met Method for continuous, frame-specific click-stream recording By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT A method for tracking a user's movements between network addresses can include, subsequent to a request for a (current) network address from a user, receiving the network address and an identifier for a region associated with the network address. The method can also include locating a record that contains the identifier for the region and a time that immediately precedes the request for the network address from the user. The record may further contain a prior network address. The method can further include generating an entry for a table that includes the identifier for the region, the current network address, and the prior network address. A server computer or a client computer can generate the entry. Improved accountability and improved user profile accuracy can be obtained with the method. A data processing system readable medium can comprise code that includes instructions for carrying out the method. Full Article
met Method and system for low-latency networking By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT Various aspects of a method and system for low-latency networking are provided. Latency requirements of traffic to be communicated along a network path comprising one or more Ethernet links may be determined. A maximum size of Ethernet frames utilized for communicating the traffic may be determined based on the latency requirements. The maximum size of the Ethernet frames may be determined based on a data rate of one or more Ethernet links along the network path. A single device may utilize different maximum packet sizes for different ports/links on which it communicates. One or more messages indicating the determined maximum size may be communicated among devices along the network path to coordinate maximum packet sizes. Full Article
met System and method for protecting data in an enterprise environment By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT Provided are a system and method for protecting data in an electronic communications environment. An interested entity establishes one or more controls for a received unit of data. At a source device in the electronic communications network, the unit of data is encapsulated with self-protection security data that includes the one or more controls. The encapsulated unit of data is delivered from the source device to a destination device in the electronic communications network. A data broker facilitates the delivery of the data to the destination device according to the controls. Facilitating the delivery of the data includes: identifying for the receiving device a collection of services corresponding to the controls independently of the network. Full Article
met System and method for using a multicast group to support a flooding mechanism in a middleware machine environment By www.freepatentsonline.com Published On :: Tue, 09 Jun 2015 08:00:00 EDT A system and method can support a flooding mechanism using a multicast group in a middleware machine environment. The middleware machine environment can comprise a gateway instance that includes an external port for receiving one or more data packets from an external network. The middleware machine environment also comprises one or more host servers, each of which is associated with one or more virtual machines that can process the data packets. Furthermore, said host servers can provide virtual interfaces that belong to a virtual hub associated with the gateway instance. At least one said packet is a flooded packet that is specified with an unknown destination address when it is received at the external port. The gateway instance operates to send the flooded packet to the multicast group that operates to forward the flooded packet to one or more said host servers in the multicast group. Full Article
met MU-MIMO-OFDMA systems and methods for servicing overlapping co-scheduled users By www.freepatentsonline.com Published On :: Tue, 09 Jun 2015 08:00:00 EDT Methods and systems for conveying or transmitting to any given user in an OFDMA-MU-MIMO system scheduling information of other co-scheduled users to permit the user to perform error-correction on received data and/or interference reduction on its received signals. The scheduling information can include resource block assignment, modulation constellations employed, coding rates employed, power levels utilized and precoder matrix indices used. Further, the scheduling information can be conveyed in part through dedicated reference symbol layers or pilot streams. Moreover, a base station may transmit a preliminary estimate of the total number of users the base station expects to schedule, or an upper-bound on the total number of users, to the MU-MIMO users to permit the MU-MIMO users to determine preferred precoder matrix indices and indications of channel quality indices. Full Article
met Information processing apparatus, computer-readable recording medium, and control method By www.freepatentsonline.com Published On :: Tue, 23 Jun 2015 08:00:00 EDT An abnormality detection unit provided in at least one node among a plurality of nodes included in an information processing apparatus detects abnormality in a data transmission path of data transmission using a shared memory area sharable in a single node and other node, which is included in the storage unit provided in the single node or other nodes. An error information generation unit provided in the single node generates error information, based on the abnormality detected by the abnormality detection unit, and generates an interrupt with respect to a processor within a self node. The processor provided in the single node performs recovery processing, based on the error information according to the interrupt. Full Article
met Systems and methods for prioritizing and scheduling packets in a communication network By www.freepatentsonline.com Published On :: Tue, 23 Jun 2015 08:00:00 EDT Systems and methods provide a parameterized scheduling system that incorporates end-user application awareness and can be used with scheduling groups that contain data streams from heterogeneous applications. Individual data queues within a scheduling group can be created based on application class, specific application, individual data streams or some combination thereof. Application information and Application Factors (AF) are used to modify scheduler parameters such as weights and credits to differentiate between data streams assigned to a scheduling group. Dynamic AF settings may adjust relative importance of user applications to maximize user Quality of Experience (QoE) in response to recurring network patterns, one-time events, application characteristics, protocol characteristics, device characteristics, service level agreements, or combinations thereof. Scheduling parameters may be dynamic and incorporate the notions of “duration neglect” and “recency effect” in an end-user's perception of video quality in order to optimally manage video traffic during periods of congestion. Full Article
met Double ring network system and communication control method thereof, and transmission station, and program for transmission stations By www.freepatentsonline.com Published On :: Tue, 04 Aug 2015 08:00:00 EDT A double ring network system configured with two or more transmission stations each including a pair of bi-directionally communicative communication ports, including any adjacent two transmission stations as terminal stations, and any transmission station as a base, as mutually connected in a ring form by communication ports through a transmission line, for intercommunications between transmission stations, in which the transmission stations are each adapted to determine whether or not frame signals are received from adjacent transmission stations, transmit route identifying frame signals for identification of routes to adjacent transmission stations, when having failed in reception, and set own station as a terminal station substituting for a current terminal station, when having received no responses to the route identifying frames from adjacent transmission stations, so they are kept from arriving at ring-like connected subsequent transmission stations. Full Article
met Data transmitting apparatus, data receiving apparatus, data transreceiving system, data transmitting method, data receiving method and data transreceiving method By www.freepatentsonline.com Published On :: Tue, 06 Oct 2015 08:00:00 EDT A data transmitting apparatus is provided. The data transmitting apparatus includes a packet generator configured to generate a packet including a plurality of sub packets and a transmitter configured to transmit the generated packet to a data receiving apparatus. Each of the plurality of sub packets includes audio data corresponding to content among a plurality of contents. Full Article
met Method and apparatus for measurement for inter-cell interference coordination in radio communication system By www.freepatentsonline.com Published On :: Tue, 13 Oct 2015 08:00:00 EDT A wireless communication system and, more specifically, a measurement method and apparatus for inter-cell interference coordination in a wireless communication system are disclosed. Herein, a method for supporting measurement of a User Equipment (UE) by a first base station in a wireless communication system includes the steps of acquiring information of downlink subframe configuration of a second base station, determining measurement objects of downlink resource of the first base station based on the downlink subframe configuration of the second base station; transmitting information of the measurement objects to the UE, and receiving measurement result for the measurement objects from the UE. Full Article
met Reception apparatus, reception method, and reception program By www.freepatentsonline.com Published On :: Tue, 10 Nov 2015 08:00:00 EST A reception apparatus is configured to receive data including a plurality of packets each of which has information on a time point when the packet is generated; to extract a terminal packet which is a packet included in the data received and which has information on a time point which is nearest to a current time point; and to control an operation clock by comparing the information on the time point included in the terminal packet with information on an elapsed time obtained by adding information on a time point, which is included in a terminal packet of preceding data, to an elapsed time from when the preceding data is received to the current time point. Full Article
met Network system and frame communication method By www.freepatentsonline.com Published On :: Tue, 01 Dec 2015 08:00:00 EST A network system has: a communication device configured to perform frame transmission and reception; a network configured to transfer the frame; a gateway connected between the communication device and the network; and a controller configured to perform management of the communication device and the network. The frame is classified into a control frame for communicating control information necessary for communication and a data frame for communicating data between communication devices. The gateway determines whether a frame received from a source communication device is the control frame or the data frame, forwards the control frame to the controller, and forwards the data frame to the network. The controller performs the management based on the control frame received from the gateway. The network transfers the data frame received from the gateway to a destination communication device without through the controller. Full Article
met Channel-sounding method using a plurality of antennas, and apparatus for same By www.freepatentsonline.com Published On :: Tue, 23 Feb 2016 08:00:00 EST The present invention relates to a wireless communication system. More particularly, the present invention relates to a method and to an apparatus for transmitting an SRS in a multi-antenna system. The method comprises the steps of: acquiring specific information for discriminating a first antenna group and a second antenna group from among a plurality of antennas, wherein said first antenna group includes one or more antennas which are set to a turned-on state to perform communication with a base station, and said second antenna group includes one or more other antennas which are set to a turned-off state; transmitting an SRS to the base station if a predetermined condition is satisfied, under the condition that the second antenna group is set to the turned-off state; and setting the second antenna group to a turned-off state after the transmission of the SRS. Full Article
met Mobile user terminal, mobile communication system, base station, and communication method By www.freepatentsonline.com Published On :: Tue, 03 May 2016 08:00:00 EDT A mobile user terminal, which communicates with a base station in an intermittent fashion, the mobile user terminal includes a radio transmitter which transmits downlink channel quality information indicating downlink channel quality and an uplink pilot signal to a base station in an intermittent fashion; and a transmit time controller which synchronizes transmit time of the downlink quality information and transmit time of the uplink pilot signal relative to each other, such that the downlink quality information and the uplink pilot signal are sent in adjacent different timings in a period corresponding to a state of intermittent communicate. Full Article
met Automotive timing chain system component and method thereof By www.freepatentsonline.com Published On :: Tue, 31 Mar 2015 08:00:00 EDT One embodiment may include an automotive timing chain system component (10, 12) such as a tensioner arm (10) or a chain guide (12) that, during use, bears directly or indirectly against a chain (22) of an automotive timing chain system (14). The component (10, 12) may have an elongated body (16, 116) made into a generally hollow shape by a hydroforming process. The body may have a first open free end (26, 126) and a second open free end (28, 128). Full Article
met Method for joining structural elements onto a shaft By www.freepatentsonline.com Published On :: Tue, 21 Apr 2015 08:00:00 EDT A method for joining structural elements onto a shaft may include generating at least one projection at a respective joining position on the shaft, sliding at least one of the structural elements over at least one projection and maintaining the structural elements in at least on projection. Full Article
met Secondary assembly drive of an internal combustion engine and method for operating same By www.freepatentsonline.com Published On :: Tue, 19 May 2015 08:00:00 EDT A secondary assembly drive of an internal combustion engine and a method for operating same are provided. The secondary assembly drive includes: a first drive wheel (1) which can be rotatably connected to a crank shaft (CR) of the internal combustion engine, an electric machine which can be operated either as a generator (AL) of as a motor (M) and a second drive wheel (2) which can be rotatably connected to the electric machine (AL, M), an air-conditioning compressor (A/C) and a third drive wheel (3) which can be rotatably connected to the air-conditioning compressor, a traction element (4) which rotates infinitely and which wraps around the drive wheels, and an actuable clutch (7) for disconnecting the drive of the electric machine and of the air-conditioning compressor from the crankshaft when necessary. In addition, the air-conditioning compressor is designed for operation in both rotational directions, and a reversal of the rotational direction between the generator operating mode and the motor operating mode of the electric machine is provided. Full Article
met Method for electronically controlling a bicycle gearshift and electronically servo-assisted bicycle gearshift By www.freepatentsonline.com Published On :: Tue, 19 May 2015 08:00:00 EDT A method for electronically controlling a bicycle gearshift comprising at least one derailleur is disclosed, comprising the sequential steps of: a) imparting a movement on the derailleur of the gearshift until the derailleur is in an intended position;b) waiting for a predetermined time period,c) performing a check whether the derailleur is in the intended position, within a possible predetermined tolerance,d) in case said check has a negative outcome, imparting a movement on the derailleur of the gearshift until the derailleur is in the intended position. A derailleur and an electronically servo-assisted bicycle gearshift comprising control electronics comprising modules adapted to carry out the method outlined above are also disclosed. Full Article
met Secondary assembly drive of an internal combustion engine and method for operating same By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT A secondary assembly drive of an internal combustion engine and a method for operating same are provided. The secondary assembly drive includes, in two drive planes, an assembly drive (2) and a starter drive (12) and permits, in addition to a normal operating mode, the following operating modes: —starting of the internal combustion engine, —boosting of the internal combustion engine, —air-conditioning, and —deactivation of the assembly drive (2). Full Article
met Method for modifying plant architecture and enhancing plant biomass and/or sucrose yield By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT The present invention relates to methodology and constructs for modifying plant architecture and enhancing plant biomass and/or sucrose yield. Full Article
met Herbicide tolerant soybean plants and methods for identifying same By www.freepatentsonline.com Published On :: Tue, 23 Jun 2015 08:00:00 EDT The invention provides specific transgenic soybean plants, plant material and seeds, characterized in that these products harbor a stack of specific transformation events at specific locations in the soybean genome (elite event EE-GM3 and elite event EE-GM2, or elite event EE-GM3 and elite event EE-GM1). The invention also provides for methods of producing soybean plants and seeds having elite event EE-GM3 and elite event EE-GM2, or elite event EE-GM3 and elite event EE-GM1. Full Article
met Method and apparatus for conveying a cellulosic feedstock By www.freepatentsonline.com Published On :: Tue, 14 Apr 2015 08:00:00 EDT A method and apparatus for conveying a cellulosic feedstock are disclosed. The apparatus, such as a holding tank, has a passage. At the outlet to the passage, a conveyance member is provided to convey the cellulosic feedstock laterally across the outlet. The conveyance member, e.g., at least one screw conveyor, may have a variable pitch along its length. The method comprises passing the cellulosic feedstock through an impregnation chamber to an outlet of the impregnation chamber; passing the cellulosic feedstock from the outlet of the impregnation chamber to an inlet of a holding tank; passing the cellulosic feedstock downwardly through the holding tank; maintaining a generally constant residence time in the holding tank; and subsequently subjecting the cellulosic feedstock to a hydrolysis process. Full Article
met Device and method for depositing a powder mixture for forming an object with composition gradients By www.freepatentsonline.com Published On :: Tue, 21 Apr 2015 08:00:00 EDT A device for depositing a mixture of powders to form an object with composition gradients, including: a plurality of tanks respectively configured to contain different powders; a powder mixer placed under the tanks and including a rotatably mounted mixing member; a plurality of powder dispensing mechanisms respectively cooperating with the tanks, and each configured to regulate mass flow rate of the powder escaping from a respective of the tanks towards the mixer; a powder mixture collector placed under the mixer; and a powder mixture dispenser placed under the collector. Full Article
met Apparatus and method for entraining fluids By www.freepatentsonline.com Published On :: Tue, 21 Apr 2015 08:00:00 EDT A method of entraining a second fluid in a first fluid is provided. The method comprises supplying a first fluid to a processing passage (4) having an inlet (6) and an outlet (8), and supplying an entrainment fluid to a nozzle (10) which opens into the processing passage (4) intermediate the passage inlet (6) and the passage outlet (8). A second fluid which will undergo a change of phase and/or state when added to the first fluid is also provided, and supplied to a first port (22) opening into the processing passage (4) adjacent the nozzle (10). The entrainment fluid is injected from the nozzle (10) into the processing passage (4) so as to form a dispersed phase of the first and second fluids in a continuous vapor phase, and the vapor phase is condensed downstream of the nozzle (10). A device suitable for carrying out such a method is also provided. Full Article
met Method and apparatus for conveying a cellulosic feedstock By www.freepatentsonline.com Published On :: Tue, 21 Apr 2015 08:00:00 EDT An apparatus for conveying a cellulosic feedstock is disclosed. The apparatus comprises an enclosed volume having a lower surface comprising a plurality of longitudinally extending portions. Each longitudinally extending portion has an inner surface that is arcuate in transverse section. A plurality of conveyance members are provided within the enclosed volume. Each conveyance member is associated with one of the inner surfaces and configured to sweep the one of the inner surfaces. Additionally, a method for treating a cellulosic feedstock is disclosed. The method comprises providing a cellulosic feedstock being less than 100% saturated moisture. The cellulosic feedstock is introduced into a longitudinally extending enclosed volume, and conveyed longitudinally through the enclosed volume while being mixed. Full Article
met Method and an apparatus/universal combine for agitation of liquids By www.freepatentsonline.com Published On :: Tue, 21 Apr 2015 08:00:00 EDT A method of mixing together liquids or liquid/solid combinations, and mixing apparatus/universal combine utilizing a vertical spinning container or vessel having a rib, or a cross rib in its bottom wall. The container is spun about a vertical axis with no wobbling component to the motion. Meshed elements are used for high shear mixing. Start/stop routines, and variable acceleration/speed values are used, to facilitate complete mixing. Use of ‘impeller’ blade stirrers is completely eliminated. Full Article
met Gravimetric blender with power hopper cover By www.freepatentsonline.com Published On :: Tue, 21 Apr 2015 08:00:00 EDT A gravimetric blender has a frame; a resin material storage hopper supported by the frame, including a hopper cover; a weigh bin located below the hopper for receiving resin material from the hopper downwardly discharging the bin contents after the contents have been weighed; a load cell, connecting the frame and the weigh bin, for sensing weight of the weigh bin; a mixer connected to the frame, below the hopper, for mixing received contents of the weigh bin; and a guide connected to the frame, for movement of the hopper cover therealong. Full Article
met Apparatus, system and method for mixing and dispensing dental impression materials By www.freepatentsonline.com Published On :: Tue, 21 Apr 2015 08:00:00 EDT An apparatus, system and method for mixing and dispensing dental impression materials is described. A dental impression material mixing machine comprises a water dispenser fluidly coupled to a hollow mixing axle, the mixing axle extending through a pulley, wherein an inner circumference of the hollow mixing axle forms a water conduit and an outer circumference of the hollow mixing axle forms a hub connector, a closeable valve inserted at a water entrance to the water conduit and electronically coupled to a water pump, an electronically commutated motor rotatably coupled to the pulley, wherein the hub connector receives a tubular rotatable hub of a disposable mixing vessel comprising dry dental impression powder, and wherein water is dispensed from the water dispenser into the disposable mixing vessel through the water conduit and hub orifice. Full Article
met Mixing apparatus and method By www.freepatentsonline.com Published On :: Tue, 21 Apr 2015 08:00:00 EDT A mixing apparatus includes a housing having an inner chamber, an inlet, and an outlet; an outlet conduit having a first and second end, the second end providing communication between the inner chamber and the outlet; and one or more dispersion members configured to mix one or more fluids, the one or more dispersion members extending between the outlet conduit and the housing. The dispersion members include a plate having a first and second side, a first opening in the plate for receiving an outlet conduit of the mixing device, and a plurality of second openings in the plate. The plurality of second openings has a first and second side. The first and second sides of the plurality of second openings have chamfered edges. Full Article
met Method and devices for sonicating liquids with low-frequency high energy ultrasound By www.freepatentsonline.com Published On :: Tue, 21 Apr 2015 08:00:00 EDT A method and devices comprise a low frequency high energy ultrasound system having at least one sonotrode projecting into a reactor vessel through which the liquid passes via at least one inlet orifice and at least one outlet orifice. To avoid cavitation at the sonotrode, in a close region of the oscillation-transducing sonotrode surface a pressure/amplitude combination close to or above the pressure-amplitude characteristic line is generated at which considerably reduced or no cavitation occurs and in the adjacent region in the vessel at least in a region and at least at times a pressure/amplitude combination is maintained below the pressure-amplitude characteristic line at which cavitation is generated. A device has an inlet orifice arranged such that the liquid impacts directly onto the oscillation-transducing sonotrode surface, and is shaped that in the close region of the oscillation-transducing sonotrode surface a pressure close to or above the pressure-amplitude characteristic line prevails. Full Article
met Eddy current minimizing flow plug for use in flow conditioning and flow metering By www.freepatentsonline.com Published On :: Tue, 28 Apr 2015 08:00:00 EDT An eddy-current-minimizing flow plug has an outer radial wall with open flow channels formed between the plug's inlet and outlet. The plug has a central region coupled to the inner surface of the outer radial wall. Each open flow channel includes (i) a first portion originating at the inlet and converging to a location in the plug where convergence is contributed to by changes in thickness of the outer radial wall and divergence of the central region, and (ii) a second portion originating in the plug and diverging to the outlet where divergence is contributed to by changes in thickness of the outer radial wall and convergence of the central region. For at least a portion of the open flow channels, a central axis passing through the first and second portions is non-parallel with respect to the given direction of the flow. Full Article
met Mixing and kneading machine for continual compounding and method of implementing continual compounding by means of a mixing and kneading machine By www.freepatentsonline.com Published On :: Tue, 05 May 2015 08:00:00 EDT A mixing and kneading machine (1) for continual compounding comprises a screw shaft (3) rotating in a casing (2) and simultaneously moving axially translationally. To sustainably enhance the efficiency of the machine as regards its material thruput per unit of time the screw shaft (3) comprises at least four groups of radial screw vanes (4a, 4b, 4c, 4d) evenly distributed circumferentially, each group consisting of a plurality of screw vanes in axial sequence. The outer diameter (Da) of the screw shaft ranges from 400 to 800 millimeters. The rotary speed of the screw shaft (3) ranges from 30 to 80 rpm. A mixing and kneading machine (1) engineered as such is particularly suitable for compounding an anodic mass in the production of electrodes—anodes—for the aluminum industry. Full Article
met Dissolution generator, method of dissolving powder, and mixing system By www.freepatentsonline.com Published On :: Tue, 05 May 2015 08:00:00 EDT A dissolution generator includes: an upright housing; a screen assembly extending across an interior of the housing, and configured to support a column of powder thereabove; a spray nozzle disposed below the screen assembly and directed towards the screen assembly; and a pressure mechanism disposed above the screen assembly, and configured to apply a substantially constant downward pressure. Full Article
met Method and apparatus for high intensity ultrasonic treatment of baking materials By www.freepatentsonline.com Published On :: Tue, 12 May 2015 08:00:00 EDT The present invention discloses a high intensity ultrasonic treatment method and apparatus that is used in conjunction with an existing commercial dough or batter mixer to enhance the rheological, aeration and textural properties of the dough or batter. This change in properties is a result of the phenomenon of acoustic cavitation induced in the dough or batter by treatment with high intensity ultrasonic waves. The present invention discloses a mixing bowl (20) of an existing mixer system that is preloaded with dough or batter, the bowl (20) is located at the center of an ultrasonic bath tank (101) filled with a working fluid. The effect of ultra-sonic waves with power levels above 1 kW can be observed over the entire or partial mixing period of the dough or batter. The ultra-sonic waves of the present invention are generated by a plurality of ultrasonic wave generators (104A, 104B) and piezoelectric transducers (1) mounted on a stainless steel tank (101). The electrical energy received in each transducer (1) will be converted into appropriate mechanical expansion and contractions in the piezoelectric ceramics of the transducer (1) thus leading to pressure waves being transmitted to the dough or batter to be mixed. The generation and transmission of high intensity ultrasonic waves to the dough or batter affects its rheological, aeration and textural properties. Full Article
met Stirring device and method for manufacturing same By www.freepatentsonline.com Published On :: Tue, 19 May 2015 08:00:00 EDT Provided is a stirrer including a stirring section formed of a plurality of wire members and a handle section to which ends of the respective wire members are mounted, which is capable of preventing, with a simple configuration, liquid such as water from entering inside the handle section from gaps between a mounting part of the handle section and root parts of the respective wire members. The stirrer includes: a stirring section including a plurality of wire members; a fitting body including one or both of grooves and through-holes into which ends of the respective wire members are fitted; and a handle section including a mounting recess to which the fitting body is fitted and fixed under a state in which the ends of the respective wire members are fitted into the one or both of grooves and through-holes. Full Article
met Method and apparatus for forming multiple emulsions By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT The present invention generally relates to multiple emulsions, and to methods and apparatuses for making multiple emulsions. A multiple emulsion generally describes larger droplets that contain one or more smaller droplets therein. The larger droplets may be suspended in a third fluid in some cases. These can be useful for encapsulating species such as pharmaceutical agents, cells, chemicals, or the like. In some cases, one or more of the droplets can change form, for instance, to become solidified to form a microcapsule, a liposome, a polymerosome, or a colloidosome. Multiple emulsions can be formed in one step in certain embodiments, with generally precise repeatability, and can be tailored to include one, two, three, or more inner droplets within a single outer droplet (which droplets may all be nested in some cases). Full Article
met Pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives and methods of use By www.freepatentsonline.com Published On :: Tue, 19 May 2015 08:00:00 EDT This disclosure is directed to pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives. Pharmaceutical compositions comprising the compounds are also provided, as are methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and/or a neuronal disorder. The compounds may bind to and antagonize receptor α2B, α1B or α2A. The compounds may find use in therapy, e.g., to (i) reduce blood pressure and/or (ii) promote renal blood flow and/or (iii) decrease or inhibit sodium reabsorption, or to regulate blood glucose level, increase insulin secretion and treat diseases or conditions that are, or are expected to be, responsive to an increase in insulin production. The compounds may also be used to treat diseases or conditions that are expected to be responsive to a decrease in blood pressure. Use of the compounds to treat cardiovascular, renal disorders or type 2 diabetes is particularly described. Full Article
met Ethanamine compounds and methods of using the same By www.freepatentsonline.com Published On :: Tue, 19 May 2015 08:00:00 EDT The present invention is directed to ethanamine compounds, pharmaceutical compositions comprising the same, and methods of treating depression by administering the ethanamine compound. Full Article
met CCR9 inhibitors and methods of use thereof By www.freepatentsonline.com Published On :: Tue, 19 May 2015 08:00:00 EDT The invention relates to compounds represented by Structural Formula I, which can bind to CCR9 receptors and block the binding of a ligand (e.g., TECK) to the receptors. The invention also relates to a method of inhibiting a function of CCR9, and to the use compounds represented by Structural Formula I in research, therapeutic, prophylactic and diagnostic methods. Full Article
met Phosphorus-containing metal complexes By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT The present invention relates, inter alia, to metal complexes having improved solubility, to processes for the preparaion of the metal complexes, to devices comprising these metal complexes and to the use of the metal complexes. Full Article
met Chlorobis copper (I) complex compositions and methods of manufacture and use By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT A method of manufacturing an anhydrous copper complex of formula C12H10CICuN2O4 and methods of treating neuromuscular and other diseases, including but not limited to fibromyalgia, multiple sclerosis, muscular dystrophy, rheumatoid arthritis, pain, fatigue, sleeplessness, loss of fine motor control, speech loss, inflexibility, Alzheimer's, dementia, amyotrophic lateral sclerosis, depression, lyme disease, lyme disease co-infection, gastroparesis (GP), myopathy, chronic inflammation and/or incontinence. The anhydrous copper complex preferably is administered in a pharmaceutical and/or dietary supplement composition of the invention. Full Article
met Fused tetracyclic pyrido [4,3-B] indole and pyrido [3,4-B] indole derivatives and methods of use By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT This disclosure is directed to fused tetracyclic pyrido[4,3-b>]indole and pyrido[3,4-b]indole derivatives. Pharmaceutical compositions comprising the compounds are also provided, as are methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and/or a neuronal disorder. Full Article
met Phenoxyisobutyric acid compounds and method of synthesis By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT The present invention provides a process for the synthesis of substituted phenoxymethylpropionic acid and related compounds. The compounds are useful for inhibiting the formation of AGEs (Advanced Glycation End Products). Full Article
met Methine-substituted cyanine dye compounds By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT Cyanine dye compounds having a substituted methine moiety that are nucleic acid stains, particularly for fluorescent staining of RNA, including compounds having the formula where R1 is a C1-C6 alkyl, sulfoalkyl, carboxyalkyl or C1-C6 alkoxy; each R2 is independently selected from the group consisting of H, C1-C6 alkyl, C1-C6 alkoxy, fused benzo, trifluoromethyl, amino, sulfo, carboxy and halogen, that is optionally further substituted; at least one of R3, R4, and R5 is an alkyl, aryl, heteroaryl, cyclic, or heterocyclic moiety that is optionally substituted by alkyl, amino, aminoalkyl, carboxy, nitro, or halogen; and the remaining R3, R4 or R5 are hydrogen; X is S, O, or Se; and D is a substituted or unsubstituted pyridinium, quinolinium or benzazolium moiety. Full Article
met BAX agonist, compositions, and methods related thereto By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT The disclosure relates to BAX activators and therapeutic uses relates thereto. In certain embodiments, the disclosure relates to methods of treating or preventing cancer, such as lung cancer, comprising administering a therapeutically effective amount of a pharmaceutical composition comprising a compound disclosed herein or pharmaceutically acceptable salt to a subject in need thereof. Full Article
met Method of preparing benzoimidazole derivatives By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT This invention relates to a method of preparing a benzoimidazole derivative at high purity and high yield so as to enable the production of the benzoimidazole derivative compound as an antagonist against a vanilloid reactor-1, and particularly to a method of preparing a benzoimidazole derivative at high purity and high yield, wherein the benzoimidazole derivative is synthesized using a novel intermediate, namely, benzaldehyde, and thereby the preparation process is simple so that it can be applied to production. Full Article
met Method for producing pyridazinone compounds and intermediate thereof By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT The present invention relates to a novel method for producing a pyridazinone compound and an intermediate thereof as shown in the following scheme: wherein the symbols are as defined in the specification. Full Article
met Method for making threaded tube By www.freepatentsonline.com Published On :: Tue, 22 Jan 2013 08:00:00 EST The invention includes a method, and a component made according to the method having at least one thread pattern formed thereon from a stamping method. The invention includes a tubular member comprising a body having a wall formed from a wrapped sheet of stock to define an interior wall and an exterior wall, a seam in the wall defining a first and second end of the wrapped sheet of stock, and a thread pattern stamped on the exterior wall. The method comprises the steps of forming a blank from sheet of stock having a first surface. A thread pattern is formed onto the first surface while in a substantially sheet-like form. A bending operation then forms the sheet stock into a tubular member such that the thread pattern, located on the tube's external surface, is substantially aligned about its circumference. Full Article
met Electronic device, washer and method for manufacturing washer By www.freepatentsonline.com Published On :: Tue, 19 Feb 2013 08:00:00 EST An electronic device includes, a circuit board including a through hole, a member including a screw hole, a screw including a screw body having an outer diameter smaller than an inner diameter of the through hole and a screw head having an outer diameter larger than the inner diameter of the through hole, wherein the screw body penetrates through the through hole to engage with the screw hole and the screw head is disposed on an opposite side of the circuit board to the member, and a first washer provided between the screw head and the circuit board, the first washer including a first washer body and a plurality of first washer legs extending from the first washer body toward the circuit board, the first washer legs being in contact with the circuit board and having a characteristic of reducing stress on the circuit board upon being heated. Full Article
met Method and device for manufacturing fastenings or fasteners with radial outer contours, especially screws or threaded bolts By www.freepatentsonline.com Published On :: Tue, 26 Feb 2013 08:00:00 EST A method of manufacturing fastenings or fasteners with radial outer contours, especially screws or threaded bolts, made of solid metal is performed by a device. The method manufactures the fastenings or fasteners preferably on a multi-stage press. Several recesses running in an axial direction at a fixed radial distance are formed in the shank-shaped section of a blank. The prefabricated blank with the recesses is inserted into a multi-part split mold within a multi-stage press, whose die stocks have an inner profiling forming the outer contour, and are opened in the starting position, that at the places where the die stocks are opened, there are the recesses. During the closing movement of the die stocks, at least one radial outer contour is pressed on the shank-shaped section of the blank by radial action of forces, with the recesses preventing material from getting between the die stocks during the pressing process. Full Article