The Bermuda Football Association [BFA] announced that Bermuda’s U20 Women’s National Team will be participating in the 2025 Concacaf U-20 Women’s Qualifiers and Championship. A spokesperson said, “The Bermuda Football Association [BFA] is excited to announce that Bermuda’s U20 Women’s National Team will be participating in the 2025 Concacaf U-20 Women’s Qualifiers and Championship. This […]

Nic Narraway faced a challenging day at the UCI World Championships during the U23 road race, a demanding 173.6km event from Uster to Zurich. A spokesperson said, “Out of 184 starters, Narraway was among the 80 riders who did not finish the race. “Competing in harsh conditions of pouring rain, strong winds, and hail, the […]

The 2024 Eastern Caribbean Volleyball Association (ECVA) Under 21 Beach Volleyball Championships saw further action in St. Kitts & Nevis. Bermuda’s Isabella Sousa and Hailey Trott secured their spot in the semi-finals with a 2-0 (21-12, 21-6) victory over Saint Vincent’s Nayelli Fergus and Reanna Robinson. On the men’s side, Bermuda’s Riley Morbey and Marcus […]

VU2ZP Yank Radio.... Bangalore: The Brochure...

Bristol City midfielder George Earthy called up to the England Under-21 squad for the first time after a series of withdrawals due to either injury or transitions into the senior squad.

Asia’s rising stars discovered their opponents following the conclusion of the AFC U23 Asian Cup Uzbekistan 2022 Qualifiers Draw in Tashkent. The Qualifiers are scheduled for October 23 to 31, 2021. Out of 47 AFC Member Associations, a total of 42 teams entered the competition and were drawn into nine groups of four teams and two groups of three team. The 11 group winners and four best second-placed teams will seal their qualification to the Finals, along with Uzbekistan who have already confirmed their place as hosts. The Finals will be held between 1-19 June 2022. Players born on or after 1 January 1999 are eligible to compete in the tournament.



India is hoping to qualify to the Finals of the tournament for the first time since its inception and was drawn in Group E alongside Kyrgyz Republic, Oman and UAE, who will host the group. 

India's Fixture
MD1: 27 October 2021 - India vs Oman
MD2: 29 October 2021 - India vs UAE
MD3: 31 October 2021 - India vs Kyrgyz Republic

AGU24 is just around the corner and our Science Policy and Government Relations team has a jam-packed agenda for our members at this year’s meeting in Washington, DC. From science policy 101 to understanding how scientists can engage with congress after the election to exploring science policy careers, we are here to help you make the most of your meeting. Explore our day-by-day schedule below:  Monday, 9 December  What’s Next for …

The post Join AGU Science Policy at AGU24 in DC appeared first on AGU Blogosphere.

AGU24 is just around the corner and our Science Policy and Government Relations team has a jam-packed agenda for our members at this year’s meeting in Washington, DC. From science policy 101 to understanding how scientists can engage with congress after the election to exploring science policy careers, we are here to help you make the most of your meeting. Explore our day-by-day schedule below:    Monday through Thursday, daily: Free …

The post Join AGU Science Policy at AGU24 in Washington DC appeared first on AGU Blogosphere.

AGU24 is just around the corner and our Science Policy and Government Relations team has a jam-packed agenda for our members at this year’s meeting in Washington, DC. From science policy 101 to understanding how scientists can engage with congress after the election to exploring science policy careers, we are here to help you make the most of your meeting. Explore our day-by-day schedule below:    Monday through Thursday, daily: Free …

The post Join AGU Science Policy at AGU24 in Washington DC appeared first on The Bridge: Connecting Science and Policy.

Bermudian sprinter Norre Robinson took to the track at the World Athletics Under-20 Championships in Peru, competing in the highly competitive men’s 100 meters event. Robinson, drawn in heat 3, clocked a time of 10.99 seconds, securing a seventh-place finish in his heat. Overall, Robinson’s performance placed him 61st in the field of talented young […]

Cavan retain the Ulster Under-21 Football title as they edge out Tyrone 1-10 to 0-10 in Wednesday's final at Brewster Park.

High-throughput sequencing of hematologic malignancies and other cancers has revealed recurrent mis-sense mutations of genes encoding pre-mRNA splicing factors. The essential splicing factor U2AF2 recognizes a polypyrimidine-tract splice-site signal and initiates spliceosome assembly. Here, we investigate representative, acquired U2AF2 mutations, namely N196K or G301D amino acid substitutions associated with leukemia or solid tumors, respectively. We determined crystal structures of the wild-type (WT) compared with N196K- or G301D-substituted U2AF2 proteins, each bound to a prototypical AdML polypyrimidine tract, at 1.5, 1.4, or 1.7 Å resolutions. The N196K residue appears to stabilize the open conformation of U2AF2 with an inter-RNA recognition motif hydrogen bond, in agreement with an increased apparent RNA-binding affinity of the N196K-substituted protein. The G301D residue remains in a similar position as the WT residue, where unfavorable proximity to the RNA phosphodiester could explain the decreased RNA-binding affinity of the G301D-substituted protein. We found that expression of the G301D-substituted U2AF2 protein reduces splicing of a minigene transcript carrying prototypical splice sites. We further show that expression of either N196K- or G301D-substituted U2AF2 can subtly alter splicing of representative endogenous transcripts, despite the presence of endogenous, WT U2AF2 such as would be present in cancer cells. Altogether, our results demonstrate that acquired U2AF2 mutations such as N196K and G301D are capable of dysregulating gene expression for neoplastic transformation.

Read the in depth Review of AmazonBasics 55 inches 4K Ultra HD Smart LED TV (AB55U20PS) TV. Know detailed info about AmazonBasics 55 inches 4K Ultra HD Smart LED TV (AB55U20PS) configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.

The one watershed album that spurred bands to stardom and changed their fortunes forever

The teams were locked 1-1 at half time, but India stepped up the assault in the second half to leave Mongolia's defence in tatters

The top teams of the 10 groups, along with the five best second-place finishers, will qualify for the AFC U20 Asian Cup 2025 in China

Rietveld/MEM analysis applied to synchrotron powder X-ray diffraction data of dehydrated CHA zeolites with catalytically active Cu2+ reveals Cu2+ in both the six- and eight-membered rings in the CHA framework, providing the first complete structural model that accounts for all Cu2+. Density functional theory calculations are used to corroborate the experimental structure and to discuss the Cu2+ coordination in terms of the Al distribution in the framework.

Single crystals of the title compound barium zinc copper, BaCu2.6Zn2.4, were obtained from a sample prepared by heating metal chips of Ba, Cu, and Zn in an Ar atmosphere up to 973 K, followed by slow cooling. Single-crystal X-ray structure analysis revealed that BaCu2.6Zn2.4 crystallizes in an ortho­rhom­bic cell [a = 12.9858 (3), b = 5.2162 (1), and c = 6.6804 (2) Å] with an α-SrZn5-type structure (space group Pnma). The three-dimensional framework consists of Cu and Zn atoms, with Ba atoms in the tunnels extending in the b-axis direction. Although the Ba atom is larger than the Sr atom, the cell volume of BaCu2.6Zn2.4 [452.507 (19) Å3] is smaller than that of α-SrZn5 [466.08 Å3]. This decrease in volume can be attributed to the partial substitution of Cu atoms by Zn atoms in the framework because the Cu—Zn and Cu—Cu bonds are shorter than the Zn—Zn bond. The increase in Ba—Zn inter­atomic distances from the Sr—Zn distances is cancelled out by the partial replacement of Zn with Cu atoms, which leads to shorter average Ba—Zn/Cu distances.

Mitochondrial calcium uptake proteins 1 and 2 (MICU1 and MICU2) mediate mitochondrial Ca2+ influx via the mitochondrial calcium uniporter (MCU). Its molecular action for Ca2+ uptake is tightly controlled by the MICU1–MICU2 heterodimer, which comprises Ca2+ sensing proteins which act as gatekeepers at low [Ca2+] or facilitators at high [Ca2+]. However, the mechanism underlying the regulation of the Ca2+ gatekeeping threshold for mitochondrial Ca2+ uptake through the MCU by the MICU1–MICU2 heterodimer remains unclear. In this study, we determined the crystal structure of the apo form of the human MICU1–MICU2 heterodimer that functions as the MCU gatekeeper. MICU1 and MICU2 assemble in the face-to-face heterodimer with salt bridges and me­thio­nine knobs stabilizing the heterodimer in an apo state. Structural analysis suggests how the heterodimer sets a higher Ca2+ threshold than the MICU1 homodimer. The structure of the heterodimer in the apo state provides a framework for understanding the gatekeeping role of the MICU1–MICU2 heterodimer.

AFC TOTTON will host Saints U23s’ Hampshire FA Senior Cup third round tie against Fleet Town on Monday, December 3 (7.45pm).

Dr. Grace Farris is chief of hospital medicine at Mount Sinai West in Manhattan. She also writes a monthly comics column in the Annals of Internal Medicine called "Dr Mom." You can find her on Instagram @coupdegracefarris . Copyright 2020 NPR. To see more, visit https://www.npr.org.

Dr. Grace Farris is chief of hospital medicine at Mount Sinai West in Manhattan. She also writes a monthly comics column in the Annals of Internal Medicine called "Dr Mom." You can find her on Instagram @coupdegracefarris . Copyright 2020 NPR. To see more, visit https://www.npr.org.

Dr. Grace Farris is chief of hospital medicine at Mount Sinai West in Manhattan. She also writes a monthly comics column in the Annals of Internal Medicine called "Dr Mom." You can find her on Instagram @coupdegracefarris . Copyright 2020 NPR. To see more, visit https://www.npr.org.

Dr. Grace Farris is chief of hospital medicine at Mount Sinai West in Manhattan. She also writes a monthly comics column in the Annals of Internal Medicine called "Dr Mom." You can find her on Instagram @coupdegracefarris . Copyright 2020 NPR. To see more, visit https://www.npr.org.

Dr. Grace Farris is chief of hospital medicine at Mount Sinai West in Manhattan. She also writes a monthly comics column in the Annals of Internal Medicine called "Dr Mom." You can find her on Instagram @coupdegracefarris . Copyright 2020 NPR. To see more, visit https://www.npr.org.

Dr. Grace Farris is chief of hospital medicine at Mount Sinai West in Manhattan. She also writes a monthly comics column in the Annals of Internal Medicine called "Dr Mom." You can find her on Instagram @coupdegracefarris . Copyright 2020 NPR. To see more, visit https://www.npr.org.

Dr. Grace Farris is chief of hospital medicine at Mount Sinai West in Manhattan. She also writes a monthly comics column in the Annals of Internal Medicine called "Dr Mom." You can find her on Instagram @coupdegracefarris . Copyright 2020 NPR. To see more, visit https://www.npr.org.

Dr. Grace Farris is chief of hospital medicine at Mount Sinai West in Manhattan. She also writes a monthly comics column in the Annals of Internal Medicine called "Dr Mom." You can find her on Instagram @coupdegracefarris . Copyright 2020 NPR. To see more, visit https://www.npr.org.

Perma.cc archive of https://publications.europa.eu/en/publication-detail/-/publication/5d4f8cde-de25-11e7-a506-01aa75ed71a1 created on 2020-05-08 17:18:55+00:00..

This item belongs to: web/perma_cc.

This item has files of the following types: Metadata

Call them victory anthems. Every time a patient with COVID-19 is well enough to be discharged, hospitals in New York and elsewhere play songs of celebration over the intercom. A doctor explains.