Cheesecake: 1/4 cups chocolate or coconut biscuit crumbs 80g butter, melted 500g cream cheese, softened 1/4 cup caster sugar 2 teaspoons gelatine dissolved in 1/4 cup boiling water 200g dark chocolate melted and cooled slightly 2 splashes of rum 1 cup Baffle Creek Cream, softly whipped Salted Caramel Popcorn: 1 1/2 cup caster sugar 1/2 cup water 2/3 cup brown sugar 300ml thickened cream 1/2 - 1 tablespoon sea salt flakes 200g popcorn, popped

Quick easy fresh summer dish.

Green king prawns in a delish summer dish.

Summer entertaining; breakfast/lunch

To work safely, self-driving cars must avoid obstacles -- including those just out of sight. And for this to happen, we need technology that sees better than humans can, says electrical engineer David Lindell. Buckle up for a quick, groundbreaking tech demo as Lindell explains the significant and versatile potential of a high-speed camera that can detect objects hidden around corners.

London : J. & A. Churchill, 1875.

London : J. and A. Churchill, 1884.

Our ongoing celebration of the Library of Congress National Book Festival continues with crime writer Patricia Cornwell discussing "Red Mist,” her 19th Kay Scarpetta novel, on the Fiction & Mystery stage at the 2012 Festival.

An OMer in Hungary shares how God intervened in the lives of women in the sex industry through the Bus4Life ministry

Cornelia de Lange syndrome (CdLS) is a genetic syndrome with multisystem abnormalities. Infections are a significant cause of morbidity and mortality in affected patients and are typically attributed to anatomic abnormalities.

This study identified a high frequency of antibody immunodeficiency in CdLS subjects, indicating a critical need for screening and management of immunodeficiency in CdLS patients with a history of severe or recurrent infections. (Read the full article)

If warming continues unabated in the Midwest, in 50 years we can expect the best conditions for corn and soybean production to have shifted from Iowa and Illinois to Minnesota and the Dakotas, according to Penn State researchers.

easyJet is significantly expanding its flight offers from Berlin this summer. A total of 10 new summer destinations and two new year-round connections will be offered from Schönefeld and Tegel with the start of the summer flight schedule. These include ...

This week’s episode of #EntrepreneurCorner features Antoinette Prophy, who talks about starting her own business at the age of 26, and the benefits of surrounding yourself with smart employees.

A couple out shopping, decides to buy a mixer grinder when faced with the ‘tough’ task of choosing between two kurtas for the husband. Preposterous can be funny, but this one just falls flat.

Start meditation and yoga for physical gain especially mental toughness. Today, you are likely to attain economic benefits due to your children. This will make you very happy. Good advice from family members will decrease your mental pressure. Today, you will not be able to fulfill any of your promises, which can make your lover grumpy. You can waste your free time today on surfing on mobile or watching TV. Seeing this can annoy your spouse, as you will not show any interest in talking to them. You might fight today on an old issue with your spouse like he/she forgot your birthday, or something like that. But, everything will be alright at the end of the day. Avoid stepping out of your boundaries while joking with friends, as it can ruin your friendship.

For beginners, how marketers can learn to create advanced data models from time series data

Using R programming, marketers can create a marketing mix model to determine how sustainable their audience channels are, and make better ad spend decisions. Here's how

Advanced analytics programs can incorporate geospatial data. Learn how such data can be used to augment local marketing plans

The GLA-Class is expected to be launched in India soon as the German brand has displayed the vehicle on its India website.

SR 1, TYBOUTS CORNER LEFT EXIT SIGNING

Company faring better than peers on operational front due to its focus on exports; lower costs to aid margin; ‘Buy’ maintained.

Winds are from the Northwest at 11.5 gusting to 25.3 MPH (10 gusting to 22 KT). The pressure is 1013.0 mb and the humidity is 52%. The wind chill is 31. Last Updated on May 9 2020, 11:53 am EDT.

It's more than tossing bags at a cookout. KC Joyner looks at the deeper levels of strategy and skill.

Imagine you’re dreaming, and it’s a really, really bad dream. It’s night, and something is chasing you down a dark street. You’re running and running and running, trying to get away. All the windows are dark. No lights are on in any of the houses and apartments along the street. You bang on doors, but no one answers. You try the door handles, but the doors are all locked. When you cry out for help, no words come out of your mouth. No one can hear you. You keep running and running and running… This article first appeared in Salon. This is why Donald Trump is awake at 2:30 a.m., rage-tweeting. When he sleeps, he dreams, and his dreams are nightmares. He’s a...

In a cornfield in India, Urbasi Sinha ran an experiment that may challenge the rules of quantum mechanics and paves the way for higher dimensional quantum computing

Artist Ryu Jong-dae experiments with various cornstarch-based bioplastic in the bid to protect the Earth. Rosanna Philpott reports.

Title: Expert Offers Advice on Treating Corns, Calluses
Category: Health News
Created: 4/24/2016 12:00:00 AM
Last Editorial Review: 4/25/2016 12:00:00 AM

The autosomal dominant disorder Schnyder corneal dystrophy (SCD) is caused by mutations in UbiA prenyltransferase domain-containing protein-1 (UBIAD1), which uses geranylgeranyl pyrophosphate (GGpp) to synthesize the vitamin K₂ subtype menaquinone-4 (MK-4). SCD is characterized by opacification of the cornea, owing to aberrant build-up of cholesterol in the tissue. We previously discovered that sterols stimulate association of UBIAD1 with ER-localized HMG-CoA reductase, which catalyzes a rate-limiting step in the synthesis of cholesterol and nonsterol isoprenoids, including GGpp. Binding to UBIAD1 inhibits sterol-accelerated ER-associated degradation (ERAD) of reductase and permits continued synthesis of GGpp in cholesterol-replete cells. GGpp disrupts UBIAD1-reductase binding and thereby allows for maximal ERAD of reductase as well as ER-to-Golgi translocation of UBIAD1. SCD-associated UBIAD1 is refractory to GGpp-mediated dissociation from reductase and remains sequestered in the ER to inhibit ERAD. Here, we report development of a biochemical assay for UBIAD1-mediated synthesis of MK-4 in isolated membranes and intact cells. Using this assay, we compared enzymatic activity of WT UBIAD1 with that of SCD-associated variants. Our studies revealed that SCD-associated UBIAD1 exhibited reduced MK-4 synthetic activity, which may result from its reduced affinity for GGpp. Sequestration in the ER protects SCD-associated UBIAD1 from autophagy and allows intracellular accumulation of the mutant protein, which amplifies the inhibitory effect on reductase ERAD. These findings have important implications not only for the understanding of SCD etiology but also for the efficacy of cholesterol-lowering statin therapy, which becomes limited, in part, because of UBIAD1-mediated inhibition of reductase ERAD.

Diabetic keratopathy occurs in ~70% of all people with diabetes. This study was designed to examine the effects of vitamin D receptor knockout (VDR^–/–) and vitamin D deficiency (VDD) on corneal epithelial wound healing and nerve density in diabetic mice. Diabetes was induced using the low-dose streptozotocin method. Corneal epithelial wounds were created using an Algerbrush, and wound healing was monitored over time. Corneal nerve density was measured in unwounded mice. VDR^–/– and VDD diabetic mice (diabetic for 8 and 20 weeks, respectively) had slower healing ratios than wild-type diabetic mice. VDR^–/– and VDD diabetic mice also showed significantly decreased nerve density. Reduced wound healing ratios and nerve densities were not fully rescued by a supplemental diet rich in calcium, lactose, and phosphate. We conclude that VDR^–/– and VDD significantly reduce both corneal epithelial wound healing and nerve density in diabetic mice. Because the supplemental diet did not rescue wound healing or nerve density, these effects are likely not specifically related to hypocalcemia. This work supports the hypothesis that low vitamin D levels can exacerbate preexisting ophthalmic conditions, such as diabetes.

स्वरूपरानी नेहरू चिकित्सालय में सर्जरी विभाग की पीजी छात्रा प्रथम वर्ष की कोरोना की जांच रिपोर्ट निगेटिव आई है। इसके बाद चिकित्सालय प्रशासन ने राहत की सांस ली है। उधर, ओपीडी में आने वालों में चार लोगों को संदिग्ध मानते हुए भर्ती किया गया है।

ebb software has released a new trailer for the Xbox Series X version of the atmospheric first-person horror adventure, Scorn. The game is in development for the Xbox Series X and Windows PC via Steam and Windows Store.

View the Xbox Series X trailer below:

Here is an overview of the game:

Scorn is set in a nightmarish universe of odd forms and somber tapestry. It is designed around the idea of "being thrown into the world". Isolated and lost inside this dream-like world, you will explore different interconnected regions in a non-linear fashion. Every location contains its own theme, puzzles and characters that are integral in creating a cohesive world.

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel dedicated to gaming Let's Plays and tutorials. You can contact the author at wdangelo@vgchartz.com or on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/443422/horror-adventure-game-scorn-xbox-series-x-trailer-released/

This is the Popcorn Popping Lid with Butter Vents available from Uncommon Goods ($11). You just fill a microwave-safe 10-inch bowl with your choice of popping corn, set the lid on top, add a pat of butter to each of the lid's butter vents, and let the microwaving begin! Of course if you're anything like me you'll balance as much butter as you can atop each of those vents because, I don't know if you knew this about me, but I love butter. I don't really like it cold but *microwave beeping* sometimes when I'm really feeling down I'll just melt two sticks and drink it. Keep going for a couple more shots because they exist.

Today, Microsoft and Ebb Studios revealed that Xbox Series X would be getting the launch exclusivity for Scorn

Blizzard has some announcements. Square Enix has money! Jon doesn’t have a 3DS…still. And you have a new podcast.

Soundgarden have claimed Chris Cornell's widow used charity money for personal purposes.

The Duchess of Cornwall has revealed she has taken up ballet and is practising her poses and positions to keep fit in lockdown.

Police have launched an investigation after 23 cows and calves were reported missing from a farm in Cornwall.

Platform connects international students to universities, colleges and high schools with one application system

Australian researcher and reef guide Jacinta Shackleton is now one of the few people to have ever seen the rare and endangered ornate eagle ray. Shackleton was conducting research near Lady Elliot Island on the Great Barrier Reef when she saw the ray, something she said was an 'unforgettable and emotional experience'. With little more than 50 sightings recorded worldwide, divers have dubbed the ray ’the unicorn of the sea’

Sen. John Cornyn (R-TX) came back at Rep. Joaquin Castro (D-TX) with the Twitter equivalent of “I can’t hear you!”...

The Seattle rock icons filed a countersuit Wednesday accusing Vicky Cornell of withholding money raised through a star-studded benefit concert held last year in the late singer’s honour, instead using it for personal purposes — an accusation Cornell denies.

In 2018 there were 15 unicorns born with at least one female founder. This year, there were 21 startups founded or co-founded by a female that became unicorns.

Keep on reading: Female-founded Unicorns Were Born at an Unprecedented Pace in 2019

"Today, here in Ignacio, Colorado, I am proud to announce the Department of Justice’s tribal grants for Fiscal Year 2011," said Associate Attorney General Tom Perrelli.

"We have reason to hope because over the last three and a half years, President Obama and Attorney General Holder have been unmistakable and unwavering in making Indian country issues in general -- and tribal sovereignty in particular -- a high, Administration priority, consistent with our desire to see all tribes thrive as prosperous, vibrant, and safe communities," said Acting Associate Attorney General West.