Proposed U.S. rules on Chinese connected car tech and Israel’s pager attacks indicate the changing focus of global supply chains — from resilience to security

The book house plans diverse activities tocelebrate Ramanuja millennium

India’s exam integrity crisis tackled with blockchain innovation

Protection of Sanatana Dharma, Hindu temples from violation and temple properties from encroachments are among some of their demands

Chainmail has come to represent creativity and defiance, marking a departure from traditional fabrics toward something bold and unique.

Omise dominates in Thailand thanks to its extensive relationships, but other markets pose more of a challenge.

The post Thai fintech startup Omise is betting on blockchain to cash in on e-commerce growth appeared first on DealStreetAsia.

Felix‘s hole feels a little tighter no? Pobrecito had broken his arm when rollerblading and is now recovering. So now he needs to catch up on all the cock he’s missed. Robert Royal, TimTales‘ flavor of the month has one beautiful long raw cock waiting for him. Time for Felix to get a little physical... View Article

The post TimTales: Robert Royal and Felix Hain appeared first on QueerClick.

Inter-α-inhibitor is a proteoglycan essential for mammalian reproduction and also plays a less well-characterized role in inflammation. It comprises two homologous “heavy chains” (HC1 and HC2) covalently attached to chondroitin sulfate on the bikunin core protein. Before ovulation, HCs are transferred onto the polysaccharide hyaluronan (HA) to form covalent HC·HA complexes, thereby stabilizing an extracellular matrix around the oocyte required for fertilization. Additionally, such complexes form during inflammatory processes and mediate leukocyte adhesion in the synovial fluids of arthritis patients and protect against sepsis. Here using X-ray crystallography, we show that human HC1 has a structure similar to integrin β-chains, with a von Willebrand factor A domain containing a functional metal ion-dependent adhesion site (MIDAS) and an associated hybrid domain. A comparison of the WT protein and a variant with an impaired MIDAS (but otherwise structurally identical) by small-angle X-ray scattering and analytical ultracentrifugation revealed that HC1 self-associates in a cation-dependent manner, providing a mechanism for HC·HA cross-linking and matrix stabilization. Surprisingly, unlike integrins, HC1 interacted with RGD-containing ligands, such as fibronectin, vitronectin, and the latency-associated peptides of transforming growth factor β, in a MIDAS/cation-independent manner. However, HC1 utilizes its MIDAS motif to bind to and inhibit the cleavage of complement C3, and small-angle X-ray scattering–based modeling indicates that this occurs through the inhibition of the alternative pathway C3 convertase. These findings provide detailed structural and functional insights into HC1 as a regulator of innate immunity and further elucidate the role of HC·HA complexes in inflammation and ovulation.

Students at OM Russia’s Discipleship Centre help plant churches, start a rehab centre and begin a farming business.

Hobbled by a shortage of workers, companies are finding it hard to resume operations at an optimal scale and with migrants moving back home, it could be a while before factories hum with activity.

Welcome to this week's patchwork of questions and answers about political advertising, ABM, voice search, blockchain, and loyalty

"I totally support your mask policy," a comment on Costco's Facebook said. "It is small minded individuals who don't understand the reason for it."

This meeting aimed to identify practical policy options for Latin American governments in the formulation of their investment promotion strategies with a specific focus on international value chains.

Participants in this multi-stakeholder meeting launched the Gold Implementation programme and advanced implementation of due diligence in the 3Ts supply chain to ensure that companies avoid contributing to conflict through their mineral or metal purchasing decisions and practices.

Technological advances, less costly shipping and trade liberalisation have transformed the way in which companies make products and distribute them worldwide. Governments that become more open to trade and investment, and encourage innovation will help firms better integrate the global value chains that are driving growth in increasingly interconnected economies, according to new OECD research.

Global value chains (GVCs) have become a dominant feature of world trade and investment, offering new prospects for growth, development and jobs, according to a new joint report by the Organization for Economic Cooperation and Development (OECD), the World Trade Organization (WTO) and the United Nations Conference on Trade and Development (UNCTAD).

Participants in this multi-stakeholder meeting reviewed and discussed the implementation of the OECD Due Diligence Guidance and in the 3Ts supply chain to ensure that companies avoid contributing to conflict through their mineral or metal purchasing decisions and practices.

This workshop focused on how to comply with international regulations on conflict-free gold supply chains and how to make the most of the OECD Due Diligence Guidance for Responsible Supply Chains of Minerals from Conflict-Affected and High-Risk Areas.

This meeting provided the opportunity to review and discuss implementation of the OECD Due Diligence Guidance and the ICGLR Regional Certification Mechanism. Issues pertinent to the tin, tantalum and tungsten (3Ts) and gold supply chains were addressed during the three-day forum.

Participants at the forum adopted a communiqué calling for companies to confront challenges they encounter openly and transparently by publicly reporting on due diligence in accordance with the OECD Due Diligence Guidance for Responsible Supply Chains of Minerals from Conflict-Affected and High-Risk Areas

Global Value Chains (GVCs) are a dominant feature of the world economy that impact growth, jobs and development, but numerous challenges remain to ensure that all countries and all firms have the opportunity to participate and benefit.

This meeting provided the opportunity to review and discuss implementation of the OECD Due Diligence Guidance, the ICGLR Regional Certification Mechanism, and other initiatives to enable responsible mineral supply chains. Issues pertinent to the tin, tantalum and tungsten (3Ts) and gold supply chains were also addressed during the Forum.

The German Federal Institute for Geosciences and Natural Resources (BGR), supported by the OECD, has initiated a study to assess the contribution of small and medium-scale enterprises (SMEs) to due diligence for responsible mineral supply chains. To gather information for this study, SMEs were invited to take part on a confidential survey of due diligence activities by SMEs.

This public consultation was held to gather comments on the draft FAO-OECD guidance for responsible agricultural supply chains which is designed to help enterprises observe standards of responsible business conduct along their agricultural supply chains. The deadline for comment was 20 February 2015.

This public consultation is being held to gather comments on the draft Chinese Due Diligence Guidelines for Responsible Mineral Supply Chains. They are intended to align Chinese company due diligence with international standards and allow for mutual recognition with existing international initiatives and legislations.

The workshop will discuss the first results of the OECD Secretariat’s work on integrating FDI statistics into the analysis of Global Value Chains (OECD-WTO Trade in Value Added Initiative) to better account for foreign ownership.

Focused mainly on the Democratic Republic of the Congo, this report takes stock of 5 years of implementation of national and international programmes and initiatives designed to operationalise the recommendations of the OECD Due Diligence Guidance on Responsible Supply Chains of Minerals from Conflict-Affected and High-Risk Areas in the Great Lakes Region of Central Africa.

This meeting will provide the opportunity to discuss the role of governments, international partners and businesses in promoting responsible mineral supply chains from conflict-affected and high-risk areas. Participants will learn first hand about international standards and approaches, and be able to ask questions to experts in supply chain due diligence implementation.

This OECD report lays an empirical foundation for structuring economic policies to facilitate Chile’s participation in global value chains and to maximise the associated benefits for national firms and workers.

11 March, Paris, France: This high-level launch event included a panel discussion that addressed the potential impacts of companies operating in agricultural supply chains on human, labour and tenure rights.

This report is the first of a series of assessments on Colombian gold supply chains and aims to develop an initial approach and analysis for how risks outlined in Annex II of the OECD Due Diligence Guidance for Responsible Supply Chains of Minerals from Conflict-Affected and High-Risk Areas are relevant in the Colombian context.

10-12 May, Paris: The 2016 forum focused on compliance and implementation of the OECD Due Diligence Guidance, including how to maximise the positive impacts on livelihoods through due diligence; viable options for trade in artisanal and small-scale mined gold; and identifying and preventing the worst forms of child labour in the mineral supply chain.

Practical actions for companies to identify and address the worst forms of child labour in mineral supply chains is for use by companies to help them identify, mitigate and account for the risks of child labour in their mineral supply chains. It builds on the due diligence framework of the OECD Due Diligence Guidance for Responsible Supply Chains of Minerals from Conflict-Affected and High-Risk Areas.

This paper synthesises the main policy implications of OECD work focusing on the interplay between participation and positioning in global value chains (GVCs), employment demand and supply, and workforce skills endowment.

Evidence on the role played by investment in global value chains (GVCs) can assist policy work on GVCs, trade, investment and development. Drawing on new and improved measures of trade and investment, these country notes provide relevant statistical information from OECD databases on trade, investment, the activities of multinational enterprises and global value chains.

30/01/2018 - The China National Textile and Apparel Council (CNTAC) and the OECD today signed a Memorandum of Understanding (MoU) that sets out their commitment to intensify co-operation to promote responsible business in global textile and apparel supply chains.

This report is part of a series of assessments on Colombian gold supply chains and the OECD Due Diligence Guidance for Responsible Supply Chains of Minerals from Conflict-Affected and High-Risk Areas. It analyses conditions of mineral extraction and related risks.

As part of the implementation strategy for the recently adopted OECD Due Diligence Guidance for Responsible Supply Chains in the Garment and Footwear Sector, the OECD is conducting a series of surveys that target SMEs operating within the sector.

This joint OECD-UNIDO report identifies investment and related policies to enhance linkages between small and medium-sized enterprises (SMEs) in Southeast Asia and multinational enterprises (MNEs) and their impacts on SME outcomes in Southeast Asia.