Why is the Lenten Journey so challenging? Fr. Steven Ritter gives us some answers.

What happens when you lose your Medicaid coverage?

The post The Unwinding was curated by information for practice.

Last month, I had the opportunity to offer testimony in support of the Environmental Protection Agency (EPA) proposal to modestly scale back the amount of ethanol required to be produced under the Renewable Fuel Standard (RFS). 

Generator field winding is an integral part of the generator set which is responsible for generating the magnetic field that induces the stator emf when the rotor rotates. Regulation of current in this winding with the help of an AVR... Read more

The post Failures, Testing and Protections Associated with Field Winding of a Generator appeared first on EEP - Electrical Engineering Portal.

RecQ family helicases are highly conserved from bacteria to humans and have essential roles in maintaining genome stability. Mutations in three human RecQ helicases cause severe diseases with the main features of premature aging and cancer predisposition. Most RecQ helicases shared a conserved domain arrangement which comprises a helicase core, an RecQ C-terminal domain, and an auxiliary element helicase and RNaseD C-terminal (HRDC) domain, the functions of which are poorly understood. In this study, we systematically characterized the roles of the HRDC domain in E. coli RecQ in various DNA transactions by single-molecule FRET. We found that RecQ repetitively unwinds the 3'-partial duplex and fork DNA with a moderate processivity and periodically patrols on the ssDNA in the 5'-partial duplex by translocation. The HRDC domain significantly suppresses RecQ activities in the above transactions. In sharp contrast, the HRDC domain is essential for the deep and long-time unfolding of the G4 DNA structure by RecQ. Based on the observations that the HRDC domain dynamically switches between RecA core- and ssDNA-binding modes after RecQ association with DNA, we proposed a model to explain the modulation mechanism of the HRDC domain. Our findings not only provide new insights into the activities of RecQ on different substrates but also highlight the novel functions of the HRDC domain in DNA metabolisms.

The synthesis of cholesterol requires more than 20 enzymes, many of which are intricately regulated. Post-translational control of these enzymes provides a rapid means for modifying flux through the pathway. So far, several enzymes have been shown to be rapidly degraded through the ubiquitin–proteasome pathway in response to cholesterol and other sterol intermediates. Additionally, several enzymes have their activity altered through phosphorylation mechanisms. Most work has focused on the two rate-limiting enzymes: 3-hydroxy-3-methylglutaryl CoA reductase and squalene monooxygenase. Here, we review current literature in the area to define some common themes in the regulation of the entire cholesterol synthesis pathway. We highlight the rich variety of inputs controlling each enzyme, discuss the interplay that exists between regulatory mechanisms, and summarize findings that reveal an intricately coordinated network of regulation along the cholesterol synthesis pathway. We provide a roadmap for future research into the post-translational control of cholesterol synthesis, and no doubt the road ahead will reveal further twists and turns for this fascinating pathway crucial for human health and disease.

At a new park in Bosnia and Herzegovina, two dozen gardeners have spent years replicating the Dutch artist's masterpiece using the land as their canvas

A survey of low-income adults in Arkansas, Kentucky, Louisiana, and Texas revealed that one in eight respondents who had enrolled in Medicaid at some

Why a business that wants to down shutters must be offered the right kind of support

Prioritise mornings with running, balanced diet, revitalizing workouts and meditation for mental health, says Nishant Pitti, CEO and Co-Founder, EaseMyTrip

Ritesh Kumar’s daily routine includes yoga, a plant-based diet, contemplation, tennis, and unwinding with a good book.

A couple of evenings ago, my cousin Debika and I were discussing how we’d react if we were told we had just a few months to live. She said she would try and do everything she liked in that time, and surround herself with her family. I said that I’d be inclined to save people I cared for the pain of watching me die—whatever that took. Ironically and unexpectedly, shortly after this conversation, we found ourselves watching François Ozon’s remarkable film Time to Leave.

The film begins with its protagonist, Romain, discovering that he is terminally ill with cancer, and deciding not to bother with treatment. He does not tell his friends or family of his condition. He is rude to his sister, and drives her to tears. He tells his lover, Sasha, that he does not love him, and drives him to move out of their house. This is a transparent lie, but though we see it, Sasha doesn’t. He confides to his grandmother—marvellously played by Jeanne Moreau—because she is like him, and “will die soon.” But even in this winding up, complications ensue.

Melvil Poupaud plays Romain, and is magnificent – understated, yet effortlessly expressive. But it is Ozon’s storytelling that makes this film memorable. It is spare, focussing only on the essential, and revealing its essence. There is not a frame out of place in this heartbreaking film that ends, like Romain, too soon and in great beauty.

Rave Out © 2007 IndiaUncut.com. All rights reserved.
India Uncut * The IU Blog * Rave Out * Extrowords * Workoutable * Linkastic

Researchers mapped the route food takes from farms to homes.

HP continues to divulge bits and pieces of a road map for the ill-starred and nearly-orphaned webOS. The company has followed up its December plan to release webOS mobile platform and development tools with a proposed timeline, with a full release set before year’s end.  Some people see a life for the associated Enyo JavaScript Read the rest...

A balun including a first conductor winding, a first inductor, a second inductor, a third inductor, and a fourth inductor. The first conductor winding has a figure eight shape including a first loop and a second loop. The first inductor and the second inductor substantially surround the first loop. The third inductor and the fourth inductor substantially surround the second loop.

A method and device for winding a rotor or a stator (2), of a rotary electrical machine, having a series of teeth (21) which are delimited by notches (22). In each notch there are inserted M continuous electric wires (3) constituting a turn; M being equal to 1 or more, characterised in that n×M wires (3) are wound simultaneously in a number n of notches (22), n corresponding to the number of phases and being ≧2. The assembly of the M wires (3) constituting a phase, being inserted in a single notch (22). The device for winding has at least two carriages (4, 5), with a series of teeth, delimited by n notches (40, 50). And, likewise corresponding to the winding, each set of M continuous electric wires (3) constituting a turn, is characterised in that M×n wires (3) are inserted simultaneously in the extension of the n notches (22) of the rotary electrical machine in the n notches (40, 50) in the respective carriages (4, 5). All of the M×n wires (3) are bent together at least twice by bending the carriages (4, 5) relative to one another, and all of the M×n wires (3) thus bent are folded back in the following successive n1 notches (22) of the rotary electrical machine.

A system and process is described for producing spirally wound products. According to the process of the present disclosure, two or more webs are conveyed together in a superimposed relationship. The webs are then separated such that one web goes to a first winding module while a second web goes to a second winding module, etc. In this manner, at least two spirally wound products can be produced simultaneously. The process and system of the present disclosure are particularly well suited for processing tissue webs, such as paper towels and bath tissue. The process of the present disclosure can effectively at least double throughput on existing winding systems.

In a webbing winding device, even when a piston moves toward the other side in a movement direction due to a reaction when the piston moves to a maximum movement position, an engagement surface of a hook portion comes into contact with a subject engagement surface of a subject engagement portion, so that the movement of the piston toward the other side in the movement direction is restricted. Accordingly, the piston is prevented from returning to a standby position, and a pawl is prevented from returning to a lock position. For this reason, a state where a rotation of a locking ring in the pull-out direction is maintained. Accordingly, after the piston moves from the standby position to the maximum movement position, the piston is prevented from returning to the standby position, and the force limiter load is prevented from being changed.

A filament winding apparatus prevents a fiber bundle supplied to a liner from interfering with other fiber bundles and fiber supplying guides. First and second guide units include a plurality of fiber supplying guides arranged radially and extending and contracting in a direction approximately perpendicular to a liner central axis. When a fiber bundle supplied from a first supplying guide of the first guide unit crosses between a second supplying guide of the second guide unit and the liner, the distance from the second supplying guide to the liner central axis is made larger than the distance from the first supplying guide to the liner central axis, and in the reverse case, the distance from the first supplying guide to the liner central axis is made larger than the distance from the second supplying guide to the liner central axis.

A web rewinding apparatus having a mandrel cupping assembly for releaseably engaging unsupported ends of a plurality of mandrels is disclosed. Each of the plurality of mandrels extends generally parallel to the web winding turret assembly axis. Each of the mandrels is driven in a closed mandrel path about the web winding turret assembly axis. The mandrel cupping assembly comprises a cupping arm turret having a cupping arm turret central axis, a mandrel cup cooperatively associated with each mandrel of the plurality of mandrels, at least three motion limiting devices disposed upon the cupping arms, and a first actuator.

The wire winding apparatus includes: a wire feeding member provided to a supporting member so as to be operable, for feeding a wire; a lock mechanism capable of inhibiting an operation of the wire feeding member; a winding mechanism for rotating a core about an axis thereof to wind the wire fed from the wire feeding member around the outer circumference of the core; a feed mechanism for moving the supporting member in an axial direction of the core in synchronization with the winding performed by the winding mechanism; a proximity sensor for detecting a movement amount of the wire feeding member with respect to the supporting member; and a control section for controlling an operation of the feed mechanism to adjust a movement amount of the supporting member moved by the feed mechanism based on a detection output from the proximity sensor.

A filament winding apparatus prevents a fiber bundle supplied to a liner from interfering with other fiber bundles and fiber supplying guides. First and second guide units include a plurality of fiber supplying guides arranged radially and extending and contracting in a direction approximately perpendicular to a liner central axis. When a fiber bundle supplied from a first supplying guide of the first guide unit crosses between a second supplying guide of the second guide unit and the liner, the distance from the second supplying guide to the liner central axis is made larger than the distance from the first supplying guide to the liner central axis, and in the reverse case, the distance from the first supplying guide to the liner central axis is made larger than the distance from the second supplying guide to the liner central axis.

Laser light is emitted to a sheet member wound on a forming drum in a range which includes the entire width of the sheet member and distance data on a distance to a reflecting surface is obtained, using a two-dimensional laser sensor which has a detection range along a drum circumferential direction, while moving either the two-dimensional laser sensor or the forming drum in a drum width direction. Further, the positions of width-directional opposite end sections of the sheet member are calculated on the basis of the obtained distance data.

To provide a wire unwinding auxiliary device capable of, compared to a conventional device, effectively preventing an unwound wire material from getting twisted, entangled or flawed. A wire unwinding auxiliary device used for guiding an unwound wire material when unwinding the wire material which is wound in a coiled shape. The device comprises a plurality of rotation members 1a-1e on which the unwound wire material is set to run therethrough, and a non-rotation member 2 provided adjacent to at least a rotation member 1a through which the wire material passes first in the plurality of rotation members 1a-1e, thereby a running path of the wire material is stabilized between the non-rotation member 2 and the rotation member 1a.

A stranding of long winding material using a substantially cylindrical rotary body. The rotary body includes a first passage for guiding a first winding material through the cylindrical rotary body and a second passage for guiding a second winding material through the cylindrical rotary body. The first passage connects a first offset inlet on a first end side of the rotary body to a first offset outlet on a second end side of the rotary body, which opposes the first end side. The second passage connects a second input, arranged on a surface of the rotary body extending between the two end sides, to a second offset output on the second or first end side of the rotary body.

In a bead wire winding and forming device, a guide mechanism guiding a bead wire to a former is supported to be movable in a tangential direction of the former and includes a movable body capable of clamping and unclamping the bead wire, a guide body supported on the movable body to be swingable in a plane parallel to a rotational axis of the former and having a guide portion for guiding the bead wire in the tangential direction of the former, and a restriction member for allowing the swing motion of the guide body when the movable body is at a retracted position but for restricting the swing motion of the guide body when the movable body is at an advanced position.

The winding mandrel includes a pair of generally rounded-cube shaped or orthogonally flat-sided spherical main bodies connected together and having a plurality of cylindrical posts for forming vasoocclusive coils. The main bodies are connected together by a transition post, and the posts of the two main bodies are typically offset. A front end post and back end post are disposed on the front and rear ends of the mandrel. A short winding post member may be added between the connections of the two main bodies to provide additional winding posts.

A lower thread ending region detection apparatus prevents problems associated with false stitchings occurring from inability to detect lower thread's exhaustion during sewing operation. The lower thread ending region detection apparatus comprises: light control unit, which contacts a part of lower thread wound on a thread bobbin and activates or inactivates at least one of the functions of emitting light, reflecting light, passing light and blocking light, due to the effect of the physical movement force generated depending on whether the lower thread of the ending region is unwound; light receiving unit, which receives the light transferred out by the light control unit and outputs a detection signal; and control and notification unit, which analyzes the detection signal output from the light receiving unit to determine whether the lower thread has reached the ending region and outputs the result to the user.

A winding tool for tightening a torsion spring for a sectional overhead door. The winding tool features two half hub assembles that wrap around an overhead door shaft, wherein a translational sprocket is disposed on the hub assemblies. The hub assemblies connect to the winding cone of a torsion spring via fingers that engage the hub assemblies. A winding box is removably attached to the hub assemblies. The winding box features a worm gear that engages the translational sprocket. A handle bar can be rotated with a drill to cause rotation of the worm gear. Rotation of the worm gear causes rotation of the translational sprocket and ultimate winding of the torsion spring.

A system for safely and effectively winding a garage door spring features a hub assembly having a cylindrical hub with a cylindrical channel located there through. The hub assembly features a wheel gear located around the hub and a plurality of engagement prongs designed to snuggly engage a torsion spring winding cone. The hub assembly is divided into a first hub component and a second hub component. The system features a base with a semi-cylindrical notch and an arcuate lid pivotally located thereon. A plurality of support rollers are adjustably located around an inside of the notch and the lid. The hub assembly is positioned on the support rollers. A worm gear that interfaces with the wheel gear is attached to a drive shaft assembly that features a drive shaft that extends from the base for remote operation of the worm gear.

An SZ laying machine for umbilical/power umbilical is described. Starting from an input end the machine includes: a first die receiving and collecting a first set of elongate elements substantially rectilinear from respective supplies of elongate elements, a second static die which receives and collects a second set of elongate elements substantially rectilinear from respective supplies of elongate elements and this second set is closed together with the first set into an assembled bundle, at least one supporting means which keeps the assembled bundle radially in place; a revolving device able to torsional rotate the bundle back and forth in an oscillating SZ manner, and a tape or band winding apparatus which in immediate proximity to the revolving device applies band or tape circumferentially onto the SZ laid bundle of elongate elements.

A winding device includes: a separation unit that separates sheets layered and simultaneously transported; a winding unit that winds one of the sheets separated by the separation unit; and a pressure contact unit that presses the one of the sheets wound by the winding unit from outside of the wound sheet toward the winding unit.

The present invention generally relates to an improved winding apparatus useful in the production of filament wound products and particularly wound tubular products having high length to diameter ratios. The improved winding apparatus comprises a support means for supporting a rotatable mandrel during the manufacture of wound products, the support means comprising a plurality of axially spaced pins extending circumferentially around the mandrel, and a support assembly having a semicircular inner face and an opening, wherein a portion of the plurality of pins is brought into contact with the inner face of the support assembly when the mandrel is rotated.

(United States Ninth Circuit) - Affirmed. Plaintiff filed suit against the Commissioners of the California Public Utilities commission alleging that the California Renewable Market Adjust Tariff (Re-MAT) program violated the Public Utility Regulatory Policies Act (PURPA). The district court granted summary judgment in favor of the Plaintiff, but declined to grant Plaintiff a contract with PG&E at a specified price. The Ninth Circuit held that the Re-MAT program violated the PURPA and therefore is preempted by PURPA, but the Ninth Circuit would not grant the contract because PG&E was not a party to the suit.

(United States Ninth Circuit) - Affirmed. Plaintiff filed suit against the Commissioners of the California Public Utilities commission alleging that the California Renewable Market Adjust Tariff (Re-MAT) program violated the Public Utility Regulatory Policies Act (PURPA). The district court granted summary judgment in favor of the Plaintiff, but declined to grant Plaintiff a contract with PG&E at a specified price. The Ninth Circuit held that the Re-MAT program violated the PURPA and therefore is preempted by PURPA, but the Ninth Circuit would not grant the contract because PG&E was not a party to the suit.

(United States Ninth Circuit) - Affirmed. Plaintiff filed suit against the Commissioners of the California Public Utilities commission alleging that the California Renewable Market Adjust Tariff (Re-MAT) program violated the Public Utility Regulatory Policies Act (PURPA). The district court granted summary judgment in favor of the Plaintiff, but declined to grant Plaintiff a contract with PG&E at a specified price. The Ninth Circuit held that the Re-MAT program violated the PURPA and therefore is preempted by PURPA, but the Ninth Circuit would not grant the contract because PG&E was not a party to the suit.

Knowledge of the molecular events in mitochondrial DNA (mtDNA) replication is crucial to understanding the origins of human disorders arising from mitochondrial dysfunction. Twinkle helicase is an essential component of mtDNA replication. Here, we employed atomic force microscopy imaging in air and liquids to visualize ring assembly, DNA binding, and unwinding activity of individual Twinkle hexamers at the single-molecule level. We observed that the Twinkle subunits self-assemble into hexamers and higher-order complexes that can switch between open and closed-ring configurations in the absence of DNA. Our analyses helped visualize Twinkle loading onto and unloading from DNA in an open-ringed configuration. They also revealed that closed-ring conformers bind and unwind several hundred base pairs of duplex DNA at an average rate of ∼240 bp/min. We found that the addition of mitochondrial single-stranded (ss) DNA–binding protein both influences the ways Twinkle loads onto defined DNA substrates and stabilizes the unwound ssDNA product, resulting in a ∼5-fold stimulation of the apparent DNA-unwinding rate. Mitochondrial ssDNA-binding protein also increased the estimated translocation processivity from 1750 to >9000 bp before helicase disassociation, suggesting that more than half of the mitochondrial genome could be unwound by Twinkle during a single DNA-binding event. The strategies used in this work provide a new platform to examine Twinkle disease variants and the core mtDNA replication machinery. They also offer an enhanced framework to investigate molecular mechanisms underlying deletion and depletion of the mitochondrial genome as observed in mitochondrial diseases.

Knowledge of the molecular events in mitochondrial DNA (mtDNA) replication is crucial to understanding the origins of human disorders arising from mitochondrial dysfunction. Twinkle helicase is an essential component of mtDNA replication. Here, we employed atomic force microscopy imaging in air and liquids to visualize ring assembly, DNA binding, and unwinding activity of individual Twinkle hexamers at the single-molecule level. We observed that the Twinkle subunits self-assemble into hexamers and higher-order complexes that can switch between open and closed-ring configurations in the absence of DNA. Our analyses helped visualize Twinkle loading onto and unloading from DNA in an open-ringed configuration. They also revealed that closed-ring conformers bind and unwind several hundred base pairs of duplex DNA at an average rate of ∼240 bp/min. We found that the addition of mitochondrial single-stranded (ss) DNA–binding protein both influences the ways Twinkle loads onto defined DNA substrates and stabilizes the unwound ssDNA product, resulting in a ∼5-fold stimulation of the apparent DNA-unwinding rate. Mitochondrial ssDNA-binding protein also increased the estimated translocation processivity from 1750 to >9000 bp before helicase disassociation, suggesting that more than half of the mitochondrial genome could be unwound by Twinkle during a single DNA-binding event. The strategies used in this work provide a new platform to examine Twinkle disease variants and the core mtDNA replication machinery. They also offer an enhanced framework to investigate molecular mechanisms underlying deletion and depletion of the mitochondrial genome as observed in mitochondrial diseases.

Knowledge of the molecular events in mitochondrial DNA (mtDNA) replication is crucial to understanding the origins of human disorders arising from mitochondrial dysfunction. Twinkle helicase is an essential component of mtDNA replication. Here, we employed atomic force microscopy imaging in air and liquids to visualize ring assembly, DNA binding, and unwinding activity of individual Twinkle hexamers at the single-molecule level. We observed that the Twinkle subunits self-assemble into hexamers and higher-order complexes that can switch between open and closed-ring configurations in the absence of DNA. Our analyses helped visualize Twinkle loading onto and unloading from DNA in an open-ringed configuration. They also revealed that closed-ring conformers bind and unwind several hundred base pairs of duplex DNA at an average rate of ∼240 bp/min. We found that the addition of mitochondrial single-stranded (ss) DNA–binding protein both influences the ways Twinkle loads onto defined DNA substrates and stabilizes the unwound ssDNA product, resulting in a ∼5-fold stimulation of the apparent DNA-unwinding rate. Mitochondrial ssDNA-binding protein also increased the estimated translocation processivity from 1750 to >9000 bp before helicase disassociation, suggesting that more than half of the mitochondrial genome could be unwound by Twinkle during a single DNA-binding event. The strategies used in this work provide a new platform to examine Twinkle disease variants and the core mtDNA replication machinery. They also offer an enhanced framework to investigate molecular mechanisms underlying deletion and depletion of the mitochondrial genome as observed in mitochondrial diseases.

A couple of evenings ago, my cousin Debika and I were discussing how we’d react if we were told we had just a few months to live. She said she would try and do everything she liked in that time, and surround herself with her family. I said that I’d be inclined to save people I cared for the pain of watching me die—whatever that took. Ironically and unexpectedly, shortly after this conversation, we found ourselves watching François Ozon’s remarkable film Time to Leave.

The film begins with its protagonist, Romain, discovering that he is terminally ill with cancer, and deciding not to bother with treatment. He does not tell his friends or family of his condition. He is rude to his sister, and drives her to tears. He tells his lover, Sasha, that he does not love him, and drives him to move out of their house. This is a transparent lie, but though we see it, Sasha doesn’t. He confides to his grandmother—marvellously played by Jeanne Moreau—because she is like him, and “will die soon.” But even in this winding up, complications ensue.

Melvil Poupaud plays Romain, and is magnificent – understated, yet effortlessly expressive. But it is Ozon’s storytelling that makes this film memorable. It is spare, focussing only on the essential, and revealing its essence. There is not a frame out of place in this heartbreaking film that ends, like Romain, too soon and in great beauty.

Rave Out © 2007 IndiaUncut.com. All rights reserved.
India Uncut * The IU Blog * Rave Out * Extrowords * Workoutable * Linkastic

In Re Saint Benedict's Land Trust ...

Chancellor Rishi Sunak is considering options to taper off the Government's furlough scheme which is supporting workers staying at home during the coronavirus outbreak.

UFC 249, to take place Saturday in Jacksonville, Fla., without fans, will be perhaps the most unique pay-per-view event the promotion company has staged.

Night brun

Vice-president makes suggestion even as number of deaths across the country spikes

Borussia Dortmund star Erling Haaland has rewritten the goalscoring handbook since arriving on the scene with Red Bull Salzburg and has now revealed the secrets behind his success.

Borussia Dortmund star Erling Haaland has rewritten the goalscoring handbook since arriving on the scene with Red Bull Salzburg and has now revealed the secrets behind his success.