A local partner cares for 5,500 orphans in the Near East, compromising personal health and safety for the children’s sake.

Youth: Müller was born in Kroppenstaedt (now Kroppenstedt), a village near Halberstadt in the Kingdom of Prussia. In 1810, the Müller family moved to nearby Heimersleben, where Müller's father was appointed a collector of taxes. He had an older brother, Friedrich Johann Wilhelm (1803 - 7 Oct 1838) and, after his widowed father remarried, a half-brother, Franz (b 1822). His early life was not marked by righteousness - on the contrary, he was a thief, a liar and a gambler. By the age of 10, Müller was stealing government money from his father. While his mother was dying, he, at 14 years of age, was playing cards with friends and drinking. Müller's father hoped to provide him with a religious education that would allow him to take a lucrative position as a clergyman in the state church. He studied divinity in the University of Halle, and there met a fellow student (Beta) who invited him to a Christian prayer meeting. There he was welcomed, and he began regularly reading the Bible and discussing Christianity with the others who attended the meetings. After seeing a man praying to God on his knees, he was convinced of his need for salvation. As soon as he got home he went to his bed where he knelt and prayed. He asked God to help him in his life and to bless him wherever he went and to forgive him of his sins. He immediately stopped drinking, stealing and lying, and began hoping to become a missionary. He began preaching regularly in nearby churches and continued meeting with the other churches. -- Early work: In 1828, Müller offered to work with Jews in England through the London Society for Promoting Christianity Amongst the Jews, but upon arriving in 1829, he fell ill, and did not think that he would survive. He was sent to Teignmouth to recuperate and, whilst there, met Henry Craik, who became his life-long friend. When he recovered, however, he dedicated himself to doing the will of God. He soon left the London Society, convinced that God would provide for his needs as he did Christian work. Craik invited him to become a minister with him in Teignmouth and he became the pastor of Ebenezer Chapel in Devon and soon after, married Mary Groves, the sister of Anthony Norris Groves. During his time as the pastor of the church, he refused a regular salary, believing that the practice could lead to church members giving out of duty, not desire. He also eliminated the renting of church pews, arguing that it gave unfair prestige to the rich (based primarily on James 2:1-9). -- Theology: The theology that guided George Müller's work is not widely known, but was shaped by an experience in his mid twenties when he "came to prize the Bible alone as [his] standard of judgement". He records in his Narratives that "That the word of God alone is our standard of judgment in spiritual things; that it can be explained only by the Holy Spirit; and that in our day, as well as in former times, he is the teacher of his people. The office of the Holy Spirit I had not experimentally understood before that time. Indeed, of the office of each of the blessed persons, in what is commonly called the Trinity, I had no experimental apprehension. I had not before seen from the Scriptures that the Father chose us before the foundation of the world; that in him that wonderful plan of our redemption originated, and that he also appointed all the means by which it was to be brought about. Further, that the Son, to save us, had fulfilled the law, to satisfy its demands, and with it also the holiness of God; that he had borne the punishment due to our sins, and had thus satisfied the justice of God. And, further, that the Holy Spirit alone can teach us about our state by nature, show us the need of a Saviour, enable us to believe in Christ, explain to us the Scriptures, help us in preaching, etc. It was my beginning to understand this latter point in particular which had a great effect on me; for the Lord enabled me to put it to the test of experience, by laying aside commentaries, and almost every other book, and simply reading the word of God and studying it. The result of this was, that the first evening that I shut myself into my room, to give myself to prayer and meditation over the Scriptures, I learned more in a few hours than I had done during a period of several months previously. But the particular difference was, that I received real strength for my soul in doing so. I now began to try by the test of the Scriptures the things which I had learned and seen, and found that only those principles which stood the test were really of value."

Dr. Rossi interviews Fr. Nicholas Andruchow, Associate Director of Project Mexico.

Christian Alliance for Orphans celebrated 20 years of ministry at its annual summit where 2,400 supporters from 46 countries came together at Brentwood Baptist Church in Nashville, Tennessee.

OM Malawi opens a new school to help educate children in need.

The OM team in Odessa, Ukraine, regularly visits orphanages in the province, bringing love and the good news to children.

OM Ukraine's team in Odessa heads up the annual All-Ukrainian Day of Prayer for Orphans in the Odessa province.

Long-term follower of Jesus, Nikolay, stepped out in faith to help orphans in Ukraine, and partners with OM in this ministry to children.

Low-efficacy mu opioid receptor (MOR) agonists may serve as novel candidate analgesics with improved safety relative to high-efficacy opioids. This study used a recently validated assay of pain-depressed behavior in mice to evaluate a novel series of MOR-selective C9-substituted phenylmorphan opioids with graded MOR efficacies. Intraperitoneal injection of dilute lactic acid (IP acid) served as a noxious stimulus to depress locomotor activity by mice in an activity chamber composed of two compartments connected by an obstructed door. Behavioral measures included (1) crosses between compartments (vertical activity over the obstruction) and (2) movement counts quantified as photobeam breaks summed across compartments (horizontal activity). Each drug was tested alone and as a pretreatment to IP acid. A charcoal-meal test and whole-body-plethysmography assessment of breathing in 5% CO₂ were also used to assess gastrointestinal (GI) inhibition and respiratory depression, respectively. IP acid produced a concentration-dependent depression in crosses and movement that was optimally alleviated by intermediate- to low-efficacy phenylmorphans with sufficient efficacy to produce analgesia with minimal locomotor disruption. Follow-up studies with two low-efficacy phenylmorphans (JL-2-39 and DC-1-76.1) indicated that both drugs produced naltrexone-reversible antinociception with a rapid onset and a duration of ~1 h. Potency of both drugs increased when behavior was depressed by a lower IP-acid concentration, and neither drug alleviated behavioral depression by a non-pain stimulus (IP lithium chloride). Both drugs produced weaker GI inhibition and respiratory depression than fentanyl and attenuated fentanyl-induced GI inhibition and respiratory depression. Results support further consideration of selective, low-efficacy MOR agonists as candidate analgesics.

It is estimated that the landslide has robbed five children of their parents; currently they are with their immediate relatives at the relief camp

A local partner cares for 5,500 orphans in the Near East, compromising personal health and safety for the children’s sake.

Through The Learning Tea in Atlanta, entrepreneur Katrell Christie is helping educate teenage orphan girls in India so they can achieve their dreams.

King's Orphan Schools (New Town, Tas.)

OM Malawi opens a new school to help educate children in need.

The OM team in Odessa, Ukraine, regularly visits orphanages in the province, bringing love and the good news to children.

OM Ukraine's team in Odessa heads up the annual All-Ukrainian Day of Prayer for Orphans in the Odessa province.

Long-term follower of Jesus, Nikolay, stepped out in faith to help orphans in Ukraine, and partners with OM in this ministry to children.

Initial plans to use UK special forces to repatriate the children of a dead Islamic State fighter were met with strong resistance from the Cabinet, prompting a Foreign Office rethink.

In Anantapur, farm suicides are fewer than they were in 2002. But they still happen and could rise again in this fragile region. As elsewhere, agriculture is plagued by uncertainty, writes P Sainath.

Ignored by the government, shunned by society and caught in a time-warp of their own, the nomadic castes and tribes of India are almost "non citizens" of the land. R. Akhileshwari describes the abysmal plight of such people from Andhra Pradesh and highlights the injustice and neglect that they are subject to.

Historian Cathy Hellier describes the poignant histories of children left without parents. The question of providing for colonial orphans was split between the courts and the children’s caretakers. Listen this week to learn how colonial society looked after its littlest citizens.

Historian Cathy Hellier describes the poignant histories of children left without parents. The question of providing for colonial orphans was split between the courts and the children’s caretakers. Listen this week to learn how colonial society looked after its littlest citizens.