नई द‍िल्‍ली: कोरोना वायरस के संक्रमण को रोकन के लिए देश भर में 3 मई तक लॉकडाउन है। ऐसे में सब कुछ बंद है ज्‍यादातर लोग घर में रह रहे है। अगर आप भी सोने में निवेश करने की सोच रहे

नई दिल्ली। आज यानी रविवार 26 अप्रैल को अक्षय तृतिया है। भारत में इस दिन को सोने की खरीदारी के लिए काफी शुभ माना जाता है। यही कारण है कि हर साल अक्षय तृतिया के दिन गोल्ड की बिक्री का नया

नई द‍िल्‍ली: आज अक्षय तृतीया है। भारतीय इस दिन सोना खरीदना शुभ मानते हैं। लेकिन कोरोनावायरस महामारी की वजह से देश में 3 मई तक लॉकडाउन लागू है। इस वजह से सब लोग अपने घरों में बंद हैं। ऐसे में बाहर

नई दिल्ली। पिछले काफी समय से देश और दुनिया में खराब खबरें ही आ रही हैं। अभी तो कोरोना का कहर जारी है, लेकिन इससे पहले अर्थव्यवस्था में सुस्ती लोगों को परेशान कर रही थी। दूसरी तरफ कारोबार को बढ़ावा देने

नई द‍िल्‍ली: कोरोना वायरस ने दुनियाभर के देशों को अपनी चपेट में ले लिया है। संक्रमण को रोकने के लिए चल रहे देशव्यापी लॉकडाउन के कारण सर्राफा बाजार बंद है। ऐसे वक्त जब शेयरों और बॉन्ड में निवेश से ज्यादा रिटर्न

नई दिल्ली। दुनिया में कोरोना महामारी का कहर हो या विश्व युद्ध जैसे हालात। लेकिन गोल्ड ने कभी भी निवेशकों को निराश नहीं किया है। ऐसा ही इस बार भी हुआ है। जब कोरोना महामारी अपनी चरम पर दिख रही और

नयी दिल्ली। कोरोनावायरस के कारण लॉकडाउन से लोगों के सामने अब घर चलाने तक में दिक्कतें आने लगी हैं। ऐसे में लोग किसी न किसी तरह से पैसे जुटाने की कोशिश करेंगे। अगर आपके सामने भी इस तरह की दिक्कत आ

नई दिल्ली। आज मदर्स डे है और लोग सोच रहे हैं कि वह अपनी मां के लिए ऐसा क्या कर दें, कि उनके चेहने पर प्यारी सी मुस्कान आ जाए। भारत में महिलाओं का गोल्ड से प्रेम छिपा हुआ नहीं है।

Ram Charan is in family man mode, sharing glimpses on social media, and the netizens are loving it. His recent video with his grandmother, wherein he learns to make fresh butter was way too cute to miss. Well, him sharing beautiful

Rakul Preet Singh found herself in trouble as a video of hers went viral amid the lockdown. Recently, a clip of the actress wearing a mask and carrying a small bottle has surfaced on the internet. Unfortunately, the clip went viral

Lewis Library - ML410.K7356 K67 2019

Silver, gaining 4%, outperformed gold, which stayed flat last week

Senco Gold & Diamonds, one of the largest jewellery retail chains, has reopened 11 stores across green and orange zones in West Bengal, Odisha, A

With Mother's Day today, why not take a look at the TV moms from the older and simpler times.

Quantum House holds drive by parade | WTVX  cw34.com

Medical officer advises older people to remain cautious as restrictions are eased  Ballarat Courier

There are mixed feelings among executives about the idea, ranging from frustration to begrudging acceptance.

Since the Middle Ages, alchemists have sought to transmute elements, the most famous example being the long quest to turn lead into gold. Now, Princeton University theorists have proposed a different approach to this ancient ambition — just make one material behave like another. The researchers demonstrate that any two systems can be made to look alike, even if just for the smallest fraction of a second.

Princeton University awarded degrees to 1,268 undergraduates in the Class of 2017, three from former classes and 520 graduate students at its 270th Commencement Tuesday, June 6.

Last year's success will be hard to duplicate for Purdue's defense, but the standard has been set.

While the phased-in reopening of schools in South Africa in the midst of Covid-19 remains provisional and sensitive, the Western Cape Education Department has advised principals and school management teams to wait a few more days before returning.

Several local food trucks held a pop-up drive-thru at the Southgate Mall parking lot on Saturday.

The DML News App offers the best in news reporting.

The post REPORT: Here’s What Comey Told Congress About Whether Flynn Lied To FBI: Transcript appeared first on Dennis Michael Lynch.

John Hillman - the 101-year-old Second World War veteran who has been walking laps around the courtyard of his Oak Bay retirement home in hopes of raising $101,000 for charity - has surpassed his goal.

A department store that served Vancouver's Gastown and Downtown Eastside neighbourhoods for decades is closing, along with four other Army and Navy locations, because of the COVID-19 pandemic.

The following article, NYC Nurse Steals Credit Card From 70-Yr-Old Dying COVID-19 Patient On Ventilator, was first published on 100PercentFedUp.com.

"She is a despicable human being"

Continue reading: NYC Nurse Steals Credit Card From 70-Yr-Old Dying COVID-19 Patient On Ventilator ...

Mary Wardell posted a photo:

This old lighthouse keeper stared out into the storm to see if there were any ships out there caught in the wnds and waves .

"Passing along a message from Mother Nature," the National Weather Service in Binghamton, New York, tweeted alongside a photo of a car covered in light snow. "Happy Mother's Day Weekend."

Lethal infections by strains of the highly-pathogenic avian influenza virus (HPAIV) H5N1 pose serious threats to both the poultry industry and public health worldwide. A lack of confirmed HPAIV epitopes recognized by cytotoxic T lymphocytes (CTLs) has hindered the utilization of CD8+ T-cell–mediated immunity and has precluded the development of effectively diversified epitope-based vaccination approaches. In particular, an HPAIV H5N1 CTL-recognized epitope based on the peptide MHC-I–β2m (pMHC-I) complex has not yet been designed. Here, screening a collection of selected peptides of several HPAIV strains against a specific pathogen-free pMHC-I (pBF2*1501), we identified a highly-conserved HPAIV H5N1 CTL epitope, named HPAIV–PA123–130. We determined the structure of the BF2*1501–PA123–130 complex at 2.1 Å resolution to elucidate the molecular mechanisms of a preferential presentation of the highly-conserved PA123–130 epitope in the chicken B15 lineage. Conformational characteristics of the PA123–130 epitope with a protruding Tyr-7 residue indicated that this epitope has great potential to be recognized by specific TCRs. Moreover, significantly increased numbers of CD8+ T cells specific for the HPAIV–PA123–130 epitope in peptide-immunized chickens indicated that a repertoire of CD8+ T cells can specifically respond to this epitope. We anticipate that the identification and structural characterization of the PA123–130 epitope reported here could enable further studies of CTL immunity against HPAIV H5N1. Such studies may aid in the development of vaccine development strategies using well-conserved internal viral antigens in chickens.

The C-type lectin receptors (CLRs) form a family of pattern recognition receptors that recognize numerous pathogens, such as bacteria and fungi, and trigger innate immune responses. The extracellular carbohydrate-recognition domain (CRD) of CLRs forms a globular structure that can coordinate a Ca2+ ion, allowing receptor interactions with sugar-containing ligands. Although well-conserved, the CRD fold can also display differences that directly affect the specificity of the receptors for their ligands. Here, we report crystal structures at 1.8–2.3 Å resolutions of the CRD of murine dendritic cell-immunoactivating receptor (DCAR, or Clec4b1), the CLR that binds phosphoglycolipids such as acylated phosphatidyl-myo-inositol mannosides (AcPIMs) of mycobacteria. Using mutagenesis analysis, we identified critical residues, Ala136 and Gln198, on the surface surrounding the ligand-binding site of DCAR, as well as an atypical Ca2+-binding motif (Glu-Pro-Ser/EPS168–170). By chemically synthesizing a water-soluble ligand analog, inositol-monophosphate dimannose (IPM2), we confirmed the direct interaction of DCAR with the polar moiety of AcPIMs by biolayer interferometry and co-crystallization approaches. We also observed a hydrophobic groove extending from the ligand-binding site that is in a suitable position to interact with the lipid portion of whole AcPIMs. These results suggest that the hydroxyl group-binding ability and hydrophobic groove of DCAR mediate its specific binding to pathogen-derived phosphoglycolipids such as mycobacterial AcPIMs.

Fucosylation of the innermost GlcNAc of N-glycans by fucosyltransferase 8 (FUT8) is an important step in the maturation of complex and hybrid N-glycans. This simple modification can dramatically affect the activities and half-lives of glycoproteins, effects that are relevant to understanding the invasiveness of some cancers, development of mAb therapeutics, and the etiology of a congenital glycosylation disorder. The acceptor substrate preferences of FUT8 are well-characterized and provide a framework for understanding N-glycan maturation in the Golgi; however, the structural basis of these substrate preferences and the mechanism through which catalysis is achieved remain unknown. Here we describe several structures of mouse and human FUT8 in the apo state and in complex with GDP, a mimic of the donor substrate, and with a glycopeptide acceptor substrate at 1.80–2.50 Å resolution. These structures provide insights into a unique conformational change associated with donor substrate binding, common strategies employed by fucosyltransferases to coordinate GDP, features that define acceptor substrate preferences, and a likely mechanism for enzyme catalysis. Together with molecular dynamics simulations, the structures also revealed how FUT8 dimerization plays an important role in defining the acceptor substrate-binding site. Collectively, this information significantly builds on our understanding of the core fucosylation process.

Almost five years ago, lawmakers on a bipartisan committee of Parliament agreed unanimously to amend the law to give the Independent Commission of Investigations (INDECOM) the power to arrest and prosecute cops. That proposed amendment, which was...

I just got sent an electronic message from one of the employers stating that I am unsuitable for the role based on my police record. I'm under the impression some people are still choosing to impersonate me on several job search engines by giving each employer the idea I'm an ex-con with work skills that came out of prison. Is there a chance they can see my old name?

yesterday night i had come from the cold and i was freezing!. i immediately got into a hot shower - i don't know why but i started feeling dizzy: my vision started going and i was confused then my ears started ringing and i was scared. i shouted for someone and my brother came: he asked if i was ok but i said i felt dizzy and i couldn't really see him at all. i said i felt faint and he said sit down slowly - so i did. eventually i closed my eyes and it helped; i feel better now but why did it happen?!.

In the ongoing struggle to address health care disparities in rural communities across the U.S., a recent Oregon State University study found that the perfect partner may be hiding in plain sight.

(May 8, 2020) On May 4, 2020, the Administrative Court of Uppsala ruled that sales of Zandcell AB’s COVID-19 test kits were prohibited in Sweden because the producer had not proven that the product met the legal requirements for medical devices under Swedish and European Union law. (Uppsala Administrative Court, Decision No. 240-20 (May 4, […]

Gold bonds open tomorrow for subscription when investment demand is rising  LivemintHere's All You Need to Know About Sovereign Gold Bond Scheme Opening on Monday  News18Sovereign Gold Bond opens tomorrow: Issue price fixed at Rs 4,...

Instead of planning for their retirement, Rose and Matthew Gibson followed God's calling to full-time missions with OM Italy.

A Turkish believer remains strong in his faith through persecution.

While other couples in their fifties talk about retirement, Philip and Riana Dyason are talking about a new beginning: pioneer ministry in Russia.

OM Russia is now accepting pensioners to study at its Discipleship and Missionary Training Centre.

When Rev Graham Clay, Pastor of Stratford-Upon-Avon Baptist Church, decided to have an OM ministry team work with his church, he didn’t hesitate to take action.

One couple talks about how God has answered 50-year old prayers for the Middle East North Africa region.

Source: www.justjared.com - Saturday, May 09, 2020
Alec Baldwin is back as President Trump on Saturday Night Live ! The actor once again impersonated the president on the sketch show’s season finale on Saturday (May 9). Alec as Trump made an appearance during the cold open, which featured a virtual graduation for college students. “I’m so honored to be your vale-dictator,” Alec as Trump said. “But today’s not about me. It’s about you. Although I should spend a little time on me first, because I’ve been treated very poorly, even worse than they treated Lincoln.” “You’re actually lucky to be graduating right now there are so many exciting new jobs out there, like grocery store bouncer, cam-girl, porch pirate, amateur nurse and coal,” he continued. “Don’t forget about coal. It’s in the ground, and you just dig down and grab it.” At the end of the cold open, Alec broke character, suggesting that this is his last time playing Trump . “And taped from my home, one last time,” Alec said, “it’s Saturday night.” Alec has been playing Trump for the past four years since the 2016 U.S. presidential election.