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En este episodio de El Alargue analizamos el futuro de James Rodríguez y buscamos respuestas al flojo presente del Liverpool de Luis Díaz.

Tulio Gómez, máximo accionista del América de Cali, no se guardó nada en diálogo con El Alargue de Caracol Radio. Gómez habló de la llegada de Tulio Gómez, la ilusión de alcanzar la estrella 16, los refuerzos que se han sumado al equipo y la situación de algunos jugadores. Aunque no se arrepintió por no haber fichado a Hugo Rodallega, contó que no se sumó al equipo por el anterior cuerpo técnico de Alexandre Guimaraes.

Ximena Echavarría, abogada experta en derecho electoral y quien interpuso la demanda de nulidad contra el Partido En Marcha, explicó en 6AM los argumentos que la llevaron a adoptar esta decisión frente a este y otros tres partidos políticos 

Willy Alejandro Rodríguez, alcalde de San José del Guaviare, compartió en 6AM algunos detalles frente al presunto atentado con explosivos que se buscaría perpetrar contra el diplomático

El expresidente colombiano se refirió en 6AM a la posibilidad de que el Gobierno de Gustavo Petro convoque a una nueva Asamblea Nacional Constituyente 

En el recurso judicial, Enrique Vargas mencionó las cuatro publicaciones en las que el presidente Gustavo Petro emitió fuertes críticas sobre los manejos financieros de la Nueva Eps.

Qué información tienen sobre los perpetradores del asesinato del ganadero, Esteban Urueta, y de dos de los trabajadores de una de las fincas del comerciante.

Nathalia Calero, colombiana en Valencia, habló sobre cómo ha avanzado la crisis en esa ciudad de España tras los desastres en los últimos días 

The German writer spoke with Eleanor Wachtel, who chaired the International Booker Prize jury, in 2015.

De verplichting om AI-geletterd te zijn is een onderbelicht onderdeel van de AI Act. Dat moet elke organisatie al zijn per februari 2025. Hoe kun je dat goed organiseren? Wat is AI-geletterdheid? AI-geletterdheid gaat over vaardigheden, kennis en begrip van AI-systemen. Iedereen die met AI werkt, moet het geïnformeerd kunnen inzetten. Ook moet er awareness […]

Interpol has announced a live LP, recorded direct-to-acetate at Third Man Records Nashville's Blue Room venue on June 13, 2024

It's gonna be mosh central.

Enerplus Corp. merged with Chord Energy Corp. earlier this year in $11 billion deal.

Something is rotten with this family.

Interpath announced the launch of a new Bermuda office, with Rachelle Frisby appointed CEO of Interpath’s network of offices across the Caribbean,. A spokesperson said, “Interpath, a leading international financial advisory firm, is proud to announce the launch of a new office in Bermuda as the firm continues to strengthen its suite of restructuring and advisory […]

The Corporation of Hamilton said they will be correcting the “Kerp Clear” road marking located on Front Street, and explained that what happened was an “oversight” as the “worker only had one ‘E’ stencil so he used the ‘R’ as a place-marker when laying out the word with the intent to re-use the ‘E’ after […]

1. Hallo kroket! Mike De Decker vermorzelt Michael Smith en treft Luke Littler in Grand Slam of Darts  Gazet van Antwerpen
2. Sterke Van den Bergh en De Decker stoten door in Grand Slam of Darts, onverwachte exit Van Gerwen  sporza.be
3. VIDEO. Hallo kroket! Mike De Decker vermorzelt Michael Smith en treft Luke Littler in 1/8ste finale Grand Slam of Darts  Het Nieuwsblad
4. VIDEO. Dimitri Van den Bergh flitst naar 1/8ste finales Grand Slam of Darts, met dank aan een muntje: “Ik ga iets uit mijn achterzak pakken...”  Gazet van Antwerpen
5. Mike De Decker bij laatste 16 op Grand Slam of Darts  RTV

“Absurde toestanden” bij verplichting zonnepanelen voor grote verbruikers: “Zelfs bedrijf dat niets meer produceert, moet er leggen”  Het Laatste Nieuws

Izegem zet verder koers richting coalitie met Vlaams Belang: “We hebben hier een omgekeerd cordon sanitaire”  Gazet van AntwerpenHele verhaal bekijken via Google Nieuws

AI-powered search engine Perplexity says it’ll begin experimenting with ads on its platform starting this week. Ads will appear in the U.S. to start, formatted as “sponsored follow-up questions.” (E.g., “How can I use LinkedIn to enhance my job search?”) Paid media will be positioned to the side…

INTERPOL on Tuesday said it took down more than 22,000 malicious servers linked to various cyber threats as part of a global operation. Dubbed Operation Synergia II, the coordinated effort ran from April 1 to August 31, 2024, targeting phishing, ransomware, and information stealer infrastructure. "Of the approximately 30,000 suspicious IP addresses identified, 76 per cent were taken down and 59

Alban Forcione, an internationally renowned scholar of 17th-century literature of “Golden Age” Spain, the Walter S. Carpenter Jr., Professor of Language, Literature and Civilization of Spain, Emeritus, and Princeton alumnus, died Sept. 14 at age 82.

Koalas are the only non-primates with fingerprints. How is that possible—and why?

Guam tem 40 vezes mais aranhas do que as ilhas vizinhas — e uma população de cobras invasoras tão vorazes que acabaram com os pássaros das florestas.

Is the Premier League title race down to two teams after just 11 games? BBC Sport looks at the chances of the top four.

Implementing Enterprise AI – Online workshop By Ajit Jaokar and Cheuk Ting Ho   Early bird discounted rate $599 USD     Introduction Launched for the first time, jointly delivered by Ajit Jaokar and Cheuk Ting Ho – Implementing Enterprise AI workshop is an online workshop targeting developers and strategists.  The workshop enables you to develop [...]

IVT released its latest upgrades to its MediaPlatform software.

Click to view the announcement.

Forbes.com published an article by Dan Woods where he describes a battle between the traditional enterprise software providers (Microsoft, SAP, and Oracle) and Saas providers like Salesforce.com and NetSuite.

According to Woods, SaaS applications are easier to use because they offer streamlined interfaces that are modeled after successful web consumer sites like Amazon.com, Yahoo!, eBay, Google, etc. These SaaS interfaces were designed to be easily configurable.

Traditional enterprise software is not as easy to use because user interfaces are often created before it is known exactly how the software would be used. Customization to the user interface is often done at installation by systems integrators who do not have any actual user behavior on which to base their customizations.

The Big Three are well aware of the usability gap between their products and SaaS software, but it is unclear how to solve the problem. Oracle emphasizes Fusion as an integration platform. SAP recently announced an experiment called Blue Ruby that is attempting to adapt Ruby on Rails as a user interface and programming technology for its applications. But is it possible to affordably automate a business starting with a configurable application platform that must be adapted to the specific user interfaces and business processes in a company? The SaaS model starts with a usable interface and a working automation of common processes, and then has the configuration proceed from there. The hosted nature of SaaS removes the deployment barriers.

Video is beginning to fulfill its promise as a transformational technology. Beyond merely cutting communications costs, video is starting to change the way companies do business, and is rapidly being accepted as a "need to have" rather than a "nice to have."

Cisco CEO John Chambers predicts video traffic on the internet will increase six fold by 2012. Here is a link to Cisco's August 5 earnings call where he makes that prediction.

A classic example of the power of video is that of electronics manufacturer NEC. They have a network of nearly 500 dealers across the United States that sell their products. They saved more than $250,000 annually in training costs by delivering product training with video webcasting rather than sending trainers to the dealers or bringing the dealers to the trainers.

They also dramatically reduced the time it takes to train the entire network on new products. Click here to watch a video case study.

A newer example shows how video can literally transform the way a company does business. A major sneaker company manufacturers its products in China. Each time they re-tooled to manufacture a new sneaker, executives would have to fly to China to ensure the tooling was correct and the sneakers were meeting specifications before they began mass production.

They began to use high definition cameras at the plant in China to webcast video of the sneakers to allow executives to make their inspection virtually. Sure, they save money on travel to China. But more importantly, there was a practical limit to the amount of people who could go to China to see the actual design come off the assembly line. The video process allows them to solicit input from a much broader segment of the company, and even get input from retailers while there is still time to respond to suggestions.

The end result is that they can bring their products to market faster than their competition, which creates a significant competitive advantage. Click here to see the video discussion.

I am particularly pleased to see clear evidence of unmistakable, game-changing ROI.

Here is a link to a recent post by Roger Courville on his "The Virtual Presenter" blog. It reads

A VFAQ (VERY frequently asked question) I get is “what’s the difference between web conferencing, webinars, and webcasts?”

The short answer, these days, is “not very much and a whole bunch.”

Seriously, the lines have blurred from the days that “webcasting” was akin to broadcasting (using streaming media) with virtually no interactivity, whereas web conferencing was (and remains) live, totally realtime (you don’t want any delay when you’re talking on a phone conference, right? In many use cases, you don’t on the web either).

Webinar is simply a portmanteau of web seminar – arguably a use case rather than a technology. That is brief, but it’s as deep as I’m going as I introduce IVT and their enterprise video communications.

I recently had the pleasure of speaking with Mitch, Hugh, Jim, and Ryan, all at the same time. In addition to the knowledge and passion and history (Hugh’s a fellow ex-Microsoftie with some common connections), what I’m most enthused by is their clarity of mission.

Hello software

First, IVT’s a software company. You can host the software, but for reasons I’ll not get into, you want to take advantage of the fact that they host the software for you. What’s interesting here isn’t a “right or wrong,” it’s a commitment to a business model. Many (if not most) companies who have solutions for webcasting also provide professional production/event management services. IVT is committed to their robust partner community who deliver value-added services atop the IVT platform. Again, this isn’t a right or wrong, but you have to appreciate focus.

Hello production tools

It’s hard to tell you how important the backend of a product is. It’s what economists call an “experience good” …you have to have been there to get it and appreciate it. As it just so happens I spent many years running organizations in the production business, let me say the two words that will bring any accountants to their needs and get the producers all excited: labor and labor. Labor is expensive. Technology, especially over time, often gets less expensive. If you’ve ever produced an event, let alone a bunch of them, you know that the project management time can create a big sucking sound in your budget. This is where producers get excited… not only will they find the flexibility on the back end of IVT’s platform a joy when meeting numerous and disparate client/stakeholder needs, but it’ll save them time.

Hello customization

Okay, so many different solutions offer degrees of customization, but far fewer have down-to-the-pixel capabilities. When clients demand that, you’ve got to deliver. Further, there’s customization of user experiences, such as different tools you might make available to a presenter versus what the marketing department sees when they need to pull down a report. And then there are web services for the data integration geeks (I say that with love, mind you).

Hello remote presenters – but wait, there’s more

A point of differentiation here is multiple presenters, each with different camera types. One can have a webcam in Sydney, one can be standing in front of a hi-def broadcast camera at a conference in a New York hotel…you get the idea. Need to switch back and forth like a television newscast? Can do.

As is my style, my goal isn’t a vendor-by-vendor shootout, to talk about price, or make a recommendation. I’m excited and privileged to be independent, talk to great people with their own angle on the market, and share with you my own spin on it. It sounds like IVT has a solution if you need to reasonably reach 100 people and the horsepower to reach 20K if you need. If you need flexibility and reach and a commitment to knowing their core biz, IVT (or one of their partners) might be someone to add to your must-investigate list.

Alexey I. Nesvizhskii
Oct 1, 2005; 4:1419-1440
Tutorial

Gijs den Besten
Sep 1, 2013; 54:2325-2340
Reviews

V. G. Lysov
Trans. Moscow Math. Soc. 83 (), 291-304.
Abstract, references and article information

The kinesin-3 family contains the fastest and most processive motors of the three neuronal transport kinesin families, yet the sequence of states and rates of kinetic transitions that comprise the chemomechanical cycle and give rise to their unique properties are poorly understood. We used stopped-flow fluorescence spectroscopy and single-molecule motility assays to delineate the chemomechanical cycle of the kinesin-3, KIF1A. Our bacterially expressed KIF1A construct, dimerized via a kinesin-1 coiled-coil, exhibits fast velocity and superprocessivity behavior similar to WT KIF1A. We established that the KIF1A forward step is triggered by hydrolysis of ATP and not by ATP binding, meaning that KIF1A follows the same chemomechanical cycle as established for kinesin-1 and -2. The ATP-triggered half-site release rate of KIF1A was similar to the stepping rate, indicating that during stepping, rear-head detachment is an order of magnitude faster than in kinesin-1 and kinesin-2. Thus, KIF1A spends the majority of its hydrolysis cycle in a one-head-bound state. Both the ADP off-rate and the ATP on-rate at physiological ATP concentration were fast, eliminating these steps as possible rate-limiting transitions. Based on the measured run length and the relatively slow off-rate in ADP, we conclude that attachment of the tethered head is the rate-limiting transition in the KIF1A stepping cycle. Thus, KIF1A's activity can be explained by a fast rear-head detachment rate, a rate-limiting step of tethered-head attachment that follows ATP hydrolysis, and a relatively strong electrostatic interaction with the microtubule in the weakly bound post-hydrolysis state.

No abstract

Unspecific bone uptake (UBU) related to [¹⁸F]PSMA-1007 PET/CT imaging represents a clinical challenge. We aimed to assess whether a combination of clinical, biochemical, and imaging parameters could predict skeletal metastases in patients with [¹⁸F]PSMA-1007 bone focal uptake, aiding in result interpretation. Methods: We retrospectively analyzed [¹⁸F]PSMA-1007 PET/CT performed in hormone-sensitive prostate cancer (PCa) patients at 3 tertiary-level cancer centers. A fourth center was involved in performing an external validation. For each, a volume of interest was drawn using a threshold method to extract SUV_max, SUV_mean, PSMA tumor volume, and total lesion PSMA. The same volume of interest was applied to CT images to calculate the mean Hounsfield units (HU_mean) and maximum Hounsfield units. Clinical and laboratory data were collected from electronic medical records. A composite reference standard, including follow-up histopathology, biochemistry, and imaging data, was used to distinguish between PCa bone metastases and UBU. PET readers with less (n = 2) or more (n = 2) experience, masked to the reference standard, were asked to visually rate a subset of focal bone uptake (n = 178) as PCa metastases or not. Results: In total, 448 bone [¹⁸F]PSMA-1007 focal uptake specimens were identified in 267 PCa patients. Of the 448 uptake samples, 188 (41.9%) corresponded to PCa metastases. Ongoing androgen deprivation therapy at PET/CT (P < 0.001) with determination of SUV_max (P < 0.001) and HU_mean (P < 0.001) independently predicted bone metastases. A composite prediction score, the bone uptake metastatic probability (BUMP) score, achieving an area under the receiver-operating-characteristic curve (AUC) of 0.87, was validated through a 10-fold internal and external validation (n = 89 bone uptake, 51% metastatic; AUC, 0.92). The BUMP score’s AUC was significantly higher than that of HU_mean (AUC, 0.62) and remained high among lesions with HU_mean in the first tertile (AUC, 0.80). A decision-curve analysis showed a higher net benefit with the score. Compared with the visual assessment, the BUMP score provided added value in terms of specificity in less-experienced PET readers (88% vs. 54%, P < 0.001). Conclusion: The BUMP score accurately distinguished UBU from bone metastases in PCa patients with [¹⁸F]PSMA-1007 focal bone uptake at PET imaging, offering additional value compared with the simple assessment of the osteoblastic CT correlate. Its use could help clinicians interpret imaging results, particularly those with less experience, potentially reducing the risk of patient overstaging.

Tumor hypoxia, an integral biomarker to guide radiotherapy, can be imaged with ¹⁸F-fluoromisonidazole (¹⁸F-FMISO) hypoxia PET. One major obstacle to its broader application is the lack of standardized interpretation criteria. We sought to develop and validate practical interpretation criteria and a dedicated training protocol for nuclear medicine physicians to interpret ¹⁸F-FMISO hypoxia PET. Methods: We randomly selected 123 patients with human papillomavirus–positive oropharyngeal cancer enrolled in a phase II trial who underwent 123 ¹⁸F-FDG PET/CT and 134 ¹⁸F-FMISO PET/CT scans. Four independent nuclear medicine physicians with no ¹⁸F-FMISO experience read the scans. Interpretation by a fifth nuclear medicine physician with over 2 decades of ¹⁸F-FMISO experience was the reference standard. Performance was evaluated after initial instruction and subsequent dedicated training. Scans were considered positive for hypoxia by visual assessment if ¹⁸F-FMISO uptake was greater than floor-of-mouth uptake. Additionally, SUV_max was determined to evaluate whether quantitative assessment using tumor-to-background ratios could be helpful to define hypoxia positivity. Results: Visual assessment produced a mean sensitivity and specificity of 77.3% and 80.9%, with fair interreader agreement ( = 0.34), after initial instruction. After dedicated training, mean sensitivity and specificity improved to 97.6% and 86.9%, with almost perfect agreement ( = 0.86). Quantitative assessment with an estimated best SUV_max ratio threshold of more than 1.2 to define hypoxia positivity produced a mean sensitivity and specificity of 56.8% and 95.9%, respectively, with substantial interreader agreement ( = 0.66), after initial instruction. After dedicated training, mean sensitivity improved to 89.6% whereas mean specificity remained high at 95.3%, with near-perfect interreader agreement ( = 0.86). Conclusion: Nuclear medicine physicians without ¹⁸F-FMISO hypoxia PET reading experience demonstrate much improved interreader agreement with dedicated training using specific interpretation criteria.

COLOGNE, Germany, Nov. 1, 2024 — DeepL has announced it will be among the first to commercially deploy the Nvidia DGX SuperPOD with DGX GB200 systems. The Nvidia DGX SuperPOD, […]

The post DeepL to Debut Nvidia DGX SuperPOD with DGX GB200 Systems in Europe appeared first on HPCwire.

"Georgia is not heard or seen in the world, and many don't even know the location of the country," says TED Fellow and photographer Daro Sulakauri. Through her striking photographs of life in the shadows of Russian occupation, she uses her camera to create a living archive of her home country and defend against the erasure of its borders, culture and history.

During adolescence, cannabis experimentation is common, and its association with interindividual variations in brain maturation well studied. Cellular and molecular underpinnings of these system-level relationships are, however, unclear. We thus conducted a three-step study. First, we exposed adolescent male mice to -9-tetrahydrocannabinol (THC) or a synthetic cannabinoid WIN 55,212-2 (WIN) and assessed differentially expressed genes (DEGs), spine numbers, and dendritic complexity in their frontal cortex. Second, in human (male) adolescents, we examined group differences in cortical thickness in 34 brain regions, using magnetic resonance imaging, between those who experimented with cannabis before age 16 (n = 140) and those who did not (n = 327). Finally, we correlated spatially these group differences with gene expression of human homologs of mouse-identified DEGs. The spatial expression of 13 THC-related human homologs of DEGs correlated with cannabis-related variations in cortical thickness, and virtual histology revealed coexpression patterns of these 13 genes with cell-specific markers of astrocytes, microglia, and a type of pyramidal cells enriched in dendrite-regulating genes. Similarly, the spatial expression of 18 WIN-related human homologs of DEGs correlated with group differences in cortical thickness and showed coexpression patterns with the same three cell types. Gene ontology analysis indicated that 37 THC-related human homologs are enriched in neuron projection development, while 33 WIN-related homologs are enriched in processes associated with learning and memory. In mice, we observed spine loss and lower dendritic complexity in pyramidal cells of THC-exposed animals (vs controls). Experimentation with cannabis during adolescence may influence cortical thickness by impacting glutamatergic synapses and dendritic arborization.

By 2020, the Starkey Hearing Foundation plans to donate one million hearing aids to kids in the developing world

(Footage: Erin Trieb. Video Editing: Nicole Boliaux)

Video by David VanZandt