI Policy Institute (AIPI) points to a majority preference for safety standards governing the US effort to lead in AI, rather than pedal-to-the-metal development. Investment in public options on AI and the infrastructure required to develop and sustain it is a bold direction that the incoming administration should consider expanding.

Biden’s Executive Order on AI has come under fire by the Trump campaign. At a rally in Iowa, Trump explained that he would cancel the order ‘on day one’, echoing a Republican platform that described it as imposing ‘Radical Leftwing ideas’ . 

Trump does, however, have his own track record in technology policy. During his first presidency, his administration passed an Executive Order on AI, stressing that ‘continued American leadership in Artificial Intelligence is of paramount importance to maintaining the economic and national security of the United States’. The tools and institutions announced as part of the order – including AI research investment, national AI research institutes and AI regulatory guidance including on federal use of AI – echo those of the current administration. 

Four years is a long time in AI, however. As the power of this technology is revealed, talk of safety may give way to talk of security. While the candidates may disagree on the role of the federal government in setting standards, there will be close alignment on the central need for US supremacy in national security. Neither administration seems likely to erect barriers to securitization of AI should it emerge as a critical strategic asset.

AI regulation at home 

American industry will remain the pivotal force shaping the US AI ecosystem, particularly as America jostles for position as the maker of the global rules governing AI. A notable aspect of Biden’s AI Executive Order was where it staked responsibility. Reports by AI and Cloud companies on the safety of their tools and infrastructure are sent to the Department of Commerce.

Under Secretary Gina Raimondo, whose star continues to rise, the department has become significantly more engaged with technology companies. In the absence of any other legal authority, AI governance has therefore sat under the purview of a secretary who herself has noted that they are ‘not a regulator’. 

The trend of industry leaders driving the government agenda on AI is replicated in other departments. There was an outcry over the composition of the new Department of Homeland Security advisory panel, the Artificial Intelligence and Security Board, with civil society groups concerned about the preponderance of industry voices: the 22-member panel includes the CEOs of OpenAI, Anthropic, NVIDIA, IBM, AWS, Adobe, Microsoft and Alphabet.

Under a Harris presidency, these trends seem likely to continue. Plus with deadlock in Congress probable, establishing new legal authorities for emerging technology will be difficult. That will likely mean emerging tech governance remains heavily influenced by the Department for Commerce. 

Like Harris, Trump has his allies in industry. While the Biden administration has courted the CEOs of AI companies who have historically spoken out in favour of regulation, Trump’s allies tend towards a more deregulatory agenda. 

Silicon Valley billionaires Elon Musk and Marc Andreessen have backed Trump’s plans to minimize AI regulation, lauding his support for ‘little tech’. They have also backed reported plans for so-called ‘Manhattan Projects’ to develop military technology, stewarded by ‘industry-led’ agencies. Trump’s aversion to strong regulatory institutions may mean an end to Biden’s anti-trust efforts, benefitting the biggest voices in the room, though his VP pick may disagree. JD Vance has somewhat surprisingly come out strongly in defence of the current chair of the Federal Trade Commission, Lina Khan, and her anti-trust efforts targeting US big tech.

Regardless, business interests will likely shape either a Harris or Trump administration’s approach as the US grapples with balancing the ambitions of its industry with an increasingly protectionist stance towards its biggest import market, China.

Competition abroad

China looms large in the imaginations of both campaigns. 

The US has signalled to its allies that American AI standards should replace Chinese standards. Export controls on semiconductors were expanded in September this year, with key voices in the industry – notably the Netherlands, Japan and South Korea – describing the restrictions as ‘economically motivated’ despite nominally being tied to national security by the US. 

Loss and damage: Where are we now and what happens next? 25 January 2022 — 1:00PM TO 2:00PM Anonymous (not verified) 17 January 2022 Online

This event discusses the progress of the loss and damage agenda within climate negotiations. 

Loss and damage refers to harms and destruction caused by climate change impacts that cannot be avoided through mitigation or adaptation.

While it has gained increasing recognition in international climate change negotiations, turning the concept of loss and damage into tangible action for climate-vulnerable countries has been contentious.

Loss and damage is interwoven with issues of fairness and equity. The issue is highly disputed due to its connection with the historical responsibility of developed countries in causing climate change, as well as associated calls for compensation from developing countries.

At COP26, Scotland became the first government to pledge funds for loss and damage for countries in the Global South. However, most climate-vulnerable countries left disappointed by the failure of the Glasgow Climate Pact to secure the establishment of a dedicated loss and damage financing facility.

Developing countries have made it clear that they will continue to push for a new financing facility in the Glasgow Dialogue, a set of international discussions on loss and damage kicking off in June.

The Environment and Society Discussion Series is hosting two events on loss and damage ahead of that date. This first event outlines the key debates and discuss what progress has been made on advancing the loss and damage agenda within climate negotiations to date.

The second event focuses on solutions and possible ways forward, looking ahead to the COP27 negotiations in Egypt later in 2022, where loss and damage is expected to be a high-profile agenda item.

A deep dive into loss and damage solutions 8 February 2022 — 1:00PM TO 2:15PM Anonymous (not verified) 31 January 2022 Online

This second event of our loss and damage series cuts through polarized debate by bringing together international experts to discuss innovative legal and financial approaches.

This event will focus on a deep dive into constructive solutions and progress made to address loss and damage.

Following the first event of this two-part series, ‘Loss and Damage – where are we now and what happens next’, this event focuses on a deep dive into constructive solutions and progress made to address loss and damage.

Loss and damage refers to harms and destruction caused by climate change impacts that cannot be avoided through mitigation or adaptation. While it has gained increasing recognition in international climate change negotiations, turning the concept of loss and damage into tangible action for climate-vulnerable countries has been contentious.

Loss and damage is interwoven with issues of fairness and equity. The issue is highly disputed due to its connection with the historical responsibility of developed countries in causing climate change, as well as associated calls for compensation from developing countries.

At COP26, Scotland became the first government to pledge funds for loss and damage for countries in the Global South. However, most climate-vulnerable countries left disappointed by the failure of the Glasgow Climate Pact to secure the establishment of a dedicated loss and damage financing facility.

Developing countries have made it clear that they will continue to push for a new financing facility in the Glasgow Dialogue, a set of international discussions on loss and damage kicking off in June. The Environment and Society Discussion Series is hosting two events on loss and damage ahead of that date.

This second event convenes a deep dive into the progress and potential on loss and damage solutions, while also examining the hurdles that are still to overcome to make loss and damage support a reality.

Katherine Baker, Lehel Banjai and Mariya Ptashnyk
Math. Comp. 93 (), 2711-2743.
Abstract, references and article information

We have observed overexpression of PACS-1, a cytosolic sorting protein in primary cervical tumors. Absence of exonic mutations and overexpression at the RNA level suggested a transcriptional and/or posttranscriptional regulation. University of California Santa Cruz genome browser analysis of PACS-1 micro RNAs (miR), revealed two 8-base target sequences at the 3' terminus for hsa-miR-34a and hsa-miR-449a. Quantitative RT-PCR and Northern blotting studies showed reduced or loss of expression of the two microRNAs in cervical cancer cell lines and primary tumors, indicating dysregulation of these two microRNAs in cervical cancer. Loss of PACS-1 with siRNA or exogenous expression of hsa-miR-34a or hsa-miR-449a in HeLa and SiHa cervical cancer cell lines resulted in DNA damage response, S-phase cell cycle arrest, and reduction in cell growth. Furthermore, the siRNA studies showed that loss of PACS-1 expression was accompanied by increased nuclear γH2AX expression, Lys382-p53 acetylation, and genomic instability. PACS-1 re-expression through LNA-hsa-anti-miR-34a or -449a or through PACS-1 cDNA transfection led to the reversal of DNA damage response and restoration of cell growth. Release of cells post 24-h serum starvation showed PACS-1 nuclear localization at G1-S phase of the cell cycle. Our results therefore indicate that the loss of hsa-miR-34a and hsa-miR-449a expression in cervical cancer leads to overexpression of PACS-1 and suppression of DNA damage response, resulting in the development of chemo-resistant tumors.

This article has been withdrawn by the authors as part of this review overlapped with the contents of Pietrangelo A and Ridgway ND. 2018. Cellular and Molecular Life Sciences. 75; 3079-98.

In nucleotide excision repair, bulky DNA lesions such as UV-induced cyclobutane pyrimidine dimers are removed from the genome by concerted dual incisions bracketing the lesion, followed by gap filling and ligation. So far, two dual-incision patterns have been discovered: the prokaryotic type, which removes the damage in 11–13-nucleotide-long oligomers, and the eukaryotic type, which removes the damage in 24–32-nucleotide-long oligomers. However, a recent study reported that the UvrC protein of Mycobacterium tuberculosis removes damage in a manner analogous to yeast and humans in a 25-mer oligonucleotide arising from incisions at 15 nt from the 3´ end and 9 nt from the 5´ end flanking the damage. To test this model, we used the in vivo excision assay and the excision repair sequencing genome-wide repair mapping method developed in our laboratory to determine the repair pattern and genome-wide repair map of Mycobacterium smegmatis. We find that M. smegmatis, which possesses homologs of the Escherichia coli uvrA, uvrB, and uvrC genes, removes cyclobutane pyrimidine dimers from the genome in a manner identical to the prokaryotic pattern by incising 7 nt 5´ and 3 or 4 nt 3´ to the photoproduct, and performs transcription-coupled repair in a manner similar to E. coli.

Timely repair of DNA double-strand breaks (DSBs) is essential to maintaining genomic integrity and preventing illnesses induced by genetic abnormalities. We previously demonstrated that the E3 ubiquitin ligase SMURF2 plays a critical tumor suppressing role via its interaction with RNF20 (ring finger protein 20) in shaping chromatin landscape and preserving genomic stability. However, the mechanism that mobilizes SMURF2 in response to DNA damage remains unclear. Using biochemical approaches and MS analysis, we show that upon the onset of the DNA-damage response, SMURF2 becomes phosphorylated at Ser384 by ataxia telangiectasia mutated (ATM) serine/threonine kinase, and this phosphorylation is required for its interaction with RNF20. We demonstrate that a SMURF2 mutant with an S384A substitution has reduced capacity to ubiquitinate RNF20 while promoting Smad3 ubiquitination unabatedly. More importantly, mouse embryonic fibroblasts expressing the SMURF2 S384A mutant show a weakened ability to sustain the DSB response compared with those expressing WT SMURF2 following etoposide treatment. These data indicate that SMURF2-mediated RNF20 ubiquitination and degradation controlled by ataxia telangiectasia mutated–induced phosphorylation at Ser384 constitutes a negative feedback loop that regulates DSB repair.

A pair of strong earthquakes has struck off the southern coast of Cuba, inflicting damage and causing landslides.