The project will support increased contributions of clean energy in Mongolia's energy mix while also supporting energy security, efficiency, and resilience. The project will finance the construction of a new 220 kilovolt (kV) transmission line to connect to the 90-megawatt (MW) Erdeneburen hydropower plant (HPP) to the existing grid network, which will increase supply in the Western Energy System (WES), eliminate costly and high-emission imports from the Russian Federation, and facilitate maximized utilization of wind and solar generating capacity.

The TA is proposed to develop Bhutan's overall power dispatch options and strategies for domestic electricity consumption and international power trade. It will look into strategic views to maximize power export from various potential energy sources of hydropower, solar power, and wind power while meeting growing domestic electricity consumption.

The TA will provide implementation support to a series of ongoing and ensuing projects. It's objective will be to strengthen the quality of implementation of ongoing projects. The focus will be on procurement, contract management, DPP/TAPP approvals, project design and management.

The Sustainable Urban Transport Project aims to support Perum DAMRI (DAMRI), the state-owned bus operator, in replacing its aging fleet of internal combustion engine (ICE) buses with battery electric buses (BEBs), and in improving the quality and resilience of its public transport facilities and services. The project is aligned with the following impact: Acceleration of electric vehicle deployment to increase energy conservation in the transportation sector, improve air quality, and reduce greenhouse gas emissions (Presidential Regulation No.

Horses experience hyperflexion, or rollkur, when their necks bend far towards their chests – it could place the animal at a greater risk of physical discomfort and stress

From artificial retinas to ageing mice, here are five of the most promising results from research performed on the ISS – and what they might mean for humans on Earth and in space

We instinctively know that relaxing feels good, but we are now figuring out what it does to the brain and uncovering the best ways to unwind to maximise its benefits

Peaks in appetite and metabolism driven by our body's inbuilt clocks mean that eating at the wrong time can have consequences for our health and waistline

An independent task force formed by NASA to look into unidentified anomalous phenomena found no evidence of alien craft, and suggests that if we want to find proof of visitors we need better data

Peaks in appetite and metabolism driven by our body's inbuilt clocks mean that eating at the wrong time can have consequences for our health and waistline

Feedback is intrigued by new research into how major sports tournaments "were associated with increases in the number of babies born" nine months later - but only for supporters of the winning teams

Title: 6 Deaths Reported From Diabetes Drug Byetta
Category: Health News
Created: 8/28/2008 12:00:00 AM
Last Editorial Review: 8/28/2008 12:00:00 AM

Title: Tobacco Use Kills 6 Million People Annually: Report
Category: Health News
Created: 8/25/2009 4:10:00 PM
Last Editorial Review: 8/26/2009 12:00:00 AM

Title: Report: Vaccines Generally Safe, Cause Few Health Problems
Category: Health News
Created: 8/26/2011 11:01:00 AM
Last Editorial Review: 8/26/2011 12:00:00 AM

Title: Report: 164 Million Obese Adults by 2030
Category: Health News
Created: 8/26/2011 11:00:00 AM
Last Editorial Review: 8/26/2011 12:00:00 AM

Title: New Policy Supports Choice for Male Circumcision
Category: Health News
Created: 8/27/2012 11:00:00 AM
Last Editorial Review: 8/27/2012 12:00:00 AM

Title: Little Evidence on Value of Treatments for Autism: Report
Category: Health News
Created: 8/28/2012 10:05:00 AM
Last Editorial Review: 8/28/2012 12:00:00 AM

Title: Not Enough Data to Support Kidney Disease Screening, Task Force Says
Category: Health News
Created: 8/27/2012 6:05:00 PM
Last Editorial Review: 8/28/2012 12:00:00 AM

Title: Most Medications OK During Breast-Feeding, Report Says
Category: Health News
Created: 8/26/2013 9:35:00 AM
Last Editorial Review: 8/26/2013 12:00:00 AM

Title: Fewer U.S. Kids Buying Tobacco Products: Report
Category: Health News
Created: 8/27/2013 4:36:00 PM
Last Editorial Review: 8/28/2013 12:00:00 AM

Title: Hundreds of Thousands of Teens Use Pot, Alcohol Each Day: Report
Category: Health News
Created: 8/29/2013 2:36:00 PM
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Title: What Parents Need to Know About Sports Participation
Category: Health News
Created: 8/24/2014 9:35:00 AM
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Title: Excessive Sports Training Hurts Kids, Expert Warns
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Title: Five Local Zika Cases Reported in Miami Beach
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Last Editorial Review: 8/22/2016 12:00:00 AM

Title: Survey Finds Support for Limits on Indoor Tanning
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Last Editorial Review: 8/22/2016 12:00:00 AM

Title: Five More Cases of Local Zika Infection Reported in Florida
Category: Health News
Created: 8/24/2016 12:00:00 AM
Last Editorial Review: 8/24/2016 12:00:00 AM

Title: New Case of Local Zika Infection Reported in Florida
Category: Health News
Created: 8/25/2016 12:00:00 AM
Last Editorial Review: 8/26/2016 12:00:00 AM

Title: Obamacare Enrollee Numbers Aren't Falling: Report
Category: Health News
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Title: First Death Tied to Lung Injury From Vaping Reported in Illinois
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Title: Every Sudden Infant Death Deserves a Closer Look: Report
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Title: Confirmed Case of Coronavirus Reinfection Reported
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Created: 8/25/2020 12:00:00 AM
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Title: Olympian Usain Bolt Reported to Have COVID-19
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Title: Hospitals Must Report COVID-19 Data or Be Penalized
Category: Health News
Created: 8/28/2020 12:00:00 AM
Last Editorial Review: 8/28/2020 12:00:00 AM

Title: Parents' Poll Finds Strong Support for Vaccination of Students, Teachers
Category: Health News
Created: 8/23/2021 12:00:00 AM
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Title: AHA News: Native People Find Support, 'Sacred Space' Through This Nonprofit's Work
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Created: 8/23/2021 12:00:00 AM
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Title: One Activity Causes 4 Out of 5 Sports-Linked Spinal Injuries
Category: Health News
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Last Editorial Review: 8/25/2021 12:00:00 AM

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Category: Health News
Created: 8/26/2021 12:00:00 AM
Last Editorial Review: 8/26/2021 12:00:00 AM

Title: Half of American Workers Support COVID Vaccination, Mask Mandates in Workplace
Category: Health News
Created: 8/27/2021 12:00:00 AM
Last Editorial Review: 8/27/2021 12:00:00 AM

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Category: Health News
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Title: New Reports on Polio: How Worried Should We Be?
Category: Health News
Created: 8/15/2022 12:00:00 AM
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Title: Get Moving! Any Sports Can Lower Seniors' Odds of Early Death
Category: Health News
Created: 8/25/2022 12:00:00 AM
Last Editorial Review: 8/26/2022 12:00:00 AM

Most studies of genome organization have focused on intrachromosomal (cis) contacts because they harbor key features such as DNA loops and topologically associating domains. Interchromosomal (trans) contacts have received much less attention, and tools for interrogating potential biologically relevant trans structures are lacking. Here, we develop a computational framework that uses Hi-C data to identify sets of loci that jointly interact in trans. This method, trans-C, initiates probabilistic random walks with restarts from a set of seed loci to traverse an input Hi-C contact network, thereby identifying sets of trans-contacting loci. We validate trans-C in three increasingly complex models of established trans contacts: the Plasmodium falciparum var genes, the mouse olfactory receptor "Greek islands," and the human RBM20 cardiac splicing factory. We then apply trans-C to systematically test the hypothesis that genes coregulated by the same trans-acting element (i.e., a transcription or splicing factor) colocalize in three dimensions to form "RNA factories" that maximize the efficiency and accuracy of RNA biogenesis. We find that many loci with multiple binding sites of the same DNA-binding proteins interact with one another in trans, especially those bound by factors with intrinsically disordered domains. Similarly, clustered binding of a subset of RNA-binding proteins correlates with trans interaction of the encoding loci. We observe that these trans-interacting loci are close to nuclear speckles. These findings support the existence of trans-interacting chromatin domains (TIDs) driven by RNA biogenesis. Trans-C provides an efficient computational framework for studying these and other types of trans interactions, empowering studies of a poorly understood aspect of genome architecture.

Background:

Continuous glucose monitoring (CGM) for patients with type 1 and type 2 diabetes is associated with improved clinical, behavioral, and psychosocial patient health outcomes and is part of the American Diabetes Association’s Standards of Medical Care. CGM prescription often takes place in endocrinology practices, yet 50% of adults with type 1 diabetes and 90% of all people with type 2 diabetes receive their diabetes care in primary care settings. This study examined primary care clinicians’ perceptions of barriers and resources needed to support CGM use in primary care.

Massively parallel reporter assays (MPRAs) are powerful tools for quantifying the impacts of sequence variation on gene expression. Reading out molecular phenotypes with sequencing enables interrogating the impact of sequence variation beyond genome scale. Machine learning models integrate and codify information learned from MPRAs and enable generalization by predicting sequences outside the training data set. Models can provide a quantitative understanding of cis-regulatory codes controlling gene expression, enable variant stratification, and guide the design of synthetic regulatory elements for applications from synthetic biology to mRNA and gene therapy. This review focuses on cis-regulatory MPRAs, particularly those that interrogate cotranscriptional and post-transcriptional processes: alternative splicing, cleavage and polyadenylation, translation, and mRNA decay.

Internal ribosomal entry sites (IRESs) recruit the ribosome to promote translation, typically in an m7G cap-independent manner. Although IRESs are well-documented in viral genomes, they have also been reported in mammalian transcriptomes, where they have been proposed to mediate cap-independent translation of mRNAs. However, subsequent studies have challenged the idea of these "cellular" IRESs. Current methods for screening and discovering IRES activity rely on a bicistronic reporter assay, which is prone to producing false positive signals if the putative IRES sequence has a cryptic promoter or cryptic splicing sites. Here, we report an assay for screening IRES activity using a genetically encoded circular RNA comprising a split nanoluciferase (nLuc) reporter. The circular split nLuc reporter is less susceptible to the various sources of false positives that adversely affect the bicistronic IRES reporter assay and provides a streamlined method for screening IRES activity. Using the circular split nLuc reporter, we find that nine reported cellular IRESs have minimal IRES activity. Overall, the circular split nLuc reporter offers a simplified approach for identifying and validating IRESs and exhibits reduced propensity for producing the types of false positives that can occur with the bicistronic reporter assay.