The victory of Donald Trump in the US presidential election intensified the demand for crypto assets. XRP is on its journey to the broader crypto market. The growth of XRP was capped by the Securities and Exchange Council’s plan to appeal crucial rulings in the ripple case. The appeal from the SEC has negatively impacted [...]

Kabanov, P; Vandenberg, R; Pelchat, P; Cameron, M; Dewing, K. arktos 2020 p. 1-14, https://doi.org/10.1007/s41063-020-00074-z
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/20180326.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/20180326.jpg" title="arktos 2020 p. 1-14, https://doi.org/10.1007/s41063-020-00074-z" height="150" border="1" /></a>

On this episode of Remnant X Radio, Brad the Nephilimkiller will be hosting another round table discussion on "What's Wrong With The Church." He will be joined by Dana and Shawn, our friends from Ohio! Please plan to join us as we discuss the failure of the American church.

I will be joined by a very special guest Alex Grenier of the website Calvary Chapel Abuse. We will sit down and discuss the CC movement and the patterns of abuse that are growing at an alarming matter. We will discuss his meeting with Chuck Smith and Calvary Chapel lawyer Janet Carter. Just a warning, this will not be for the weak of stomach or those who freely drink down the Calvary Chapel Kool-Aid! Please plan to join us as we deal with Devils! -- This just in! We were able to get Chuck Smith on the phone and he was open and honest about his feelings toward Alex and the problems concerning the "movement". I was shocked at his willingness to talk. This is a must listen you will get a truly unique look behind the Calvary Chapel curtain - Check out our web-site @ www.remnantXradio.com

Hello, I'm not sure what happened but I've always been able to tunnel to my xrdp GUI using a ssh putty session. Now when I try to connect after connecting via SSH it just shows a blank screen with an...

A new processing technique for synchrotron scanning 3D X-ray diffraction data is introduced, utilizing symmetric Bragg reflections hkl and hkl, known as Friedel pairs. This technique is designed to tackle the difficulties associated with large, highly deformed, polyphase materials, especially geological samples.

The present study introduces a processing strategy for synchrotron scanning 3D X-ray diffraction (s3DXRD) data, aimed at addressing the challenges posed by large, highly deformed, polyphase materials such as crystalline rocks. Leveraging symmetric Bragg reflections known as Friedel pairs, our method enables diffraction events to be precisely located within the sample volume. This method allows for fitting the phase, crystal structure and unit-cell parameters at the intra-grain scale on a voxel grid. The processing workflow incorporates several new modules, designed to (i) efficiently match Friedel pairs in large s3DXRD datasets containing up to 108 diffraction peaks; (ii) assign phases to each pixel or voxel, resolving potential ambiguities arising from overlap in scattering angles between different crystallographic phases; and (iii) fit the crystal orientation and unit cell locally on a point-by-point basis. We demonstrate the effectiveness of our technique on fractured granite samples, highlighting the ability of the method to characterize complex geological materials and show their internal structure and mineral composition. Additionally, we include the characterization of a metal gasket made of a commercial aluminium alloy, which surrounded the granite sample during experiments. The results show the effectiveness of the technique in recovering information about the internal texture and residual strain of materials that have undergone high levels of plastic deformation.

A plug-flow fixed-bed cell for synchrotron powder X-ray diffraction (PXRD) and X-ray absorption fine structure (XAFS) idoneous for the study of heterogeneous catalysts at high temperature, pressure and under gas flow is designed, constructed and demonstrated. The operating conditions up to 1000°C and 50 bar are ensured by a set of mass flow controllers, pressure regulators and two infra-red lamps that constitute a robust and ultra-fast heating and cooling method. The performance of the system and cell for carbon dioxide hydrogenation reactions under specified temperatures, gas flows and pressures is demonstrated both for PXRD and XAFS at the P02.1 (PXRD) and the P64 (XAFS) beamlines of the Deutsches Elektronen-Synchrotron (DESY).

xrdPlanner is a software package designed to aid in the planning and preparation of powder X-ray diffraction and total scattering beam times at synchrotron facilities. Many modern beamlines provide a flexible experimental setup and may have several different detectors available. In combination with a range of available X-ray energies, it often makes it difficult for the user to explore the available parameter space relevant for a given experiment prior to the scheduled beam time. xrdPlanner was developed to provide a fast and straightforward tool that allows users to visualize the accessible part of reciprocal space of their experiment at a given combination of photon energy and detector geometry. To plan and communicate the necessary geometry not only saves time but also helps the beamline staff to prepare and accommodate for an experiment. The program is tailored toward powder X-ray diffraction and total scattering experiments but may also be useful for other experiments that rely on an area detector and for which detector placement and achievable momentum-transfer range are important experimental parameters.

The in situ measurement technique for a metal/metal-oxide mixture at extra-high temperature above 2000 K has been desired in the field of nuclear safety engineering. In the present study, we succeeded in simultaneous XAFS–XRD measurements of the Zr oxidation [Zr + O → Zr(O) + ZrO2] up to 1952 K and ZrO2–Y2O3 reaction from 1952 to 2519 K. The chemical shift during Zr oxidation was observed in the absorption spectra around the Zr K-edge, and the interatomic cation–cation and cation–oxygen distances obtained by the fitting analysis of EXAFS during the Y2O3–ZrO2 reaction are explained. Also, the temperature dependency of the anharmonic effect was investigated by comparing the fitted second- and third-order cumulants with the theoretical ones in which the Morse potential was applied as an interatomic potential, giving a good explanation about the local structure dynamics. Finally, the applicability of the developed system to investigation of nuclear fuel materials, such as UO2–Zr, is discussed.

Here, the novel technique of extended-range high-energy-resolution fluorescence detection (XR-HERFD) has successfully observed the n = 2 satellite in manganese to a high accuracy. The significance of the satellite signature presented is many hundreds of standard errors and well beyond typical discovery levels of three to six standard errors. This satellite is a sensitive indicator for all manganese-containing materials in condensed matter. The uncertainty in the measurements has been defined, which clearly observes multiple peaks and structure indicative of complex physical quantum-mechanical processes. Theoretical calculations of energy eigenvalues, shake-off probability and Auger rates are also presented, which explain the origin of the satellite from physical n = 2 shake-off processes. The evolution in the intensity of this satellite is measured relative to the full Kα spectrum of manganese to investigate satellite structure, and therefore many-body processes, as a function of incident energy. Results demonstrate that the many-body reduction factor S02 should not be modelled with a constant value as is currently done. This work makes a significant contribution to the challenge of understanding many-body processes and interpreting HERFD or resonant inelastic X-ray scattering spectra in a quantitative manner.

Mineral identification and quantification are key to the understanding and, hence, the capacity to predict material properties. The method of choice for mineral quantification is powder X-ray diffraction (XRD), generally using a Rietveld refinement approach. However, a successful Rietveld refinement requires preliminary identification of the phases that make up the sample. This is generally carried out manually, and this task becomes extremely long or virtually impossible in the case of very large datasets such as those from synchrotron X-ray diffraction computed tomography. To circumvent this issue, this article proposes a novel neural network (NN) method for automating phase identification and quantification. An XRD pattern calculation code was used to generate large datasets of synthetic data that are used to train the NN. This approach offers significant advantages, including the ability to construct databases with a substantial number of XRD patterns and the introduction of extensive variability into these patterns. To enhance the performance of the NN, a specifically designed loss function for proportion inference was employed during the training process, offering improved efficiency and stability compared with traditional functions. The NN, trained exclusively with synthetic data, proved its ability to identify and quantify mineral phases on synthetic and real XRD patterns. Trained NN errors were equal to 0.5% for phase quantification on the synthetic test set, and 6% on the experimental data, in a system containing four phases of contrasting crystal structures (calcite, gibbsite, dolomite and hematite). The proposed method is freely available on GitHub and allows for major advances since it can be applied to any dataset, regardless of the mineral phases present.

Proteins are well known `shapeshifters' which change conformation to function. In crystallography, multiple conformational states are often present within the crystal and the resulting electron-density map. Yet, explicitly incorporating alternative states into models to disentangle multi-conformer ensembles is challenging. We previously reported the tool FLEXR, which, within a few minutes, automatically separates conformational signal from noise and builds the corresponding, often missing, structural features into a multi-conformer model. To make the method widely accessible for routine multi-conformer building as part of the computational toolkit for macromolecular crystallography, we present a graphical user interface (GUI) for FLEXR, designed as a plugin for Coot 1. The GUI implementation seamlessly connects FLEXR models with the existing suite of validation and modeling tools available in Coot. We envision that FLEXR will aid crystallographers by increasing access to a multi-conformer modeling method that will ultimately lead to a better representation of protein conformational heterogeneity in the Protein Data Bank. In turn, deeper insights into the protein conformational landscape may inform biology or provide new opportunities for ligand design. The code is open source and freely available on GitHub at https://github.com/TheFischerLab/FLEXR-GUI.

A whole new experience with fan-made XR contents and Metaverse worldview

Lending partnership furthers XR Terra's goal of inclusion in tech by lowering financial barriers

The new facility features technology that expands the company’s ability to provide dependable inspection and QA Hold resolution services with shorter shipping times and reduced freight charges to the Southeast region.

Manufacturing

Company's Linear Motion and Assembly Technologies Group increases sales by 40 percent, leads by 25 percent, with redesigned Web site featuring downloadable 3D models

Read the in depth Review of Asus ROG Zephyrus S GX701GXR Laptops. Know detailed info about Asus ROG Zephyrus S GX701GXR configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.

Read the in depth Review of Sony BRAVIA XR 65 inch 4K OLED TV (65A80K) TV. Know detailed info about Sony BRAVIA XR 65 inch 4K OLED TV (65A80K) configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.

Read the in depth Review of Sony A80L 65 inch Smart OLED Google TV (XR-65A80L) TV. Know detailed info about Sony A80L 65 inch Smart OLED Google TV (XR-65A80L) configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.

Hello,


I would like to use the simulation software xrun/simvision that comes with XCELIUM. We are currently using classroom licenses and want to disable all ip addresses on the student pcs except the license server ip. We want to make sure that students cannot copy confidential data from the Cadence tools.


Problem:

When I launch the xrun simulation while all ip addresses are blocked, it starts but the performance is very slow. The GUI starts after 5 minutes and the simulation is ready after 10 minutes. The interesting thing is that when I enable all blocked ip addresses, everything works at a reasonable speed.

Terminal Output (execution without internet connection):

xrun -gui design.vhd

waiting for SimVision/Verisium Debug to connect...


Is there a way to run the simulation tools without an Internet connection? Or can you give me the ip addresses that are used by the simulation tools so that I can enable only those specific ips?


Regards,

Max

I'm completely new to Cadence. I've been able to run a very simple simulation with the -gui option. Simvision opens, I add the variables to the waveform viewer, and press run. All is good.

I don't understand the flow when using the -nogui option. It appears that the simulation runs and returns control to the OS. When I launch Simvision, is there a database or file that I can open to display the already-simulated data?

My command is of the form:

xrun -gui -64bit -sv -access +rwc -top tb_top.sv <src files>

I want to do a 2-step build->simulate as follow:

1. Make multiple builds using xrun -elaborate [other options]. The purpose is to create multiple builds with different compile-time macros (+define+MACROA +define+MACROB=ABC). Each build is located in a different directory.

2. Run simulation with xrun -r. This is where I need help. How do I specify which build to simulate? Also, I need the simulation directory (with log files, …) to be different than the build directory.

Has anyone been able to achieve this or similar solutions?

We are trying to run compilation, elab and sim with command xrun -r -u alu, where alu is one of the units to execute. we are getting the following errors.

1) xmsim: *E,DLMKDF: Unable to add default DEFINE std       /home/xxxx/Cad/xcelium/tools/inca/files/STD.
    xmsim: *E,DLMKDF: Unable to add default DEFINE synopsys  /home/xxxx/Cad/xcelium/tools/inca/files/SYNOPSYS

2) xmsim: *W,DLNOHV: Unable to find an 'hdl.var' file to load in.

What is the purpose of hdl.var

3) xmsim: *F,NOSNAP: Snapshot 'alu' does not exist in the libraries.

I cannot see in log files, which libraries is it referring to??

Any one request you to help on how to debug these.

Both, the BMW F 900 XR and the S 1000 XR are expected to be launched by mid this year with bookings likely to open next month.

The Fiesta XR2 was popular with boy racers in the 1980s but is now a collectors' item. Auctioneers in Cheshire say the restored Fiesta is the best example they have ever seen.

ഇറ്റാലിയന്‍ ബ്രാന്‍ഡില്‍ നിന്നുള്ള ആദ്യത്തെ മാക്‌സി-സ്‌കൂട്ടര്‍ ഓഫറാണ് അപ്രീലിയ SXR160. 2020 ഓട്ടോ എക്‌സ്‌പോയിലാണ് സ്‌കൂട്ടറിനെ കമ്പനി അവതരിപ്പിക്കുന്നത്.

A new diamond-anvil cell apparatus for in situ synchrotron X-ray diffraction measurements of liquids and glasses, at pressures from ambient to 5 GPa and temperatures from ambient to 1300 K, is reported. This portable setup enables in situ monitoring of the melting of complex compounds and the determination of the structure and properties of melts under moderately high pressure and high temperature conditions relevant to industrial processes and magmatic processes in the Earth's crust and shallow mantle. The device was constructed according to a modified Bassett-type hydro­thermal diamond-anvil cell design with a large angular opening (θ = 95°). This paper reports the successful application of this device to record in situ synchrotron X-ray diffraction of liquid Ga and synthetic PbSiO3 glass to 1100 K and 3 GPa.

A series of Co2−xRuxMnSi (x = 0, 0.25, 0.5, 0.75, 1) Heusler compounds were successfully synthesized. The heat-treatment conditions were crucial to make the materials form a single phase with a Heusler structure. With increasing Ru content, the half-metallic gap, lattice parameters and magnetization are continuously adjustable in a wide range. The Co2−xRuxMnSi (x = 0, 0.25) compounds are rigorous half-metals and show a T3 dependence of resistance at low temperature. The Co2−xRuxMnSi (x = 0.5, 0.75, 1) Heusler compounds are the nearly half-metallic materials and show a semiconductive dependence of resistance at low temperature. The experimental magnetization is consistent with that in theory and follows the Slater–Pauling rule. The Curie temperature is higher than 750 K for all Co2−xRuxMnSi Heusler compounds.

Two methods for reconstructing intragranular strain fields are developed for scanning three-dimensional X-ray diffraction (3DXRD). The methods are compared with a third approach where voxels are reconstructed independently of their neighbours [Hayashi, Setoyama & Seno (2017). Mater. Sci. Forum, 905, 157–164]. The 3D strain field of a tin grain, located within a sample of approximately 70 grains, is analysed and compared across reconstruction methods. Implicit assumptions of sub-problem independence, made in the independent voxel reconstruction method, are demonstrated to introduce bias and reduce reconstruction accuracy. It is verified that the two proposed methods remedy these problems by taking the spatial properties of the inverse problem into account. Improvements in reconstruction quality achieved by the two proposed methods are further supported by reconstructions using synthetic diffraction data.

Going against the safety guidelines of the Consumer Product Safety Commission (CPSC) could cause inaccurate test reports and unsafe jewelry to be sold in California.

One of the leading companies in electric rideables has announced their latest series of affordable commuter grade electric scooters. These scooters start as low as $299.99 and reach distances of up to 16 miles per charge.

The invention relates to compounds of formula (I): wherein R is ethyl, propyl or allyl, and pharmaceutically acceptable salts, solvates or amino acid conjugates thereof. The compounds of formula (I) are useful as FXR agonists.

Systems and methods for implementing FlexRay communications between FlexRay nodes using Ethernet are provided. An Ethernet switch includes ports, each of which receives an Ethernet data packet (EDP) from a respective FlexRay node. Each EDP includes a FlexRay message, which includes at least one of a data frame and a frame identification (ID). A first EDP is received at a first port no later than a second EDP is received at a second port. The Ethernet switch also includes a controller module that determines whether the second EDP has higher priority than the first EDP based on the frame IDs associated with the first and second EDPs. The controller module is configured to route the second EDP to a second destination no later than routing the first EDP to a first destination and meet FlexRay transmission cycle times when it has been determined that the second EDP has higher priority.

A novel soybean variety, designated XR31L13 is provided. Also provided are the seeds of soybean variety XR31L13, cells from soybean variety XR31L13, plants of soybean XR31L13, and plant parts of soybean variety XR31L13. Methods provided include producing a soybean plant by crossing soybean variety XR31L13 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety XR31L13, methods for producing other soybean varieties or plant parts derived from soybean variety XR31L13, and methods of characterizing soybean variety XR31L13. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety XR31L13 are further provided.

Lipid-rich myelin forms electrically insulating, axon-wrapping multilayers that are essential for neural function, and mature myelin is traditionally considered metabolically inert. Surprisingly, we discovered that mature myelin lipids undergo rapid turnover, and quaking (Qki) is a major regulator of myelin lipid homeostasis. Oligodendrocyte-specific Qki depletion, without affecting oligodendrocyte survival, resulted in rapid demyelination, within 1 week, and gradually neurological deficits in adult mice. Myelin lipids, especially the monounsaturated fatty acids and very-long-chain fatty acids, were dramatically reduced by Qki depletion, whereas the major myelin proteins remained intact, and the demyelinating phenotypes of Qki-depleted mice were alleviated by a high-fat diet. Mechanistically, Qki serves as a coactivator of the PPARβ-RXRα complex, which controls the transcription of lipid-metabolism genes, particularly those involved in fatty acid desaturation and elongation. Treatment of Qki-depleted mice with PPARβ/RXR agonists significantly alleviated neurological disability and extended survival durations. Furthermore, a subset of lesions from patients with primary progressive multiple sclerosis were characterized by preferential reductions in myelin lipid contents, activities of various lipid metabolism pathways, and expression level of QKI-5 in human oligodendrocytes. Together, our results demonstrate that continuous lipid synthesis is indispensable for mature myelin maintenance and highlight an underappreciated role of lipid metabolism in demyelinating diseases.

It's episode 105, and David Price takes on hosting duties as the team dissect the best and absolute worst of the week's tech developments.

Scott Carey talks us through the troubling and wide-ranging allegations of sexual misconduct at Google, and discusses how this relates to the tech industry's culture of protected privilege, and to the #metoo movement.

Then Henry Burrell, fresh from a briefing at Apple HQ, reports his distinctly positive first impressions of the iPhone XR, which he would gladly recommend to tech newbie grandmas, and also to Scott.

See acast.com/privacy for privacy and opt-out information.

Bile acids (BAs) facilitate intestinal absorption of lipid-soluble nutrients and modulate various metabolic pathways through the farnesoid X receptor (FXR) and Takeda G-protein-coupled receptor 5. These receptors are targets for therapy in cholestatic and metabolic diseases. However, dissimilarities in BA metabolism between humans and mice complicate translation of preclinical data. Cytochrome P450 family 2 subfamily c polypeptide 70 (CYP2C70) was recently proposed to catalyze the formation of rodent-specific muricholic acids (MCAs). With CRISPR/Cas9-mediated somatic genome editing, we generated an acute hepatic Cyp2c70 knockout mouse model (Cyp2c70^ako) to clarify the role of CYP2C70 in BA metabolism in vivo and evaluate whether its activity modulates effects of pharmacologic FXR activation on cholesterol homeostasis. In Cyp2c70^ako mice, chenodeoxycholic acid (CDCA) increased at the expense of βMCA, resulting in a more hydrophobic human-like BA pool. Tracer studies demonstrated that, in vivo, CYP2C70 catalyzes the formation of βMCA primarily by sequential 6β-hydroxylation and C7-epimerization of CDCA, generating αMCA as an intermediate metabolite. Physiologically, the humanized BA composition in Cyp2c70^ako mice blunted the stimulation of fecal cholesterol disposal in response to FXR activation compared with WT mice, predominantly due to reduced stimulation of transintestinal cholesterol excretion. Thus, deletion of hepatic Cyp2c70 in adult mice translates into a human-like BA pool composition and impacts the response to pharmacologic FXR activation. This Cyp2c70^ako mouse model may be a useful tool for future studies of BA signaling and metabolism that informs human disease development and treatment.

Hi all,

I need to develop a digital design/verification solution to compile,elaborate and simulate SV designs (basically a complex xrun wrapper). I am an experienced user of xrun and I have done a number of these wrappers over the years but this one is to be more of a tool, intented to be used Company-wise, so it needs to be very well thought and engineered.

It needs to be robust, simple and extensible. It needs to support multi-snapshot elaboration, run regressions on machine farms, collect coverage, create reports, etc.

I've been browsing the vast amount of documentation on XCELIUM and, although very good, I can't find any document which puts together all the pieces of what I am trying to achieve. I suppose I am more clear on the elaboration, compilation and simulation part but I am really lacking on the other areas like : LSF, regressions coverage, where does vManager fits in all this, etc.

I'd appreciate if someone can comment on whether there is a document which depicts how such a DV flow can be put together from scratch, or whether there is a kind of RAK with some example xrun wrapper.

Thanks

Hi,

I found a basic Specman E/Verilog program at http://www.asic-world.com/examples/specman/memory.html and I would like to run it through a vsif file, with vManager.

I'm able to run it, without problems, with this command : xrun -Q -unbuffered '-timescale' '1ns/1ns' '-access' '+rw' memory_tb.v mem_tb_top.e test_write_read_all.e.

I wrote a first vsif which look like this:

---- vm_basic.vsif -----

session vm_basic {
        top_dir : /home/cadence/xrunTest/;
        output_mode: terminal;
};

group basic {
        test test {
                run_script: xrun -Q -unbuffered '-timescale' '1ns/1ns' '-access' '+rw' memory_tb.v mem_tb_top.e test_write_read_all.e
        };
};

----------------------------

This solution didn't work due to the prompt change with xrun, and I have no clue how to manage this issue.

Have you any idea?

Best regards,

Yohan