In some embodiments, the present disclosure pertains to a method for retrieving at least one molecular recognition element in a fixed tissue. In some embodiments the method comprises preparing a solution comprising at least one aldehyde-scavenging agent. In some embodiments, the method comprises contacting the fixed tissue with the solution. In some embodiments, the tissue is fixed with an aldehyde-based cross-linking agent. In some embodiments, a reaction of the aldehyde-scavenging agent with the aldehydes comprising the cross-linking agent retrieves the at least one molecular recognition t. In some embodiments, the at least one rolecular recognition element comprises of amino acids, peptides, proteins, nucleic acids, carbohydrates, lipids, or a combination thereof. In some embodiments, the at least one aldehyde-scavenging agent comprises of beta-dicarbonyl compounds, mono or di-amide scavengers, ethyl alcohols, sulfur containing compounds, mercaptoethylamines, mercaptoethanols, hydrazines, ethanolamines, hydroxylamines, anilines, variation of amines, activated charcoal, phenols, or mixtures and combinations thereof.

The present disclosure relates to use of high-concentration aldehyde-based fixatives to fix tissue samples. Aldehyde concentrations are selected that significantly increase rate of diffusion of the fixative solution into the tissue. When combined in the cold-temperature step of a two-temperature fixation, a substantial improvement in the preservation of post-translationally modified proteins is achieved.

The invention is drawn to novel nanostructures comprising hollow nanospheres and nanotubes for use as chemical sensors, conduits for fluids, and electronic conductors. The nanostructures can be used in microfluidic devices, for transporting fluids between devices and structures in analytical devices, for conducting electrical currents between devices and structure in analytical devices, and for conducting electrical currents between biological molecules and electronic devices, such as bio-microchips.

The present invention provides methods of determining cell sensitivity to a therapeutic agent.

Light harvesting luminescent multichromophores that are configured upon excitation to transfer energy to, and amplify the emission from, an acceptor signaling chromophore in energy-receiving proximity therewith are provided. Also provided are compositions for labelling a target. The labelling composition may include a donor light harvesting multichromophore and an acceptor signaling chromophore in energy-receiving proximity to the donor light harvesting multichromophore. Also provided is an aqueous composition for labelling a target, including: a donor light harvesting multichromophore; an acceptor signaling chromophore in energy-receiving proximity therewith; and a sensor biomolecule. Methods for using the subject compositions are also provided.

The present invention relates to a novel method for detecting a detection object in a sample, and a detection device using the same. The detecting method of the present invention uses a “bridge composite” in which gold nanoparticles and an antibody specific to a detection object are coupled in order to induce a sufficient coupling reaction between the antibody and the detection object, thereby improving reactivity. Accordingly, since excellent resolution is provided, the method of the present invention has advantages of enabling accurate concentration measurement of a detection object in a sample, and amplifying a measurement signal. In addition, the method of the present invention can effectively detect small molecules such as hormones, vitamins, etc. having a small molecular weight.

Methods of screening for expression of an RNA associated with a post-kidney transplant complication include collecting vesicles from urine, isolating vesicle-associated RNA, and analyzing expression patterns. In particular, AIF1, BTN3A3, CCL5, CD48, HAVCR1, or SLC6A6 mRNA expression patterns are analyzed.

Methods and compositions are described for categorizing and treating autoimmune disease, using single cell network profiling (SCNP), where activation levels of one or more activatable elements are determined in single cells, with or without modulation, to categorize or determine treatment for the autoimmune disease.

The present invention relates to in vitro methods of assessing the susceptibility or responsiveness of a subject to the treatment with an epidermal growth factor receptor (EGFR) inhibitor/antagonist, wherein the subject has been diagnosed or suspected of suffering from inflammation-associated. These methods comprise determining the level of expression of EGFR in myeloid cells in a sample from the subject, wherein an expression of EGFR in the myeloid cells is indicative of the subject being susceptible to the treatment with an EGFR inhibitor/antagonist. The invention also relates to EGFR inhibitors/antagonists for use in the treatment or amelioration of inflammation-associated cancer. The invention furthermore provides in vitro methods of prognosing the survival time, progression-free survival time or disease course of a subject that has been diagnosed or suspected of suffering from from inflammation-associated cancer. In addition thereto, the invention relates to in vitro diagnostic methods of assessing the proneness of a subject to develop inflammation-associated cancer in which the expression of EGFR is determined in myeloid cells from the subject.

The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations. Several exemplary diseases that can be analyzed using the invention include AML, MDS, and MPN.

A method to detect prostate cancer comprising contacting a sample of prostate cells from the patient with a set of detectably labeled probes under hybridization conditions and determining the presence of chromosomal abnormalities in prostate tumor tissue, PIN (intra-epithelial neoplasia), histologically benign tissue and benign prostatic hyperplasia (BPH); a method to combine immunofluorescence and FISH (IF-FISH) to facilitate the assessment of chromosomal abnormalities; a set of probes; and a kit comprising the set of probes and instructions for diagnosing prostate cancer in a patient.

We have discovered a protein in humans, herein referred to as collagen like gene (CLG) product (SEQ ID NOS: 12 and 13), that is expressed in human prostate cancer and breast cancer cell lines but not in normal adult, placenta, lung, liver, skeletal muscle, kidney or pancreas tissues. We have also discovered that the level of CLG mRNA expression correlates positively with the metastatic potential of the cancer cell lines tested.

The present invention provides detection methods for detecting a pre-cancerous epithelial cell signature. The present invention further provides reagents for use in the detection methods. A subject detection method is useful in various imaging, diagnostic, prognostic, and patient monitoring methods, which are also provided.

The diagnosis of male infertility is based predominantly on the results of standard semen analysis for concentration, total motility, progressive motility, volume, pH, viscosity and/or morphology. When sperm enter the female reproductive tract, they must undergo a series of physiological changes, known as capacitation, in order to fertilize an egg. This process involves plasma membrane changes that occur in response to stimuli within the female tract. These changes include removal of sterols and redistribution of the ganglioside GM1. Semen analysis identifies only half the cases of male infertility due to standard semen analysis providing little information on sperm functional competence. Previous data demonstrated that localization of the ganglioside, GM1, identifies sub-populations of sperm capable of undergoing the functional maturation process known as capacitation and tracks strongly with fertility.

Methods for multiplexed delivery of agents to a solid tissue in vivo followed by assessment of efficacy with mass spectrometry are described.

A system and method for detecting a biomarker in exhaled breath condensate nanodroplets comprises noninvasively collecting exhaled breath condensate nanodroplets of a subject, and analyzing said nanodroplets utilizing immuno-quantitative polymerase chain reaction to detect one or more target biomarkers.

Provided are a detection agent for detecting hydroxy vitamin D, preparation method thereof, and use thereof in 25-hydroxy vitamin D immunological detection. The detection agent comprises a conjugate formed by a 25-hydroxy vitamin D antigen derivative and protein carrier, and magnetic spheres coated by the conjugate. Also provided is a 25-hydroxy vitamin D detection kit comprising the detection agent.

A population of bright and stable nanocrystals is provided. The nanocrystals include a semiconductor core and a thick semiconductor shell and can exhibit high extinction coefficients, high quantum yields, and limited or no detectable blinking.

The present disclosure provides a method and a system for protecting an electrical device. The method includes: acquiring coordinate data of the electronic device; determining whether the coordinate data exceeds a data range corresponding to a preset state of the electronic device; and disabling the electronic device when the coordinate data exceeds the data range corresponding to the preset state.

A ground fault circuit interrupter (GFCI) breaker testing system can include an enclosure having at least one wall that forms a cavity. The system can also include at least one GFCI breaker disposed within the cavity. The system can further include a sensing circuit assembly having at least one switch, where the at least one switch is electrically coupled to the at least one GFCI breaker. The system can also include a user interface assembly disposed, at least in part, outside the cavity, where the user interface assembly is coupled to the sensing circuit assembly, where the user interface assembly instructs the at least one switch to test the at least one GFCI breaker.

Electronic device heat transfer technology is disclosed. In an example, an electronic device package can include a substrate. The electronic device package can also include a heat transfer component. The electronic device package can further include a heat-generating electronic component coupled to the substrate between the substrate and the heat transfer component. The electronic device package can also include a viscous thermal interface material (TIM) providing a heat transfer pathway between the electronic component and the heat transfer component. In addition, the electronic device package can include a barrier about at least a portion of a periphery of the viscous TIM to maintain the viscous TIM within a confined location in proximity to the electronic component. The TIM is uninterrupted by the barrier within the periphery.

A flexible circuit board includes a first circuit substrate, a second circuit substrate and a bonding layer. The first circuit substrate includes a first base layer, a first circuit layer, a second circuit layer and metal coating layer. The first circuit layer includes a signal line and at least two grounding lines. The metal coating layer encloses the signal line. The second circuit substrate includes a third circuit layer. The bonding layer is located between and bonding the first circuit substrate and the second circuit substrate. The second circuit layer, the third circuit layer are electrically coupled with the grounding lines by a plurality of electrically conductive holes. The first base layer, the bonding layer and the second circuit substrate cooperatively enclose a hermetic medium layer receiving the signal line. The hermitic medium layer is filled with air. A method for manufacturing the flexible circuit board is also provided.

An electronic device is provided. The electronic device includes a support member including at least a portion formed of a conductive material, an enclosure member configured to receive the support member and including at least a portion of which is formed of a conductive material. The conductive material portion of the enclosure member and the conductive material portion of the support member are insulated from each other.

The semiconductor device according to the present invention has an upper electrode, a first lower layer wiring that also functions as a lower electrode, an electrical resistance-changing film interposed between the upper electrode and the first lower layer wiring, a second lower layer wiring, and a contact plug, the contact plug connecting to the upper electrode and to the second lower layer wiring. The present invention yields a semiconductor device with which it is possible to dispose elements in high density while maintaining the reliability and manufacturing yield of the electrical resistance-changing element.

An organic light emitting display (OLED) device can include a substrate on which first to third light emitting portions are defined, first electrodes respectively positioned on the first to third light emitting portions, a first stack formed on the first electrodes and including first, second and third light emitting layers corresponding to the first, second and third light emitting portions, respectively, an N-type charge generation layer (CGL) positioned on the first stack, a transition metal oxide layer positioned on the N-type CGL, a second stack positioned on the transition metal oxide layer and including fourth, fifth and sixth light emitting layers corresponding to the first, second and third light emitting portions, respectively, and a second electrode positioned on the second stack.

A light emitting device and a method for manufacturing the same are disclosed. Herein, the light emitting device comprises: a substrate having a light emitting region and a sealing region surrounding the light emitting region; an OLED unit disposed over the light emitting region; a protection layer disposed over the OLED unit; a support unit disposed over the sealing region, wherein materials of the protection layer and the support unit are the same, and the support unit connects to the protection layer; and a cover disposed over the protection layer and the support unit; wherein a first height is between a surface of the support unit adjacent to the cover and a surface of the substrate, a second height is between a surface of the protection layer adjacent to the cover and the surface of the substrate, and the first height is larger than the second height.

The present disclosure provides an OLED display panel, an electronic device, and a manufacturing method. The OLED display panel comprises a substrate, a first electrode, a light-emitting function layer, and a second electrode including Ag or a metal alloy containing Ag. When the second electrode is made of the metal alloy containing Ag, a content of Ag in the second electrode is more than a sum of contents of all other elements in the second electrode.

The present disclosure provides a method for packaging an organic light-emitting diode (OLED) display panel. The method includes providing a first substrate and a second substrate; forming a first bonding layer in a packaging region of the first substrate; and forming a second bonding layer in a packaging region of the second substrate. The method also includes bonding the first substrate with the second substrate by molecular bonding between the first bonding layer and the second bonding layer.

The present disclosure provides a display substrate and fabricating method, a display panel, and a display apparatus. The display substrate includes a substrate including a sealing region and a driving wire on the substrate. At least a portion of the driving wire is in the sealing region. The portion of the driving wire includes: a first surface, a second surface opposite to the first surface, and sides there-between connecting to the first surface and the second surface. Each side has a projection width on the substrate of at least about 1 μm.

A light emitting device having a structure in which oxygen and moisture are prevented from reaching light emitting elements, and a method of manufacturing the same, are provided. Further, the light emitting elements are sealed by using a small number of process steps, without enclosing a drying agent. The present invention has a top surface emission structure. A substrate on which the light emitting elements are formed is bonded to a transparent sealing substrate. The structure is one in which a transparent second sealing material covers the entire surface of a pixel region when bonding the two substrates, and a first sealing material (having a higher viscosity than the second sealing material), which contains a gap material (filler, fine particles, or the like) for protecting a gap between the two substrates, surrounds the pixel region. The two substrates are sealed by the first sealing material and the second sealing material. Further, reaction between electrodes of the light emitting elements (cathodes or anodes) and the sealing materials can be prevented by covering the electrodes with a transparent protective layer, for example, CaF2, MgF2, or BaF2.

A display apparatus including a substrate; a display unit disposed on the substrate; a sealing layer disposed on the display unit; a touch screen layer disposed on the sealing layer; and a buffer layer disposed between the sealing layer and the touch screen layer. The sealing layer includes n sealing units each including an organic layer and an inorganic layer, in which n is an integer of 1 or greater. The organic layer and the inorganic layer are sequentially stacked on the display unit. The organic layer includes a cured product for forming an organic layer including a first photocurable monomer. The buffer layer includes a cured product for forming a buffer layer including a second and third photocurable monomer. The first and second photocurable monomers include a photocurable functional group. The third photocurable monomer is represented by Formulae 1A to 1C.

A display device, which includes a display region constituted by a plurality of pixels, includes a first substrate having a hygroscopic agent formed in a peripheral region outside the display region and a sealing film covering the hygroscopic agent, a second substrate disposed facing the first substrate, and an adhesive layer, at least a portion of which is disposed closer to the side of the display region than the hygroscopic agent, and which bonds the first substrate to the second substrate.

The present application discloses a light emitting diode comprising a plurality of sub-pixels comprising a first electrode layer, wherein the first electrode layer is a reflective electrode layer; a second electrode layer; a light emitting layer between the first electrode layer and the second electrode layer; a first microcavity tuning layer sandwiched by the first electrode layer and the light emitting layer within the plurality of sub-pixels; and a second microcavity tuning layer sandwiched by the first microcavity tuning layer and the light emitting layer within at least one of the plurality of sub-pixels, and the first microcavity tuning layer is sandwiched by the first electrode layer and the second microcavity tuning layer within the at least one of the plurality of sub-pixels. The first microcavity tuning layer is made of a material including a transparent conductive material in a first state and the second microcavity tuning layer is made of a material including a transparent conductive material in a second state, the first state and the second state are different states selected from a crystalline state and an amorphous state.

An OLED display panel with a method manufacturing the same includes: a substrate; an OLED display device, formed on the substrate; a cover plate, disposed on the substrate to seal the OLED display device; and a first resonant cavity layer, formed on the OLED display device and below the cover plate, configured to absorb blue light with wavelengths between 400 and 440 nm. By adjusting a resonant cavity length of the resonant cavity, the present disclosure changes a proportion of energy of blue light to a preset wavelength band in emitting light, significantly reduces a proportion of a spectrum below 435 nm to the preset wavelength band, and reduces material use of the resonant cavity layer, being conducive to improving device efficiency and reducing production cost, and being able to obtain eye-protecting effect at the same time.

Provided is a display device and a manufacturing method of the same. The display device includes: a base substrate having a top surface and a side surface, a display region over the top surface, a terminal over the top surface and between the display region and the side surface, the terminal being electrically connected to the display region, and an anisotropic conductive film over the terminal. An edge portion of the anisotropic conductive film is spaced from the side surface, and its distance is equal to or larger than 10 μm and equal to or smaller than 1 mm.

There is provided coal gasification unit including: a coal gasifier; a char recovery unit; flare equipment; an air flow rate adjustment valve and an oxygen supply flow passage that supply oxygen-containing gas to the coal gasifier; an inert gas supply flow passage that supplies nitrogen gas to an upstream side of the char recovery unit; and a control unit that controls a supply amount of the oxygen-containing gas and a supply amount of the nitrogen gas, in which the coal gasifier has a starting burner, and in which the control unit controls the supply amount of the nitrogen gas prior to starting combustion of starting fuel by the starting burner so that an oxygen concentration of mixed gas in which combustion gas generated by combustion of the oxygen-containing gas and the starting fuel has been mixed with the nitrogen gas becomes not more than an ignition concentration.

In one embodiment, a plant control apparatus is configured to control a power generating plant that includes a gas turbine configured to be driven by a gas, an exhaust heat recovery boiler configured to generate steam by using heat of an exhaust gas from the gas turbine, a temperature reducing apparatus configured to cool, through a cooling medium, the steam generated by the exhaust heat recovery boiler, and a steam turbine configured to be driven by the steam cooled by the temperature reducing apparatus. The plant control apparatus includes an output controller configured to control output of the gas turbine, and a temperature reduction controller configured to control a cooling operation of the steam by the temperature reducing apparatus while the output controller controls the output of the gas turbine.

In a method of reducing pollutants of a combustion engine, exhaust gas, generated by a cylinder of the combustion engine, is fed to an exhaust gas aftertreatment system as a function of a predefined condition solely via a first exhaust channel which communicates with a first one of first and second exhaust valves of the cylinder. The first exhaust channel is hereby coated, at least in part, by a thermally insulating layer selected such that a heat input is transmitted to the exhaust gas aftertreatment system which heat input is greater than a heat input in a second exhaust channel communicating with a second one of the first and second exhaust valves. The predefined condition is defined as a function of a coolant temperature of the combustion engine.

An exhaust treatment system comprising a first oxidation catalyst to oxidise nitrogen and/or carbon compounds in an exhaust stream and a first dosage device downstream of said first oxidation catalyst to supply a first additive. A first reduction catalyst device is arranged downstream of said first dosage device for reduction of nitrogen oxides using said first additive, and for the generation of heat, through at least one exothermal reaction with said exhaust stream. A particulate filter arranged downstream of said first reduction catalyst device to catch soot particles and a second dosage device, arranged downstream of said particulate filter to supply a second additive. A second reduction catalyst device is arranged downstream of said second dosage device for reduction of nitrogen oxides in said exhaust stream, through the use of at least one of said first and said second additive.

A controller is provided, which detects operating conditions of an internal combustion engine on the basis of detection results from a group of sensors and drives an actuator that modifies an opening position of a wastegate valve on the basis of the operating conditions. When driving the wastegate valve to a fully closed opening, the controller initially drives the actuator toward a preset provisional fully closed position, and after determining on the basis of a detection result from a position sensor that an actual opening of the wastegate valve has reached the provisional fully closed opening, switches a target opening to the fully closed opening and drives the actuator accordingly.

A required opening correction amount is calculated based on a target supercharging pressure and an actual supercharging pressure, a target opening is calculated based on a required opening and the required opening correction amount, an actual operating position of a wastegate valve is determined to correspond to a fully closed position when the wastegate valve is in a fully closed condition, an actual opening of the wastegate valve is calculated based on the fully closed position and the actual operating position, an operation amount of an actuator for aligning the target opening with the actual opening is calculated based on the target opening and the actual opening, and when the target opening corresponds to the fully closed condition and the actual operating position is not decreased at or above a prescribed rate, the fully closed position is updated to the actual operating position.

A gas turbine engine system and method of operating gas turbine engines are provided. The gas turbine engine assembly includes a gas turbine engine includes a power shaft configured to rotate about an axis of rotation. The gas turbine engine assembly also includes a first fan and a second fan coupled to the power shaft coaxially with the gas turbine engine. The gas turbine engine assembly also includes a first fan duct configured to direct a first stream of air to the first fan. The gas turbine engine assembly also includes a second fan duct configured to direct a second stream of air to the second fan. The gas turbine engine assembly also includes an exhaust duct configured to direct a stream of exhaust gases of the gas turbine engine in a direction of the axis of rotation.

A system includes a gas turbine system having a turbine combustor, a turbine driven by combustion products from the turbine combustor, and an exhaust gas compressor driven by the turbine. The exhaust gas compressor is configured to compress and supply an exhaust gas to the turbine combustor. The gas turbine system also has an exhaust gas recirculation (EGR) system. The EGR system is configured to recirculate the exhaust gas along an exhaust recirculation path from the turbine to the exhaust gas compressor. The system further includes a main oxidant compression system having one or more oxidant compressors. The one or more oxidant compressors are separate from the exhaust gas compressor, and the one or more oxidant compressors are configured to supply all compressed oxidant utilized by the turbine combustor in generating the combustion products.

The heat exchanger system includes a first heat exchanger assembly including a plurality of airfoil members circumferentially spaced in a flow stream of an annular duct. Each airfoil member including a radially inner end and a radially outer end and a first internal flowpath configured to channel a flow of cooled fluid therethrough. The heat exchanger assembly includes a second heat exchanger assembly including a plurality of fin members extending proximate the flow stream and a second internal flowpath configured to channel a flow of cooled fluid therethrough. The heat exchanger assembly includes a header system including a conduit path configured to couple the first heat exchanger assembly and the second heat exchanger assembly in flow communication. The header system includes an inlet connection configured to receive a flow of hot fluid from thermal loads and an outlet connection configured to direct cooled fluid to thermal loads.

A gas turbine engine cooling system includes a gas turbine engine. The gas turbine engine includes a core engine, a cold sink, a core undercowl space, and a core cowl at least partially surrounding the core engine and defining a radially outer wall of the core undercowl space. The gas turbine engine cooling system includes an undercowl component positioned in the core undercowl space. The gas turbine engine cooling system also includes a heat pipe including a first end, a second end, and a conduit extending therebetween. The first end is thermally coupled to the undercowl component, and the second end is thermally coupled to the cold sink. The heat pipe facilitates transfer of a quantity of heat from the undercowl component to the cold sink.

The heat exchanger assembly includes a first internal flow path configured to channel a flow of fluid to be cooled from a first inlet to a first outlet. The heat exchanger assembly also includes a second internal flow path configured to channel a flow of a first coolant from a first inlet to a first outlet. The heat exchanger assembly further includes an external flow path configured to receive a flow of a second coolant proximate a surface of the external flow path.

A method for controlling a pressure control mechanism in a turbofan engine having a precooler permitting heat exchange between ambient air and bleed air includes detecting at least one of an engine failure or a bleed system failure, detecting at least one of an ice condition or an activation of an anti-ice system, and actuating the pressure control mechanism, thereby altering the heat exchange between the ambient air and the bleed air.

In a rotary machine, a method of assembling a rotary machine, and a method of performing maintenance of a rotary machine, a combustor casing as an outer casing configured from upper and lower casings forming a half split shape, an intermediate shaft cover as an inner casing configured from upper and lower casings forming a half split shape and supporting a combustor in the combustor casing, and a pressing support mechanism that presses and supports a portion to be fit of the combustor casing and a fitting portion of the intermediate shaft cover in an axial direction of a rotor are provided, and thus, detachment of the casing is made easy and maintainability of an inside thereof is improved in the method of performing maintenance of a rotary machine.

A method for operating a stationary gas turbine at partial load, having at least one compressor, at least one expansion turbine and a combustion chamber provided with at least one burner, which gas turbine further includes a hydraulic gap adjuster, wherein the method has the following steps: operating the gas turbine at partial load; operating the a hydraulic gap adjuster; during the operation of the hydraulic gap adjuster, increasing the fuel supply to the burner while increasing the temperature of the combustion gases which are guided to the expansion turbine.

The invention is in the field of engine building technology and may be used in space technology or aviation. Liquid-propellant rockets with Laval nozzles are well known, and they have the following insufficiencies: (1) high fuel consumption rates, which lead to increased dimensions and engine weight and boosters; (2) a relatively low combustion efficiency, because the low mass of the combustion products are emitted into the environment; (3) the large length of the de Laval nozzles with increased expansion ratios increase the dimensions and the engine weight; (4) use of high temperature rocket propellants—combustion products—in the camera and de Laval nozzle. These insufficiencies suppress using liquid-propellant rockets in space technology. The goal of the invention is decreasing the influence of these insufficiencies and obtaining an engine with improved efficiency. The goal is achieved with the creation of an engine with the subsonic discharge of combustion products and the creation of a simple nozzle construction.