my Treatment of Onychomycosis in Diabetic Patients By clinical.diabetesjournals.org Published On :: 2006-10-01 Jason A. WinstonOct 1, 2006; 24:160-166Feature Articles Full Article
my Plasma and Dietary Linoleic Acid and 3-Year Risk of Type 2 Diabetes After Myocardial Infarction: A Prospective Analysis in the Alpha Omega Cohort By care.diabetesjournals.org Published On :: 2020-01-20T12:00:30-08:00 OBJECTIVE To study plasma and dietary linoleic acid (LA) in relation to type 2 diabetes risk in post–myocardial infarction (MI) patients. RESEARCH DESIGN AND METHODS We included 3,257 patients aged 60–80 years (80% male) with a median time since MI of 3.5 years from the Alpha Omega Cohort and who were initially free of type 2 diabetes. At baseline (2002–2006), plasma LA was measured in cholesteryl esters, and dietary LA was estimated with a 203-item food-frequency questionnaire. Incident type 2 diabetes was ascertained through self-reported physician diagnosis and medication use. Hazard ratios (with 95% CIs) were calculated by Cox regressions, in which dietary LA isocalorically replaced the sum of saturated (SFA) and trans fatty acids (TFA). RESULTS Mean ± SD circulating and dietary LA was 50.1 ± 4.9% and 5.9 ± 2.1% energy, respectively. Plasma and dietary LA were weakly correlated (Spearman r = 0.13, P < 0.001). During a median follow-up of 41 months, 171 patients developed type 2 diabetes. Plasma LA was inversely associated with type 2 diabetes risk (quintile [Q]5 vs. Q1: 0.44 [0.26, 0.75]; per 5%: 0.73 [0.62, 0.86]). Substitution of dietary LA for SFA+TFA showed no association with type 2 diabetes risk (Q5 vs. Q1: 0.78 [0.36, 1.72]; per 5% energy: 1.18 [0.59, 2.35]). Adjustment for markers of de novo lipogenesis attenuated plasma LA associations. CONCLUSIONS In our cohort of post-MI patients, plasma LA was inversely related to type 2 diabetes risk, whereas dietary LA was not related. Further research is needed to assess whether plasma LA indicates metabolic state rather than dietary LA in these patients. Full Article
my In-Hospital Prognosis of Ppatients With Fasting Hyperglycemia After First Myocardial Infarction By care.diabetesjournals.org Published On :: 1991-08-01 John J O'SullivanAug 1, 1991; 14:758-760Short Report Full Article
my Diabetic Cardiomyopathy By care.diabetesjournals.org Published On :: 1990-11-01 Frederick S FeinNov 1, 1990; 13:1169-1179Supplement 4: Diabetes 80 Black Populations: Current State of Knowledge Full Article
my Latin American business leaders optimistic about region’s post-pandemic economy By www.upi.com Published On :: Wed, 06 May 2020 18:44:51 -0400 Despite worrying economic projections, business leaders in Latin America remain optimistic about post-pandemic economy. Full Article
my Bank of England: British economy could decline 14 percent By www.upi.com Published On :: Thu, 07 May 2020 07:29:45 -0400 A Bank of England report said Thursday the British economy could fall as much as 14 percent this year, which would be its worst showing in more than 300 years. Full Article
my New ADA course to answer army of questions about coding accurately By www.ada.org Published On :: Fri, 10 Apr 2020 12:12:00 -0500 As the source of dental procedure codes, the ADA has created a new online training course to ensure that dentists and their team members confidently understand CDT codes and how to use them correctly. Full Article
my Oil prices ease on renewed concern about a weaker economy By www.upi.com Published On :: Mon, 14 Jan 2019 09:09:34 -0500 Crude oil prices fell Monday amid renewed concerns about potentially declining crude oil demand resulting from weaker economic outlook. Full Article
my Diabetes Is Associated With Worse Long-term Outcomes in Young Adults After Myocardial Infarction: The Partners YOUNG-MI Registry By care.diabetesjournals.org Published On :: 2019-09-23T15:12:23-07:00 OBJECTIVEWe sought to determine the prevalence of diabetes and associated cardiovascular outcomes in a contemporary cohort of young individuals presenting with their first myocardial infarction (MI) at age ≤50 years.RESEARCH DESIGN AND METHODSWe retrospectively analyzed records of patients presenting with a first type 1 MI at age ≤50 years from 2000 to 2016. Diabetes was defined as a hemoglobin A1c ≥6.5% (48 mmol/mol) or a documented diagnosis of or treatment for diabetes. Vital status was ascertained for all patients, and cause of death was adjudicated.RESULTSAmong 2,097 young patients who had a type 1 MI (mean age 44.0 ± 5.1 years, 19.3% female, 73% white), diabetes was present in 416 (20%), of whom 172 (41%) were receiving insulin. Over a median follow-up of 11.2 years (interquartile range 7.3–14.2 years), diabetes was associated with a higher all-cause mortality (hazard ratio 2.30; P < 0.001) and cardiovascular mortality (2.68; P < 0.001). These associations persisted after adjusting for baseline covariates (all-cause mortality: 1.65; P = 0.008; cardiovascular mortality: 2.10; P = 0.004).CONCLUSIONSDiabetes was present in 20% of patients who presented with their first MI at age ≤50 years and was associated with worse long-term all-cause and cardiovascular mortality. These findings highlight the need for implementing more-aggressive therapies aimed at preventing future adverse cardiovascular events in this population. Full Article
my Reduced Myocardial Perfusion Reserve in Type 2 Diabetes Is Caused by Increased Perfusion at Rest and Decreased Maximal Perfusion During Stress By care.diabetesjournals.org Published On :: 2020-03-19T15:14:52-07:00 OBJECTIVETo examine differences in myocardial blood flow (MBF) at rest and during stress between patients with type 2 diabetes and controls, and to identify potential predictors of changes in MBF at rest and during stress.RESEARCH DESIGN AND METHODSA cross-sectional study of 193 patients with type 2 diabetes and 20 age- and sex-matched controls. Cardiovascular magnetic resonance was used in order to evaluate left ventricular structure and function, and MBF at rest and during adenosine-induced stress. MBF was derived as the mean of the flow within all segments of a midventricular slice.RESULTSPatients with type 2 diabetes had higher global MBF at rest (0.81 ± 0.19 mL/min/g) and lower global MBF during stress (2.4 ± 0.9 mL/min/g) than did controls (0.61 ± 0.11 at rest, 3.2 ± 0.8 mL/min/g under stress; both P < 0.01). Patients with macroalbuminuria had lower MBF during stress (1.6 ± 0.5 mL/min/g) than did patients with microalbuminuria (2.1 ± 0.7 mL/min/g; P = 0.04), who in turn had lower MBF during stress than did normoalbuminuric patients (2.7 ± 0.9 mL/min/g; P < 0.01). Patients with severe retinopathy had lower MBF during stress (1.8 ± 0.6 mL/min/g) than did patients with simplex retinopathy (2.3 ± 0.7 mL/min/g; P < 0.05) and those who did not have retinopathy (2.6 ± 1.0 mL/min/g; P < 0.05). Albuminuria and retinopathy were associated with reduced MBF during stress in a multiple regression analysis. Stress-related MBF inversely correlated with myocardial extracellular volume (P < 0.001; R2 = 0.37), a measure of diffuse myocardial fibrosis. A trend toward lower basal MBF was observed in patients treated with sodium–glucose cotransporter 2 inhibitors (P = 0.07).CONCLUSIONSPatients with type 2 diabetes have higher global MBF at rest and lower maximal MBF during vasodilator-induced stress than do controls. Reduced MBF during stress is associated with diabetes complications (albuminuria and retinopathy) and is inversely correlated with diffuse myocardial fibrosis. Full Article
my 2017 American Academy of Pediatrics Clinical Practice Guideline: Impact on Prevalence of Arterial Hypertension in Children and Adolescents With Type 1 Diabetes By care.diabetesjournals.org Published On :: 2020-03-30T13:26:58-07:00 OBJECTIVEIn 2017, the American Academy of Pediatrics introduced a new guideline (2017 Clinical Practice Guideline of the American Academy of Pediatrics [AAP 2017]) to diagnose arterial hypertension (HTN) in children that included revised, lower normative blood pressure (BP) values and cut points for diagnosing high BP in adolescents. We studied the impact of the new AAP 2017 guideline on prevalence of HTN in children with type 1 diabetes mellitus (T1DM).RESEARCH DESIGN AND METHODSUp to September 2018, 1.4 million office BP measurements in 79,849 children and adolescents (aged 5–20 years) with T1DM have been documented in the DPV (Diabetes Prospective Follow-up) registry. BP values of the most recent year were aggregated, and BP values of 74,677 patients without antihypertensive medication were analyzed (median age 16 years and diabetes duration 5.3 years and 52.8% boys). BP values were classified according to AAP 2017 and the references of the German Health Interview and Examination Survey for Children and Adolescents (KiGGS) (2011) and the Fourth Report on the Diagnosis, Evaluation, and Treatment of High Blood Pressure in Children and Adolescents (fourth report) (2004).RESULTSOf the patients, 44.1%, 29.5%, and 26.5% were hypertensive according to AAP 2017, KiGGS, and fourth report, respectively. Differences in prevalence of HTN were strongly age dependent: <10 years, AAP 2017 31.4%, KiGGS 30.7%, fourth report 19.6%; 10 to <15 years, AAP 2017 30.9%, KiGGS 31.2%, fourth report 22.4%; and ≥15 years, AAP 2017 53.2%, KiGGS 28.4%, fourth report 30.0%. Among teenagers ≥15 years, 59.1% of boys but only 46.3% of girls were classified as hypertensive by AAP 2017 but only 21.1%/26% of boys and 36.7%/34.4% of girls by KiGGS/fourth report, respectively.CONCLUSIONSClassification of BP as hypertension depends strongly on the normative data used. Use of AAP 2017 results in a significant increase in HTN in teenagers ≥15 years with T1DM, particularly in boys. AAP 2017 enhances the awareness of elevated BP in children, particularly in patients with increased risk for cardiovascular disease. Full Article
my Why is My Child Defiant or Explosive? By schoolpsychologistfiles.blogspot.com Published On :: Fri, 24 Aug 2012 14:56:00 +0000 Dedicated to the lady at Walmart with the screaming kid and all of us "good parents" who have been that lady at Walmart.One of the most difficult behaviors for parents or teachers to address is explosive behavior, a child who has little control over emotions and "melts down" in the classroom or at home. It is frustrating, it is embarrassing, it is anxiety producing, it causes intense emotions in ourselves. Parents agonize over why it happens or what they did wrong? Often the parents are blamed or judged by bystanders in stores, family members, friends, or school staff. However, I have seen parents with a variety of parenting styles have kids with poor emotional control, including those who are strict, those who are quick to give in, those who spank, those who use time out, those who take away privileges, and a whole lot of parents who feel like they have tried everything. I know children with very little emotional control from homes that are falling apart, from homes that are loving and supportive, from poor families, from affluent families, from parents who have no clue how to parent, from parents with excellent skills, even from School Psychologists. This is not to say that parenting styles do not have a role in this, but there IS more to it. We have to stop judging each other and get to the root of the problem. What is the Root of the Problem?The problem, the reason some children "explode" or act out with little emotional control, is because he or she is lacking a skill. Emotional control is a skill. Most kids will learn this skill through consistent discipline strategies, but some do not. Another way to look at it.We don't tell our kids how to read and then expect them to do it. We show them step by step. Some kids will pick it up easy, others will need to be taught and retaught and retaught and will need extensive help in doing so. Do we blame ourselves? Do we look at our friends judgementally and think to ourselves "look at the book she is using, it's all wrong?" No, we assume the child has a problem learning to read and we find a way to teach him. WE HAVE TO START LOOKING AT BEHAVIOR IN THE SAME WAY. When a child is exploding, the first step should not be to label the child or blame the parent. Lets start looking for the skill that is lacking. When we find that skill, lets teach it.It's NOT always a control issue. Sometimes kids act out because they have not been taught to obey and respect authority, but sometimes they act out in spite of good training at home. The explosions lead to self esteem problems in the child and the child feeling like a "bad kid," which in turn makes explosions bigger and more frequent. Have you ever looked at a screaming child and demanded he control himself right now or "act your age." It's a common thing to do. Have you ever looked at a child with a Learning Disability and said "read on your grade level, now!" or "I have told you and told you how to read, why aren't you reading?" Of course you haven't. We work with the reader at his level and patiently try different strategies to improve reading. We can't demand them to be good readers and we can't demand that a child who does not have the skills to control his emotions "act his age." These explosive kids need skills and truth be told, we who work with these kids need skills. If you are a parent with a child who acts "out of control" stop blaming yourself. It isn't necessarily because you spanked or didn't spank or were too strict or too lenient. Your child is lacking the skills she needs to control her emotions. Also, realize you are going to need to learn new skills to help your child learn the lacking skills. You are no longer in the Parenting 101 class, you need to move on to the Advanced skill- teaching parenting class. The BEST book I have read on this topic is The Explosive Child by Ross Greene. He addresses the skills these children might be lacking and he has great strategies to address the issue. (see Amazon link below)If you are a teacher and have an "explosive child" in your class, rethink your perspective of the student. The child needs to learn skills, so lets focus on teaching the skills and being patient with the children who are slower to learn emotional control. We as school staff can not make excuses or blame the parents. We have to reach the child at her level. We teach a child to read at her level. We must teach a child to control emotions at her level as well. Challenge for EveryoneLet us stop labeling these kids with emotional skill deficits as "bad kids" and stop judging the parents. Let's be honest with ourselves and recognize we all have shortcomings and could use skills in certain areas. Maybe our kids need skills in emotional control, maybe we do, maybe we need skills in teaching emotional control, or maybe we need skills in some other area all together. Let's be patient with our children and our peers and ourselves. Let's stop criticizing ourselves and others and start learning and teaching new skills. We don't live in a world with bad kids, we live in a world will kids who need skills, so let's teach. Full Article Interventions
my Labor Dept.: U.S. economy lost 20.5M jobs in April, unemployment near 15% By www.upi.com Published On :: Fri, 08 May 2020 08:33:06 -0400 The United States economy shed more than 20 million jobs last month, the greatest month-to-month decline in history, the Labor Department said Friday in its monthly employment analysis. Full Article
my White House press secretary Kayleigh McEnany: President Donald Trump can revive economy again By www.upi.com Published On :: Fri, 08 May 2020 14:41:16 -0400 Presidential press secretary Kayleigh McEnany said Friday the Trump administration is confident in a major economic recovery after several weeks of closures due to the coronavirus pandemic. Full Article
my A Tribute to My Colleagues and All Those Working in Mental Health By psychcentral.com Published On :: Sat, 09 May 2020 17:00:00 +0000 During a time when the world is focused on the current COVID-19 pandemic, a physical health crisis, and all those treating the physical symptoms of this pandemic, we must not... Full Article General Psychotherapy Suicide Treatment coronavirus COVID-19 Mental Health Care Providers
my [ Dogs ] Open Question : I've come to a conclusion,Dogs section on YA is not worth my time or energy, it is bad enough it is full of what I assume are teenagers? By answers.yahoo.com Published On :: Sat, 09 May 2020 17:14:50 +0000 playing games but now I am being repeatedly harassed and accused of being a troll named Sophie. Well you all can just keep this grimy pool. I am not wasting my time or energy. Enjoy yourselves. Full Article
my [ Polls & Surveys ] Open Question : Poll: Is it okay if I make love to my gin and tonic instead ? By answers.yahoo.com Published On :: Sat, 09 May 2020 17:16:07 +0000 It's lockdown after all. Full Article
my [ Other - Holidays ] Open Question : What should I give my mom for Mother’s Day ? By answers.yahoo.com Published On :: Sat, 09 May 2020 17:16:37 +0000 No pets no electronics so maybe something that is nice and simple but homemade Full Article
my [ Singles & Dating ] Open Question : I miss my ex girlfriend's daughter what can I do ? By answers.yahoo.com Published On :: Sat, 09 May 2020 17:18:00 +0000 Hello I am a man 36 years old and, My ex girlfriend and I and I were together from January to August 2012, my ex girlfriend's daughter was very affectionate with me, I miss her what I can do I was very fond of her, what can I do ? Full Article
my [ United States ] Open Question : Is my $1,200 stimulus check taxable as income? By answers.yahoo.com Published On :: Sat, 09 May 2020 17:18:26 +0000 Full Article
my [ Religion & Spirituality ] Open Question : My mother keeps turning water into wine, walking on water and resurrecting from the dead. Is she a witch? By answers.yahoo.com Published On :: Sat, 09 May 2020 17:20:02 +0000 Full Article
my [ Politics ] Open Question : Why are other countries like New Zealand and Australia destroying the virus while America is killing people off to restart the economy? By answers.yahoo.com Published On :: Sat, 09 May 2020 17:22:00 +0000 Full Article
my The Myth of the Iron Lady By www.washingtonpost.com Published On :: Mon, 12 Nov 2007 00:00:00 EST If you consult the online encyclopedia Wikipedia, which is democratically created by Internet users, you will see a pattern emerge in the phrases used to describe the first female leaders of many countries. Full Article Opinions The Myth of the Iron Lady
my My Team vs. Your Team: The Political Arena Lives Up to Its Name By www.washingtonpost.com Published On :: Mon, 29 Sep 2008 00:00:00 EDT With America divided right down the middle for the third presidential election in a row, most people would not be surprised to hear that Democratic and Republican partisans perceive a widening gap between their presidential choices. In 2004, for example, die-hards in both parties felt that the... Full Article Opinions My Team vs. Your Team: The Political Arena Lives Up to Its Name
my Integrating Refugees and Asylum Seekers into the German Economy and Society: Empirical Evidence and Policy Objectives By www.migrationpolicy.org Published On :: Tue, 17 Dec 2019 10:32:57 -0500 As the top destination in Europe for asylum seekers in recent years, Germany has rolled out a number of integration policy changes. Based on an early look at how newcomers’ integration is progressing, the report finds the policies have had ambiguous implications. The report also provides insights into the demographic and socioeconomic characteristics of the asylum seeker and refugee population. Full Article
my My Mother's Fried Rice By www.abc.net.au Published On :: Tue, 12 Jan 2016 14:53:00 +1100 Lorraine Elliott is the author of Not Quite Nigella. You can find her blog at www.notquitenigella.com This recipe was featured on Foodie Tuesday, every 3:30 PM Tuesday, 774 ABC Melbourne Drive show. Full Article ABC Local melbourne Lifestyle and Leisure:Recipes:All Australia:VIC:Melbourne 3000
my Creamy Mushroom Soup By www.abc.net.au Published On :: Tue, 07 Jun 2016 13:28:00 +1000 This recipe features on Foodie Tuesday, a weekly segment on 774 Drive with Raf Epstein, 3.30PM, courtesy of Alice Zaslavsky, Full Article ABC Local melbourne Lifestyle and Leisure:Recipes:All Australia:VIC:Melbourne 3000
my MY MUM'S PUMPKIN & DATE SCONES By www.abc.net.au Published On :: Thu, 16 Jun 2016 12:29:00 +1000 I have clear memories of being about four year's old standing on a little stool next to my mum while she made batches of these golden scones. I always loved being in the kitchen with her and she was endlessly patient, letting me help mix, stir, roll and shape all manner of things (in this case turning a blind eye when I smuggled little nuggets raw dough and dates into my mouth.) We would chat away as we went and she would explain to me what she was doing. I remember to this day her telling me the secret to making good scones was to use the lightest touch possible when you're mixing the dough together...we had no food processor then so everything was mixed by hand and I loved rubbing the flour and butter together, lifting my hands high as she had taught me to help keep the scones light. Although I whiz these up in a processor now, every so often I make a batch by hand, and am immediately whisked back into that childhood kitchen and can almost feel and see Cooee, my mum, beside me in her wonderful cinch-waisted 60's polka dot dress...it's a wonderful image. Full Article ABC Local northcoast Lifestyle and Leisure:Food and Cooking:All Lifestyle and Leisure:Recipes:All Lifestyle and Leisure:Recipes:Main Australia:NSW:Lismore 2480
my Lemony myrtle delicious pudding By www.abc.net.au Published On :: Fri, 19 Aug 2016 10:25:00 +1000 Sometimes these old desserts are just the ticket on a winter's night. We have used a little lemon myrtle powder to add that native home growing touch to this gorgeous pudding. Full Article ABC Local northcoast Lifestyle and Leisure:Food and Cooking:All Lifestyle and Leisure:Recipes:All Lifestyle and Leisure:Recipes:Main Australia:NSW:Lismore 2480
my Sammy and Bishoo spark India collapse By www.abc.net.au Published On :: Tue, 08 Nov 2011 07:32:00 +1100 Darren Sammy and Devendra Bishoo shared five wickets to trigger India's collapse on the second day of the opening Test against the West Indies in New Delhi. Full Article
my Performance of the ESC 0/1-h and 0/3-h Algorithm for the Rapid Identification of Myocardial Infarction Without ST-Elevation in Patients With Diabetes By care.diabetesjournals.org Published On :: 2020-01-20T12:00:30-08:00 OBJECTIVE Patients with diabetes mellitus (DM) have elevated levels of high-sensitivity cardiac troponin (hs-cTn). We investigated the diagnostic performance of the European Society of Cardiology (ESC) algorithms to rule out or rule in acute myocardial infarction (AMI) without ST-elevation in patients with DM. RESEARCH DESIGN AND METHODS We prospectively enrolled 3,681 patients with suspected AMI and stratified those by the presence of DM. The ESC 0/1-h and 0/3-h algorithms were used to calculate negative and positive predictive values (NPV, PPV). In addition, alternative cutoffs were calculated and externally validated in 2,895 patients. RESULTS In total, 563 patients (15.3%) had DM, and 137 (24.3%) of these had AMI. When the ESC 0/1-h algorithm was used, the NPV was comparable in patients with and without DM (absolute difference [AD] –1.50 [95% CI –5.95, 2.96]). In contrast, the ESC 0/3-h algorithm resulted in a significantly lower NPV in patients with DM (AD –2.27 [95% CI –4.47, –0.07]). The diagnostic performance for rule-in of AMI (PPV) was comparable in both groups: 0/1-h (AD 6.59 [95% CI –19.53, 6.35]) and 0/3-h (AD 1.03 [95% CI –7.63, 9.7]). Alternative cutoffs increased the PPV in both algorithms significantly, while improvements in NPV were only subtle. CONCLUSIONS Application of the ESC 0/1-h algorithm revealed comparable safety to rule out AMI comparing patients with and without DM, while this was not observed with the ESC 0/3-h algorithm. Although alternative cutoffs might be helpful, patients with DM remain a high-risk population in whom identification of AMI is challenging and who require careful clinical evaluation. Full Article
my Myocardial Ischemic Burden and Differences in Prognosis Among Patients With and Without Diabetes: Results From the Multicenter International REFINE SPECT Registry By care.diabetesjournals.org Published On :: 2020-01-20T12:00:30-08:00 OBJECTIVE Prevalence and prognostic impact of cardiovascular disease differ between patients with or without diabetes. We aimed to explore differences in the prevalence and prognosis of myocardial ischemia by automated quantification of total perfusion deficit (TPD) among patients with and without diabetes. RESEARCH DESIGN AND METHODS Of 20,418 individuals who underwent single-photon emission computed tomography myocardial perfusion imaging, 2,951 patients with diabetes were matched to 2,951 patients without diabetes based on risk factors using propensity score. TPD was categorized as TPD = 0%, 0% < TPD < 1%, 1% ≤ TPD < 5%, 5% ≤ TPD ≤ 10%, and TPD >10%. Major adverse cardiovascular events (MACE) were defined as a composite of all-cause mortality, myocardial infarction, unstable angina, or late revascularization. RESULTS MACE risk was increased in patients with diabetes compared with patients without diabetes at each level of TPD above 0 (P < 0.001 for interaction). In patients with TPD >10%, patients with diabetes had greater than twice the MACE risk compared with patients without diabetes (annualized MACE rate 9.4 [95% CI 6.7–11.6] and 3.9 [95% CI 2.8–5.6], respectively, P < 0.001). Patients with diabetes with even very minimal TPD (0% < TPD < 1%) experienced a higher risk for MACE than those with 0% TPD (hazard ratio 2.05 [95% CI 1.21–3.47], P = 0.007). Patients with diabetes with a TPD of 0.5% had a similar MACE risk as patients without diabetes with a TPD of 8%. CONCLUSIONS For every level of TPD >0%, even a very minimal deficit of 0% < TPD < 1%, the MACE risk was higher in the patients with diabetes compared with patients without diabetes. Patients with diabetes with minimal ischemia had comparable MACE risk as patients without diabetes with significant ischemia. Full Article
my Reduction in Global Myocardial Glucose Metabolism in Subjects With 1-Hour Postload Hyperglycemia and Impaired Glucose Tolerance By care.diabetesjournals.org Published On :: 2020-02-20T11:55:30-08:00 OBJECTIVE Impaired insulin-stimulated myocardial glucose uptake has occurred in patients with type 2 diabetes with or without coronary artery disease. Whether cardiac insulin resistance is present remains uncertain in subjects at risk for type 2 diabetes, such as individuals with impaired glucose tolerance (IGT) or those with normal glucose tolerance (NGT) and 1-h postload glucose ≥155 mg/dL during an oral glucose tolerance test (NGT 1-h high). This issue was examined in this study. RESEARCH DESIGN AND METHODS The myocardial metabolic rate of glucose (MRGlu) was measured by using dynamic 18F-fluorodeoxyglucose positron emission tomography combined with a euglycemic-hyperinsulinemic clamp in 30 volunteers without coronary artery disease. Three groups were studied: 1) those with 1-h postload glucose <155 mg/dL (NGT 1-h low) (n = 10), 2) those with NGT 1-h high (n = 10), 3) and those with IGT (n = 10). RESULTS After adjusting for age, sex, and BMI, both subjects with NGT 1-h high (23.7 ± 6.4 mmol/min/100 mg; P = 0.024) and those with IGT (16.4 ± 6.0 mmol/min/100 mg; P < 0.0001) exhibited a significant reduction in global myocardial MRGlu; this value was 32.8 ± 9.7 mmol/min/100 mg in subjects with NGT 1-h low. Univariate correlations showed that MRGlu was positively correlated with insulin-stimulated whole-body glucose disposal (r = 0.441; P = 0.019) and negatively correlated with 1-h (r = –0.422; P = 0.025) and 2-h (r = –0.374; P = 0.05) postload glucose levels, but not with fasting glucose. CONCLUSIONS This study shows that myocardial insulin resistance is an early defect that is already detectable in individuals with dysglycemic conditions associated with an increased risk of type 2 diabetes, such as IGT and NGT 1-h high. Full Article
my Diabetes Self-management Education and Support in Type 2 Diabetes: A Joint Position Statement of the American Diabetes Association, the American Association of Diabetes Educators, and the Academy of Nutrition and Dietetics By clinical.diabetesjournals.org Published On :: 2016-04-01 Margaret A. PowersApr 1, 2016; 34:70-80Position Statements Full Article
my Amylin Replacement With Pramlintide in Type 1 and Type 2 Diabetes: A Physiological Approach to Overcome Barriers With Insulin Therapy By clinical.diabetesjournals.org Published On :: 2002-07-01 John B. BuseJul 1, 2002; 20:Feature Articles Full Article
my I’m a Cisgender Woman and My Husband Watches Trans Porn: Does That Mean He’s Not Into Me? By feedproxy.google.com Published On :: Fri, 24 Apr 2020 14:00:00 +0000 A reader submitted the following question: “I recently discovered that my husband is attracted to transsexuals (MTF - non op). This is the only type of porn that he looks at. He also role plays online with men for sexual play and chat. I discovered this after I started snooping because I had some red flags. He is very embarrassed and uncomfortable discussing it. He has apologized for the online chatting (as we had agreed this was out of bounds for our relationship). He says he likes them because they are feminine but his primary attraction is to women (with female parts). However, I just am not sure I believe him. I am terrified that when we are intimate (which I have to pretty much beg for), he can only do it when its dark and I am fearful he is fantasizing that I have a penis. This bothers me deeply on a number of different levels. Are there men who are only interested in transsexuals? Is it possible he is no longer turned on by my female genitalia?” There’s a lot to unpack in this question, but let’s start here: over the years, I’ve received several emails from women describing similar stories and concerns, so you’re not alone in feeling the way that you do. Full Article Sex Question Friday Sexual Problems and Solutions
my 5 Common Myths About Sexually Transmitted Infections By feedproxy.google.com Published On :: Mon, 27 Apr 2020 14:00:00 +0000 April is STD Awareness Month, so let’s take a little time to set the record straight on some popular myths about sexually transmitted infections and diseases. In this post, we’ll explore five of the most common misconceptions. Full Article Fact Check Contraception & Safer Sex
my Rates of Consensual and Nonconsensual Nonmonogamy Among Heterosexual, Gay, and Bisexual Adults By feedproxy.google.com Published On :: Mon, 04 May 2020 14:00:00 +0000 I was recently invited to write a book chapter on nonmonogamy in LGBTQ+ relationships, and one of the things I wanted to do in it was compare the prevalence of both consensual nonmonogamy (polyamory, open relationships, swinging) and nonconsensual nonmonogamy (cheating/infidelity). Further, I wanted to look at whether rates of these practices were similar or different for LGBTQ+ persons compared to heterosexual persons. However, I found it surprisingly difficult to locate reliable data points. The problem I kept running into is that study after study conflated consensual nonmonogamy with nonconsensual nonmonogamy. In other words, researchers were putting all of these folks into the same category without attempting to distinguish whether they were permitted under the rules of the relationship or not. Full Article Relationships Research Sexual Orientation
my The beautiful, mysterious science of how you hear | Jim Hudspeth By feedproxy.google.com Published On :: Fri, 13 Mar 2020 14:57:05 +0000 Have you ever wondered how your ears work? In this delightful and fascinating talk, biophysicist Jim Hudspeth demonstrates the wonderfully simple yet astonishingly powerful mechanics of hair cells, the microscopic powerhouses that make hearing possible -- and explains how, when it's really quiet, your ears will begin to beam out a spectrum of sounds unique to you. Full Article Higher Education
my An ethical plan for ending the pandemic and restarting the economy | Danielle Allen By feedproxy.google.com Published On :: Tue, 07 Apr 2020 15:04:19 +0000 As COVID-19 continues to spread, the world is facing two existential threats at once: a public health emergency and an economic crisis. Political theorist Danielle Allen describes how we can ethically and democratically address both problems by scaling up "smart testing," which would track positive cases with peer-to-peer software on people's cell phones -- so we can end the pandemic and get back to work. (This virtual conversation is part of the TED Connects series, hosted by head of TED Chris Anderson and business curator Corey Hajim. Recorded April 6, 2020) Full Article Higher Education
my What coronavirus means for the global economy | Ray Dalio By feedproxy.google.com Published On :: Thu, 09 Apr 2020 15:05:51 +0000 "I'm a capitalist. I believe in the system. I believe you can increase the size of the pie and you could divide it well," says Ray Dalio, founder of Bridgewater Associates. He offers wide-ranging insight and advice on how we might recover from the global economic fallout of the coronavirus crisis -- and use it as an opportunity to reform the systems that help grow our economy. (This virtual conversation is part of the TED Connects series, hosted by head of TED Chris Anderson and business curator Corey Hajim. Recorded April 8, 2020) Full Article Higher Education
my Trump pushes economy reopening, says virus could kill 100K By feedproxy.google.com Published On :: 2020-05-04T14:04:11-04:00 Full Article Education
my Trump pushes economy reopening, says virus could kill 100K By feedproxy.google.com Published On :: 2020-05-04T15:09:16-04:00 Full Article Education
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