The Trump administration has continued to weaken air pollution regulations despite warnings that long-term exposure to dirty air relates to higher COVID-19 death rates. Harvard researchers made the first statistical link between the two last month, just before the administration loosened some clean air regulations and failed to tighten others.

Season two will exclusively stream on Amazon Prime Video in more than 200 countries and territories worldwide.

Registration is now open for the 2021 National Jamboree to be held at The Summit Bechtel Reserve ...

Just when it seemed like robots couldn't get any cooler, Cornell University researchers have created a soft robot muscle that can regulate its temperature through sweating.

There are a few days left to put in a submission on the Electoral (Registration of Sentences Prisoners) Amendment Bill.
The bill would allow prisoners serving sentence of imprisonment under three years to vote, essentially restoring the status quo ante that existed before the members bill advanced by then National MP Paul Quinn was passed by a slim majority
For anyone interested in my views, they're published below. I've been sufficiently organised this time to publish them here a few days before submissions close, so if there are any errors, please let me know. 
The Justice Committee
Electoral (Registration of…

My dear, beloved friend, whom I loved more than life itself, is gone. My darling Reggie, the Plymouth Rock rooster, was snatched from my arms by a sudden

The problem: if you publish any document as PDF, in print, etc. and the text contains URLs, there is a chance that one day those URLs won't work anymore. There's nothing to do about that, it happens.

Luckily, this is a solved problem. The solution is to link to a stable and trustworthy website, that is, one that you maintain and host (of course, you're trustworthy!). Then in the document you link to that website, and the website redirects visitors to the actual location.

An example: my book contains a link to https://enjoy.gitstore.app/repositories/matthiasnoback/read-with-the-author. When I moved that repository to a new organization on GitHub, this link resulted in a 404 Page not found error. The proper URL is now https://enjoy.gitstore.app/repositories/read-with-the-author/read-with-the-author. Chris from Gitstore was able to save the day by setting up a redirect on their site, but I wanted to make sure this kind of problem would never be a problem for me again.

The ingredients for the solution:

• A domain name (I registered advwebapparch.com)
• A simple website that can redirect visitors to the actual locations

I wanted to hook this new website into my existing Docker-based setup which uses Traefik to forward traffic to the right container based on labels. It turns out, with a simple Nginx image and some custom setup we can easily set up a website that is able to redirecting visitors.

The Dockerfile for such an image:

FROM nginx:stable-alpine
COPY default.conf /etc/nginx/conf.d/default.conf

Where default.conf looks like this:

server {
    listen 80 default_server;
    index index.html;
    root /srv;

    error_page 404 /404.html;

    rewrite /repository https://enjoy.gitstore.app/repositories/read-with-the-author/read-with-the-author redirect;
}

This already works, and when I deploying the resulting image to the server that receives traffic for advwebapparch.com, a request for /repository will indeed redirect a visitor to https://enjoy.gitstore.app/repositories/read-with-the-author/read-with-the-author using a temporary redirect.

Generating the Nginx configuration from a text file

When I'm working on my book, I don't want to manually update a server configuration file every time I'm adding a URL. Instead, I'd like to work with a simple text file. Let's name this file forwards.txt:

/repository https://enjoy.gitstore.app/repositories/read-with-the-author/read-with-the-author
/blog https://matthiasnoback.nl

And then I want the Docker image build process to add rewrite rules automatically, So I wrote a little PHP script that does this runs during the build. Here's what the Dockerfile looks like. It uses a multi-stage build:

FROM php:7.4-alpine as php
# This will copy build.php from the build context to the image
COPY . .
# This will generate default.conf based on template.conf
RUN php build.php

FROM nginx:stable-alpine
# Copy the default.conf from the php image to the nginx image
COPY --from=php default.conf /etc/nginx/conf.d/default.conf

Here's what happens inside the PHP script:

function insertRewritesInNginxConf(string $conf): string
{
    $rewrites = [];

    foreach (file('forwards.txt') as $line) {
        $line = trim($line);
        if (empty($line)) {
            continue;
        }

        $rewrites[] = '    ' . 'rewrite ' . $line . ' redirect;';
    }

    return str_replace(
        '%INSERT_URL_REWRITES_HERE%',
        implode("
", $rewrites),
        $conf
    );
}

/*
 * Generate the Nginx configuration which includes all the actual
 * redirect instructions
 */
file_put_contents(
    'default.conf',
    insertRewritesInNginxConf(file_get_contents('template.conf'))
);

We should add a bit of validation for the data from the forwards.txt file so we don't end up with a broken Nginx configuration, but otherwise, this works just fine.

Generating an html page which can be crawled for broken links

I don't want to manually check that all the links that are inside the "link registry" still work. Instead, I'd like to use Oh Dear for that, which does uptime monitoring and checks for broken links as well.

For this purpose I added another function to the PHP script, which, based

Truncated by Planet PHP, read more at the original (another 1844 bytes)

One of the key points we've been making concerning Attorney General William Barr and his DOJ's eager support for the terrible EARN-IT Act, is that much of it really seems to be to cover up the DOJ's own failings in fighting child porn and child exploitation. The premise behind the EARN IT Act is that there's a lot of child exploitation/child abuse material found on social media... and that social media companies should do more to block that content. Of course, if you step back and think about it, you'd quickly realize that this is a form of sweeping the problem under the rug. Rather than actually tracking down and arresting those exploiting and abusing children, it's demanding private companies just hide the evidence of those horrific acts.

And why might the DOJ and others be so supportive of sweeping evidence under the rug and hiding it? Perhaps because the DOJ and Congress have literally failed to live up to their mandates under existing laws to actually fight child exploitation. Barr's DOJ has been required under law to produce reports showing data about internet crimes against children, and come up with goals to fight those crimes. It has produced only two out of the six reports that were mandated over a decade ago. At the same time, Congress has only allocated a very small budget to state and local law enforcement for fighting internet child abuse. While the laws Congress passed say that Congress should give $60 million to local law enforcement, it has actually allocated only about half of that. Oh, and Homeland Security took nearly half of its "cybercrimes" budget and diverted it to immigration enforcement, rather than fighting internet crimes such as child exploitation.

So... maybe we should recognize that the problem isn't social media platforms, but the fact that Congress and law enforcement -- from local and state up to the DOJ -- have literally failed to do their job.

At least some elected officials have decided to call the DOJ's bluff on why we need the EARN IT Act. Led by Senator Ron Wyden (of course), Senators Kirsten Gillbrand, Bob Casey, Sherrod Brown and Rep. Anna Eshoo have introduced a new bill to actually fight child sex abuse online. Called the Invest in Child Safety Act, it would basically make law enforcement do its job regarding this stuff.

The Invest in Child Safety Act would direct $5 billion in mandatory funding to investigate and target the pedophiles and abusers who create and share child sexual abuse material online. And it would create a new White House office to coordinate efforts across federal agencies, after DOJ refused to comply with a 2008 law requiring coordination and reporting of those efforts. It also directs substantial new funding for community-based efforts to prevent children from becoming victims in the first place.

Basically, the bill would do a bunch of things to make sure that law enforcement is actually dealing with the very real problem of child exploitation, rather than demanding that internet companies (1) sweep evidence under the rug, and (2) break encryption:

• Quadruple the number of prosecutors and agents in DOJ’s Child Exploitation and Obscenity Section from 30 FTEs to 120 FTEs;
• Add 100 new agents and investigators for the Federal Bureau of Investigation’s Innocent Images National Initiative, Crimes Against Children Unit, Child Abduction Rapid Deployment Teams, and Child Exploitation and Human Trafficking Task Forces;
• Fund 65 new NCMEC analysts, engineers, and mental health counselors, as well as a major upgrade to NCMEC’s technology platform to enable the organization to more effectively evaluate and process CSAM reports from tech companies;
• Double funding for the state Internet Crimes Against Children (ICAC) Task Forces;
• Double funding for the National Criminal Justice Training Center, to administer crucial Internet Crimes Against Children and Missing and Exploited Children training programs;
• Increase funding for evidence-based programs, local governments and non-federal entities to detect, prevent and support victims of child sexual abuse, including school-based mental health services and prevention programs like the Children’s Advocacy Centers and the HHS’ Street Outreach Program;
• Require tech companies to increase the time that they hold evidence of CSAM, in a secure database, to enable law enforcement agencies to prosecute older cases;
• Establish an Office to Enforce and Protect Against Child Sexual Exploitation, within the Executive Office of the President, to direct and streamline the federal government’s efforts to prevent, investigate and prosecute the scourge of child exploitation;
• Require the Office to develop an enforcement and protection strategy, in coordination with HHS and GAO; and
• Require the Office to submit annual monitoring reports, subject to mandatory Congressional testimony to ensure timely execution.

It is time. We need a new Regism and cannot go to the pub to think of one. Can you help?

It is no secret that we like to use the odd bit of shorthand at The Register when biting the hand that feeds IT. Now we need a fresh one for Microsoft.…

We previously established that global deletion of the enhancer of trithorax and polycomb (ETP) gene, Asxl2, prevents weight gain. Because proinflammatory macrophages recruited to adipose tissue are central to the metabolic complications of obesity, we explored the role of ASXL2 in myeloid lineage cells. Unexpectedly, mice without Asxl2 only in myeloid cells (Asxl2ΔLysM) were completely resistant to diet-induced weight gain and metabolically normal despite increased food intake, comparable activity, and equivalent fecal fat. Asxl2ΔLysM mice resisted HFD-induced adipose tissue macrophage infiltration and inflammatory cytokine gene expression. Energy expenditure and brown adipose tissue metabolism in Asxl2ΔLysM mice were protected from the suppressive effects of HFD, a phenomenon associated with relatively increased catecholamines likely due to their suppressed degradation by macrophages. White adipose tissue of HFD-fed Asxl2ΔLysM mice also exhibited none of the pathological remodeling extant in their control counterparts. Suppression of macrophage Asxl2 expression, via nanoparticle-based siRNA delivery, prevented HFD-induced obesity. Thus, ASXL2 controlled the response of macrophages to dietary factors to regulate metabolic homeostasis, suggesting modulation of the cells’ inflammatory phenotype may impact obesity and its complications.

Regenerative pain medicine, which seeks to harness the body’s own reparative capacity, is rapidly emerging as a field within pain medicine and orthopedics. It is increasingly appreciated that common analgesic mechanisms for these treatments depend on neuroimmune modulation. In this Review, we discuss recent progress in mechanistic understanding of nociceptive sensitization in chronic pain with a focus on neuroimmune modulation. We also examine the spectrum of regenerative outcomes, including preclinical and clinical outcomes. We further distinguish the analgesic mechanisms of regenerative therapies from those of cellular replacement, creating a conceptual and mechanistic framework to evaluate future research on regenerative medicine.

Fibroblasts are key effector cells in tissue remodeling. They remain persistently activated in fibrotic diseases, resulting in progressive deposition of extracellular matrix. Although fibroblast activation may be initiated by external factors, prolonged activation can induce an “autonomous,” self-maintaining profibrotic phenotype in fibroblasts. Accumulating evidence suggests that epigenetic alterations play a central role in establishing this persistently activated pathologic phenotype of fibroblasts. We demonstrated that in fibrotic skin of patients with systemic sclerosis (SSc), a prototypical idiopathic fibrotic disease, TGF-β induced the expression of DNA methyltransferase 3A (DNMT3A) and DNMT1 in fibroblasts in a SMAD-dependent manner to silence the expression of suppressor of cytokine signaling 3 (SOCS3) by promoter hypermethylation. Downregulation of SOCS3 facilitated activation of STAT3 to promote fibroblast-to-myofibroblast transition, collagen release, and fibrosis in vitro and in vivo. Reestablishment of the epigenetic control of STAT3 signaling by genetic or pharmacological inactivation of DNMT3A reversed the activated phenotype of SSc fibroblasts in tissue culture, inhibited TGF-β–dependent fibroblast activation, and ameliorated experimental fibrosis in murine models. These findings identify a pathway of epigenetic imprinting of fibroblasts in fibrotic disease with translational implications for the development of targeted therapies in fibrotic diseases.

Have you ever noticed that the Internal Revenue Service's regulations often are illogical? Does anyone at the IRS think through its regulations? Continue reading →

Questions surrounding Hillary Clinton and the Clinton Foundation continue to grow. On Sunday, Democratic National Committee interim chairperson Donna Brazile defended Clinton’s meetings as secretary of state with Clinton Foundation donors, saying, "When Republicans meet with their donors, with their supporters, their activists, they call it a meeting. When Democrats do that, they call it a conflict." Donna Brazile’s comments come in response to an Associated Press investigation revealing that while Hillary Clinton served as secretary of state, more than half of the private citizens she met with during the reporting period had donated to the Clinton Foundation. The AP investigation comes after a three-year battle to gain access to State Department calendars. The analysis shows that at least 85 of 154 people Hillary Clinton had scheduled phone or in-person meetings with were foundation donors. We speak to Pulitzer Prize-winning journalist Glenn Greenwald of The Intercept. His most recent piece is headlined "Why Did the Saudi Regime and Other Gulf Tyrannies Donate Millions to the Clinton Foundation?" Continue reading →

Donald Trump sold out his supporters and the 99% by selecting Wall Streeters and war mongers for his top cabinet positions. Continue reading →

IBM today announced plans to acquire Promontory Financial Group, a global market-leading risk management and regulatory compliance consulting firm. Upon close, the capabilities of Promontory combined with IBM's deep industry expertise and Watson’s cognitive capabilities will directly address the massive operational effort and manual cost of escalating regulation and risk management requirements.

The IBM board of directors today declared a regular quarterly cash dividend of $1.50 per common share, payable March 10, 2018 to stockholders of record February 9, 2018. IBM has paid consecutive quarterly dividends every year since 1916.

IBM anunció la primer app educacional IBM MobileFirst para iOS. La app, IBM Watson Element for Educators, permite un nuevo nivel de compromiso de los maestros al proveer una visión holística en la palma de las manos de cada estudiante, incluyendo data en intereses, logros, desempeño académico, asistencia, comportamientos y actividades de aprendizaje. Como resultado, los maestros están siendo empoderados con la visión de los datos que les ayudará a abarcar necesidades individuales a fin de poder llegar potencialmente a mejores resultados a través de las experiencias de los alumnos K-12 (Primaria y Secundaria).

A convocation of the Lover Triad of United States Grand Lodge will be held in Cleveland, Ohio, August 14-16 2020. Registration for the convocation is now open. See this site for more information.

1. 173 gestrande Belgen eindelijk thuis na quarantaine in Tenerife: “Regering liet ons aan ons lot over. We hebben twee maanden op ons terras moeten doorbrengen”  Het Laatste Nieuws
2. 173 gestrande Belgen eindelijk thuis na quarantaine in Tenerife: “Regering heeft te weinig gedaan!”  Het Laatste Nieuws
3. Na quarantaine in Tenerife: 173 Belgen eindelijk weer thuis  De Morgen
4. Belgen die vastzaten op Tenerife charterden zelf vliegtuig naar huis  De Standaard
5. West-Vlaming regelt repatriëring gestrande Belgen  Focus en WTV
6. Hele verhaal bekijken via Google Nieuws

1. Betogers uit erg diverse hoeken protesteren tegen coronamaatregelen in Duitsland  VRT NWS
2. Duitsland demonstreert tegen coronamaatregelen  De Standaard
3. Duitse ME grijpt in bij protest tegen coronamaatregelen  Telegraaf.nl
4. Hele verhaal bekijken via Google Nieuws

If you're more timeless than trendy, don't go all in on these decorating ideas and materials. READ MORE...

Michael McEwan has a conversation with Greg Campbell, a support worker who works with vulnerable adults.

Greg speaks about his motivations for pursuing a career in care, the transition from education to practice and the positive and challenging experiences.

It's an inspiring message for others, and particularly men, who may be considering a career in care.

Transcript of episode

Music Credit: Something Elated by Broke For Free

Andrew Klein, Principle with AS Klein Engineering, and Lynne Kilpatrick, Fire Marshal in Sunnyvale, CA led an education session on ‘On-Demand Mobile Fueling; Enforcing Existing Regulations and Evaluating Future Needs” at NFPA Conference &

It's a bumper crop of BonusCash at your local Rite-Aid this week, with not 1, 2, 3, but 4 gaming GC's, and 1 of those gives you even more options!

• Nike, GameStop, Netflix ... $5 BonusCash when you buy $25 of these items.*
• Google Play, AMC Theatres, Apple AppStore/iTunes, Fandango, XBOX, Panera Bread, Regal Theatres ... $6 BonusCash when you buy $30 of these items.*

FYI, "GameStop" is a big win, because not only can you purchase (additional) XBOX, PSN, Nintendo, and Steam credit there, but you order the GC credit from their website, and get a redemption code instantly after checkout.
 
For those who are new to the "Rite-Aid wellness+ reward BonusCash" program, you'll receive the $$$ amount when you purchase the minimum amount specified. Gift-cards within the same bullet-point share the same "limit 2 offers per customer", but you can earn rewards on the other bullet-point lines as well. For example, you can purchase $25 each of GameStop & Netflix (or $50 of GameStop) ... and still be able to purchase another $60 mix of Google & Apple & XBOX, and can stagger your 4 GC purchases throughout the week.

Screenshot of 2 separate GC offers (bullet points) included here:

• if you've met the limit of 2 items per BonusCash group with the current transaction, or
• if the transaction you're about to complete exceeds the limit of 2 per week, or
• when your BonusCash rewards will expire.

Luckily the mobile RiteAid app (and website) list your individual accumulation & cashing out on a per transaction basis, so that's a good way to keep tabs on the expiration dates, since you only get 30 days to spend the BonusCash once earned. Good luck!