Privind aprobarea contului de execuţie al bugetului local al Municipiului Timisoara la 31 Decembrie 2019

The Reserve Roastery Chicago opens Friday, transforming the former Crate & Barrel space into five floors of coffee wonderland.

A trade between the Dodgers and Angels that made a big difference sent Andy Messersmith to L.A. and Frank Robinson to Anaheim, but Steve Garvey stayed put.

PRINCESS ANNE, 69, appeared in a video on the Royal Family Instagram to celebrate the International Day of the Midwife. A video of the Princess Royal, the Queen's only daughter, was posted to the IGTV of the account.

Celtic boss Neil Lennon should replace the suspended Ryan Christie with Scott Sinclair in his starting line-up to face Ross County today, according to Rangers hero Alan Hutton.

A film that has never previously been broadcast shows crowds gathered at City Hall and Royal Avenue.

You might never think of Germany as a cricket nation, but there has been a huge transformation over the past five years.

1. Netizens swoon over Sunil Lahri's son's handsomeness; a look at rare and unseen pics of the cast of Ramayan's family members  Times of India
2. Ramayan actor Dipika Chikhlia would love to play Kaikeyi, Sunil Lahri wishes to play Raavan’s role if...  Hindustan Times
3. Throwback: Ramanand Sagar had THIS condition for roping in Arun Govil for Ram’s role in Ramayan  PINKVILLA
4. Buoyed by Ramayans record-breaking run, Kapil Sharmas episode with stars to air again - Republic World  Republic World
5. Ramayan's Sita Dipika Chikhlia and Lakshman Sunil Lahri on making of the show  Hindustan Times
6. View Full coverage on Google News

The musician pointed out that she hails from Texas and is familiar with hunting and gun culture, but she said the recent tragedies deserve a different response.

Punitive Medicaid work requirements are being rolled back.

It took hundreds of exposures and a complex method of removing occlusions, but this "lucky" shot is the result: a depiction of the hot regions lurking under Jupiter's uppermost clouds.

The picture was captured in infared by the Gemini North Telescope in Hawaii, and is one of the sharpest observations of the planet ever made from the ground. To achieve the resolution, scientists used a technique called "lucky imaging" which scrubs out the blurring effect of looking through Earth's turbulent atmosphere. This method involves acquiring multiple exposures of the target and only keeping those segments of an image where that turbulence is at a minimum.

Rare coins can add beauty and value to any collection. It is a piece of history that any man or woman hold in their hand. It could belong to an ancient era and certain empires such as the Romanian world or maybe it’s a silver dollar that pioneered in the wild east. Coin collectors are […]

The post Start Your Coin Collection With These Rare Coins appeared first on Dumb Little Man.

(Purdue University) New environmentally friendly technologies promise to be 'game changers' in the rare earth metals field and enable the US to create a more stable and reliable domestic source of these essential metals. Purdue University patented extraction and purifying processes using ligand-assisted chromatography are shown to remove and purify such metals from coal ash, recycled magnets and raw ore safely, efficiently and with virtually no detrimental environmental impact.

Dozens of United States children have been hospitalised with a serious inflammatory condition possibly linked with the coronavirus and first seen in Europe. New York authorities announced Wednesday that 64 potential cases had been reported to...

Most replicated genetic determinants for type 1 diabetes are common (minor allele frequency [MAF] >5%). We aimed to identify novel rare or low-frequency (MAF <5%) single nucleotide polymorphisms with large effects on risk of type 1 diabetes. We undertook deep imputation of genotyped data followed by genome-wide association testing and meta-analysis of 9,358 type 1 diabetes case and 15,705 control subjects from 12 European cohorts. Candidate variants were replicated in a separate cohort of 4,329 case and 9,543 control subjects. Our meta-analysis identified 27 independent variants outside the MHC, among which 3 were novel and had MAF <5%. Three of these variants replicated with P_replication < 0.05 and P_combined < P_discovery. In silico analysis prioritized a rare variant at 2q24.3 (rs60587303 [C], MAF 0.5%) within the first intron of STK39, with an effect size comparable with those of common variants in the INS and PTPN22 loci (combined [from the discovery and replication cohorts] estimate of odds ratio [OR_combined] 1.97, 95% CI 1.58–2.47, P_combined = 2.9 x 10^–9). Pharmacological inhibition of Stk39 activity in primary murine T cells augmented effector responses through enhancement of interleukin 2 signaling. These findings provide insight into the genetic architecture of type 1 diabetes and have identified rare variants having a large effect on disease risk.

Invitation Only Research Event

PET using radiolabeled prostate-specific membrane antigen (PSMA) is now being more widely adopted as a valuable tool to evaluate patients with prostate cancer (PC). Recently, 3 different criteria for interpretation of PSMA PET were published: the European Association of Nuclear Medicine (EANM) criteria, the Prostate Cancer Molecular Imaging Standardized Evaluation criteria, and the PSMA Reporting and Data System. We compared these 3 criteria in terms of interreader, intrareader, and intercriteria agreement. Methods: Data from 104 patients prospectively enrolled in research protocols at our institution were retrospectively reviewed. The cohort consisted of 2 groups: 47 patients (mean age, 64.2 y old) who underwent Glu-NH-CO-NH-Lys-(Ahx)-[⁶⁸Ga(HBED-CC)] (⁶⁸Ga-PSMA11) PET/MRI for initial staging of biopsy-proven intermediate- or high-risk PC, and 57 patients (mean age, 70.5 y old) who underwent ⁶⁸Ga-PSMA11 PET/CT because of biochemically recurrent PC. Three nuclear medicine physicians independently evaluated all ⁶⁸Ga-PSMA11 PET/MRI and PET/CT studies according to the 3 interpretation criteria. Two of them reevaluated all studies 6 mo later in the same manner and masked to the initial reading. The Gwet agreement coefficient was calculated to evaluate interreader, intrareader, and intercriteria agreement based on the following sites: local lesion (primary tumor or prostate bed after radical prostatectomy), lymph node metastases, and other metastases. Results: In the PET/MRI group, interreader, intrareader, and intercriteria agreement ranged from substantial to almost perfect for any site according to all 3 criteria. In the PET/CT group, interreader agreement ranged from substantial to almost perfect except for judgment of distant metastases based on the PSMA Reporting and Data System (Gwet agreement coefficient, 0.57; moderate agreement), in which the most frequent cause of disagreement was lung nodules. Intrareader agreement ranged from substantial to almost perfect for any site according to all 3 criteria. Intercriteria agreement for each site was also substantial to almost perfect. Conclusion: Although the 3 published criteria have good interreader and intrareader reproducibility in evaluating ⁶⁸Ga-PSMA11 PET, there are some factors causing interreader disagreement. Further work is needed to address this issue.

OBJECTIVE

To characterize the status of cardiometabolic risk factors after late relapse of type 2 diabetes mellitus (T2DM) and to identify factors predicting relapse after initial diabetes remission following bariatric surgery to construct prediction models for clinical practice.

On February 9, 1945, two submarines are poised to engage in a direct, underwater confrontation. It's the first - and only - underwater submarine dog fight

Their coloration is unusual. Their fate, sadly, is not

The new wound further diminishes Earth’s protective shield against damaging solar radiation

Visitors can get up close and personal with augmented reality versions of historic globes recently digitized by the British Library

SPENDING less on skin care products can be tempting. Aren’t all the products the same? Don’t they all just use the same ingredients? You’re basically just paying for the brand name, right? It’s far too easy to fall into this trap – the trap which leads us to try and convince ourselves that the dollar store brand stuff is just as good as high-end beauty products.

Rare diseases in childhood can be debilitating and require lifelong care. Since 1983, the Orphan Drug Act incentives have stimulated the development and significantly improved the availability of treatment products for patients with rare diseases.

We report an increasing pediatric orphan product designations and approvals from 2000 to 2009. The trend indicates that the Orphan Drug Act has continued to address this important unmet need. (Read the full article)

Gaining intravenous access in children can be difficult. Recently, several near-infrared devices have been introduced attempting to support intravenous cannulation by visualizing veins underneath skin. Only one of those devices has been evaluated systemically thus far and results are inconclusive.

Although it was possible to visualize veins with near-infrared in most patients, the VascuLuminator did not improve the success of cannulation. An explanation is that the main problem is probably not localization of the vein but insertion of the cannula. (Read the full article)

A five-year-old boy in New York state has died from a rare inflammatory disease believed to be caused by the new coronavirus, Governor Andrew Cuomo said Friday.

#VictoryPages presents rare historical footage of the Battle of Berlin for the first time in color as part of RT’s tribute to the 75th anniversary of the defeat of fascism.
Read Full Article at RT.com

The term supermoon has only prevailed in the common lexicon for 40 years or so. It was coined by astrologer Richard Nolle in 1979.

Michael Gewitz, Physician-in-Chief of Maria Fareri Children's Hospital, where the boy passed away, said the child suffered "serious neurological complications" from the pediatric multi-symptom inflammatory syndrome.

A rare wolf snake with two fully formed heads was recently discovered in Odisha.

When the sun sets on a remote desert outpost and solar panels shut down, what energy source will provide power through the night? A battery, perhaps, or an old diesel generator? Perhaps something strange and new.

On 7 August 2018, ESMA published a letter from Steven Maijoor, ESMA Chair, to Gabriel Bernardino, EIOPA Chair. The letter addressed the question of whether ESMA would consider borrowing arrangements and derivative arrangements entered into by an Alt...

Mother's Day weekend got off to an unseasonably snowy start in the northeast Saturday thanks to the polar vortex.

A child died in a New York City hospital this week from what appeared to be a rare syndrome linked to the coronavirus that causes life-threatening inflammation in critical organs. ......

'This is every parents' nightmare, right, that your child may actually be affected by this virus,' said New York Governor Andrew Cuomo.

NEW YORK: A five-year-old boy in New York state has died from a rare inflammatory disease believed to be caused by the new coronavirus, Governor Andrew Cuomo said on Friday.“There have been 73 reported cases in NY of children getting severely ill with symptoms similar to Kawasaki disease...

A 5-year old boy has died in New York from a rare inflammatory syndrome believed to be linked to the novel coronavirus, highlighting a potential new risk for children in the pandemic, Governor Andrew Cuomo said on Friday.

Three children in New York have died from a rare inflammatory syndrome believed to be linked to the novel coronavirus, Governor Andrew Cuomo told a daily briefing on Saturday.

A 1966 manuscript, on which a young Bob Dylan typed and wrote lyrics for a track on his "Blonde on Blonde" album and another song he later abandoned, went on sale at Sotheby's auction house from Tuesday.

Black paint usually absorbs heat, but a new two-layer polymer paint reflects infrared light and keeps objects 16°C cooler, which could help make buildings more energy efficient

Title: Brineura Approved for Rare Genetic Illness Affecting Kids
Category: Health News
Created: 4/28/2017 12:00:00 AM
Last Editorial Review: 5/1/2017 12:00:00 AM

Title: Rare, Serious Illness May Occur in Children With COVID-19
Category: Health News
Created: 4/28/2020 12:00:00 AM
Last Editorial Review: 4/28/2020 12:00:00 AM

Title: Condition Affecting Kids With COVID-19 Remains Very Rare, Heart Group Says
Category: Health News
Created: 5/7/2020 12:00:00 AM
Last Editorial Review: 5/8/2020 12:00:00 AM

The IR Biotyper is a new automated typing system based on Fourier-transform infrared (FT-IR) spectroscopy that gives results within 4 h. We aimed (i) to use the IR Biotyper to retrospectively analyze an outbreak of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae (ESBL-KP) in a neonatal intensive care unit and to compare results to BOX-PCR and whole-genome sequencing (WGS) results as the gold standard and (ii) to assess how the cutoff values used to define clusters affect the discriminatory power of the IR Biotyper. The sample consisted of 18 isolates from 14 patients. Specimens were analyzed in the IR Biotyper using the default analysis settings, and spectra were analyzed using OPUS 7.5 software. The software contains a feature that automatically proposes a cutoff value to define clusters; the cutoff value defines up to which distance the spectra are considered to be in the same cluster. Based on FT-IR, the outbreak represented 1 dominant clone, 1 secondary clone, and several unrelated clones. FT-IR results, using the cutoff value generated by the accompanying software after 4 replicates, were concordant with WGS for all but 1 isolate. BOX-PCR was underdiscriminatory compared to the other two methods. Using the cutoff value generated after 12 replicates, the results of FT-IR and WGS were completely concordant. The IR Biotyper can achieve the same typeability and discriminatory power as genome-based methods. However, to attain this high performance requires either previous, strain-dependent knowledge about the optimal technical parameters to be used or validation by a second method.