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Associations of Cardiac, Kidney, and Diabetes Biomarkers With Peripheral Neuropathy among Older Adults in the Atherosclerosis Risk in Communities (ARIC) Study

Abstract
Background
The aim of this study was to assess the association of high-sensitivity cardiac troponin (hs-cTnT) and other cardiac, kidney, hyperglycemia, and inflammatory biomarkers with peripheral neuropathy (PN) in a community-based population.
Methods
We conducted a cross-sectional analysis of 3056 black and white participants in the Atherosclerosis Risk in Communities (ARIC) study who underwent standardized monofilament PN testing and had measures of cardiac function (hs-cTnT, N-terminal pro–B-type natriuretic peptide [NT-proBNP], and growth differentiation factor 15 [GDF15]), kidney function (serum creatinine, cystatin C, β-2 microglobulin, urine albumin-to-creatinine ratio), hyperglycemia (fasting glucose, hemoglobin A1c [Hb A1c], fructosamine, glycated albumin, 1,5-anhydroglucitol), and inflammation (C-reactive protein) assessed at visit 6 (2016–2017; age 71–94 years). We used logistic regression to assess the associations of these biomarkers (modeled in diabetes-specific tertiles) with PN in older adults with and without diabetes after adjusting for traditional risk factors.
Results
In total, 33.5% of participants had PN (37.3% with diabetes and 31.9% without diabetes). There was an independent association of hs-cTnT with PN regardless of diabetes status (diabetes T3 vs. T1: odds ratio [OR], 2.15 [95% CI, 1.44–3.22]; no diabetes: OR, 2.31 [95%CI, 1.76–3.03]; P = 0.72 for interaction). Among participants without diabetes, there were also significant associations of NT-proBNP (OR, 1.40 [95% CI, 1.08–1.81]) and urine albumin-to-creatinine ratio (OR, 1.55 [95% CI, 1.22–1.97]) with PN. Associations of hyperglycemia biomarkers including Hb A1c (OR, 1.76 [95% CI, 1.22–2.54]), fructosamine (OR, 1.71 [95% CI, 1.19–2.46]), and glycated albumin (OR, 1.45 [95% CI, 1.03–2.03]) with PN were significant only among participants with diabetes.
Conclusions
Overall, hs-cTnT appears to be a global marker of end organ damage, including PN. Laboratory biomarkers may be able to help us identify those individuals with PN.




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Recurrent Aphthous Stomatitis: Consider Anemia and Celiac Disease




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Meropenem-Vaborbactam versus Ceftazidime-Avibactam for Treatment of Carbapenem-Resistant Enterobacteriaceae Infections [Clinical Therapeutics]

The comparative efficacy of ceftazidime-avibactam and meropenem-vaborbactam for treatment of carbapenem-resistant Enterobacteriaceae (CRE) infections remains unknown. This was a multicenter, retrospective cohort study of adults with CRE infections who received ceftazidime-avibactam or meropenem-vaborbactam for ≥72 hours from February 2015 to October 2018. Patients with a localized urinary tract infection and repeat study drug exposures after the first episode were excluded. The primary endpoint was clinical success compared between treatment groups. Secondary endpoints included 30- and 90-day mortality, adverse events (AE), 90-day CRE infection recurrence, and development of resistance in patients with recurrent infection. A post hoc subgroup analysis was completed comparing patients who received ceftazidime-avibactam monotherapy, ceftazidime-avibactam combination therapy, and meropenem-vaborbactam monotherapy. A total of 131 patients were included (ceftazidime-avibactam, n = 105; meropenem-vaborbactam, n = 26), 40% of whom had bacteremia. No significant difference in clinical success was observed between groups (62% versus 69%; P = 0.49). Patients in the ceftazidime-avibactam arm received combination therapy more often than patients in the meropenem-vaborbactam arm (61% versus 15%; P < 0.01). No difference in 30- and 90-day mortality resulted, and rates of AE were similar between groups. In patients with recurrent infection, development of resistance occurred in three patients that received ceftazidime-avibactam monotherapy and in no patients in the meropenem-vaborbactam arm. Clinical success was similar between patients receiving ceftazidime-avibactam and meropenem-vaborbactam for treatment of CRE infections, despite ceftazidime-avibactam being used more often as a combination therapy. Development of resistance was more common with ceftazidime-avibactam monotherapy.




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[Molecular Pathology] The Formation of Coronary Vessels in Cardiac Development and Disease

Understanding how coronary blood vessels form and regenerate during development and progression of cardiac diseases will shed light on the development of new treatment options targeting coronary artery diseases. Recent studies with the state-of-the-art technologies have identified novel origins of, as well as new, cellular and molecular mechanisms underlying the formation of coronary vessels in the postnatal heart, including collateral artery formation, endocardial-to-endothelial differentiation and mesenchymal-to-endothelial transition. These new mechanisms of coronary vessel formation and regeneration open up new possibilities targeting neovascularization for promoting cardiac repair and regeneration. Here, we highlight some recent studies on cellular mechanisms of coronary vessel formation, and discuss the potential impact and significance of the findings on basic research and clinical application for treating ischemic heart disease.




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8 loại cây cảnh tốt cho phòng ngủ giúp bạn ngon giấc mỗi đêm

Nghiên cứu từ Cơ quan Hàng không và Vũ trụ Hoa Kỳ (NASA) cho thấy, với sự hiện diện của những loại cây cảnh tốt cho phòng ngủ dưới đây, giấc ngủ của chúng ta chắc chắn sẽ được cải thiện đáng kể.




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Phòng mới, Tân Bình, giờ giấc tự do (giảm 15% tiền phòng tháng 05)

Mô tả. - Giá 3tr5 đến 4tr5. - Phòng sạch sẽ, mới xây, ánh sáng tự nhiên. - Diện tích 18m2 - 22m2. - Giờ giấc tự do bảo vệ 24/24. - Phòng trọ thích hợp cho sinh viên và nhân viên văn phòng. - Nội thất: + Máy lạnh. + Có WC riêng. + Có khu vực bếp và bồn rửa riêng. + Máy giặt free. ...




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Child, three, has fatal cardiac arrest as mother kept on 111 hold for over an hour

A sick child died after their mother was kept on hold by the NHS 111 helpline for more than an hour as she desperately sought medical help.




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Brian Howe dead: Bad Company frontman dies of cardiac arrest aged 66

Bad Company frontman Brian Howe has died at the age of 66, a family member has confirmed.




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YouTube TV subscribers getting access to Viacom channels including VH1, BET, MTV and others

MTV, Nickelodeon, Paramount Network and TV Land are among the channels launching on YouTube TV in the coming months.

      




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VitalPatch Wins FDA Emergency Use Authorization for Cardiac Monitoring in COVID Patients

VitalConnect announced that it has received FDA Emergency Use Authorization status for use of its VitalPatch to detect changes in the QT interval of hospitalized patients undergoing drug treatment for COVID-19. Hydroxychloroquine and chloroquine, used to treat some COVID-19 patients, are associated with risk of prolonged QT interval that can lead to life-threatening arrhythmias. VitalPatch allows […]




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Attorney General Eric Holder Speaks at the International Association of Chiefs of Police (IACP) Conference

"Talk alone isn’t going to keep crime rates down. Talk alone isn’t going to protect innocent victims. Talk alone isn’t going to stop rival gangs from shooting up our streets, or drug dealers from peddling dope in our schools, or terrorists from attacking our cities. Indeed, we all know that the best ideas in the world are worth little without the resources to implement them."




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Minnesota-based St. Jude Medical Pays U.S. $3.65 Million to Settle Claims That It Overcharged for Implantable Cardiac Devices

St. Jude Medical Inc. has agreed to pay the United States $3.65 million to resolve civil allegations under the False Claims Act that the company inflated the cost of replacement pacemakers and defibrillators purchased by the Departments of Defense and Veterans Affairs, the Justice Department announced today. St. Paul, Minn.-based St. Jude Medical develops, manufactures and distributes cardiovascular and implantable neurostimulation medical devices.



  • OPA Press Releases

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Justice Department and Lesley University Sign Agreement to Ensure Meal Plan Is Inclusive of Students with Celiac Disease and Food Allergies

The Justice Department today announced an agreement with Lesley University in Cambridge, Mass., to ensure that students with celiac disease and other food allergies can fully and equally enjoy the university’s meal plan and food services in compliance with the Americans with Disabilities Act (ADA).



  • OPA Press Releases

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Kentucky Hospital Agrees to Pay Government $16.5 Million to Settle Allegations of Unnecessary Cardiac Procedures

Saint Joseph Health System Inc. has agreed to pay $16.5 million to resolve allegations that Saint Joseph Hospital violated the False Claims Act by submitting false claims to the Medicare and Kentucky Medicaid programs for a variety of medically unnecessary cardiac procedures, the Justice Department announced today.



  • OPA Press Releases

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Court Enters Judgment Against Pontiac, Mich., Law Firm and Permanently Enjoins the Firm from Continuing to Pay Wages to Employees Without Paying Associated Payroll Taxes

A U.S. District Court for the Eastern District of Michigan issued a judgment against the law firm Hatchett, DeWalt & Hatchett PLLC for unpaid federal employment and unemployment taxes and penalties for late filing partnership income tax returns for various tax periods from 2003 to 2012.



  • OPA Press Releases

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King’s Daughters Medical Center to Pay Nearly $41 Million to Resolve Allegations of False Billing for Unnecessary Cardiac Procedures and Kickbacks

Ashland Hospital Corp. d/b/a King’s Daughters Medical Center (KDMC) has agreed to pay $40.9 million to resolve allegations that it submitted false claims to the Medicare and Kentucky Medicaid programs for medically unnecessary coronary stents and diagnostic catheterizations.



  • OPA Press Releases

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OmniActive Expands Gingever Range and Showcases New Prototypes at Engredea 2018

At Engredea 2018 in March in Anaheim, CA, OmniActive will be highlighting the latest addition to its ginger ingredient range, Gingever 10% powder, expanding its application to tablets, capsules and beverages.




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AAV-mediated cardiac gene transfer of wild-type desmin in mouse models for recessive desminopathies




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An acellular artificial cardiac patch for myocardial repair




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Siachen back in the news—but don't look for peace yet


Editor's Note : In this piece from South Asia Hand, Teresita Schaffer and her husband, Howard Schaffer, reflect on how India and Pakistan sometimes find it difficult to shift gears to solve problems, even when they would greatly benefit from doing so. The authors develop this theme more fully in their forthcoming book, "India at the Global High Table: The Quest for Regional Primacy and Strategic Autonomy." The book will be published by Brookings Institution Press this spring.

A deadly avalanche that killed ten Indian soldiers earlier this month on the disputed 20,000 foot high Siachen glacier in Kashmir received extensive coverage in the Indian and Pakistani media. The avalanche prompted some commentators in both countries to call for an early settlement of what seemed to them and to many others (including ourselves) a senseless dispute.

Their voices were largely drowned out in India by an outpouring of patriotic fervor that cast the dead soldiers as “Bravehearts” who had died for their country. The Indian Defense Minister publicly dismissed pleas that both sides pull back from the 47-mile long glacier where they have confronted one another since 1984. Possibilities for a settlement seem remote.

Siachen is one of several disputes between India and Pakistan that range in importance from the future status of Kashmir to the precise location of a small stretch of their international boundary near the Indian Ocean. The Siachen dispute arose because the Line of Control drawn between the contending armies in Kashmir terminates in the high Himalayas. India and Pakistan have different versions of where it should go from there as it makes its way toward the Chinese border. This made the glacier a no-man’s land.

Anticipating a Pakistani move in 1984 to seize Siachen, the Indian army struck first. Since then it has controlled most of the glacier, including the main range. Pakistan also deploys troops in the area. Published figures say that the two countries together maintain about 150 outposts. Published figures would put the numbers of troops somewhere around 1000-2000 for each side. These are small numbers for both armies, but there is a long and complicated logistical and support chain that goes with them. India’s formal reports to parliament put the numbers of soldiers killed from 1984 to date at just under 900; Pakistani losses are variously estimated at 1000-3000.

Some fighting took place in the earlier years, but a ceasefire was worked out in 2003 and remains in place. The real enemy is nature, in this high altitude freezing desert. There have been no deaths by enemy fire in recent years. At the post most recently struck by an avalanche, the oxygen is so thin that it cannot support fire for cooking. Over time, both sides learned to deal more effectively with the bitter cold and piercing winds. The mudslides and avalanches that have kept up a steady stream of death have been triggered both by climate change and by human activity that unsettled the packed snow on the glacier itself. The recent disaster was by no means the most deadly: in April 2012, 140 Pakistani soldiers were buried by another avalanche.

Sporadic efforts to resolve the dispute have included the idea of converting Siachen into an “international peace park.” Less idealistic approaches have focused on the demilitarization of the glacier, but only after both sides had reached an agreement delineating the areas they had occupied before withdrawing and pledging not to try to take them back. These efforts won some support within the government headed by Indian National Congress party leader Manmohan Singh in the 2000s. But they were stoutly opposed by the Indian Army, one of the few security issues on which the normally apolitical uniformed military has taken a public stand.

This was particularly evident in 2006, when India and Pakistan seemed to be coming close to an agreement on the issue. In a telegram later released by Wikileaks, the U.S. Embassy in New Delhi reported in May of that year that “Army Chief J.J. Singh appears on the front page of the Indian Express seemingly fortnightly to tell readers the Army cannot support a withdrawal from Siachen.” The embassy went on to note that “given India’s high degree of civilian control over the armed forces, it is improbable that Gen. Singh could repeatedly make such statements without Ministry of Defense civilians giving it at least tacit approval.” It concluded that “[w]hether or not this is the case, a Siachen deal is improbable while his – and the Army’s – opposition continues to circulate publicly.” After the most recent tragedy, LtGen D. S. Hooda, who heads the Northern Command of the Indian army, has maintained this position. He was quoted in a Kashmiri paper as saying that despite these tragic casualties, India must remain in its present positions. He specifically ruled out the mutual demilitarization suggested by Pakistan.

The Indian public has had ample opportunity to read about the terrible human cost of Siachen, but civilian public opinion is unlikely to force the issue. For Indians, the avalanche tragedy was heightened by the apparently miraculous survival of one of the soldiers, who was reportedly buried under twenty-five feet of snow for six days before being rescued. Medically evacuated to New Delhi, he was visited in the hospital by Prime Minister Narendra Modi and became an instant, highly publicized hero. His death a couple of days later made him a national martyr.

Siachen has been one of the issues discussed between India and Pakistan in the on-again, off-again dialogue they initiated in the late ‘90s. Plans to recommence these wide-ranging discussions in January were postponed following the attack on an Indian air base by Kashmiri dissidents whom the Indians were convinced had been directed from within Pakistan.

Progress on Siachen is unlikely when and if these talks actually begin. Although the Modi government was willing to exchange with Bangladesh a small number of enclaves along their border, abandoning territory in Kashmir would strike a much different nerve both in the ruling BJP, the army, and the country at large. (It would be easier for the Pakistanis to accept since their military, which calls the shots on these issues, could argue that Pakistan had got the better deal by forcing the Indians off the main glacier range.)

So the issue is likely to continue to perplex outsiders like ourselves. Retired Indian Army friends have told us how important Siachen is for Indian security. But we find it difficult to accept the assertion that Siachen is a potential invasion route. The difficulty both Pakistan and India have had sustaining small forces in that terrain would be magnified many-fold if one attempted a major military operation. By the same token, we wonder how important Siachen would be in India’s strategy against China. It has long struck us as a great waste of men and material which, were the two sides to act rationally, could be satisfactory resolved. Worse, the deaths suffered by both sides are only likely to increase as climate change increases the risk of avalanches and mudslides.

But Indians and Pakistanis are not the only people in the world who don’t always act rationally on emotionally-charged issues.

Authors

Publication: South Asia Hand
Image Source: © Faisal Mahmood / Reuters
     
 
 




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EvanEco goes to the Carnival, Monbiot on Biochar, Accidental Eco Maniac Highlights Women + Water, and More

EvanEco: Carnival of the Green 172 by Don Bosch "Got milk? Grab a glass of the white stuff and a chocolate chip cookie, and join me for some green bloggy goodness..."Guardian Ethical Living: Ethical Superstore and Natural Collection merge into giant




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Stocks making the biggest moves in the premarket: Raytheon, ViacomCBS, Moderna, JetBlue & more

The stocks making the biggest moves in premarket trading include Raytheon, ViacomCBS, Moderna, JetBlue, and more.




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IAC CEO Joey Levin on the company's earnings and outlook

Joey Levin, CEO of IAC, joins "Squawk Alley" to discuss the company's earnings amid the coronavirus pandemic.




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Former tennis star Caroline Wozniacki is a red-hot baker!

Former Danish tennis star Caroline Wozniacki has turned to baking during weekends during the Coronavirus lockdown.

On Sunday, the former World No. 1 Instagrammed this picture to her 1.4 million followers, of a red velvet cake she baked and wrote: "Weekdays are for fitness. Weekends are for baking [and eating]. First time baking a layered red velvet cake with homemade vanilla cream cheese frosting! I think it was a success!" To this, her NBA star hubby David Lee replied: "Definitely a success! Two pieces in and I'm ready for a nap."

Caroline Wozniacki is the first female from a Scandinavian country to be the number one player in WTA rankings. Wozniacki has won a total of 30 singles titles in her entire career. Wozniacki's highest point in her tennis career came when she won the 2019 Australian Open. Her career statistics are 635-264 with a winning percentage of 70.6.

Caroline Wozniacki is married to NBA champion David Lee. They tied the knot in June 2019.

Catch up on all the latest sports news and updates here. Also download the new mid-day Android and iOS apps to get latest updates.

Mid-Day is now on Telegram. Click here to join our channel (@middayinfomedialtd) and stay updated with the latest news




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Approach for Patients at Risk of Medication-induced Cardiac Death in COVID-19

Medications being used to treat COVID-19 are known to cause prolongation of the QTc in some people. The QTc is an indicator of the health of the heart's electrical recharging system.




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Statins Under-prescribed to Prevent Cardiac Diseases: Study

Statins, the most commonly used cholesterol-lowering agents, were found to be significantly underutilized to treat lipid abnormalities in patients who




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New Drug Prevents Cardiac Events in Children Undergoing Chemotherapy for Leukemia

In pediatric patients undergoing chemotherapy for acute myeloid leukemia (AML), the cardioprotective drug dexrazoxane preserved cardiac function without




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Only 81% of Cardiac Arrest Patients Were Given CPR In Dialysis Units: Study

bHighlights/b (and) #61548;When kidney failure patients experienced cardiac arrest at outpatient dialysis facilities, CPR initiated by dialysis staff




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HIV Infection Linked to Sudden Cardiac Death Risk

In people with HIV infections more disruptions of electrical resetting between heartbeats were observed, stated study conducted by Johns Hopkins Medicine researchers and collaborators.




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Most Deaths Related to Noncardiac Surgery More Likely to Occur after Surgery and Hospital Discharge

Most deaths in adults undergoing noncardiac surgery occur after surgery, and even after discharge from the hospital, reports a new study. It's not




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Substance in Chinese Medicine can Cause Cardiac Arrhythmia: Study

The natural substances dehydroevodiamine (DHE) and hortiamine isolated from Evodia rutaecarpa, a medicinal plant used in Traditional Chinese Medicine




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Invitation to OECD-BIAC public briefing session on TRACE and FATCA

Invitation to attend the OECD-BIAC public briefing session on TRACE and FATCA




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Cardiac arrest or dizzy spell: Why is world trade so weak, what can policy do about it?

World trade growth was rapid in the two decades prior to the global financial crisis but has halved subsequently.




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YouTube TV to gain 14 more ViacomCBS channels in expanded distribution deal

YouTube TV is expanding its lineup of channels thanks to a new, multi-year distribution agreement with ViacomCBS, announced this morning. The Google-owned streaming TV service is gaining 14 new ViacomCBS channels as a result of the deal, including news, sports, and entertainment offerings. It will also continue to carry CBS broadcast stations, CBS Sports Network, […]




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YouTube TV to gain 14 more ViacomCBS channels in expanded distribution deal

YouTube TV is expanding its lineup of channels thanks to a new, multi-year distribution agreement with ViacomCBS, announced this morning. The Google-owned streaming TV service is gaining 14 new ViacomCBS channels as a result of the deal, including news, sports, and entertainment offerings. It will also continue to carry CBS broadcast stations, CBS Sports Network, […]




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Caroline Wozniacki and David Lee exude newlywed bliss at Serena Williams' New York Fashion Week show

It was a see-and-be-seen event at New York Fashion Week on Tuesday, with some of the best and brightest showing up to view the self-titled collection of tennis pro Serena Williams. 




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Mikel Arteta praises Pierre-Emerick Aubameyang's reaction to defeat against Olympiacos

Mikel Arteta has praised the reaction of Pierre-Emerick Aubameyang after his skipper missed a last-gasp chance as Arsenal crashed out of the Europa League to Olympiacos.




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Italy 2-0 China: Giacinti and Galli strike to ease Azzurre into Women's World Cup quarter-finals

Giacinti opened the scoring following a goalmouth scramble inside 15 minutes, while Galli double Le Azzurre's lead four minutes into the second half with a long range strike.




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Bad Company singer Brian Anthony Howe dead at 66 due to cardiac arrest

TMZ reported on Tuesday morning that the talented musician passed away at his home in Florida while possibly on his way to the hospital according to a relative.




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Wolves await clarification from UEFA as clash at Olympiacos is set to be played behind closed doors

Wolves were on Sunday night awaiting confirmation from UEFA that their Europa League match at Olympiacos would be played behind closed doors because of the coronavirus.




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The Block's Shelley Craft steals a kiss from her husband Christian Sergiacomi

Shelley Craft is not letting the rumble in the ratings get her down.




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Horrific photo shows eight-year-old New York boy on a ventilator after suffering a cardiac arrest

Jayden Hardowar had complained of a fever and diarrhea just five days before his heart failed and he was placed on a ventilator at a New York City medical center.




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Spotlight on Tokyo Olympics, Qatar World Cup and cash for Russian doping cover-ups at Diack trial

ROB DRAPER AND PETER ALLEN IN PARIS: A criminal trial will start on Monday with some huge names on the International Olympic Committee sweating to see if they are named in court.




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Lamine Diack set for 'trial of century' after being accused of conspiring to cover up drugs tests

A courtroom battle billed as sport's trial of the century is set to start in Paris on Monday. Lamine Diack and six others will stand trial accused of conspiring to cover up positive drugs tests




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Former World Athletics president Lamine Diack's trial in Paris for corruption adjourned until June

The trial of Lamine Diack, the former president of World Athletics, has been adjourned until June and the 86-year-old's request to return from Senegal has been refused.




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World Athletics will sue former boss Diack and five defendants for £35m but corruption trial stalls

MIKE KEEGAN IN PARIS: World Athletics is to sue Lamine Diack and his co-defendants for £35million. The ex-head of the sport's governing body, formerly known as the IAAF, was in a Paris court on Monday.




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Heidi Cruz reacts to the online rumor that Ted is the Zodiac killer 

Heidi Cruz responded today to one of the internet's weirdest conspiracy theories  – that Sen. Ted Cruz, her husband, was the 'Zodiac Killer.'




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McGregor oversees the delivery of 'cardiac monitors, oxygen concentrators and 50,000 masks'

Thousands of pieces of medical equipment have been delivered to hospitals in Ireland as a result of Conor McGregor's €1million donation to the fight against coronavirus.




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Champions League play-off review: Red Star Belgrade, Dinamo Zagreb and Olympiacos reach group stages

Old rivals Red Star Belgrade and Dinamo Zagreb advanced to the Champions League group stage Tuesday after making it through their playoff second-leg games.




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Ben Okri, Nicolás Giacobone and Kate Furnivall: This week's best new fiction reviews

Okri is always good company and these 20-odd tales showcase his lucid prose and freewheeling imagination.