‘They can operate with 33% workforce in red zones, including GHMC area’

A division bench of the Kerala High Court will hold a special sitting on Sunday to consider issues pertaining to the transport of Keralites from acros

Document had Mumbai Police’s emblem and ‘Essential Service Pass’ written on it

Universities in Bengal would hold undergraduate and postgraduate end-semester examinations within a month of the lockdown being lifted, education minister Partha Chatterjee said on Saturday after a discussion with vice-chancellors of state varsities.

"If cancer could do me no harm, what can Covid do?" This was the confidence that 74-year-old Yusuf Hotelwala exuded while leaving for the Covid care centre in Vadodara after testing positive a week ago. On Saturday, Hotelwala, who suffers from peritoneal mesothelioma and has already survived two heart attacks was beaming as doctors confirmed his recovery.

The incident took place back in 2014 during India's test match against New Zealand.

Five persons of a family were brutally hacked to death in Hamirpur village, 27 km from Rapar town of Kutch, as the simmering animosity between members of two communities came to a boil on Saturday.

Of the total three patients discharged on Saturday, a 18-month-old child was also discharged after defeating Covid-19.The total patients discharged in the city stands at 24.

Holderness coast: Major cliff landslides 'every six years'  BBC News

Dr Tim Gregory Works with a Meteorite That's Older Than The Earth  LeftLion

In the title polymeric complex, {[Fe(CN)2(C10H8N2)2(H2O)2][Au(CN)2]}n, the FeII ion, which is located on a twofold rotation axis, has a slightly distorted FeN4O2 octa­hedral geometry. It is coordinated by two phenyl­pyrazine mol­ecules, two water mol­ecules and two di­cyano­aurate anions, the Au atom also being located on a second twofold rotation axis. In the crystal, the coordinated di­cyano­aurate anions bridge the FeII ions to form polymeric chains propagating along the b-axis direction. In the crystal, the chains are linked by Owater—H⋯Ndi­cyano­aurate anions hydrogen bonds and aurophillic inter­actions [Au⋯Au = 3.5661 (3) Å], forming layers parallel to the bc plane. The layers are linked by offset π–π stacking inter­actions [inter­centroid distance = 3.643 (3) Å], forming a supra­molecular metal–organic framework.

The structure of the title compound, C32H51NO6, was determined from 62-year-old crystals at room temperature and refined with 100 K data in a monoclinic (C2) space group. This compound with a triterpenoid structure, now confirmed by this study, played an important role in the determination of the structure of lanosterol. The mol­ecules pack in linear O—H⋯O hydrogen-bonded chains along the short axis (b), while parallel chains display weak van der Waals inter­actions that explain the needle-shaped crystal morphology. The structure exhibits disorder of the flexible methyl­heptane chain at one end of the main mol­ecule with a small void around it. Crystals of the compounds were resistant to data collection for decades with the available cameras and Mo Kα radiation single-crystal diffractometer in our laboratory until a new instrument with Cu Kα radiation operating at 100 K allowed the structure to be solved and refined.

The in meso in situ serial X-ray crystallography method was developed to ease the handling of small fragile crystals of membrane proteins and for rapid data collection on hundreds of microcrystals directly in the growth medium without the need for crystal harvesting. To facilitate mounting of these in situ samples on a goniometer at cryogenic or at room temperatures, two new 3D-printed holders have been developed. They provide for cubic and sponge phase sample stability in the X-ray beam and are compatible with sample-changing robots. The holders can accommodate a variety of window material types, as well as bespoke samples for diffraction screening and data collection at conventional macromolecular crystallography beamlines. They can be used for convenient post-crystallization treatments such as ligand and heavy-atom soaking. The design, assembly and application of the holders for in situ serial crystallography are described. Files for making the holders using a 3D printer are included as supporting information.

Mitochondrial calcium uptake proteins 1 and 2 (MICU1 and MICU2) mediate mitochondrial Ca2+ influx via the mitochondrial calcium uniporter (MCU). Its molecular action for Ca2+ uptake is tightly controlled by the MICU1–MICU2 heterodimer, which comprises Ca2+ sensing proteins which act as gatekeepers at low [Ca2+] or facilitators at high [Ca2+]. However, the mechanism underlying the regulation of the Ca2+ gatekeeping threshold for mitochondrial Ca2+ uptake through the MCU by the MICU1–MICU2 heterodimer remains unclear. In this study, we determined the crystal structure of the apo form of the human MICU1–MICU2 heterodimer that functions as the MCU gatekeeper. MICU1 and MICU2 assemble in the face-to-face heterodimer with salt bridges and me­thio­nine knobs stabilizing the heterodimer in an apo state. Structural analysis suggests how the heterodimer sets a higher Ca2+ threshold than the MICU1 homodimer. The structure of the heterodimer in the apo state provides a framework for understanding the gatekeeping role of the MICU1–MICU2 heterodimer.

The room-temperature experiment has been revisited for macromolecular crystallography. Despite being limited by radiation damage, such experiments reveal structural differences depending on temperature, and it is expected that they will be able to probe structures that are physiologically alive. For such experiments, the humid-air and glue-coating (HAG) method for humidity-controlled experiments is proposed. The HAG method improves the stability of most crystals in capillary-free experiments and is applicable at both cryogenic and ambient temperatures. To expand the thermal versatility of the HAG method, a new humidifier and a protein-crystal-handling workbench have been developed. The devices provide temperatures down to 4°C and successfully maintain growth at that temperature of bovine cytochrome c oxidase crystals, which are highly sensitive to temperature variation. Hence, the humidifier and protein-crystal-handling workbench have proved useful for temperature-sensitive samples and will help reveal temperature-dependent variations in protein structures.

A new temperature-controllable humidifier for X-ray diffraction has been developed. It is shown that the humidifier can successfully maintain protein crystal growth at a temperature lower than room temperature.

The design and assembly of two 3D-printed holders for high-throughput in meso in situ fixed-target crystallographic data collection are described.

The fossil teeth of a 15- to 18-million-year-old three-toed browsing horse, Anchitherium clarencei, were recently discovered by scientists from the Smithsonian Tropical Research Institute and the […]

The post Fossil teeth of 15-million-year-old browsing horse found in Panama Canal excavations. appeared first on Smithsonian Insider.

Successes in animal health care presents many new challenges for veterinarians. Longer life spans in captivity mean zoo animals are now experiencing age-related health problems that their zoo predecessors never lived long enough to develop—like diabetes in cheetahs, arthritis in big cats and dental issues for coatis.

The post Golden years at the Zoo: Veterinarians work to help animals live longer, stay healthy appeared first on Smithsonian Insider.

Native to Africa and Madagascar, females of the species have a body length of 1.5 inches and a leg span of 4 to 5 inches. Males are tiny in comparison.

The post Females are giants in newly discovered species of golden orb weaver spider appeared first on Smithsonian Insider.

“Spinning under the influence” is one way to describe recent activities in the Costa Rican laboratory of Smithsonian scientist William Eberhard. An entomologist at the Smithsonian’s Tropical Research Institute, Eberhard recently carried out a series of experiments in which he observed the web-building behavior of dozens of spiders under the influence of drugs—specifically, a chemical injected into their bodies by parasitic wasps.

The post Drugged spiders’ web spinning may hold keys to understanding animal behavior appeared first on Smithsonian Insider.

On Aug, 31, the Smithsonian’s National Zoo welcomed this year’s second litter of African lion (Panthera leo) cubs. Five-year-old Shera (shown at right) gave birth […]

The post Shera, a 5-year-old lioness at the National Zoological Park appeared first on Smithsonian Insider.

Meet Sahelanthropus tchadensis. This newly unveiled bust by artist John Gurche is now on view in the the Hall of Human Origins at the Smithsonian's National Museum of Natural History.

The post Artist’s recreation of 7- to 6-million-year-old early human unveiled in Hall of Human Origins appeared first on Smithsonian Insider.

There is a new candidate for coldest known star: a brown dwarf with about the same temperature as a hot cup of coffee. That’s cool enough to begin crossing the blurry line between small cold stars and big hot planets.

The post New candidate for “coldest star” is same temperature as a hot cup of coffee appeared first on Smithsonian Insider.

The National Zoo’s great cat program recently expanded with the arrival of two-and-a-half-year-old female Sumatran tiger, Damai, who is now out of quarantine and spending time outside in her exhibit where visitors can see her.

The post Damai, a two-and-a-half-year-old female Sumatran tiger, makes her debut at the National Zoo appeared first on Smithsonian Insider.

Alaska’s pristine coastline is ripe for an influx of invasive marine species such as the European green crab and the rough periwinkle (an Atlantic sea snail) warns a new study by a team of scientists from the Smithsonian Environmental Research Center.

The post Alaska’s cold waters no barrier to invasive marine species, scientists say appeared first on Smithsonian Insider.

New research shows that some old stars might be held up by their rapid spins, and when they slow down, they explode as supernovae. Thousands of these "time bombs" could be scattered throughout our Galaxy.

The post Our galaxy might hold thousands of ticking “time bombs” appeared first on Smithsonian Insider.

In a laboratory at the Smithsonian Environmental Research Center in Edgewater, Md., scientist João Canning Clode and colleagues tested the cold-water tolerances of a number of invasive green porcelain crabs.

The post Cold spells spell trouble for warm-weather invasives appeared first on Smithsonian Insider.

An excavation at a site in South Africa has unearthed the 190-million-year-old dinosaur nesting site of the prosauropod dinosaur Massospondylus–revealing significant clues about the evolution of complex reproductive behavior in early dinosaurs.

The post 190-million-year-old dinosaur nesting site discovered in South Africa appeared first on Smithsonian Insider.

A newly described species of toothed whale that lived some 3-4 million years ago during the Pliocene, is causing scientists to reconsider what is known about its living cold-water relatives: narwhals and belugas.

The post New fossil whale species raises mystery regarding why narwhals and belugas live only in cold water appeared first on Smithsonian Insider.

Jeholopsyche liaoningensis is a new genus and species of flying insect from northeastern China, recently revealed in two new fossil specimens.

The post Meet the 125-million-year-old pollinator “Jeholopsyche liaoningensis” appeared first on Smithsonian Insider.

Roy Clarke, curator at the Smithsonian’s National Museum of Natural History, is shown in 1977 with the Old Woman Meteorite, the second largest meteorite ever […]

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Scientists have discovered several specimens of tiny insects covered with pollen grains in two pieces of amber, revealing the first record of pollen transport and social behavior in this group of animals.

The post First ever record of insect pollination captured in 100 million-year-old amber appeared first on Smithsonian Insider.

Recent geologic mapping of the Medusae Fossae Formation on Mars—an intensely eroded deposit near the northern edge of the cratered highlands—has revealed a wider distribution of its western component than was previously recognized.

The post New mapping of Mars shows Medusae Fossae Formation older than once thought appeared first on Smithsonian Insider.

Astronomers have discovered that one well-known elliptical galaxy has a split personality. Centaurus A is hiding a gassy spiral in its center.

The post Split-personality elliptical galaxy holds a hidden spiral appeared first on Smithsonian Insider.