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Natural nutrition for plants

How about getting plants to produce some of the nutrition they need?




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Home-grown solutions to life’s little problems

Subashree has proved a home garden is all it takes to have good health, good looks and a good life




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The ABC of soil disinfection

Plants dying mysteriously in your kitchen garden? It could be root disease, says Hema Vijay




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A passion bearing fruit

Sreekumar Menon’s tropical fruit garden has some of the most exotic varieties from diverse countries




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The bite of the scorpion

Shantini Rajkumar has some hot news about a new discovery she made




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Time to lift restrictions on planting sandalwood?

Hema Vijay writes on the benefits of growing this fragrant tree at home




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Microencapsulation of broccoli sulforaphane using whey and pea protein: in vitro dynamic gastrointestinal digestion and intestinal absorption by Caco-2-HT29-MTX-E12 cells

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO03446E, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Ali Ali Redha, Luciana Torquati, John R. Bows, Michael J. Gidley, Daniel Cozzolino
Sulforaphane-rich extract was prepared from broccoli. The extract was encapsulated with whey and pea protein isolates by freeze-drying. The products were characterised and assessed for in vitro bioaccessibility and bioavailability.
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Along the gut-bone marrow signaling pathway: use of longan polysaccharides to regenerate blood cells after chemotherapy-induced myelosuppression

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO03758H, Paper
Shiai Zeng, Lan Gao, Kai Wang, Xuwei Liu, Zhuoyan Hu, Lei Zhao
TLPL promoted the production of Lactobacillus in myelosuppressed mice, and promoted the haematopoiesis of bone marrow cells via the gut-bone marrow axis.
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Abnormal enterohepatic circulation of bile acids caused by fructooligosaccharide supplementation along with a high-fat diet

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO03353A, Paper
Fang Zeng, Shi He, Ying Sun, Xue Li, Kaiyang Chen, Hongbin Wang, Shuli Man, Fuping Lu
Fructooligosaccharide (FOS) is a widely used prebiotic and health food ingredient, but few reports have focused on its risk to specific populations.
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Shatianyu (Citrus grandis L. Osbeck) whole fruit alleviated loperamide-induced constipation via enhancing gut microbiota-mediated intestinal serotonin secretion and mucosal barrier homeostasis

Food Funct., 2024, 15,10614-10627
DOI: 10.1039/D4FO02765E, Paper
Mei Deng, Jiamin Ye, Ruifen Zhang, Shuai Zhang, Lihong Dong, Dongxiao Su, Mingwei Zhang, Fei Huang
The effects of Citrus grandis Shatianyu whole fruit powder enriched in flavonoids and dietary fiber on loperamide-induced constipation after a 4-week administration in the diet, together with possible microbiota-mediated mechanisms were explored.
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Rice bran supplement ameliorates chronic restraint stress-induced depression-like behaviors in mice

Food Funct., 2024, 15,10600-10613
DOI: 10.1039/D4FO00718B, Paper
Minji Kim, Minseok Yoon, Suengmok Cho, Min Jung Kim, Min Young Um
RBS alleviates chronic stress-induced depressive-like behaviors by modulating the HPA axis, increasing neurotransmitter levels, downregulating GR, and enhancing ERK-CREB-BDNF signaling. γ-Oryzanol, a major component, acts as a GR antagonist, contributing to RBS's antidepressant effects.
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Multi-omics analysis reveals that agaro-oligosaccharides with different degrees of polymerization alleviate colitis in mice by regulating intestinal flora and arginine synthesis

Food Funct., 2024, 15,10628-10643
DOI: 10.1039/D4FO03650F, Paper
Long Yuan, Chunhui Liu, Bolun Li, Sai Wang, Jianan Sun, Xiangzhao Mao
Inflammatory bowel disease (IBD) is a common chronic disease with a complex etiology, characterized by body weight loss, intestinal barrier damage, and an imbalance of intestinal flora, posing a significant threat to people's health.
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The influence of magnesium and manganese cations on the chemical and bioactive properties of purple and green basil

Food Funct., 2024, 15,10644-10662
DOI: 10.1039/D4FO02820A, Paper
Izamara de Oliveira, Antonios Chrysargyris, Tiane C. Finimundy, Márcio Carocho, Celestino Santos-Buelga, Ricardo C. Calhelha, Nikolaos Tzortzakis, Lillian Barros, Sandrina A. Heleno
Effects of hydroponic cultivation with enriched concentrations of magnesium (+Mg), manganese (+Mn), combinations of +Mg and +Mn, or decreased concentrations of these minerals (control) on the chemical/bioactive attributes of basil, were investigated.
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Impact of complementary feeding on infant gut microbiome, metabolites and early development

Food Funct., 2024, 15,10663-10678
DOI: 10.1039/D4FO03948C, Paper
Open Access
Yudong Shi, Ran Yin, Jinzhu Pang, Yun Chen, Zhouyong Li, Shengpeng Su, Yongping Wen
Introducing complementary foods is critical for promoting infant health and development.
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Enhancement of the flavor and functional characteristics of cod protein isolate using an enzyme–microbe system

Food Funct., 2024, 15,10717-10731
DOI: 10.1039/D4FO02272F, Paper
Zheng-Fei Yan, Jia-Yu Chen, Jing Yang, Shuai Yuan, Xue-Yi Qiao, Bo Xu, Ling-Qia Su
Cod protein isolate was first debittered using Streptomyces canus aminopeptidase (ScAPase) and then deodorized through probiotic fermentation, showing the most substantial. These products showed the most substantial proliferation effect on probiotics.
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Immune-enhancing effect of Weizmannia coagulans BCG44 and its supernatant on cyclophosphamide-induced immunosuppressed mice and RAW264.7 cells via the modulation of the gut microbiota

Food Funct., 2024, 15,10679-10697
DOI: 10.1039/D4FO02452D, Paper
Open Access
Yafang Xu, Yi Wang, Tao Song, Xiaxia Li, Haolin Zhou, Oumarou Zafir Chaibou, Bing Wang, Huajun Li
W. coagulans BCG44 and its supernatant possess potential immunomodulatory activity and modulate gut microbiota dysbiosis in CTX-induced immunosuppression.
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Biological effects and mechanisms of dietary chalcones: latest research progress, future research strategies, and challenges

Food Funct., 2024, 15,10582-10599
DOI: 10.1039/D4FO03618B, Review Article
Yun Liang Zhang, Shuang Jiao Sun, Li Zeng
Chalcones are widely distributed in food and have multiple biological activities; there are limitations and drawbacks in the application of dietary chalcones in food; future research strategies and key issues for dietary chalcones.
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Effects of Clostridium butyricum and inulin supplementation on intestinal microbial composition in high-fat diet fed mice

Food Funct., 2024, 15,10870-10884
DOI: 10.1039/D4FO02963A, Paper
Jing Liu, Suhua Zhang, Huachun Weng
Clostridium butyricum and inulin could improve dislipidemia, abnormal glucose tolerance and change intestinal microbial composition in high-fat diet (HFD) mice, increasing Parabacteroides, Bacteroides and Ruminococcaceae and regulating FGF21.
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Acute supplementation with a curcuminoid-based formulation fails to enhance resting or exercise-induced NRF2 activity in males and females

Food Funct., 2024, 15,10782-10794
DOI: 10.1039/D4FO02681K, Paper
Open Access
Josh Thorley, Abrar Alhebshi, Ana Rodriguez-Mateos, Zicheng Zhang, Stephen J. Bailey, Neil R. W. Martin, Nicolette C. Bishop, Tom Clifford
Supplementation with a curcuminoid-based formulation for four days did not augment nuclear factor erythroid 2-related factor 2 (NRF2) activity in peripheral blood mononuclear cells at rest and after strenuous plyometric exercise.
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Oral delivery of electrohydrodynamically encapsulated Lactiplantibacillus plantarum CRD7 modulates gut health, antioxidant activity, and cytokines-related inflammation and immunity in mice

Food Funct., 2024, 15,10761-10781
DOI: 10.1039/D4FO02732A, Paper
Vinay Venkatesh Varada, Sachin Kumar, Sravani Balaga, Antony Johnson Thanippilly, Heartwin A. Pushpadass, Rashmi H. M., Babu Lal Jangir, Nitin Tyagi, Ashish Kumar Samanta
The current study aimed to evaluate the effects of L. plantarum CRD7 on performance and gut health biomarkers in a Swiss albino mouse model.
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Novel selenium-enriched Pichia kudriavzevii as a dietary supplement to alleviate dextran sulfate sodium-induced colitis in mice by modulating the gut microbiota and host metabolism

Food Funct., 2024, 15,10698-10716
DOI: 10.1039/D4FO02598A, Paper
Huijuan Wang, Yue Chen, Zhouli Wang, Yahong Yuan, Tianli Yue
Inflammatory bowel disease (IBD) poses persistent challenges due to its chronic and recurrent nature, exacerbated by the unsatisfactory outcomes of the traditional treatment approaches.
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Human breast milk-derived phospholipid DOPE ameliorates intestinal injury associated with NEC by inhibiting ferroptosis

Food Funct., 2024, 15,10811-10822
DOI: 10.1039/D4FO03904A, Paper
Yanjie Chen, Wenjuan Chen, Yu Dai, Xiangyun Yan, Chengyao Jiang, Fan Zhang, Min Zhang, Xiaoshan Hu, Juyi Zhao, Tingyue Wu, Shushu Li, Shuping Han, Xiaohui Chen
Human breast milk-derived dioleoyl phosphatidylethanolamine (DOPE) mitigates intestinal dysfunction in Necrotizing Enterocolitis (NEC) through the suppression of ferroptosis.
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Correction: A comparative study of the hypolipidemic effects and mechanisms of action of Laminaria japonica- and Ascophyllum nodosum-derived fucoidans in apolipoprotein E-deficient mice

Food Funct., 2024, 15,10913-10914
DOI: 10.1039/D4FO90102A, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Tian Liu, Xue Wang, Yan-Ming Wang, Feng-Rong Sui, Xue-Ying Zhang, Hai-Di Liu, Dong-Yue Ma, Xiao-Xiao Liu, Shou-Dong Guo
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Lacticaseibacillus paracasei 207-27 alters the microbiota–gut–brain axis to improve wearable device-measured sleep duration in healthy adults: a randomized, double-blind, placebo-controlled trial

Food Funct., 2024, 15,10732-10745
DOI: 10.1039/D4FO01684J, Paper
Open Access
Jinxing Li, Jincheng Zhao, Xiaolei Ze, Liang Li, Yapeng Li, Zhimo Zhou, Simou Wu, Wen Jia, Meixun Liu, Yun Li, Xi Shen, Fang He, Ruyue Cheng
Probiotics have been reported to exert beneficial effects on sleep through the gut–brain axis.
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Unravelling the potential of yolkin for nutraceutical use: the origin, structure, and functional insights of a hen egg yolk polypeptide complex

Food Funct., 2024, 15,10746-10760
DOI: 10.1039/D4FO03023K, Paper
Open Access
Aleksandra Zambrowicz, Katarzyna Kapczyńska, Paweł Kania, Jakub Stanisław Nowak, Marta Kaszowska, Katarzyna Szymczak-Kulus, Wioletta Kazana-Płuszka, Marta Piksa, Sabina Górska, Dominika Jakubczyk, Józefa Macała, Agnieszka Zabłocka
The nutraceutical potential of yolkin health benefits from hen egg yolk.
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Antigenotoxic and cosmetic potential of elderberry (Sambucus nigra) extract: protection against oxidative DNA damage

Food Funct., 2024, 15,10795-10810
DOI: 10.1039/D4FO03217A, Paper
Sara Gonçalves, Francisco Peixoto, Tayse F. F. da Silveria, Lillian Barros, Isabel Gaivão
The integrity of the genome is under constant threat from both endogenous and exogenous factors that induce oxidative stress and accelerate ageing.
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Relationships of dietary habits with prostate cancer risk: results from Mendelian randomization analyses and the National Health and Nutrition Examination Survey

Food Funct., 2024, 15,10823-10837
DOI: 10.1039/D4FO03859B, Paper
Zhen Zhou, Jin Xu, Yang Zhao, Yuanjie Niu
Prior investigations identified correlations between dietary habits and the risk of prostate cancer (PCa); however, the causative dynamics are unclear.
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Dietary supplementation with novel selenium-enriched Pichia kudriavzevii regulates gut microbiota and host metabolism in mice

Food Funct., 2024, 15,10896-10912
DOI: 10.1039/D4FO03633F, Paper
Huijuan Wang, Dan Shi, Yue Chen, Zhouli Wang, Yahong Yuan, Tianli Yue
Insufficient selenium intake can lead to serious health problems.
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Exploring the potential of sorghum with reference to its bioactivite, physicochemical properties and potential health benefits

Food Funct., 2024, Accepted Manuscript
DOI: 10.1039/D4FO04128C, Review Article
Sakshi Singh, Mehvish Habib, David J McClements, Khalid Bashir, Shumaila Jan, Kulsum Jan
Sorghum is a resilient and adaptable cereal grain recognized for its rich nutritional profile. It is a valuable source of dietary fiber (around 6%), protein (9-13%), and essential minerals such...
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Dietary Lactobacillus johnsonii-derived extracellular vesicles ameliorate acute colitis by regulating gut microbiota and maintaining intestinal barrier homeostasis

Food Funct., 2024, Accepted Manuscript
DOI: 10.1039/D4FO04194A, Paper
Zhiguo Li, Mengyu Li, Xuexun Fang, Dahai Yu, Xin Hu
Inflammatory bowel disease (IBD) is a chronic gastrointestinal disease with intricate pathogenesis, and clinical treatment is still not ideal. The imbalance of gut microbiota is associated with IBD progression. Various...
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Inhibitory effect of tea flower polysaccharides on oxidative stress and microglial oxidative damage in aging mice by regulating gut microbiota

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO03484H, Paper
Yidan Cai, Siyu Liu, Xing Ge, Lu Cheng, Xin Zhang
Tea flower polysaccharides (TFPS) can improve the disorder of gut microbiota, alleviate oxidative damage to glial cells, alleviate neuroinflammation, and play a role in delaying aging.
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Summer–autumn tea promotes adipocyte browning and thermogenesis in association with gut microbiota regulation in high-fat diet-fed mice

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO03826F, Paper
Chengcheng Yang, Luyao Liu, Yao Du, Lu Zhao, Lu Liu, Xingbin Yang, Yan Zhao
This study revealed for the first time the anti-obesity effect of summer–autumn tea aqueous extract (SATE) and its underlying mechanism.
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Gastroprotective effects of Pediococcus acidilactici GKA4 and Lactobacillus brevis GKL93 against ethanol-induced gastric ulcers via regulation of the immune response and gut microbiota in mice

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO04106B, Paper
Yun-En Huang, Sheng-Yi Chen, Tsung-Ju Li, You-Shan Tsai, Chin-Chu Chen, Gow-Chin Yen
Pediococcus acidilactici GKA4 and Lactobacillus brevis GKL93 exert gastroprotective effects against ethanol-induced gastric ulcers through multiple mechanisms.
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In vivo mechanism of interaction between trimethylamine lyase expresssion and glycolytic pathways

Food Funct., 2024, Accepted Manuscript
DOI: 10.1039/D4FO03809F, Paper
Qian Li, Di Wu, Yu Song, Lu Zhang, Ting Wang, Min Zhang
Recent findings have confirmed that the interaction between host and gut microbiota can alter the formation of the disease-associated metabolite, trimethylamine (TMA), via intestinal microbial TMA lyase. Nevertheless, little is...
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Anti-obesity and other health benefits of bioprocessed black rice bran in combination with green tea extract in 3T3-L1 preadipocyte cells and in mice on a high-fat diet

Food Funct., 2024, Accepted Manuscript
DOI: 10.1039/D4FO03210A, Paper
Ki Sun Kwon, Eun Seok Lee, Kyung Hee Lee, Woon Sang Hwang, Wha Young Lee, Jae Jung Kim, Jeanman Kim, Sang-Jong Lee, Sung Phil Kim, Mendel Friedman
Black rice bran, a waste product from the commercial milling of black rice that removes the bran and germ and leaves the starchy endosperm, contains bioactive anthocyanin, phenolic, and phytosteroid...
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Interaction of oat bran and exercise training improved exercise adaptability via alleviating oxidative stress and promoting energy homeostasis

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO03374D, Paper
Rui Dong, Hamad Rafique, Qianwen Niu, Xin Zeng, Maria Cristina Messia, Li Yuan, Lin Shi, Liang Zou, Lu Li, Xinzhong Hu
Interaction of oat bran (OB) diet and moderate intensity exercise training (MlET) reinforced the positive effect on skeletal muscle function.
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Correlation between vitamin D metabolic pathway-related gene polymorphisms and cardiovascular disease

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO03234A, Review Article
Jiao Pang, Chunshuo Yang, Jiaqi Liu, Zhilin Wang, Xueshu Tao, Zhipeng Cao
Polymorphisms in key genes in the vitamin D metabolic pathway affect susceptibility to cardiovascular disease (CVD) and play potential roles in the pathogenesis of CVD.
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Review on mechanisms of hypoglycemic effects of compounds from highland barley and potential applications

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO00940A, Review Article
Yanan Liu, Yuanqiang Jia, Yingying Wu, Huijuan Zhang, Feiyue Ren, Sumei Zhou
The value and mechanism of highland barley in the prevention of diabetes and its application in food products.
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Polyphenols for stroke therapy: the role of oxidative stress regulation

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO01900H, Review Article
Yusong Luo, Ruolan Liu, Guoqiang Yuan, Yawen Pan
Molecular mechanisms of the antioxidant effects of polyphenols in stroke.
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Investigating serum concentration profiles of orally ingested short-chain fatty acid supplements

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO04028G, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Christopher G. Green, Marilyn L. Y. Ong, Samantha N. Rowland, Tindaro Bongiovanni, Lewis J. James, Tom Clifford, Stephen J. Bailey, Liam M. Heaney
HPMC capsules containing acetate, propionate, and butyrate salts exhibit peak serum concentrations of each short-chain fatty acid within 60 min and a return to baseline within 120 min. Seven days of repeated intake does not alter basal serum levels.
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Preparation and characterization of white shrimp hydrolysate-xylooligosaccharides Maillard products and their in vivo promotive effects of zinc absorption in mice

Food Funct., 2024, Accepted Manuscript
DOI: 10.1039/D4FO03709J, Paper
Shijie Dou, Xuening Yu, Yuewen Xu, Xiaoyang Liu, Fawen Yin, Deyang Li, Da-Yong Zhou
The Maillard reaction products, as a kind of glycosylation-based reaction, possess the metal-chelating ability. In this study, the white shrimp hydrolysate (WH) and xylooligosaccharides (XOS) were used to prepare the...
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Characterisation and quantification of phenolic, anthocyanidin and terpene species in plant foods and plant food-based complementary products with antioxidant and neuroprotective properties

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO02942A, Paper
Naomi May, Jiahua Shi, Helen Clunas, Julianna Lys de Sousa Alves Neri, Celine Kelso, Jody Morgan, Yinghua Yu, Karen Charlton, Katrina Weston-Green
Phytochemicals, including phenolic compounds and terpenes, are of interest for the treatment and prevention of conditions with oxidative stress, inflammatory and neurodegenerative pathologies.
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Brassica rapa L. crude polysaccharide meditated synbiotic fermented whey beverage ameliorates hypobaric and hypoxia induced intestinal damage

Food Funct., 2024, Accepted Manuscript
DOI: 10.1039/D4FO04667F, Paper
Yuanlin Niu, Tingting Zhao, Zhenjiang Liu, Diantong Li, Dongxu Wen, Bin Li, Xiaodan Huang
Hypobaric hypoxia causes oxidative stress and inflammatory responses and disrupts the gut microbiome and metabolome. In this study, we developed a synbiotic fermented whey beverage, combining kefir and Brassica rapa...
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Bioactive compounds regulate appetite through the melanocortin system: a review

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO04024D, Review Article
Yujia Niu, Wancong Yu, Xiaohong Kou, Shuqi Wu, Mengyi Liu, Chenlong Chen, Jiaxin Ji, Ying Shao, Zhaohui Xue
The melanocortin system is regulated by long-term and short-term regulatory hormones and nutrients. Bioactive compounds influence appetite through multiple pathways: central nervous system, peripheral hormones, and intestinal microbiota.
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A probiotic multi-strain mixture combined with hydroxyectoine improves intestinal barrier function by alleviating inflammation in lipopolysaccharide stimulated differentiated Caco-2 cells

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO03130J, Paper
Azza Dabous, Antonietta Stellavato, Donatella Cimini, Valentina Vassallo, Maria D'Agostino, Chiara Schiraldi
Freeze-dried formula containing three probiotic strains and hydroxyectoine reduces LPS-induced inflammation in Caco-2 cells, assessed via RT-PCR, western blot, ELISA, and immunofluorescence for tight junction integrity.
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Goat milk derived small extracellular vesicles ameliorate LPS-induced intestinal epithelial barrier dysfunction, oxidative stress, and apoptosis by inhibiting the MAPK signaling pathway

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO04067H, Paper
Feng Gao, Xin Zhang, Zhiming Xu, Kang Zhang, Fusheng Quan
Intestinal injury is often accompanied by epithelial barrier dysfunction, oxidative stress, and apoptosis.
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Selenium-mediated alleviation of skeletal muscle atrophy through enterotype modulation in mice

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO03889D, Paper
Yixin Cheng, Xiaofan Liu, Yingao Hao, Shixu Wang, FangFang Wu, Lingzhuo Zhao, Du Peng, Du Yawen, Sun Sheng, Li Jianguo, Guangxu Ren
Selenium element improves dexamethasone-induced skeletal muscle atrophy by affecting enterotype.
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Impact of pH on the fabrication of egg white reinforced soy protein composite microgels for gastrointestinal delivery purposes

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO03997A, Paper
Feng Liu, Yi Liu, Suyun Zhang, Gang Liu, Christos Ritzoulis, Yue Zhang
Protein molecules such as soy protein isolate (SPI) and egg white (EW) are highly promising materials for developing hydrogels (especially micro/nanogels) for the encapsulation, protection and controlled release of bioactive substances.
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Investigation of the hypoglycemic bioactive components of Phyllanthi Fructus through biological assessment combined with ultrafiltration affinity mass spectrometry

Food Funct., 2024, Accepted Manuscript
DOI: 10.1039/D4FO04198D, Paper
Yifan Zhang, Qiang Yu, Peng Tan, Shimin Tian, Jun-zhi Lin, Mengqi Li, Li Han, Haozhou Huang, Ding-kun Zhang
Phyllanthi Fructus (PF) is a tropical fruit with the potential to effectively reduce postprandial blood glucose, making it highly promising for the development of functional foods. However, the lack of...
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Galacto-oligosaccharides regulates intestinal mucosal sialylation to counteract antibiotic-induced mucin dysbiosis

Food Funct., 2024, Accepted Manuscript
DOI: 10.1039/D4FO04626A, Paper
Laipeng Xu, Xuan Li, Shuibing Han, Chunlong Mu, Wei-Yun Zhu
Intestinal mucin offers a physical barrier to maintain host-commensal homeostasis. Glycosylation is essential for appropriate function of mucin. Galacto-oligosaccharides (GOS) have been used as a prebiotic with proved intestinal benefits,...
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