Extracellular vesicles (EVs) released by various cells play crucial roles in intercellular communication within the respiratory system. This review explores the historical context and significance of research into extracellular vesicles. Categorised into exosomes (sized 30–150 nm), microvesicles (sized 50–1000 nm) and apoptotic bodies (sized 500–2000nm), based on their generation mechanisms, extracellular vesicles carry diverse cargoes of biomolecules, including proteins, lipids and nucleic acids. Respiratory ailments are the primary contributors to both mortality and morbidity across various populations globally, significantly impacting public health. Recent studies have underscored the pivotal role of extracellular vesicles, particularly their cargo content, in mediating intercellular communication between lung cells in respiratory diseases. This comprehensive review provides insights into extracellular vesicle mechanisms and emphasises their significance in major respiratory conditions, including acute lung injury, COPD, pulmonary hypertension, pulmonary fibrosis, asthma and lung cancer.

Sony Interactive Entertainment on the PlayStation Blog has revealed the PlayStation Plus Game Catalog games for November 2024.

The PlayStation Plus Extra and Premium Game Catalog and Classics will be available from Tuesday, November 19.

The PlayStation Plus monthly games for November 2024 are currently available and includes Hot Wheels Unleashed 2 – Turbocharged for the PS5 and PS4, Ghostwire: Tokyo for the PS5, and Death Note Killer Within for the PS5 and PS4.

Check out the latest information below:

PlayStation Plus Extra and Premium | Game Catalog

Grand Theft Auto V* | PS4, PS5

When a young street hustler, a retired bank robber and a terrifying psychopath find themselves entangled with some of the most frightening and deranged elements of the criminal underworld, the U.S. government and the entertainment industry, they must pull off a series of dangerous heists to survive in a ruthless city in which they can trust nobody, least of all each other. Experience the interwoven stories of Franklin, Michael and Trevor in the sprawling open world of Los Santos and Blaine County.

*PlayStation Plus re-release.

Dying Light 2: Stay Human | PS4, PS5

In Dying Light 2, survival meets action adventure as you attempt to endure a hostile, post-apocalyptic world. Rival factions across The City aren’t the only enemy – a virus has turned a vast majority of the human population into monsters. Take on the role of Aiden Caldwell, a wanderer with the power to change the fate of The City, but your exceptional abilities come at a price. Haunted by memories you cannot decipher, you set out to learn the truth – and find yourself in a combat zone. Hone your skills to defeat your enemies and make allies. Unravel the dark secrets behind those that wield power, choose sides and decide your destiny. But wherever your actions take you, there’s one thing you must do – stay human.

Like a Dragon: Ishin | PS4, PS5

1860’s Kyo is plagued by widespread inequality, and one samurai will change the course of history in his search for justice. Take up the sword as Sakamoto Ryoma and venture to Kyoto to find your father’s killer, clear yourself of a framed murder, and restore your honor. In doing so, you will bring an end to the samurai era and forever change the future of Japan. Draw your blade, load your revolver, and join the revolution in this heated historical adventure that only the creators of Yakuza: Like a Dragon could produce.

MotoGP 24 | PS4, PS5

As a new season dawns, the winds of change are sweeping through the pit crews. Embark on your quest to become a MotoGP legend and shape your own epic saga. Challenge your abilities and immerse yourself in the exhilarating journey of the 2024 campaign. From humble beginnings to triumphant heights, the path is yours to forge. Engage in thrilling rivalries, build your reputation, and leave your mark on the history of your beloved team.

The Sims 4 Island Living* (Add-on only) | PS4

Welcome to Sulani, where the sun shines bright and the nights are totally chill. Escape the ordinary and enjoy a laid-back lifestyle surrounded by beaches in The Sims 4 Island Living. Explore a breezy world drenched in sun, sand, and endless fun as your Sims make their own paradise. Set sail on the glistening water in your island canoe, swim to your heart’s content, and explore the scenery on a watercraft. Everything is chill (except for the occasional sunburn) when it’s Island Living.

*Requires the original game The Sims 4. 

Digimon Survive | PS4

After getting lost on a school trip, Takuma Momozuka finds himself transported to a world inhabited by ferocious foes and new allies. Join Takuma and his friends as they fight their way back home. Digimon Survive is a hybrid visual novel and tactical RPG set in a mysterious world filled with dangerous monsters and deadly battles that will test your ability to survive. Persuade your opponents to join your team and evolve them to fight alongside you in thrilling turn-based battles. Unfold a dark tale about friendship and survival that is jam-packed with exciting drama, a unique cast of characters, and potentially grim choices.

Overcooked! All You Can Eat | PS4, PS5

Hold onto your chef hats and prepare your appetite for an XXL portion of Overcooked magic. Overcooked!, Overcooked! 2 and all additional content are blended together and remastered in this delicious definitive edition! Enjoy hundreds of levels of cooperative cooking chaos across increasingly perilous and obscure kitchens. 

Stick Fight: The Game | PS4

Stick Fight is a physics-based couch/online fighting game where you battle it out as the iconic stick figures from the golden age of the internet. Fight it out against your friends or find random sticks from around the world!

Clash: Artifacts of Chaos | PS4, PS5

Drawing upon both surreal and punk fantasy influences, the world and civilisations of Zenozoik are brimming with fascinating characters, creatures and landscapes. You play as Pseudo, a master of martial arts who lives as a recluse in the strange land of Zenozoik. When you cross paths with the Boy, a small creature whose mysterious powers have attracted the attention of Gemini, the Mistress of the Artifacts, you decide to protect him, unaware that much greater forces are involved. Roam this intriguing land and discover its paths, inhabitants and ancient secrets.

Killer Frequency | PS4, PS5

The year is 1987, and as the clock strikes midnight in small-town Gallows Creek, USA, former big city radio DJ Forrest Nash is live on air in what will turn out to be the graveyard shift of a lifetime… In this horror comedy, you must solve puzzles to save callers from being hunted down by a mysterious killer. Where every call is life and death, can you save the inhabitants of Gallows Creek? Step into the shoes of a late-night radio talk-show host – new in town and fallen from grace. The Sheriff is dead, so the townsfolk turn to you for help. You, Forrest Nash, are the only person in town who can run a phone line.

Hungry Shark World | PS4

Become a shark and spread terror on the beach! Fight man, machine and beast as you explore tropical islands, sunken temples, vast cities and frozen icebergs. Enjoy discovering expansive levels with their own distinctive enemies, hidden treasures and unique missions. Take on everything the sea throws at you, from gruesome goblin sharks and the adorable porbeagle, to prehistoric monsters and giant submarines. With rebalanced enemies and pacing, there’s a challenge around every corner!

Chivalry 2 | PS4, PS5

Return to the ultimate medieval battlefield. Chivalry 2 is a multiplayer first person slasher inspired by epic medieval movie battles. Players are thrust into the action of every iconic moment of the era – from clashing swords, to storms of flaming arrows, to sprawling castle sieges and more. Charge headfirst into stunning 64-Player cinematic battles inspired by epic medieval action films. Pick your playstyle with 4 classes and 12 subclasses, each with their own unique weapons and abilities.

PlayStation Plus Premium

Synapse | PS VR2

Dual-wield brutal firepower and surging telekinesis in the ultimate mind-breaking VR action shooter. Unleash your inner anti-hero and invade the twisted subconscious of a notorious enemy of the state. Become a mind-breaking operative and wreak havoc on the enemy’s mind with deadly weaponry in one hand and expressive telekinetic abilities in the other. Combine your powers to overcome formidable defences and delve deeper into a hostile mindscape.

Blood Omen: Legacy of Kain | PS4, PS5

Ready yourself for next month’s launch of Soul Reaver 1 & 2 Remastered by discovering the origins of this dark gothic fantasy franchise with the original PlayStation title Blood Omen: Legacy of Kain. In this top-down action adventure, embark on an epic quest through a vampire kingdom fraught with murder, magic and vengeance. Journey through an expansive world containing more than 100 hours of intense, blood-sucking, spell-casting gameplay, and enjoy cinema-quality voice-overs, dynamic lighting effects and more than 25 minutes of full-motion-video footage. 

Blood Omen 2 | PS4, PS5

Fierce attacks and brutal combos await in this action adventure, originally released on PS2 in 2002, after Soul Reaver 2’s launch the year previous. Blood Omen 2 will take you back to an alternate timeline set between the events of the first Blood Omen and Soul Reaver. Cast down from power by a mysterious warlord centuries ago, Kain reawakens in a world he barely recognizes. His armies slain, his vampire brethren nearly extinct, Kain is one of the last of his kind. With an agenda of vengeance, Kain shall unleash a wicked wrath to uncover the plot that threatens the land he seeks to conquer.

Resistance: Fall of Man

Epic military action and unnerving tension blend together in PS3’s 2006 first-person shooter Resistance: Fall of Man. Humanity faces annihilation as a relentless alien force known as the Chimera ravages Europe. Amidst the chaos, Nathan Hale emerges an unlikely hero, confronting unimaginable horrors while uncovering secrets that could change the course of the war. 

Resistance 2

Initially released in 2008 on PS3, Resistance 2 is the continuation of Insomniac Games’ science-fiction FPS saga. Now on American soil, the alien Chimera threatens Hale’s humanity in a gripping race against time to put a stop to the invasion. Once again at the forefront of humanity’s fight for survival, Nathan Hale must lead his squad through desperate missions, as new weapons and giant boss encounters increase the scale of the conflict to new heights.

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463059/playstation-plus-game-catalog-and-classics-for-november-2024-announced/

1. Chennai hospital stabbing: IMA demands ‘overhaul of security atmosphere’  Hindustan Times
2. Video: Chennai man calmly walks away after stabbing doctor, wipes knife  India Today
3. Chennai doctor stabbed, raises safety concerns among health workers, Tamil Nadu govt takes action: What happened so far  Mint
4. 'No law and order': BJP, AIADMK attack ruling DMK after government doctor stabbed in Chennai  The Times of India
5. Indian Medical Association condemns brutal attack on doctor in Chennai  The New Indian Express

Shivarajkumar, who will next be seen in ‘Bhairathi Ranagal’, said that the makers of Vijay’s ‘Thalapathy 69’ has approached him with an interesting character

After their rental agreement with a sublessor fell through, a couple asked for their deposit to be returned. They waited three weeks to no avail and decided to visit the sublessor's home for discussions. But the negotiations turned physical, with the woman brandishing a knife at the couple after she was attacked. The incident occurred at about 7pm last Sunday (Nov 10) at a condominium in Yishun, reported Shin Min Daily News. Chen, 41, said he had seen an advertisement for the four-bedroom unit on Oct 13 and contacted the poster, who said she had rented the apartment from the original tenant. The woman told Chen she could sublet the unit to him and his wife if the homeowner was agreeable to it.  After viewing pictures and videos of the apartment, the man immediately made a PayNow transfer of $1,000 to the woman as deposit. The couple viewed the unit the next day, where both parties discussed the rental agreement in detail. A week later, however, the woman told them that she had not gotten the approval of the condo owner to sublet the apartment.

Environmental defenders are raising alarm over Donald Trump’s pick to lead the Environmental Protection Agency, former New York Congressmember Lee Zeldin, who has a history of opposing critical environmental protections and clean energy job investments. Zeldin’s nomination comes as Trump is reportedly discussing moving the EPA headquarters outside of Washington, D.C., which could lead to an exodus of staff and expertise from the agency. “I really don’t think this is about government efficiency. I think this is about terrorizing the career staff,” says Judith Enck, who served as a regional administrator of the EPA in the Obama administration.

when personal Investment is matured, can we show as capital as the amount directly credited into sole propertiorship current account

what is capital gain tax rate on flat sale by nri? Is it 12.5% without indexation or 20% with indexation?

my ivew--> only 12.5% wo indexation as per section 115E (b)ii
am i wrong?

Hillary Clinton and Donald Trump today scrambled to make their final pitch to voters in the closely-contested U.S. presidential race dogged by controversies like the Democratic nominee's email scandal.

Automation and digital technologies will drive jobs of the future even as they cannibalise conventional employment while creating a large number of new opportunities, says biotech entrepreneur Kiran Mazumdar-Shaw.

Software giant IBM on Thursday announced the launch of a new state-of-the-art IBM centre in Mumbai that will help clients accelerate their digital transformation journey across industries, with a focus on banking and financial services organisations.

France, Italy and Portugal lead the teams attempting to secure a place in the UEFA Nations League quarter-finals, while England's promotion hopes have been hit by a series of withdrawals.

Malaika Arora opens up about her step-father for the first time three months post his death.

Productivity gains, include 25-30 per cent decline in customer acquisition costs, shortening account opening time to less than a day

A medical oncologist at the Kalaignar Centenary Super Speciality Hospital in Chennai was stabbed seven times on Wednesday by the son of a patient allegedly over grievances on treatment to his mother at the same facility, a hospital official said.

What do I preach here all the time? Do Not talk to your AV. Shut It Down Immediately. Once again I have failed to practice what I preach. I've been having on again off again conversations with...

William Hoesch Was Riding His Bicycle When He Was Struck By the Ambulance in 2022

I recently attended a talk by author, Bijoy Goswami. Bijoy covered team building as based on his book "The Human Fabric". I have to admit that I'm generally skeptical of the practicality of these kinds of talks, especially in cases where modern artwork is posted. Boy was I *wrong* (about both the content and the artwork - the artwork really drove some points home for me - sorry blog readers, no visual reference). All of it turns out to be great stuff. Bijoy's frameworks are useful and can be applied much like Myers-Briggs stuff can be applied (as opposed to being only descriptive).

Although I'm going to botch some of Bijoy's specific nomenclature, Bijoy's talk centered around building teams, and he talked about how successful teams need to build around three archetypes of people: the Maven, Evangelist, and Relater.

As I come from spending a good amount of time in the software world, people that are Maven-types are basically "Tools". Mavens are geniuses when it comes to technology and love architecturally cool stuff like gmail. They tend not to be good marketers.

Evangelists are thought of as people that come across as flashy, and they know exactly how to pitch a product with the one, two, and three top business points why one should buy.

Lastly, there are the Relater-types that are emphathetic and maintain relationships. They put people at ease and seek first to understand before seeking to be understood. They hate gmail, but they love Outlook because it helps the Relater stay connected with people.

In any case, Bijoy's claim is that teams (whether the team consists of two people) need to cover all bases.

As I think about my own archetype (a Relater-Evangelist), I realize that one of my past business relationships had been successful because my counterpart is an Evangelist-Maven. In one of my past client projects, I realize I plugged a key gap because of my Relater background. Now that I'm helping a friend recruit a key person for his company, aside from covering the nuts and bolts during the interview process, I'm thinking about how the new hire will round out the executive team.

Anyway, please check out Bijoy's book. I'm a believer now, and may end up buying the book for some of my clients.

Update (2/17/05): Bijoy has let me know offline that readers can take a look at the art and his website at http://www.thehumanfabric.com . Thanks, Bijoy!

Steve Shu Managing Director S4 Management Group Email: sshu@s4management.com Web: http://www.s4management.com

Background: Welsh Revival - In 1904, the Welsh Revival took place, during which approximately 100,000 people in Wales joined the movement. Internationally, evangelical Christians took this event to be a sign that a fulfillment of the prophecy in the Bible's book of Joel, chapter 2:23-29 was about to take place. Joseph Smale, pastor of the First Baptist Church in Los Angeles, went to Wales personally in order to witness the revival. Upon his return to Los Angeles, he attempted to ignite a similar event in his own congregation. His attempts were short-lived, and he eventually left First Baptist Church to found First New Testament Church, where he continued his efforts. During this time, other small-scale revivals were taking place in Minnesota, North Carolina, and Texas. By 1905, reports of speaking in tongues, supernatural healings, and significant lifestyle changes accompanied these revivals. As news spread, evangelicals across the United States began to pray for similar revivals in their own congregations. -- Los Angeles: In 1905, William J. Seymour, the one-eyed 34 year old son of former slaves, was a student of well-known Pentecostal preacher Charles Parham and an interim pastor for a small holiness church in Houston, Texas. Neely Terry, an African American woman who attended a small holiness church pastored by Julia Hutchins in Los Angeles, made a trip to visit family in Houston late in 1905. While in Houston, she visited Seymour's church, where he preached the baptism of the Holy Spirit with the evidence of speaking in tongues, and though he had not experienced this personally, Terry was impressed with his character and message. Once home in California, Terry suggested that Seymour be invited to speak at the local church. Seymour received and accepted the invitation in February 1906, and he received financial help and a blessing from Parham for his planned one-month visit. -- Seymour arrived in Los Angeles on February 22, 1906, and within two days was preaching at Julia Hutchins' church at the corner of Ninth Street and Santa Fe Avenue. During his first sermon, he preached that speaking in tongues was the first biblical evidence of the inevitable baptism in the Holy Spirit. On the following Sunday, March 4, he returned to the church and found that Hutchins had padlocked the door. Elders of the church rejected Seymour's teaching, primarily because he had not yet experienced the blessing about which he was preaching. Condemnation of his message also came from the Holiness Church Association of Southern California with which the church had affiliation. However, not all members of Hutchins' church rejected Seymour's preaching. He was invited to stay in the home of congregation member Edward S. Lee, and he began to hold Bible studies and prayer meetings there. -- Seymour and his small group of new followers soon relocated to the home of Richard and Ruth Asberry at 214 North Bonnie Brae Street. White families from local holiness churches began to attend as well. The group would get together regularly and pray to receive the baptism of the Holy Spirit. On April 9, 1906, after five weeks of Seymour's preaching and prayer, and three days into an intended 10-day fast, Edward S. Lee spoke in tongues for the first time. At the next meeting, Seymour shared Lee's testimony and preached a sermon on Acts 2:4 and soon six others began to speak in tongues as well, including Jennie Moore, who would later become Seymour's wife. A few days later, on April 12, Seymour spoke in tongues for the first time after praying all night long. -- News of the events at North Bonnie Brae St. quickly circulated among the African American, Latino and White residents of the city, and for several nights, various speakers would preach to the crowds of curious and interested onlookers from the front porch of the Asberry home. Members of the audience included people from a broad spectrum of income levels and religious backgrounds. Hutchins eventually spoke in tongues as her whole congregation began to attend the meetings. Soon the crowds became very large and were full of people speaking in tongues, shouting, singing and moaning. Finally, the front porch collapsed, forcing the group to begin looking for a new meeting place. A resident of the neighborhood described the happenings at 214 North Bonnie Brae with the following words: They shouted three days and three nights. It was Easter season. The people came from everywhere. By the next morning there was no way of getting near the house. As people came in they would fall under God's power; and the whole city was stirred. They shouted until the foundation of the house gave way, but no one was hurt. -- Azusa Street: Conditions - The group from Bonnie Brae Street eventually discovered an available building at 312 Azusa Street in downtown Los Angeles, which had originally been constructed as an African Methodist Episcopal Church in what was then a black ghetto part of town. The rent was $8.00 per month. A newspaper referred to the downtown Los Angeles building as a "tumble down shack". Since the church had moved out, the building had served as a wholesale house, a warehouse, a lumberyard, stockyards, a tombstone shop, and had most recently been used as a stable with rooms for rent upstairs. It was a small, rectangular, flat-roofed building, approximately 60 feet (18 m) long and 40 feet (12 m) wide, totaling 4,800 square feet (450 m2), sided with weathered whitewashed clapboards. The only sign that it had once been a house of God was a single gothic-style window over the main entrance. -- Discarded lumber and plaster littered the large, barn-like room on the ground floor. Nonetheless, it was secured and cleaned in preparation for services. They held their first meeting on April 14, 1906. Church services were held on the first floor where the benches were placed in a rectangular pattern. Some of the benches were simply planks put on top of empty nail kegs. There was no elevated platform, as the ceiling was only eight feet high. Initially there was no pulpit. Frank Bartleman, an early participant in the revival, recalled that "Brother Seymour generally sat behind two empty shoe boxes, one on top of the other. He usually kept his head inside the top one during the meeting, in prayer. There was no pride there.... In that old building, with its low rafters and bare floors..." -- The second floor at the now-named Apostolic Faith Mission housed an office and rooms for several residents including Seymour and his new wife, Jennie. It also had a large prayer room to handle the overflow from the altar services below. The prayer room was furnished with chairs and benches made from California Redwood planks, laid end to end on backless chairs. -- The Apostolic Faith Mission on Azusa Street, now considered to be the birthplace of Pentecostalism. -- By mid-May 1906, anywhere from 300 to 1,500 people would attempt to fit into the building. Since horses had very recently been the residents of the building, flies constantly bothered the attendees. People from a diversity of backgrounds came together to worship: men, women, children, black, white, Hispanic, Asian, rich, poor, illiterate, and educated. People of all ages flocked to Los Angeles with both skepticism and a desire to participate. The intermingling of races and the group's encouragement of women in leadership was remarkable, as 1906 was the height of the "Jim Crow" era of racial segregation, and fourteen years prior to women receiving suffrage in the United States. -- Birth of Pentecostal movement: By the end of 1906, most leaders from Azusa Street had spun off to form other congregations, such as the 51st Street Apostolic Faith Mission, the Spanish AFM, and the Italian Pentecostal Mission. These missions were largely composed of immigrant or ethnic groups. The Southeast United States was a particularly prolific area of growth for the movement, since Seymour's approach gave a useful explanation for a charismatic spiritual climate that had already been taking root in those areas. Other new missions were based on preachers who had charisma and energy. Nearly all of these new churches were founded among immigrants and the poor. -- Many existing Wesleyan-holiness denominations adopted the Pentecostal message, such as the Church of God (Cleveland, Tennessee), the Church of God in Christ, and the Pentecostal Holiness Church. The formation of new denominations also occurred, motivated by doctrinal differences between Wesleyan Pentecostals and their Finished Work counterparts, such as the Assemblies of God formed in 1914 and the Pentecostal Church of God formed in 1919. An early doctrinal controversy led to a split between Trinitarian and Oneness Pentecostals, the latter founded the Pentecostal Assemblies of the World in 1916. -- Today, there are more than 500 million Pentecostal and charismatic believers across the globe and is the fastest-growing form of Christianity today. The Azusa Street Revival is commonly regarded as the beginning of the modern-day Pentecostal Movement.

After his success with Messiah in 1742 A.D. he never performed an Italian opera again. Handel was only partly successful with his performances of English Oratorio on mythical or biblical themes, but when he arranged a performance of Messiah to benefit the Foundling Hospital (1750) the critique ended. The pathos of Handel's oratorio is an ethical one, they are hallowed not by liturgical dignity but by the moral ideals of humanity. Almost blind, and having lived in England for almost fifty years, he died a respected and rich man. -- Handel is regarded as one of the greatest composers of all time, not only because of his Water Music, and Music for the Royal Fireworks. But since the late 1960s, with the revival of baroque music and original instrument interest in Handel's opera seria has revived too. Handel composed forty operas in about thirty years; some are considered as masterpieces, with many sweeping arias and much admired improvisations. His operas contain remarkable human characterization, by a composer not known for his love affairs. -- Messiah: (HWV 56) is an English-language oratorio composed in 1741 by George Frideric Handel, with a scriptural text compiled by Charles Jennens from the King James Bible, and from the Psalms included with the Book of Common Prayer (which are worded slightly differently than their King James counterparts). It was first performed in Dublin on 13 April 1742, and received its London premiere nearly a year later. After an initially modest public reception the oratorio gained in popularity, eventually becoming one of the best-known and most frequently performed choral works in Western music.

Johannes Gutenberg was born into a noble family of the city of Mainz, Germany. His early training was in goldsmithing. In 1428, he moved to Strasbourg for political reasons, where he remained for over 20 years. It was in Strasbourg that he probably made his first experiments with moveable type. -- Gutenberg had the idea of utilizing techniques of metalworking, such as casting, punch-cutting, and stamping, for the mass production of books. European books at this time were hand written by scribes in a gothic script with many flourishes and ligatures (interconnected letter pairs). To reproduce this "look" Gutenberg fashioned a font of over 300 characters, far larger than the fonts of today. To make this possible, he invented the variable-width mold, and perfected the blend of lead, antimony, and tin used by type foundries up to the present century. -- Many years of Gutenberg's life are lost to history, but by 1450 he was back in Mainz at work on a printing press. Between 1450 and 1455, while preparing to produce a large folio Latin Bible, Gutenberg is thought to have printed a number of smaller books, a calendar, and a papal Letter of Indulgence. The Bible of 42 lines, the oldest surviving printed book in the western world, was completed by August 15, 1456, and while it is now credited to Gutenberg, he appears to have been relieved of his supervisory position, and his press, before the time of its publication. In fact, no printed material was ever credited to Gutenberg during his lifetime. -- Gutenberg is also believed to have worked on the Catholicon of Johannes de Janua, an enormous encyclopedia: 748 pages in two columns of 66 lines each. In later years, he received a position as a courtier to the archbishop of Mainz, and was buried in the town's Franciscan church.

Thomas is held in the Catholic Church to be the model teacher for those studying for the priesthood. The works for which he is best-known are the Summa Theologica and the Summa Contra Gentiles. As one of the 33 Doctors of the Church, he is considered the Church's greatest theologian and philosopher. Pope Benedict XV declared: "This (Dominican) Order ... acquired new luster when the Church declared the teaching of Thomas to be her own and that Doctor, honored with the special praises of the Pontiffs, the master and patron of Catholic schools."

Wars with the Moors [Muslims]: The conquest of Italy brought Charlemagne in contact with the Saracens who, at the time, controlled the Mediterranean. Pippin, his son, was much occupied with Saracens in Italy. Charlemagne conquered Corsica and Sardinia at an unknown date and in 799 the Balearic Islands. The islands were often attacked by Saracen pirates, but the counts of Genoa and Tuscany (Boniface) kept them at bay with large fleets until the end of Charlemagne's reign. Charlemagne even had contact with the caliphal court in Baghdad. In 797 (or possibly 801), the caliph of Baghdad, Harun al-Rashid, presented Charlemagne with an Asian elephant named Abul-Abbas and a clock. -- In Hispania [Spain], the struggle against the Moors continued unabated throughout the latter half of his reign. His son Louis was in charge of the Spanish border. In 785, his men captured Gerona permanently and extended Frankish control into the Catalan littoral for the duration of Charlemagne's reign (and much longer, it remained nominally Frankish until the Treaty of Corbeil in 1258). The Muslim chiefs in the northeast of Islamic Spain were constantly revolting against Córdoban authority, and they often turned to the Franks for help. The Frankish border was slowly extended until 795, when Gerona, Cardona, Ausona, and Urgel were united into the new Spanish March, within the old duchy of Septimania. -- In 797 Barcelona, the greatest city of the region, fell to the Franks when Zeid, its governor, rebelled against Córdoba and, failing, handed it to them. The Umayyad authority recaptured it in 799. However, Louis of Aquitaine marched the entire army of his kingdom over the Pyrenees and besieged it for two years, wintering there from 800 to 801, when it capitulated. The Franks continued to press forward against the emir. They took Tarragona in 809 and Tortosa in 811. The last conquest brought them to the mouth of the Ebro and gave them raiding access to Valencia, prompting the Emir al-Hakam I to recognize their conquests in 812 A.D.

Papal authority: Decree of Valentinian - Leo was a significant contributor to the centralisation of spiritual authority within the Church and in reaffirming papal authority. While the bishop of Rome had always been viewed as the chief patriarch in the Western church, much of the pope's authority was delegated to local diocesan bishops. Not without serious opposition did he succeed in reasserting his authority in Gaul. Patroclus of Arles (d. 426) had received from Pope Zosimus the recognition of a subordinate primacy over the Gallican Church which was strongly asserted by his successor Hilary of Arles. An appeal from Chelidonius of Besançon gave Leo the opportunity to reassert the pope's authority over Hilary, who defended himself stoutly at Rome, refusing to recognize Leo's judicial status. Feeling that the primatial rights of the bishop of Rome were threatened, Leo appealed to the civil power for support, and obtained from Valentinian III the famous decree of June 6, 445, which recognized the primacy of the bishop of Rome based on the merits of Peter, the dignity of the city, and the Nicene Creed (in their interpolated form); ordained that any opposition to his rulings, which were to have the force of ecclesiastical law, should be treated as treason; and provided for the forcible extradition by provincial governors of anyone who refused to answer a summons to Rome. Faced with this decree, Hilary submitted to the pope, although under his successor, Ravennius, Leo divided the metropolitan rights between Arles and Vienne (450). -- Dispute with Dioscorus of Alexandria: In 445, Leo disputed with Pope Dioscorus, St. Cyril's successor as Pope of Alexandria, insisting that the ecclesiastical practice of his see should follow that of Rome on the basis that Mark the Evangelist, the disciple of Saint Peter and founder of the Alexandrian Church, could have had no other tradition than that of the prince of the apostles. This, of course, was not the position of the Copts, who saw the ancient patriarchates as equals. -- Council of Chalcedon: A favorable occasion for extending the authority of Rome in the East was offered in the renewal of the Christological controversy by Eutyches, who in the beginning of the conflict appealed to Leo and took refuge with him on his condemnation by Flavian. But on receiving full information from Flavian, Leo took his side decisively. In 451 at the Council of Chalcedon, after Leo's Tome on the two natures of Christ was read out, the bishops participating in the Council cried out: "This is the faith of the fathers ... Peter has spoken thus through Leo ..." -- Battling heresies: An uncompromising foe of heresy, Leo found that in the diocese of Aquileia, Pelagians were received into church communion without formal repudiation of their errors; he wrote to rebuke them, making accusations of culpable negligence, and required a solemn abjuration before a synod. Manicheans fleeing before the Vandals had come to Rome in 439 and secretly organized there; Leo learned of this around 443, and proceeded against them by holding a public debate with their representatives, burning their books, and warning the Roman Christians against them. Nor was his attitude less decided against the Priscillianists. Bishop Turrubius of Astorga, astonished at the spread of this sect in Spain, had addressed the other Spanish bishops on the subject, sending a copy of his letter to Leo, who took the opportunity to exercise Roman policy in Spain. He wrote an extended treatise (21 July 447), against the sect, examining its false teaching in detail, and calling for a Spanish general council to investigate whether it had any adherents in the episcopate, but this was prevented by the political circumstances of Spain. -- On Dignity and Equality: In his Nativitate Domini, in the Christmas Day sermon "Christian, Remember your Dignity" Leo appears to articulate a fundamental and inclusive human dignity and equality: The saint, the sinner, and the unbeliever are all equal as sinners, and none is excluded in the call to "happiness": "Our Saviour, dearly-beloved, was born today: let us be glad. For there is no proper place for sadness, when we keep the birthday of the Life, which destroys the fear of mortality and brings to us the joy of promised eternity. No one is kept from sharing in this happiness. There is for all one common measure of joy, because as our Lord the destroyer of sin and death finds none free from charge, so is He come to free us all. Let the saint exult in that he draws near to victory. Let the sinner be glad in that he is invited to pardon. Let the gentile take courage in that he is called to life."

Christian apologist and talk show host Chris Rosebrough (Fighting For The Faith) was recently the featured guest on Stand Up For The Truth radio show. From the Stand Up For The Truth website: "We know that the God of the Bible is not the same god of the Qur'an. Yahweh of the Bible became flesh 2,000 years ago to be that perfect lamb, the Son, the atonement for our sins. The Jesus we believe in is God. But Allah of the Qur'an did not have a son. There was no atonement, no hope of a Messiah, and no grace for sinners. The Christian God and the Muslim Allah cannot be one and the same. And yet there are a growing number of Christians and Muslims who are combining the faith-syncretizing the two into one. That's called Chrislam, and it is heresy. -- This week the Orange County Register reported in an article that leadership of Pastor Rick Warren's Saddleback Church believe that Muslims and Christians believe in the same God. Is the article accurate? Is that truly what these leaders believe? Our guest today has communicated with Rick Warren twice in the past few days, and it's as close as anyone has gotten to America's Pastor to hear in his own words what is going on. -- Chris Rosebrough is host of a daily two-hour internet radio program, Fighting For The Faith, heard around the world on Pirate Christian Radio, a broadcast group he started in his hometown of Indianapolis. Chris is at the forefront of those contending for the truth of God's Word."

The program provides excellent anytime devotions and is perfect as a gift for others. Most importantly the end user can create their own comments list, add links to other websites, blogs, RSS feeds, references and documents that once combined create an inclusive individual 'Platform' for Christian research, devotionals and study projects.

New video by EJ: Tune in to the latest installment of the Jackson Kayak Dock Talk podcast, where Chad Brock sits down with Chris Walters, Marcas Grubbs, and Jason Cassetty. This lively crew dives into a conversation about the USA Bassin's Jackson Kayak Classic tournament. Don't miss out—catch all the exciting details as it unfolds live!

media:personal DE ist als Unternehmen auf die TV, Medien- und Kommunikationsbranche fokussiert. Hierbei arbeiten wir mit national und international tätigen Unternehmen, Agenturen, TV/Radio-Sendern, Verlagen sowie Produktionsunternehmen zusammen. Unser Kunde ist ein erfolgreiches Medienunternehmen (mit eigener Produktion) mit dem Schwerpunkt Handelswerbung im Bereich LEH (Prospekte Supermärkte). Das Unternehmen bietet bei dieser Position auch ein attraktives Home-Office Modell an. >>> Profil &… | media:personal DE // Personalmanagement Andreas Burg – Essen

Du hast ein Auge für’s Detail? Du liebst die Magie des Drucks, deine Ideen zu verwirklichen und im Team kreative Prozesse weiter zu entwickeln? Dann passt du perfekt zu uns! ARTEBENE ist eine international erfolgreiche Marke für feinste Papeterie und Lifestyle-Produkte. Angefangen mit hochwertigen Geschenkverpackungen wie Kartonagen und Präsenttaschen in Premiumqualität entwickelte sich die Marke zu einer Lifestyle-Brand mit einzigartiger Design-Handschrift. Herzstück von ARTEBENE ist das eigene Design… | Artebene design – Lüdinghausen

Wir suchen Dich als Verstärkung für unser Team vor Ort in Bielefeld! Zu sofort und gerne in Teilzeit (unbefristet)! Selbstverständlich kannst Du nach entsprechender Einarbeitung auch ein bis zwei Tage in der Woche im Homeoffice arbeiten. Was wir von Dir als Mediendesigner*in / Webdesigner*in (m/w/d) erwarten: - Studium oder eine vergleichbare Ausbildung zum/zur Mediendesigner*in / Webdesigner*in / Grafiker*in (m/w/d) - Versierter Umgang mit der Adobe Creative Suite - Umfangreiche Erfahrung und sicherer… | screen concept – runge – Bielefeld

Paul Mascia's first book, "Nazar's Journey," tells the story of people in 2014 fleeing ISIS on the highway between Mosul and Erbil. Proceeds benefit Brooklyn-based Aid to the Church in Need-USA.

Premier Stitching, a sewing specialty dealer in Bryan Texas, needed a new website and sewing specialty focus that was achieved by the Marketing Heroes Team to better highlight the dealer's dedicated services for clients seeking all types of sewing, quilting, and embroidery machine purchases as well as maintenance work in the greater Brazos Valley area.

Tithely continues to innovate in the realm of digital church solutions ensuring that churches can engage their communities with ease and efficiency with their redesigned Giving App for iOS and the enhanced Kiosk Giving Mode.

Berlin-based x-cardiac GmbH is pleased to announce that Freiburg University Hospital has become the second pilot customer for its AI-based software "x-c-bleeding" for predicting severe bleeding complications after cardiac surgery. With the implementation of "x-c-bleeding", the University Hospital Freiburg takes another important step towards AI-based medicine.

The Medias Hospital has officially enrolled in the accreditation program of IASIOS to further ensure highest quality standards in Interventional Oncology as an important aspect of oncological patient care.

RHEACELL announces "First Patient In": EB-Haus in Salzburg, Austria starts pivotal study for stem cell therapy for severe forms of Epidermolysis bullosa that is longed for by those affected

To break the time and accessibility barrier, Creative Family Counseling, a Kentucky-based therapy collaborative that specializes in working with children, teens, parents, and families, has partnered with the Oldham County School System and select Louisville-area private schools to provide School Facilitated Services in order to better meet the mental health needs of students while also supporting the busy schedules of parents.

Swiss identity verification provider PXL Vision AG is responding to the growing demands on businesses. With the market launch of the software-as-a-service solution PXL Ident in April this year, the provider is expanding its AI-supported biometric identification process, which offers companies a secure way of verifying identity in online interactions.

Columbus, Ohio-based leftchannel Content Design Studio was enlisted to design a modern digital art display under the creative direction of Alberto Scirocco for the iconic Sheraton Dallas Hotel.

Deutsche Hospitality and the Porsche Design Group are joining forces to present the Steigenberger Porsche Design Hotels brand, an innovative hotel concept in the Luxury Lifestyle Segment.

While existing travel websites primarily display the cheapest or fastest travel option, the new BookSmart24 app also finds the most CO2- and emission-efficient variant for the chosen route. The platform enables users to make smart and responsible booking decisions and to realize that traveling in an environmentally conscious manner does not necessarily have to be more expensive.

The Gaffney House, a historic property on River Road at 4515 Upper River Road that features the designs of famous Louisville architect James J. Gaffney, has been renovated and restored as of 2023. The house is now listed for short-term rentals, hourly rentals, weddings, corporate retreats, and boat or boat slip rentals.

The Law Firm of Hildebrand & Wilson, LLP in Pearland Texas needed a website rebranding that was achieved by the Marketing Heroes Team to better focus on the law firm's dedicated services to clients injured in car and truck accidents.

Gustitis Law in Bryan Texas needed a website transformation that was achieved by the Marketing Heroes Team to better highlight the law firm's dedicated services to clients needing a criminal defense attorney.

David Gardner's Jewelers & Gemologists of College Station Texas needed an upgraded website and new digital marketing strategy that was achieved by the Marketing Heroes Team and made their customer's website experience as friendly and helpful as when you visit their store.