The Squids 3183 Carpenter and Laborer Tool Tethering Kit contains attachment and lanyard solutions specifically for tools commonly used by carpenters and laborers working at height.

Ideal for employees working at height, the Squids 3780S/3780L Power Tool Trap securely wraps around the battery portion of drills, impact drivers and other cordless power tools while boasting a fully cast D-ring connection point to safely and easily attach a lanyard.

What’s being done to simplify the tool tethering category to make the spec process easier for safety managers and encourage adoption on the worksite?

Copper-containing nitrite reductases (CuNiRs) are found in all three kingdoms of life and play a major role in the denitrification branch of the global nitro­gen cycle where nitrate is used in place of di­oxy­gen as an electron acceptor in respiratory energy metabolism. Several C- and N-terminal redox domain tethered CuNiRs have been identified and structurally characterized during the last decade. Our understanding of the role of tethered domains in these new classes of three-domain CuNiRs, where an extra cytochrome or cupredoxin domain is tethered to the catalytic two-domain CuNiRs, has remained limited. This is further compounded by a complete lack of substrate-bound structures for these tethered CuNiRs. There is still no substrate-bound structure for any of the as-isolated wild-type tethered enzymes. Here, structures of nitrite and product-bound states from a nitrite-soaked crystal of the N-terminal cupredoxin-tethered enzyme from the Hyphomicrobium denitrificans strain 1NES1 (Hd1NES1NiR) are provided. These, together with the as-isolated structure of the same species, provide clear evidence for the role of the N-terminal peptide bearing the conserved His27 in water-mediated anchoring of the substrate at the catalytic T2Cu site. Our data indicate a more complex role of tethering than the intuitive advantage for a partner-protein electron-transfer complex by narrowing the conformational search in such a combined system.

Tethering stakes of the nature intended to be pounded flush with or below ground level. Certain of the tethering stakes include a cap on the pounding end which is adapted for ease of placement and release of a tethering line. Accordingly, the tethering line can be removed from the stake when it is to be pounded into the ground and then engaged with the stake only when tethering is desired. Certain of the embodiments include caps having uniquely shaped apertures for securing the tethering line. Another includes an aperture in communication with an aperture in the stake such that a lead cable or the like may be moved out of the way when the stake is pounded into the ground and may be fully received within the stake when tethering is not desired. Another embodiment employs a coupler passing through an aperture directly beneath the pounding surface to facilitate ease of attachment and removal of the tethering line.

A tethering stake includes a rod having a point at one end thereof and a driving cap at an opposite end. A collar is fixed to the rod adjacent to and spaced from the driving cap, thus providing a neck to receive a tether line or chain. A cap cover is slidingly received upon the rod and is adapted to be selectively engaged with the collar. The cap cover includes a central circular aperture with a radial slot extending therefrom. The centrally positioned aperture and slot allow the cover to assume a position substantially parallel to the rod during shipment and storage, while allowing it to take a position substantially orthogonal to the rod when the rod is driven into the ground.

A portable folding support structure for safely tethering an individual comprises a portable cart sized to fit through a residential doorway, having wheels and a motor that actuates at least one of the wheels. A hand-operated throttle and steering device control the cart. The cart comprises an extendable anchoring plate to prevent rolling. A substantially horizontal jib with the cart comprises a harness point for receiving a safety cable to which an individual is attached to allow safe cleaning practices and to minimize fall risk. A foldable outrigger provides stability to the cart and an anchoring pad attaches to a distal region of the outrigger to promote stability. A textile liquid-absorbing surface is positionable about an outer surface of a glass balcony to inhibit cleaning liquids from spilling below the level of the liquid-absorbing surface.

A tether device includes a magnetic base; a pole having a first end attached to the magnetic base; and a connector or clip attached at a second end of the pole, for removably connecting the tethering device to a user. Also, a method for tethering a user to a hull of a vessel including the steps of providing a tether device having a magnetic base, a pole having a first end attached to the magnetic base, and a connector or clip attached at a second end of the pole; connecting the connector or clip to the user; and engaging the magnetic base with the hull of the vessel.

fficers from the Delaware Division of Public Health (DPH) Office of Animal Welfare (OAW) arrested a Milford woman on Tuesday July 23, 2019, following the death of a dog that was tethered outside of a home during dangerously hot temperatures.

Dynamic regulation of the mitochondrial network by mitofusins (MFNs) modulates energy production, cell survival, and many intracellular signaling events, including calcium handling. However, the relative importance of specific mitochondrial functions and their dependence on MFNs vary greatly among cell types. Osteoclasts have many mitochondria, and increased mitochondrial biogenesis and oxidative phosphorylation enhance bone resorption, but little is known about the mitochondrial network or MFNs in osteoclasts. Because expression of each MFN isoform increases with osteoclastogenesis, we conditionally deleted MFN1 and MFN2 (double conditional KO (dcKO)) in murine osteoclast precursors, finding that this increased bone mass in young female mice and abolished osteoclast precursor differentiation into mature osteoclasts in vitro. Defective osteoclastogenesis was reversed by overexpression of MFN2 but not MFN1; therefore, we generated mice lacking only MFN2 in osteoclasts. MFN2-deficient female mice had increased bone mass at 1 year and resistance to Receptor Activator of NF-κB Ligand (RANKL)-induced osteolysis at 8 weeks. To explore whether MFN-mediated tethering or mitophagy is important for osteoclastogenesis, we overexpressed MFN2 variants defective in either function in dcKO precursors and found that, although mitophagy was dispensable for differentiation, tethering was required. Because the master osteoclastogenic transcriptional regulator nuclear factor of activated T cells 1 (NFATc1) is calcium-regulated, we assessed calcium release from the endoplasmic reticulum and store-operated calcium entry and found that the latter was blunted in dcKO cells. Restored osteoclast differentiation by expression of intact MFN2 or the mitophagy-defective variant was associated with normalization of store-operated calcium entry and NFATc1 levels, indicating that MFN2 controls mitochondrion–endoplasmic reticulum tethering in osteoclasts.