Dame Flora Duffy is gearing up for her first race in the T100 Triathlon World Tour in Ibiza, Spain. The five-time Olympian will compete in the fifth leg of the eight-race series on the Mediterranean island from September 28 to 29. Among the contracted women’s triathletes on the start list for Ibiza are Ashleigh Gentle, […]

Dame Flora Duffy said she is excited to test herself in her first outing in the T100 Triathlon World Tour for two years. The five-time Olympian will compete in the fifth leg of the eight-race series in Ibiza, Spain, on Saturday [September 28]. “Excited to get back to some T100 Triathlon racing this weekend in […]

[Written by Stephen Wright] Dame Flora Duffy said she is excited to be heading into unfamiliar territory as she prepares for her first T100 Triathlon World Tour race for two years. The five-time Olympian, who competes in the fifth leg of the eight-race series in Ibiza, Spain, tomorrow [September 28], is entering a new phase […]

Dame Flora Duffy said she is determined to “fight for every position” as she gears up for the Lake Las Vegas T100 Triathlon World Tour professional women’s race on Saturday [October 19]. The five-time Olympian competed in her first race of the series in Ibiza, Spain, last month and finished in ninth place. Vegas marks […]

In this series, David Legge looks at how the Minor Prophet, Habakkuk, teaches us to be 'Confident in the Chaos' around us. In these times of uncertainty and confusion, there are some clear principles that will not only help you to survive but enable you to thrive by faith! This first instalment is entitled 'The Paradox of Faith'. If you are questioning 'What on Earth God is doing?' in your life or in the world, then you'll glean some helpful truths from this message. Your questions and faith in God are not mutually exclusive. You can bring your questions to God and He will be your Answer! This message is available at https://www.preachtheword.com now in MP3 audio format and in HD video on our YouTube Channel (https://youtube.com/PreachTheWord)...

Our new series on 'The Holy Spirit' seeks to reintroduce us to the oft-neglected third Person of the Godhead. Even those who claim to move in the power of the Spirit don't always have a deep relationship with Him as a Person. So, join us as we seek a deeper knowledge and fellowship with 'God on Earth' - the Holy Spirit. In our first study, we ask the question: are you walking in everything of the Holy Spirit that God intended for you as His child? Acts 19 presents us with some 'disciples' who had not entered a full experience of the Holy Spirit. Let's see what we can learn from their interview with Paul, as he asks 'Have You Received?'. This message is available at https://www.preachtheword.com now in MP3 audio format and in HD video on our YouTube Channel (https://youtube.com/PreachTheWord)...

In this introduction to a sub-series in our wider study on 'The Holy Spirit', we consider: what exactly is the Fruit of the Spirit? Whose life is it anyway? Here in 'The Fruit Of The Spirit - God's Personality' we find the answer to why the Christian life is impossible to live in the flesh. This sermon is available at https://www.preachtheword.com now in MP3 audio format and in HD video on our YouTube Channel (https://youtube.com/PreachTheWord)...

What is the difference between Holy Spirit fruit and merely human-produced work? We will see in this study of 'The Fruit Of The Spirit - Fruit vs Works' that the Fruit of the Spirit is an indication that we are rooted in the life of Christ Himself. As the saying goes, 'A machine can do work, only life can produce fruit'. This sermon is available at https://www.preachtheword.com now in MP3 audio format and in HD video on our YouTube Channel (https://youtube.com/PreachTheWord)...

As we continue our series on 'The Holy Spirit' with a time of focus on the fruit of the Spirit, in Part 12 we discover that 'Love' is the fruit of the Spirit that all the other fruit stem from. In this episode David shows us how Christian love is meant to be the very love of God Himself - and love is how we are to be known as Christians. This message is available at https://www.preachtheword.com now in MP3 audio format and in HD video on our YouTube Channel (https://youtube.com/PreachTheWord)...

How do we understand joy? How do we secure our joy? In Part 13 of our studies in 'The Holy Spirit', we continue with our look at the Fruit of the Spirit as we consider what true 'Joy' is and how God is the source of all joy. We discover how joy is at the heart of the gospel and is an essential ingredient to the Christian life, as well as reaching others for Jesus. You'll also be given some practical steps to release more joy in your life. This episode is available at https://www.preachtheword.com now in MP3 audio format and in HD video on our YouTube Channel (https://youtube.com/PreachTheWord)...

In Part 14 of 'The Holy Spirit' we continue with a study of 'The Fruit Of The Spirit - Peace'. The peace of God is not just something He has and gives, but peace is something He is. Peace is a characteristic of God's nature. We've learned that this fruit of the Spirit is the very personality of God exhibited in us through the Holy Spirit. In this session you will learn how to cultivate a mind, heart and life of peace. How valuable this is in a world so dominated by fear and anxiety! This message is available at https://www.preachtheword.com now in MP3 audio format and in HD video on our YouTube Channel (https://youtube.com/PreachTheWord)...

'Patience' is a virtue we have mixed emotions about. We wish we had it but we don't want to need it. Often we need it when facing a trial of some sort. In Part 15 of our series on 'The Holy Spirit' we learn where we can find such patience, how we grow in it and the amazing advantages patience brings to our lives. This is a much-neglected characteristic the Spirit brings into our lives. Listen and learn more in 'The Fruit Of The Spirit - Patience'. This episode is available at https://www.preachtheword.com now in MP3 audio format and in HD video on our YouTube Channel (https://youtube.com/PreachTheWord)...

In Part 16 of 'The Holy Spirit', we continue to explore the fruit of the Spirit as we discover that 'Kindness' is evidence of love and indeed love in action! Are we known for our kindness? What does that look like in our words and our deeds? Watch and listen as we consider the great kindness of God and how we can share His kindness with our world. This episode is available at https://www.preachtheword.com now in MP3 audio format and in HD video on our YouTube Channel (https://youtube.com/PreachTheWord)...

We continue our look at 'The Fruit Of The Spirit' in Part 17 of our series on 'The Holy Spirit'. God is love, and of course all the fruit of the Spirit flow from His nature of love. Love is 'Goodness' and we have a good God because we have a loving God. In this session we look at what God's goodness means to us and for us as we display the life of Christ to others. Because God is good, we ought to manifest His goodness to the world around us! This sermon is available at https://www.preachtheword.com now in MP3 audio format and in HD video on our YouTube Channel (https://youtube.com/PreachTheWord)...

If we are to produce the fruit of 'Faithfulness' in our lives it can only be experienced out of our cultivated relationship with the Holy Spirit and the life of God Himself, which He brings to us and displays through us. In our consideration of the next gift of the Spirit, for Part 18 of our series on 'The Holy Spirit', we discover that the only way to be faithful to God and other people is to be overwhelmed by the awesome faithfulness of God Himself. This message is available at https://www.preachtheword.com now in MP3 audio format and in HD video on our YouTube Channel (https://youtube.com/PreachTheWord)...

Have you ever prayed for more gentleness? Have you ever heard teaching on 'how to be gentle'? Do you imagine God as gentle? When you think you are hearing God speak to you, is it with a gentle tone? We trust this next video on 'The Fruit of the Spirit - Gentleness', will answer these and other questions for you. 'Gentleness' or 'meekness' is a much neglected and tragically undervalued attribute that we and others would so benefit from if we experienced it through the Holy Spirit's power. Indeed, this is how we would better influence the people around us to be Christians. As Jesus put it in Matthew 5:5 'Blessed are the meek: for they shall inherit the earth'. This message is available at https://www.preachtheword.com now in MP3 audio format and in HD video on our YouTube Channel (https://youtube.com/PreachTheWord)...

In 'Revival Now', David Legge asks and seeks to answer the question: What might revival look like in the 2020s? Or, to consider it another way: What is the revival we need for today? Of course, there are common features to every revival, and yet there are always distinctives to every one. We can never second guess God in how He will move again - yet we do have desperate needs in our age that only God can meet. In this series, David looks at how we need a new move of God's Spirit to meet the contemporary needs in the church and our world in this present moment. In Part 1, we explore how the church and we as Christians need to get our focus back on Jesus. He must be the pre-eminent one and the centre of all we do and are. What idols have distracted us from the centrality of Christ? How can we give our Lord His rightful place in our lives and churches? This message is available at https://www.preachtheword.com now in MP3 audio format...

Join us for 'Helping Others To Freedom', a series based on David Legge's book, 'Breaking Through Barriers to Blessing'. We will explore how we can be set free from bondages of Satan and healed from wounds of the heart. This study is for people who need set free themselves, or for those who want to be used to help others into freedom. In this introductory episode, David lays down some biblical foundations and considers how freedom ministry is something the church is commissioned by Jesus to engage in today. This message is available at https://www.preachtheword.com now in MP3 audio format and in HD video on our YouTube Channel (https://youtube.com/PreachTheWord)...

In the concluding session of 'Helping Others To Freedom', we look at how the principles of personal healing and deliverance apply to whole regions, and are essentially the same principles that can prepare a region for revival awakening. This is 'Revival And Deliverance - The Bigger Picture' - God sets individuals free in order to heal and deliver the world. This session is available at https://www.preachtheword.com now in MP3 audio format and in HD video on our YouTube Channel (https://youtube.com/PreachTheWord)...

There is much of Jesus' early life we don't know about. We know He didn't begin His earthly ministry until around the age of 30. What did He do in those preceding years? Those years in obscurity were a vital part of 'Jesus' Preparation For Ministry'. What lessons can we learn from such obscurity and silent years? Follow Him 'From Obscurity To Prominence', as we consider this question and also the importance of Christ's baptism, holiness, obedience and His empowerment by the Spirit. This message is available at https://www.preachtheword.com now in MP3 audio format and in HD video on our YouTube Channel (https://youtube.com/PreachTheWord)...

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Blending transparency and flexibility within commercial spaces, the new Tubelite INT14 Interior Flush Glaze Framing System offers versatile design options for floor-to-ceiling room enclosures or freestanding partitions. Expanding choices for facility managers, design professionals and glazing contractors, the INT14 system provides necessary separation and prioritizes daylight, visual connection and sound reduction.

The aberrant fibrillization of huntingtin exon 1 (Httex1) characterized by an expanded polyglutamine (polyQ) tract is a defining feature of Huntington's disease, a neurodegenerative disorder. Recent investigations underscore the involvement of a small EDRK-rich factor 1a (SERF1a) in promoting Httex1 fibrillization through interactions with its N terminus. By establishing an integrated approach with size-exclusion-column-based small- and wide-angle X-ray scattering (SEC-SWAXS), NMR, and molecular simulations using Rosetta, the analysis here reveals a tight binding of two NT17 fragments of Httex1 (comprising the initial 17 amino acids at the N terminus) to the N-terminal region of SERF1a. In contrast, examination of the complex structure of SERF1a with a coiled NT17-polyQ peptide (33 amino acids in total) indicates sparse contacts of the NT17 and polyQ segments with the N-terminal side of SERF1a. Furthermore, the integrated SEC-SWAXS and molecular-simulation analysis suggests that the coiled NT17 segment can transform into a helical conformation when associated with a polyQ segment exhibiting high helical content. Intriguingly, NT17-polyQ peptides with enhanced secondary structures display diminished interactions with SERF1a. This insight into the conformation-dependent binding of NT17 provides clues to a catalytic association mechanism underlying SERF1a's facilitation of Httext1 fibrillization.

New DYU T1 20-inch 15.5mph 36V 250W electric bike with torque sensor for city riding

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A Detailed Comparison of Bodywel T16 and DYU D3F Electric Bikes for City Commuters

The HT10 True Wireless Bluetooth Earbuds by Lenovo are aimed towards consumers on a tight budget looking to get the best bang for the buck. ... [PCSTATS]

The EURUSD is pushing against its 2024 low at 1.0601. A break below that level would open the door for further downside momentum. A move to new laws would take the price to the lowest level since November 2, 2023.

There is not a lot support technically until a swing area near 1.05158 and 1.05316.

Internet Archive crawl data from the Reddit crawl, captured by crawl901.us.archive.org:reddit from Tue Nov 12 16:11:02 PST 2024 to Tue Nov 12 08:15:21 PST 2024..

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REVIEW – 3D printing is fun and challenging. You can download countless free files from sites like Thingiverse and Printables, Cults 3D, and Thangs, or create your own using Fusion 360 TinkerCAD. It takes time, patience, and a love of tinkering, but it can be great fun. Many 3D printing enthusiasts will agree that incessant […]

Knockout mouse models have been extensively used to study the antiviral activity of IFIT (interferon-induced protein with tetratricopeptide repeats). Human IFIT1 binds to cap0 (m7GpppN) RNA, which lacks methylation on the first and second cap-proximal nucleotides (cap1, m7GpppNm, and cap2, m7GpppNmNm, respectively). These modifications are signatures of “self” in higher eukaryotes, whereas unmodified cap0-RNA is recognized as foreign and, therefore, potentially harmful to the host cell. IFIT1 inhibits translation at the initiation stage by competing with the cap-binding initiation factor complex, eIF4F, restricting infection by certain viruses that possess “nonself” cap0-mRNAs. However, in mice and other rodents, the IFIT1 orthologue has been lost, and the closely related Ifit1b has been duplicated twice, yielding three paralogues: Ifit1, Ifit1b, and Ifit1c. Although murine Ifit1 is similar to human IFIT1 in its cap0-RNA–binding selectivity, the roles of Ifit1b and Ifit1c are unknown. Here, we found that Ifit1b preferentially binds to cap1-RNA, whereas binding is much weaker to cap0- and cap2-RNA. In murine cells, we show that Ifit1b can modulate host translation and restrict WT mouse coronavirus infection. We found that Ifit1c acts as a stimulatory cofactor for both Ifit1 and Ifit1b, promoting their translation inhibition. In this way, Ifit1c acts in an analogous fashion to human IFIT3, which is a cofactor to human IFIT1. This work clarifies similarities and differences between the human and murine IFIT families to facilitate better design and interpretation of mouse models of human infection and sheds light on the evolutionary plasticity of the IFIT family.

In addition to their well-known role in the control of cellular proliferation and cancer, cell cycle regulators are increasingly identified as important metabolic modulators. Several GWAS have identified SNPs near CDKN2A, the locus encoding for p16INK4a (p16), associated with elevated risk for cardiovascular diseases and type-2 diabetes development, two pathologies associated with impaired hepatic lipid metabolism. Although p16 was recently shown to control hepatic glucose homeostasis, it is unknown whether p16 also controls hepatic lipid metabolism. Using a combination of in vivo and in vitro approaches, we found that p16 modulates fasting-induced hepatic fatty acid oxidation (FAO) and lipid droplet accumulation. In primary hepatocytes, p16-deficiency was associated with elevated expression of genes involved in fatty acid catabolism. These transcriptional changes led to increased FAO and were associated with enhanced activation of PPARα through a mechanism requiring the catalytic AMPKα2 subunit and SIRT1, two known activators of PPARα. By contrast, p16 overexpression was associated with triglyceride accumulation and increased lipid droplet numbers in vitro, and decreased ketogenesis and hepatic mitochondrial activity in vivo. Finally, gene expression analysis of liver samples from obese patients revealed a negative correlation between CDKN2A expression and PPARA and its target genes. Our findings demonstrate that p16 represses hepatic lipid catabolism during fasting and may thus participate in the preservation of metabolic flexibility.

Genetic variants that increase the risk of fatty liver disease (FLD) and cirrhosis have recently been identified in the proximity of membrane bound O-acyltransferase domain-containing 7 (MBOAT7).  To elucidate the link between these variants and FLD we characterized Mboat7 liver-specific knock-out mice (Mboat7-LSKO).  Chow-fed Mboat7-LSKO mice developed fatty livers and associated liver injury.  Lipidomic analysis of liver using mass spectrometry revealed a pronounced reduction in 20-carbon polyunsaturated fatty acid content in phosphatidylinositols (PIs), but not in other phospholipids. The change in fatty acid composition of PIs in these mice was associated with a marked increase in de novo lipogenesis due to activation of SREBP-1c, a transcription factor that coordinates the activation of genes encoding enzymes in the fatty acid biosynthesis pathway. Hepatic removal of both SREBP cleavage activating protein (Scap) and Mboat7 normalized hepatic triglycerides relative to Scap only hepatic knock-out showing increased SREBP-1c processing is required for Mboat7 induced steatosis.  This study reveals a clear relationship between PI fatty acid composition and regulation of hepatic fat synthesis and delineates the mechanism by which mutations in MBOAT7 cause hepatic steatosis.

Matthew F. Glasser
Aug 10, 2011; 31:11597-11616
BehavioralSystemsCognitive

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The automotive industry revolutionized the definition of a vehicle in terms of safety, comfort, enhanced autonomy, and internet connectivity. With this trend, the automotive industry rapidly adopted automotive Ethernet such as 10Base-T1, 100Base-T1, and in some cases, 1000Base-T1. 

Faster Speed (than CAN-FD), Scalability, embedded security protocols (like MacSec), cost and energy efficiency, and simple yet redundant network made Ethernet an obvious choice over CAN(FD) and FlexRay.  

Ethernet 10Base-T1 

10BASE-T1S is defined under IEEE with 802.3cg. The S in 10BASE-T1S stands for a short distance. 10BASE-T1S uses a multidrop topology, where each node connects to a single cable. Multidrop topology eliminates the need for switches and, as a result, fewer cables/less cost. The primary goal of 10BASE-T1S is a deterministic transmission on a collision-free multidrop network. 10BASE-T1S cables use a pair of twisted wires. As per IEEE, at least eight nodes can connect to each, but more connections are feasible.    

The Physical Layer Collision Avoidance [PLCA] protocol ensures that it uses the entire 10 Mbps bandwidth. In 10BaseTs, Reconciliation Sublayer provides optional Physical Layer Collision Avoidance (PLCA) capabilities among participating stations. Using PLCA-enabled Physical Layers in CSMA/CD half-duplex shared-medium networks can provide enhanced bandwidth and improved access latency under heavily loaded traffic conditions. The working principle of PLCA is that transmit opportunities on a mixing segment are granted in sequence based on a node ID unique to the local collision domain (set by the management entity). 10BASE-T1S also supports an arbitration scheme that guarantees consistent node access to the media within a predefined time.  

The 10BASE-T1S PHY is intended to cover the low-speed/low-cost applications in the industrial and automotive environment. A large number of pins (16) required by the MII interface is one of the significant cost factors that must be addressed to fulfill this objective. The 10BASE-T1S "Transceiver" solution is suited for embedded systems where the digital portion of the PHY is fully integrated, e.g., into an MCU or an Ethernet switch core, leaving only the analog portion (the transceiver) into a separate IC. 

Ethernet 100Base-T1/1000Base-T1 

100Base-T1 and 1000Base-T1 can be used for audio/video information. With Higher bandwidth capacity, 100Base-T1/ 1000Base-T1 paired with AVB (Audio video bridging) can be used for car infotainment systems. 100Base-T1/1000Base-T1 paired with time-sensitive networking [TSN] protocol can be used to fulfill the automotive industry's mission-critical, time-sensitive, and deterministic latency needs. 

 PTP Over MacSec  

With today's automotive network, all the Electronic Control Units connected require timing accuracy and network synchronization, Precision Time Protocol (PTP), defined in IEEE 1588, provides synchronized clocks throughout a network.  While maintaining the timing accuracy for mission-critical applications, protecting the vehicle network from vulnerable threats is mandatory, and PTP over MacSec provides the consolidated solution.  

With the availability of the Cadence Verification IP for 10/100/1000BaseT1 and TSN, adopters can start working with these specifications immediately, ensuring compliance with the standard and achieving the fastest path to IP and SoC verification closure. The 10/100/1000GBaseT1 and TSN provide a full-stack solution, including support to the PHY, MAC, and TSN layers with a comprehensive coverage model and protocol checkers. Ethernet BaseT1 and TSN VIP covers all features required for complete coverage verification closure. More details are available in the Ethernet Verification IP portfolio. 

Krunal 

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Long noncoding (lnc)RNAs emerge as regulators of genome stability. The nuclear-enriched abundant transcript 1 (NEAT1) is overexpressed in many tumors and is responsive to genotoxic stress. However, the mechanism that links NEAT1 to DNA damage response (DDR) is unclear. Here, we investigate the expression, modification, localization, and structure of NEAT1 in response to DNA double-strand breaks (DSBs). DNA damage increases the levels and N6-methyladenosine (m⁶A) marks on NEAT1, which promotes alterations in NEAT1 structure, accumulation of hypermethylated NEAT1 at promoter-associated DSBs, and DSB signaling. The depletion of NEAT1 impairs DSB focus formation and elevates DNA damage. The genome-protective role of NEAT1 is mediated by the RNA methyltransferase 3 (METTL3) and involves the release of the chromodomain helicase DNA binding protein 4 (CHD4) from NEAT1 to fine-tune histone acetylation at DSBs. Our data suggest a direct role for NEAT1 in DDR.

Mitochondrial dysfunction is a hallmark of many genetic neurodegenerative diseases, but therapeutic options to reverse mitochondrial dysfunction are limited. While recent studies support the possibility of improving mitochondrial fusion/fission dynamics and motility to correct mitochondrial dysfunction and resulting neurodegeneration in Charcot-Marie-Tooth disease (CMT) and other neuropathies, the clinical utility of reported compounds and relevance of preclinical models are uncertain. Here, we describe motor and sensory neuron dysfunction characteristic of clinical CMT type 2 A in a CRISPR/Casp-engineered Mfn2 Thr105Met (T105M) mutant knock-in mouse. We further demonstrate that daily oral treatment with a novel mitofusin activator derived from the natural product piperine can reverse these neurologic phenotypes. Piperine derivative 8015 promoted mitochondrial fusion and motility in Mfn2-deficient cells in a mitofusin-dependent manner and reversed mitochondrial dysfunction in cultured fibroblasts and reprogrammed motor neurons from a human CMT2A patient carrying the MFN2 T105M mutation. Like previous mitofusin activators, 8015 exhibited stereospecific functionality, but the more active stereoisomer, 8015-P2, is unique in that it has subnanomolar potency and undergoes entero-hepatic recirculation which extends its in vivo half-life. Daily administration of 8015-P2 to Mfn2 T105M knock-in mice for 6 weeks normalized neuromuscular and sensory dysfunction and corrected histological/ultrastructural neurodegeneration and neurogenic myoatrophy. These studies describe a more clinically relevant mouse model of CMT2A and an improved mitofusin activator derived from piperine. We posit that 8015-P2 and other piperine derivatives may benefit CMT2A or other neurodegenerative conditions wherein mitochondrial dysdynamism plays a contributory role.

BACKGROUND AND PURPOSE:

A cleftlike nonenhancing hypointensity was observed repeatedly in the pituitary gland at the adenohypophysis/neurohypophysis border on contrast-enhanced 3D fat-saturated T1-MPRAGE using clinical 7T MRI. Our primary goal was to assess the prevalence of this finding. The secondary goals were to evaluate the frequency of other incidental pituitary lesions, MRI artifacts, and their effect on pituitary imaging on the contrast-enhanced 3D fat-saturated T1 MPRAGE at 7T.

BACKGROUND AND PURPOSE:

Intracranial vessel wall imaging is technically challenging to implement, given the simultaneous requirements of high spatial resolution, excellent blood and CSF signal suppression, and clinically acceptable gradient times. Herein, we present our preliminary findings on the evaluation of a deep learning–optimized sequence using T1-weighted imaging.

Writer’s Digest is celebrating its 100th anniversary, which is pretty epic. At the same time, the parent company of F&W is also declaring bankruptcy. It was the best of times, it was the worst of times… I’ve been at the writing game since the early 1990s. I was a teenager when I first mailed off […]

Malaria claims more than 600,000 lives annually, and as temperatures rise, the disease's potential spread is expanding. Although certain medications can