Investigators from the Drug Enforcement Administration and the Los Angeles Police Department served search warrants at a North Hollywood business in a federal drug trafficking investigation, authorities said.

Indiana educators are among the strongest advocates for students and deserve the utmost appreciation and respect, Jennifer McCormick writes.

A chronology of key events

Key facts, figures and dates

A chronology of key events

Key facts, figures and dates

Subscribers to Japan's biggest telephone network offered app that translates calls so they can speak to people using other languages.

Rebecca Sugar's hit series "Steven Universe" changed the Cartoon Network's policy on same-sex marriage in kids' shows.

Expectations were high for Jacksonville heading into the season. The game charters at Pro Football Focus ranked them as the league’s top secondary, the second-best pass rush and the seventh-best run-stopping unit in 2018.

The Patriots put their stamp back on the AFC East after throttling the Miami Dolphins 38-7 on Sunday. The Colts are next.

Houston’s defensive front, featuring one-man wrecking crew J.J. Watt, has the sixth-highest adjusted sack rate.

Colts have the the fifth-best run-stopping unit per PFF and the fourth-highest stuff rate per Football Outsiders.

Pittsburgh is stuffing 25 percent of rushers in 2018, eighth-most in the NFL.

Against No. 1 receiver types like Mike Evans, the Panthers rank fourth-best per Football Outsiders' Defense-adjusted Value Over Average.

Kansas City's opponent, Arizona, is scoring slightly more than a point per possession, making it the NFL's second-worst offense.

The Chargers are scoring 2.4 points per drive, the sixth-most this season, and are only forced to go three-and-out once out of every four drives.

This week’s opponent, the Arizona Cardinals, gives Aaron Rodgers and the Packers a great chance to break their losing skid.

Thursday night matchups are historically difficult on road teams like Jacksonville. Since 2016, the road team is 17-33 in these games, and that includes a 3-12 record in 2018.

Atlanta is on a five-game losing streak but their offense is scoring 2.3 points per drive in 2018, the fifth-highest rate in the NFL. That should be more than enough against Arizona's awful offense.

IPTV operators will now benefit from industry-leading revenue security solutions when using Dune HD media players, thanks to a new partnership between Dune HD and Verimatrix. Verimatrix is the specialist in securing and enhancing revenue for multi-screen digital TV services around the globe, and its Video Content Authority System for IPTV solution and embedded ViewRight security client are now available across Dune HD’s award-winning range of digital media players, enabling operators to better protect content from piracy while enhancing service revenues.

Verimatrix VCAS software-based security solutions are the most widely deployed content protection systems amongst tier-one operators globally, with a growing base of over 600 deployments. These operators and other Verimatrix partners will now be able to install Dune HD’s extensive range of digital media players and set-top boxes, which combine high performance, engineering excellence and customisable features, backed up by the highest levels of content security.

Operators looking to deploy IPTV and Video on Demand will benefit from faster, lower-risk implementations that enable them to offer more services to users through a major partnership between Dune HD and Beenius announced today at TelcoTV2012. This will be demonstrated on the Beenius booth (number 105) at TelcoTV.

As part of the partnership, Dune HD’s advanced set-top boxes have been certified by Beenius and are now integrated with Beenius’ Beesmart open, flexible, and feature-rich interactive TV middleware platform. Together this provides an adaptable, integrated and best of breed solution to operators and system integrators, backed by the engineering expertise of both partners.

Every single one of them is supposed to be exercising oversight of the executive branch.

strataconf: StrataWeek: Wireless body networks bring humans into Internet of Things http://t.co/vRgkRtTTKe Pills & tattoo authenticators & NSA leaks

strataconf: Humans as nodes, pills & electronic tattoo password authenticators & hiding data in temporal cloaks http://t.co/vRgkRtTTKe #strataconf

Rather than focus on technical decisions alone, architects and senior technologists need to combine organizational and technical knowledge to effect change in their company’s structure and processes. To accomplish that, they need to connect the IT engine room to the penthouse, where the business strategy is defined. In this guide, author Gregor Hohpe shares real-world advice and hard-learned lessons from actual IT transformations. His anecdotes help architects, senior developers, and other IT professionals prepare for a more complex but rewarding role in the enterprise.

A lack of high demand spectrum has been a long-running complaint by SA telecoms groups, who say that it is needed to reduce data prices and increase speed.

Realtors® Applaud Administration’s Calls to End...

NAR commends Senators Cotton, Duckworth for Work on...

This one-pan chicken dinner is made with potatoes, onions, garlic, cherry tomatoes, and an easy paprika sauce. Dairy-free, gluten-free. 1 hour start to finish.

Continue reading "One-Pan Paprika Chicken with Potatoes and Tomatoes" »

Shopping for potatoes? Here’s how to know which kind to buy, and the best way to store them.

Continue reading "How to Buy and Store Potatoes" »

Got potatoes? Going to cook them? Here’s what you need to know for prepping them.

Continue reading "How to Clean and Prep Potatoes for Cooking" »

Eat baked potatoes on the regular? Make your baked potatoes a meal with these winning combos and recipes for toppers!

Continue reading "10 Ways to Top a Baked Potato" »

Hear about travel to Baton Rouge as the Amateur Traveler talks to Lindsay Thomas from TheTraveluster.com about her hometown. Baton Rouge is the capital of Louisiana. It can be a great gateway to Cajun food and culture.

Hear about travel to the state of Guanajuato Mexico (including San Miguel de Allende) as the Amateur Traveler talks to Tim Leffel of perceptivetravel.com about his adopted home.

What happens when memers meet the subject of their memes? In the case of the BA Test Kitchen meeting the brains behind @meme_appetit, pure gold. Harry Kersh and Will Martin started the accounts when they discovered their shared love of BA videos, and the Instagram and Twitter accounts have since taken off. 

Now with almost 400,000 followers on Instagram, the account has a lot of fans — including some members of the test kitchen. In this video, the BA cooks explain why they love (or dislike) some of the account's memes, whether it's accurate, and whether they even "get it." Watch them react to various memes and Kersh and Martin attempt to explain their reasoning behind them. Read more...

Nicholas Love's Penguin Classics cover generator lets you upload an image and set type in humorous imitation of the label. It can also do the similar but inverted Oxford World Classics look. But sadly not the classic classics look.

Many excellent designs in this twitter thread; embedded here is my contribution. Read the rest

The DML News App offers the best in news reporting.

The post VIDEO: GOP senator says China made ‘conscious decision’ to allow COVID-19 to spread beyond border appeared first on Dennis Michael Lynch.

The following article, Video: Dallas Salon Owner Shelley Luther Gets Surprise Visit from Sen Ted Cruz for a Celebratory Haircut, was first published on 100PercentFedUp.com.

When Dallas, Texas salon owner Shelley Luther opened her salon in defiance of the lockdown order in Texas, she was visited numerous times by the local police and then sentenced to 7 days in jail with a fine of $7,000. After public outrage at her punishment, the Texas Supreme Court stepped in to demand her […]

Continue reading: Video: Dallas Salon Owner Shelley Luther Gets Surprise Visit from Sen Ted Cruz for a Celebratory Haircut ...

11 February 2020

The transcription factor forkhead box P3 (FOXP3) is a biomarker for regulatory T cells and can also be expressed in cancer cells, but its function in cancer appears to be divergent. The role of hepatocyte-expressed FOXP3 in hepatocellular carcinoma (HCC) is unknown. Here, we collected tumor samples and clinical information from 115 HCC patients and used five human cancer cell lines. We examined FOXP3 mRNA sequences for mutations, used a luciferase assay to assess promoter activities of FOXP3's target genes, and employed mouse tumor models to confirm in vitro results. We detected mutations in the FKH domain of FOXP3 mRNAs in 33% of the HCC tumor tissues, but in none of the adjacent nontumor tissues. None of the mutations occurred at high frequency, indicating that they occurred randomly. Notably, the mutations were not detected in the corresponding regions of FOXP3 genomic DNA, and many of them resulted in amino acid substitutions in the FKH region, altering FOXP3's subcellular localization. FOXP3 delocalization from the nucleus to the cytoplasm caused loss of transcriptional regulation of its target genes, inactivated its tumor-inhibitory capability, and changed cellular responses to histone deacetylase (HDAC) inhibitors. More complex FKH mutations appeared to be associated with worse prognosis in HCC patients. We conclude that mutations in the FKH domain of FOXP3 mRNA frequently occur in HCC and that these mutations are caused by errors in transcription and are not derived from genomic DNA mutations. Our results suggest that transcriptional mutagenesis of FOXP3 plays a role in HCC.

The plasmas of diabetic or uremic patients and of those receiving peritoneal dialysis treatment have increased levels of the glucose-derived dicarbonyl metabolites like methylglyoxal (MGO), glyoxal (GO), and 3-deoxyglucosone (3-DG). The elevated dicarbonyl levels can contribute to the development of painful neuropathies. Here, we used stimulated immunoreactive Calcitonin Gene–Related Peptide (iCGRP) release as a measure of nociceptor activation, and we found that each dicarbonyl metabolite induces a concentration-, TRPA1-, and Ca2+-dependent iCGRP release. MGO, GO, and 3-DG were about equally potent in the millimolar range. We hypothesized that another dicarbonyl, 3,4-dideoxyglucosone-3-ene (3,4-DGE), which is present in peritoneal dialysis (PD) solutions after heat sterilization, activates nociceptors. We also showed that at body temperatures 3,4-DGE is formed from 3-DG and that concentrations of 3,4-DGE in the micromolar range effectively induced iCGRP release from isolated murine skin. In a novel preparation of the isolated parietal peritoneum PD fluid or 3,4-DGE alone, at concentrations found in PD solutions, stimulated iCGRP release. We also tested whether inflammatory tissue conditions synergize with dicarbonyls to induce iCGRP release from isolated skin. Application of MGO together with bradykinin or prostaglandin E2 resulted in an overadditive effect on iCGRP release, whereas MGO applied at a pH of 5.2 resulted in reduced release, probably due to an MGO-mediated inhibition of transient receptor potential (TRP) V1 receptors. These results indicate that several reactive dicarbonyls activate nociceptors and potentiate inflammatory mediators. Our findings underline the roles of dicarbonyls and TRPA1 receptors in causing pain during diabetes or renal disease.

Research Event

Event participants

Yezid Sayigh, Senior Fellow, Carnegie Middle East Center
David Butter, Associate Fellow, Middle East and North Africa Programme, Chatham House
Chair: Lina Khatib, Head, Middle East and North Africa Programme, Chatham House

For successful infection of their hosts, pathogenic bacteria recognize host-derived signals that induce the expression of virulence factors in a spatiotemporal manner. The fulminating food-borne pathogen Vibrio vulnificus produces a cytolysin/hemolysin protein encoded by the vvhBA operon, which is a virulence factor preferentially expressed upon exposure to murine blood and macrophages. The Fe-S cluster containing transcriptional regulator IscR activates the vvhBA operon in response to nitrosative stress and iron starvation, during which the cellular IscR protein level increases. Here, electrophoretic mobility shift and DNase I protection assays revealed that IscR directly binds downstream of the vvhBA promoter PvvhBA, which is unusual for a positive regulator. We found that in addition to IscR, the transcriptional regulator HlyU activates vvhBA transcription by directly binding upstream of PvvhBA, whereas the histone-like nucleoid-structuring protein (H-NS) represses vvhBA by extensively binding to both downstream and upstream regions of its promoter. Of note, the binding sites of IscR and HlyU overlapped with those of H-NS. We further substantiated that IscR and HlyU outcompete H-NS for binding to the PvvhBA regulatory region, resulting in the release of H-NS repression and vvhBA induction. We conclude that concurrent antirepression by IscR and HlyU at regions both downstream and upstream of PvvhBA provides V. vulnificus with the means of integrating host-derived signal(s) such as nitrosative stress and iron starvation for precise regulation of vvhBA transcription, thereby enabling successful host infection.

Members Event

Event participants

Anders Fogh Rasmussen, Secretary-General, North Atlantic Treaty Organization (NATO)
Chair: Robin Niblett, Director, Chatham House 

Research Event

Event participants

Xenia Wickett, Project Director, US; Acting Dean, Academy for Leadership in International Affairs, Chatham House
Peter Jones, Director for Defence and International Security, Foreign & Commonwealth Office
Dr Jamie Shea, Deputy Assistant Secretary General for Emerging Security Challenges, NATO
Chair: Steven Erlanger, London Bureau Chief, New York Times

Invitation Only Research Event

Event participants

Douglas E Lute, Ambassador, Permanent Representative for the United States to NATO
Sir Adam Thomson KCMG, UK Permanent Representative to NATO
Chair: Dr Robin Niblett, Director, Chatham House

21 July 2014

For more than 60 years the North Atlantic Treaty Organization (NATO) has played a critical role in enabling transatlantic security and leading crisis management operations. However, given the current climate of austerity, the imminent end of the Afghanistan operation and recent events in Ukraine, crucial questions are being raised regarding the Alliance’s future priorities.

Invitation Only

Event participants

Robin Niblett, Director, Chatham House; Chair, NATO Group of Policy Experts
Xenia Wickett, Project Director, US; Acting Dean, Academy for Leadership in International Affairs, Chatham House

Chair
Paola Totaro, President, Foreign Press Association

Invitation Only Research Event

Event participants

Xenia Wickett, Project Director, US; Dean, Academy for Leadership in International Affairs, Chatham House
Dr Christian Moelling, International Security Division Associate, SWP-Berlin

Invitation Only Research Event

Event participants

Ignacio Garcia Bercero, Director General, Trade, European Commission
Chair: Quentin Peel, Mercator Senior Fellow, Europe Programme, Chatham House