A man who sexually assaulted and murdered a Cambodian refugee in Melbourne three decades ago is sentenced to a lengthy prison term after police use DNA technology not available at the time of the crime.

A Christian Brother who sexually assaulted boys at some of Victoria's most prestigious Catholic schools is sentenced to four and a half years in prison.

A former private investigator is using her skills to try to crack a cold case murder in her own family.

A decision more than two decades ago to stop births at the hospital on Christmas Island has had significant financial and social effects on locals in the years since.

The fiance of a 27-year-old man killed in one of Australia's worst mining disasters is still heartbroken, saying the "pain is still there" on the 30th anniversary of his death.

In 1979, the CSIRO imported a boutique wine grape from France. Since then the drop has been celebrated by growers and experts alike — but it turns out they've been enjoying a different variety all along.

'A pleasant pastime' is over for Tasmanian flower grower Peter Botting. He has pruned his last peony leaving the industry in capable hands.

Australia will import foreign-grown grain for the first time since 2007, after the Department of Agriculture approved a permit to import bulk wheat from Canada.

A refresher course is helping older drivers increase their confidence and safety on the road, often many decades after they first sat a licence test. But when the time comes, how do you tell a loved one it might be time to give up driving for good?

Leanne Liddle has been shot at and seriously assaulted working as a police officer, but none of that compares to the "despair" she felt when consulting across the NT for the Aboriginal Justice Agreement, where whole communities had been "neglected for decades".

In the 12 months to June this year, there were 2,472 residential break-ins reported to police across the Northern Territory the highest annual figure since 2008.

People in parts of tropical Far North Queensland wake to early-morning frost as the region experiences its coldest August night in more than 60 years.

Scientists fear Cape York's Iron Range (Kutini-Payamu) National Park could take decades to recover after weekend fires.

A Gosford judge describes Troy Johnson, a father of three who stalked and sexually assaulted a 12-year-old girl as she walked to school, as "hideous" and "depraved" before jailing him for almost 30 years.

Towns in regional NSW experience snowfall for the first time in 20 years as a deep polar vortex, which battered south-east Australia yesterday, moves north.

The wine industry emerges from a decade-long grape glut, with exports playing a big role in the sector's turnaround.

(United States Seventh Circuit) - Held that the Social Security Administration made errors in evaluating a woman's eligibility for disability insurance benefits and supplemental security income. The issue related to whether her bipolar disorder and other conditions limited her concentration, persistence and pace. Vacated and remanded to the agency for further proceedings.

The decades of disinvestment have placed Colorado universities in a precarious financial position with little margin to maneuver through the coronavirus pandemic. Students are already considering whether to stay home next fall. Raising tuition could cause enrollment to dip further, putting in jeopardy colleges’ main revenue source.

I largely gave up political blogging after November 8, 2016, when it became obvious that I have no idea what...

The sweetheart deal that Governor Malloy and his fellow Democrats in the General Assembly cut with state employee unions, the so-called SEBAC agreement, is protected by contract for a full decade —leaving meaningful reforms waaay down the road. The contract is the mother of all can-kicks. Continue reading →

Heh. K Tempest Bradford happened across an old photo of me and Neil — I’m in a sari, so I’m guessing this was at the Hugos. We look very young, so at least a decade ago — maybe two. 

I have seen this question asked (or its fraternal twin, “when does the new decade begin”) in a number of places, and my response is this: That’s a lousy way to phrase the question.   I will remind folks that I work at the Naval Observatory, but this blog in no way represents the official position of...

Our country is reeling under the dual onslaught of COVID-19 and runaway unemployment, but there’s one person who’s willing to give President Trump high marks for handing the situation: Donald Trump. “I think in a certain way, maybe our best work has been on what we’ve done with COVID-19,” he mused in an interview this week.

The Bell High School academic decathlon team, the L.A. area champions, studied bubonic plague and other epidemics before the coronavirus broke out.

El Camino Real Charter High School has won this year's state Academic Decathlon, narrowly edging out its perennial rival, Granada Hills Charter High School.

Glenn Gould's "Solitude Trilogy" uses dialogue as though it were musical counterpoint and explores a kind of isolation familiar in our coronavirus era.

Bill Gardner's "Rhapsody in Black" show has been a staple of L.A. radio since the early 1980s, airing classic R&B. But its future is in peril due to the coronavirus.

In NBC Sports' 'Racing Week in America', IndyCar fans will get to see some of the most exciting races from the series' last decade.

Richard Wood led Eli Lilly and Co. through prosperous times, thanks to products like Prozac. Colleagues say his foresight paid off.

"When you think about people that pay it forward, he really captured the essence of someone that consistently did that on a daily basis."

The past 10 years have shown superheroes in entertainment aren't going anywhere.

Treatment of patients with triple-negative breast cancer (TNBC) is limited by a lack of effective molecular therapies targeting this disease. Recent studies have identified metabolic alterations in cancer cells that can be targeted to improve responses to standard-of-care chemotherapy regimens. Using MDA-MB-468 and SUM-159PT TNBC cells, along with LC-MS/MS and HPLC metabolomics profiling, we found here that exposure of TNBC cells to the cytotoxic chemotherapy drugs cisplatin and doxorubicin alter arginine and polyamine metabolites. This alteration was because of a reduction in the levels and activity of a rate-limiting polyamine biosynthetic enzyme, ornithine decarboxylase (ODC). Using gene silencing and inhibitor treatments, we determined that the reduction in ODC was mediated by its negative regulator antizyme, targeting ODC to the proteasome for degradation. Treatment with the ODC inhibitor difluoromethylornithine (DFMO) sensitized TNBC cells to chemotherapy, but this was not observed in receptor-positive breast cancer cells. Moreover, TNBC cell lines had greater sensitivity to single-agent DFMO, and ODC levels were elevated in TNBC patient samples. The alterations in polyamine metabolism in response to chemotherapy, as well as DFMO-induced preferential sensitization of TNBC cells to chemotherapy, reported here suggest that ODC may be a targetable metabolic vulnerability in TNBC.

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