Watch a new series charting our planet from above, read all about the biggest living things, fend off space rocks for fun, plus more picks for your diary

An analysis of the topics that cause arguments between newly-wed heterosexual couples puts a lack of affection at the top of the list, with little concern about who sleeps on which side of the bed

Reuters blogger Felix Salmon takes to kids’ toys to explain one of the most vexing problems facing Washington: the fiscal cliff. (December 12, 2012)

A young boy chooses a nurse as the superhero he wants to play with over Batman and Spiderman in a new artwork by Banksy that encapsulates the gratitude Britons have felt toward the country's National Health Service during the coronavirus crisis.

When asteroid Armageddon is upon us, we can't just call Bruce Willis. Meet the people who really do watch the skies – and make detailed plans for our survival

Senate Democratic Leader Chuck Schumer on Thursday said it was 'dangerous' for the Trump administration to pressure states and businesses to 'reopen without a plan for a dramatic increase in testing'.

A young boy chooses a nurse as the superhero he wants to play with over Batman and Spiderman in a new artwork by Banksy that encapsulates the gratitude Britons have felt toward the country's National Health Service during the coronavirus crisis.

A bunch of asteroids near Jupiter and Neptune with orbits perpendicular to the plane of the solar system may have come here from a different star system

Stars that are similar to the sun in every way we can measure are mostly more active than the sun, which hints that the sun’s activity may ramp up someday, risking solar eruptions

Senate Democratic Leader Chuck Schumer on Thursday said it was 'dangerous' for the Trump administration to pressure states and businesses to 'reopen without a plan for a dramatic increase in testing'.

Title: How Dangerous Is Bariatric Surgery?
Category: Procedures and Tests
Created: 3/18/2020 12:00:00 AM
Last Editorial Review: 3/18/2020 12:00:00 AM

Title: Thyroid Peroxidase Test
Category: Procedures and Tests
Created: 11/18/2001 12:00:00 AM
Last Editorial Review: 11/13/2019 12:00:00 AM

Title: Is Thyroid Hormone Dangerously Overprescribed in Older Patients?
Category: Health News
Created: 4/1/2020 12:00:00 AM
Last Editorial Review: 4/2/2020 12:00:00 AM

Title: Health Tip: Help Prevent Atherosclerosis
Category: Health News
Created: 4/23/2010 10:10:00 AM
Last Editorial Review: 4/26/2010 12:00:00 AM

Title: Steroids Could Harm Heart's Pumping Ability
Category: Health News
Created: 4/27/2010 4:10:00 PM
Last Editorial Review: 4/28/2010 12:00:00 AM

Title: Sunlight May Play Role in Multiple Sclerosis Risk
Category: Health News
Created: 4/29/2010 8:10:00 PM
Last Editorial Review: 4/30/2010 12:00:00 AM

Title: Watch Your Cholesterol, Your Blood Pressure ... and This Enzyme?
Category: Health News
Created: 4/29/2010 8:10:00 PM
Last Editorial Review: 4/30/2010 12:00:00 AM

Title: Low Testosterone Raises Heart Death Rates in Impotent Men
Category: Health News
Created: 4/29/2010 2:10:00 PM
Last Editorial Review: 4/30/2010 12:00:00 AM

Title: Extreme Obesity Linked to Dangerous Behaviors in Teens
Category: Health News
Created: 4/26/2011 1:55:00 PM
Last Editorial Review: 4/27/2011 12:00:00 AM

Title: Health Tip: Don't Forget Aerobic Exercise
Category: Health News
Created: 5/1/2012 8:05:00 AM
Last Editorial Review: 5/1/2012 12:00:00 AM

Title: Secondhand Smoke Tied to Lower 'Good' Cholesterol in Teen Girls
Category: Health News
Created: 4/30/2013 2:35:00 PM
Last Editorial Review: 5/1/2013 12:00:00 AM

Title: Pot-Booze Combo More Dangerous for Teen Drivers Than Alcohol Alone
Category: Health News
Created: 4/28/2014 9:35:00 AM
Last Editorial Review: 4/28/2014 12:00:00 AM

Title: Radiation May Equal Surgery, With Easier Recovery, for Cancerous Lymph Nodes
Category: Health News
Created: 4/30/2014 2:36:00 PM
Last Editorial Review: 5/1/2014 12:00:00 AM

Title: Health Tip: Batteries May Be Dangerous for Kids
Category: Health News
Created: 5/2/2014 7:35:00 AM
Last Editorial Review: 5/2/2014 12:00:00 AM

Title: New Drug Class Slashes 'Bad' Cholesterol, Review Finds
Category: Health News
Created: 4/27/2015 12:00:00 AM
Last Editorial Review: 4/28/2015 12:00:00 AM

Title: Heroin Use Surges Among Whites Who Abuse Prescription Painkillers
Category: Health News
Created: 4/30/2015 12:00:00 AM
Last Editorial Review: 5/1/2015 12:00:00 AM

Title: FDA Cracks Down on Dangerous E-Cig Liquids That Resemble Cookies, Candy
Category: Health News
Created: 5/1/2018 12:00:00 AM
Last Editorial Review: 5/2/2018 12:00:00 AM

Title: AHA News: A Father's Death at 37 Reveals a Hidden History of Cholesterol
Category: Health News
Created: 4/30/2019 12:00:00 AM
Last Editorial Review: 5/1/2019 12:00:00 AM

Title: For People With Autism, Encounters With Police Can Turn Dangerous
Category: Health News
Created: 5/3/2019 12:00:00 AM
Last Editorial Review: 5/3/2019 12:00:00 AM

Title: HIV Meds Cut Transmission Risk to Zero, Even Without Condoms: Study
Category: Health News
Created: 5/2/2019 12:00:00 AM
Last Editorial Review: 5/3/2019 12:00:00 AM

Bill Hanage describes the many uncertainties surrounding current data examining the prevalence of SARS-CoV-2.

Just as an imperfect ruler can measure accurately if its error is constant and known, serology need not have perfect sensitivity and specificity to estimate COVID's prevalence, write Drs Jha and Murthy.

Title: Americans' Cholesterol Levels Decline: Study
Category: Health News
Created: 11/12/2019 12:00:00 AM
Last Editorial Review: 11/13/2019 12:00:00 AM

Title: Especially in the Young, Cholesterol Is No Friend to the Heart
Category: Health News
Created: 12/4/2019 12:00:00 AM
Last Editorial Review: 12/4/2019 12:00:00 AM

Title: Health Tip: Should I Get a Cholesterol Test?
Category: Health News
Created: 12/10/2019 12:00:00 AM
Last Editorial Review: 12/10/2019 12:00:00 AM

Title: HDL vs. LDL Cholesterol (Good and Bad)
Category: Diseases and Conditions
Created: 7/14/2017 12:00:00 AM
Last Editorial Review: 12/11/2019 12:00:00 AM

Title: New Cholesterol Drug Approved by FDA
Category: Health News
Created: 2/24/2020 12:00:00 AM
Last Editorial Review: 2/24/2020 12:00:00 AM

Title: Fewer Americans Have High Cholesterol
Category: Health News
Created: 4/22/2020 12:00:00 AM
Last Editorial Review: 4/23/2020 12:00:00 AM

Title: Low Testosterone (Low-T)
Category: Diseases and Conditions
Created: 12/14/2009 12:00:00 AM
Last Editorial Review: 12/2/2019 12:00:00 AM

Title: Testosterone Supplements Won't Help Most Men, Doctors' Group Says
Category: Health News
Created: 1/6/2020 12:00:00 AM
Last Editorial Review: 1/7/2020 12:00:00 AM

Title: Prescription-Strength Steroid Creams Sold Over-the-Counter Can Be Dangerous
Category: Health News
Created: 1/23/2020 12:00:00 AM
Last Editorial Review: 1/24/2020 12:00:00 AM

Title: Taking Steroids for Rheumatoid Arthritis, IBD? Your Odds for Hypertension May Rise
Category: Health News
Created: 3/23/2020 12:00:00 AM
Last Editorial Review: 3/24/2020 12:00:00 AM

Title: Are Steroids Really the Answer for Arthritic Knees?
Category: Health News
Created: 4/8/2020 12:00:00 AM
Last Editorial Review: 4/9/2020 12:00:00 AM

Title: Blood Pressure Dips Upon Standing Might Not Be as Dangerous as Thought
Category: Health News
Created: 1/28/2020 12:00:00 AM
Last Editorial Review: 1/29/2020 12:00:00 AM

Title: How Dangerous Is General Anesthesia?
Category: Procedures and Tests
Created: 3/5/2020 12:00:00 AM
Last Editorial Review: 4/7/2020 12:00:00 AM

Title: High Testosterone Levels Have Different Health Impact for Men and Women
Category: Health News
Created: 2/10/2020 12:00:00 AM
Last Editorial Review: 2/11/2020 12:00:00 AM

Title: Avonex (interferon beta 1a injection)
Category: Medications
Created: 3/2/2005 12:00:00 AM
Last Editorial Review: 4/8/2020 12:00:00 AM

Title: Dangerously Hot Days for U.S. Farm Workers Could Double by 2050
Category: Health News
Created: 5/5/2020 12:00:00 AM
Last Editorial Review: 5/6/2020 12:00:00 AM

Many clinical studies and epidemiological investigations have clearly demonstrated that women are twice as likely to develop cholesterol gallstones as men, and oral contraceptives and other estrogen therapies dramatically increase that risk. Further, animal studies have revealed that estrogen promotes cholesterol gallstone formation through the estrogen receptor (ER) α, but not ERβ, pathway. More importantly, some genetic and pathophysiological studies have found that G protein-coupled estrogen receptor (GPER) 1 is a new gallstone gene, Lith18, on chromosome 5 in mice and produces additional lithogenic actions, working independently of ERα, to markedly increase cholelithogenesis in female mice. Based on computational modeling of GPER, a novel series of GPER-selective antagonists were designed, synthesized, and subsequently assessed for their therapeutic effects via calcium mobilization, cAMP, and ERα and ERβ fluorescence polarization binding assays. From this series of compounds, one new compound, 2-cyclohexyl-4-isopropyl-N-(4-methoxybenzyl)aniline (CIMBA), exhibits superior antagonism and selectivity exclusively for GPER. Furthermore, CIMBA reduces the formation of 17β-estradiol-induced gallstones in a dose-dependent manner in ovariectomized mice fed a lithogenic diet for 8 weeks. At 32 μg/day/kg CIMBA, no gallstones are found, even in ovariectomized ERα (^–/–) mice treated with 6 μg/day 17β-estradiol and fed the lithogenic diet for 8 weeks. In conclusion, CIMBA treatment protects against the formation of estrogen-induced cholesterol gallstones by inhibiting the GPER signaling pathway in female mice. CIMBA may thus be a new agent for effectively treating cholesterol gallstone disease in women.­

The pregnane X receptor (PXR) is a nuclear receptor that can be activated by numerous drugs and xenobiotic chemicals. PXR thereby functions as a xenobiotic sensor to coordinately regulate host responses to xenobiotics by transcriptionally regulating many genes involved in xenobiotic metabolism. We have previously reported that PXR has pro-atherogenic effects in animal models, but how PXR contributes to atherosclerosis development in different tissues or cell types remains elusive. In this study, we generated an LDL receptor-deficient mouse model with myeloid-specific PXR deficiency (PXR^MyeLDLR^–/–) to elucidate the role of macrophage PXR signaling in atherogenesis. The myeloid PXR deficiency did not affect metabolic phenotypes and plasma lipid profiles, but PXR^MyeLDLR^–/– mice had significantly decreased atherosclerosis at both aortic root and brachiocephalic arteries compared with control littermates. Interestingly, the PXR deletion did not affect macrophage adhesion and migration properties, but reduced lipid accumulation and foam cell formation in the macrophages. PXR deficiency also led to decreased expression of the scavenger receptor CD36 and impaired lipid uptake in macrophages of the PXR^MyeLDLR^–/– mice. Further, RNA-Seq analysis indicated that treatment with a prototypical PXR ligand affects the expression of many atherosclerosis-related genes in macrophages in vitro. These findings reveal a pivotal role of myeloid PXR signaling in atherosclerosis development and suggest that PXR may be a potential therapeutic target in atherosclerosis management.